Tissue | Expression Dynamics | Abbreviation |
Colorectum (GSE201348) | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Colorectum/Becker/UNC13B_pca_on_diff_genes.png) | FAP: Familial adenomatous polyposis |
CRC: Colorectal cancer |
Colorectum (HTA11) | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Colorectum/Chen/UNC13B_pca_on_diff_genes.png) | AD: Adenomas |
SER: Sessile serrated lesions |
MSI-H: Microsatellite-high colorectal cancer |
MSS: Microsatellite stable colorectal cancer |
Esophagus | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Esophagus/UNC13B_pca_on_diff_genes.png) | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias |
LGIN: Low-grade intraepithelial neoplasias |
Lung | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Lung/UNC13B_pca_on_diff_genes.png) | AAH: Atypical adenomatous hyperplasia |
AIS: Adenocarcinoma in situ |
IAC: Invasive lung adenocarcinoma |
MIA: Minimally invasive adenocarcinoma |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00097492 | Colorectum | MSS | response to glucose | 64/3467 | 212/18723 | 2.43e-05 | 5.09e-04 | 64 |
GO:00093062 | Colorectum | MSS | protein secretion | 98/3467 | 359/18723 | 2.43e-05 | 5.09e-04 | 98 |
GO:00713332 | Colorectum | MSS | cellular response to glucose stimulus | 49/3467 | 151/18723 | 2.73e-05 | 5.58e-04 | 49 |
GO:00355922 | Colorectum | MSS | establishment of protein localization to extracellular region | 98/3467 | 360/18723 | 2.75e-05 | 5.58e-04 | 98 |
GO:00016782 | Colorectum | MSS | cellular glucose homeostasis | 54/3467 | 172/18723 | 3.11e-05 | 6.25e-04 | 54 |
GO:00713312 | Colorectum | MSS | cellular response to hexose stimulus | 49/3467 | 153/18723 | 4.01e-05 | 7.61e-04 | 49 |
GO:00716922 | Colorectum | MSS | protein localization to extracellular region | 99/3467 | 368/18723 | 4.17e-05 | 7.83e-04 | 99 |
GO:00713262 | Colorectum | MSS | cellular response to monosaccharide stimulus | 49/3467 | 154/18723 | 4.84e-05 | 8.80e-04 | 49 |
GO:00507141 | Colorectum | MSS | positive regulation of protein secretion | 42/3467 | 137/18723 | 3.95e-04 | 4.91e-03 | 42 |
GO:19035321 | Colorectum | MSS | positive regulation of secretion by cell | 74/3467 | 282/18723 | 7.93e-04 | 8.36e-03 | 74 |
GO:00510472 | Colorectum | MSS | positive regulation of secretion | 80/3467 | 310/18723 | 8.55e-04 | 8.75e-03 | 80 |
GO:00224062 | Colorectum | MSS | membrane docking | 28/3467 | 86/18723 | 1.27e-03 | 1.21e-02 | 28 |
GO:00990031 | Colorectum | MSS | vesicle-mediated transport in synapse | 54/3467 | 200/18723 | 1.94e-03 | 1.67e-02 | 54 |
GO:01400562 | Colorectum | MSS | organelle localization by membrane tethering | 25/3467 | 77/18723 | 2.34e-03 | 1.91e-02 | 25 |
GO:00508082 | Colorectum | MSS | synapse organization | 101/3467 | 426/18723 | 3.96e-03 | 2.89e-02 | 101 |
GO:0099504 | Colorectum | MSS | synaptic vesicle cycle | 48/3467 | 181/18723 | 4.85e-03 | 3.39e-02 | 48 |
GO:19049514 | Colorectum | FAP | positive regulation of establishment of protein localization | 82/2622 | 319/18723 | 1.83e-08 | 1.87e-06 | 82 |
GO:00512224 | Colorectum | FAP | positive regulation of protein transport | 78/2622 | 303/18723 | 3.79e-08 | 3.23e-06 | 78 |
GO:00432544 | Colorectum | FAP | regulation of protein-containing complex assembly | 101/2622 | 428/18723 | 5.18e-08 | 4.07e-06 | 101 |
GO:00313344 | Colorectum | FAP | positive regulation of protein-containing complex assembly | 62/2622 | 237/18723 | 5.03e-07 | 2.61e-05 | 62 |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
UNC13B | SNV | Missense_Mutation | novel | c.3284N>C | p.Gly1095Ala | p.G1095A | O14795 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-5L-AAT1-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Hormone Therapy | letrozol | SD |
UNC13B | SNV | Missense_Mutation | | c.74C>T | p.Thr25Ile | p.T25I | O14795 | protein_coding | deleterious_low_confidence(0) | probably_damaging(0.985) | TCGA-A2-A0D1-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | taxotere | SD |
UNC13B | SNV | Missense_Mutation | | c.2542N>T | p.Ala848Ser | p.A848S | O14795 | protein_coding | tolerated(0.18) | benign(0.067) | TCGA-A2-A0D4-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | SD |
UNC13B | SNV | Missense_Mutation | | c.202N>C | p.Gly68Arg | p.G68R | O14795 | protein_coding | deleterious_low_confidence(0) | probably_damaging(1) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
UNC13B | SNV | Missense_Mutation | | c.1477N>A | p.Glu493Lys | p.E493K | O14795 | protein_coding | deleterious(0) | probably_damaging(0.964) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
UNC13B | SNV | Missense_Mutation | rs770226679 | c.665C>T | p.Ser222Leu | p.S222L | O14795 | protein_coding | tolerated_low_confidence(0.69) | benign(0) | TCGA-AO-A128-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | SD |
UNC13B | SNV | Missense_Mutation | rs542947932 | c.1462C>G | p.Pro488Ala | p.P488A | O14795 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-B6-A0IM-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
UNC13B | SNV | Missense_Mutation | rs576351913 | c.4543N>T | p.His1515Tyr | p.H1515Y | O14795 | protein_coding | tolerated(0.32) | possibly_damaging(0.616) | TCGA-BH-A0B4-01 | Breast | breast invasive carcinoma | Male | >=65 | III/IV | Hormone Therapy | tamoxiphen | SD |
UNC13B | SNV | Missense_Mutation | novel | c.3157G>C | p.Val1053Leu | p.V1053L | O14795 | protein_coding | tolerated(0.05) | benign(0.007) | TCGA-BH-A1FC-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
UNC13B | SNV | Missense_Mutation | | c.355N>T | p.His119Tyr | p.H119Y | O14795 | protein_coding | deleterious_low_confidence(0) | probably_damaging(0.996) | TCGA-D8-A1J8-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | nolvadex | SD |