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Gene: TUSC3 |
Gene summary for TUSC3 |
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Gene information | Species | Human | Gene symbol | TUSC3 | Gene ID | 7991 |
Gene name | tumor suppressor candidate 3 | |
Gene Alias | D8S1992 | |
Cytomap | 8p22 | |
Gene Type | protein-coding | GO ID | GO:0003008 | UniProtAcc | Q13454 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
7991 | TUSC3 | LZE2T | Human | Esophagus | ESCC | 3.77e-05 | 7.75e-01 | 0.082 |
7991 | TUSC3 | LZE4T | Human | Esophagus | ESCC | 9.92e-17 | 6.66e-01 | 0.0811 |
7991 | TUSC3 | LZE20T | Human | Esophagus | ESCC | 4.22e-06 | 1.52e-01 | 0.0662 |
7991 | TUSC3 | LZE22T | Human | Esophagus | ESCC | 1.11e-08 | 7.03e-01 | 0.068 |
7991 | TUSC3 | P2T-E | Human | Esophagus | ESCC | 2.70e-130 | 2.69e+00 | 0.1177 |
7991 | TUSC3 | P4T-E | Human | Esophagus | ESCC | 7.47e-77 | 2.19e+00 | 0.1323 |
7991 | TUSC3 | P5T-E | Human | Esophagus | ESCC | 2.39e-24 | 5.69e-01 | 0.1327 |
7991 | TUSC3 | P8T-E | Human | Esophagus | ESCC | 6.71e-60 | 1.23e+00 | 0.0889 |
7991 | TUSC3 | P9T-E | Human | Esophagus | ESCC | 2.14e-09 | 5.08e-01 | 0.1131 |
7991 | TUSC3 | P10T-E | Human | Esophagus | ESCC | 6.60e-111 | 2.37e+00 | 0.116 |
7991 | TUSC3 | P11T-E | Human | Esophagus | ESCC | 2.77e-07 | 7.21e-01 | 0.1426 |
7991 | TUSC3 | P12T-E | Human | Esophagus | ESCC | 9.13e-35 | 7.76e-01 | 0.1122 |
7991 | TUSC3 | P16T-E | Human | Esophagus | ESCC | 7.46e-101 | 1.99e+00 | 0.1153 |
7991 | TUSC3 | P17T-E | Human | Esophagus | ESCC | 2.55e-08 | 8.01e-01 | 0.1278 |
7991 | TUSC3 | P19T-E | Human | Esophagus | ESCC | 3.90e-03 | 8.29e-01 | 0.1662 |
7991 | TUSC3 | P20T-E | Human | Esophagus | ESCC | 1.80e-22 | 4.23e-01 | 0.1124 |
7991 | TUSC3 | P21T-E | Human | Esophagus | ESCC | 2.18e-51 | 1.11e+00 | 0.1617 |
7991 | TUSC3 | P22T-E | Human | Esophagus | ESCC | 8.16e-75 | 1.36e+00 | 0.1236 |
7991 | TUSC3 | P23T-E | Human | Esophagus | ESCC | 6.50e-22 | 9.25e-01 | 0.108 |
7991 | TUSC3 | P24T-E | Human | Esophagus | ESCC | 9.15e-56 | 1.39e+00 | 0.1287 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:001827910 | Skin | cSCC | protein N-linked glycosylation via asparagine | 16/4864 | 23/18723 | 1.47e-05 | 1.82e-04 | 16 |
GO:00064877 | Skin | cSCC | protein N-linked glycosylation | 33/4864 | 65/18723 | 1.63e-05 | 1.99e-04 | 33 |
GO:001819610 | Skin | cSCC | peptidyl-asparagine modification | 16/4864 | 24/18723 | 3.35e-05 | 3.66e-04 | 16 |
GO:001827915 | Thyroid | PTC | protein N-linked glycosylation via asparagine | 18/5968 | 23/18723 | 6.38e-06 | 7.63e-05 | 18 |
GO:00064878 | Thyroid | PTC | protein N-linked glycosylation | 38/5968 | 65/18723 | 8.71e-06 | 9.94e-05 | 38 |
GO:001819615 | Thyroid | PTC | peptidyl-asparagine modification | 18/5968 | 24/18723 | 1.79e-05 | 1.86e-04 | 18 |
GO:00064866 | Thyroid | PTC | protein glycosylation | 94/5968 | 226/18723 | 1.25e-03 | 7.13e-03 | 94 |
GO:00434136 | Thyroid | PTC | macromolecule glycosylation | 94/5968 | 226/18723 | 1.25e-03 | 7.13e-03 | 94 |
GO:00700855 | Thyroid | PTC | glycosylation | 96/5968 | 240/18723 | 4.57e-03 | 2.15e-02 | 96 |
GO:00091013 | Thyroid | PTC | glycoprotein biosynthetic process | 123/5968 | 317/18723 | 5.05e-03 | 2.33e-02 | 123 |
GO:00091003 | Thyroid | PTC | glycoprotein metabolic process | 147/5968 | 387/18723 | 5.87e-03 | 2.64e-02 | 147 |
GO:001827916 | Thyroid | ATC | protein N-linked glycosylation via asparagine | 18/6293 | 23/18723 | 1.47e-05 | 1.39e-04 | 18 |
GO:000648715 | Thyroid | ATC | protein N-linked glycosylation | 38/6293 | 65/18723 | 3.39e-05 | 2.80e-04 | 38 |
GO:001819616 | Thyroid | ATC | peptidyl-asparagine modification | 18/6293 | 24/18723 | 4.04e-05 | 3.28e-04 | 18 |
GO:000648612 | Thyroid | ATC | protein glycosylation | 94/6293 | 226/18723 | 7.11e-03 | 2.82e-02 | 94 |
GO:004341312 | Thyroid | ATC | macromolecule glycosylation | 94/6293 | 226/18723 | 7.11e-03 | 2.82e-02 | 94 |
GO:000910011 | Thyroid | ATC | glycoprotein metabolic process | 153/6293 | 387/18723 | 7.90e-03 | 3.06e-02 | 153 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa04141211 | Esophagus | ESCC | Protein processing in endoplasmic reticulum | 147/4205 | 174/8465 | 3.29e-22 | 1.10e-19 | 5.64e-20 | 147 |
hsa0051023 | Esophagus | ESCC | N-Glycan biosynthesis | 39/4205 | 53/8465 | 3.26e-04 | 1.15e-03 | 5.89e-04 | 39 |
hsa005136 | Esophagus | ESCC | Various types of N-glycan biosynthesis | 31/4205 | 42/8465 | 1.23e-03 | 3.78e-03 | 1.93e-03 | 31 |
hsa04141310 | Esophagus | ESCC | Protein processing in endoplasmic reticulum | 147/4205 | 174/8465 | 3.29e-22 | 1.10e-19 | 5.64e-20 | 147 |
hsa0051033 | Esophagus | ESCC | N-Glycan biosynthesis | 39/4205 | 53/8465 | 3.26e-04 | 1.15e-03 | 5.89e-04 | 39 |
hsa0051313 | Esophagus | ESCC | Various types of N-glycan biosynthesis | 31/4205 | 42/8465 | 1.23e-03 | 3.78e-03 | 1.93e-03 | 31 |
hsa0414114 | Liver | Cirrhotic | Protein processing in endoplasmic reticulum | 114/2530 | 174/8465 | 1.16e-22 | 9.67e-21 | 5.96e-21 | 114 |
hsa005104 | Liver | Cirrhotic | N-Glycan biosynthesis | 32/2530 | 53/8465 | 3.82e-06 | 4.10e-05 | 2.53e-05 | 32 |
hsa005134 | Liver | Cirrhotic | Various types of N-glycan biosynthesis | 26/2530 | 42/8465 | 1.65e-05 | 1.41e-04 | 8.69e-05 | 26 |
hsa0414115 | Liver | Cirrhotic | Protein processing in endoplasmic reticulum | 114/2530 | 174/8465 | 1.16e-22 | 9.67e-21 | 5.96e-21 | 114 |
hsa0051011 | Liver | Cirrhotic | N-Glycan biosynthesis | 32/2530 | 53/8465 | 3.82e-06 | 4.10e-05 | 2.53e-05 | 32 |
hsa0051311 | Liver | Cirrhotic | Various types of N-glycan biosynthesis | 26/2530 | 42/8465 | 1.65e-05 | 1.41e-04 | 8.69e-05 | 26 |
hsa0414122 | Liver | HCC | Protein processing in endoplasmic reticulum | 146/4020 | 174/8465 | 7.34e-24 | 2.46e-21 | 1.37e-21 | 146 |
hsa0051021 | Liver | HCC | N-Glycan biosynthesis | 40/4020 | 53/8465 | 2.95e-05 | 1.87e-04 | 1.04e-04 | 40 |
hsa0414132 | Liver | HCC | Protein processing in endoplasmic reticulum | 146/4020 | 174/8465 | 7.34e-24 | 2.46e-21 | 1.37e-21 | 146 |
hsa0051031 | Liver | HCC | N-Glycan biosynthesis | 40/4020 | 53/8465 | 2.95e-05 | 1.87e-04 | 1.04e-04 | 40 |
hsa0414130 | Oral cavity | OSCC | Protein processing in endoplasmic reticulum | 143/3704 | 174/8465 | 6.82e-26 | 2.28e-23 | 1.16e-23 | 143 |
hsa005105 | Oral cavity | OSCC | N-Glycan biosynthesis | 39/3704 | 53/8465 | 9.77e-06 | 4.36e-05 | 2.22e-05 | 39 |
hsa005135 | Oral cavity | OSCC | Various types of N-glycan biosynthesis | 29/3704 | 42/8465 | 8.03e-04 | 2.32e-03 | 1.18e-03 | 29 |
hsa04141113 | Oral cavity | OSCC | Protein processing in endoplasmic reticulum | 143/3704 | 174/8465 | 6.82e-26 | 2.28e-23 | 1.16e-23 | 143 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TUSC3 | SNV | Missense_Mutation | c.344C>G | p.Ser115Cys | p.S115C | Q13454 | protein_coding | deleterious(0.01) | probably_damaging(0.998) | TCGA-C8-A12K-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
TUSC3 | SNV | Missense_Mutation | novel | c.731N>G | p.Ser244Cys | p.S244C | Q13454 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-PE-A5DE-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | taxotere | CR |
TUSC3 | insertion | Frame_Shift_Ins | novel | c.910_911insTTCAGTGTTTTTCAAGCTGTGTAGCATGGATCTCTAAAAGTTTAGAG | p.Ser304PhefsTer26 | p.S304Ffs*26 | Q13454 | protein_coding | TCGA-A8-A07J-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | 5-fluorouracil | CR | ||
TUSC3 | SNV | Missense_Mutation | novel | c.614C>T | p.Ala205Val | p.A205V | Q13454 | protein_coding | tolerated(0.72) | benign(0.034) | TCGA-UC-A7PG-06 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Chemotherapy | cisplatin | PD |
TUSC3 | SNV | Missense_Mutation | novel | c.258G>A | p.Met86Ile | p.M86I | Q13454 | protein_coding | tolerated(0.16) | benign(0.019) | TCGA-VS-A954-01 | Cervix | cervical & endocervical cancer | Female | >=65 | III/IV | Chemotherapy | cisplatin | CR |
TUSC3 | SNV | Missense_Mutation | rs755902777 | c.289N>T | p.Arg97Trp | p.R97W | Q13454 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-A6-3809-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
TUSC3 | SNV | Missense_Mutation | rs576144260 | c.200N>A | p.Arg67Gln | p.R67Q | Q13454 | protein_coding | deleterious(0.03) | possibly_damaging(0.532) | TCGA-AA-3510-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
TUSC3 | SNV | Missense_Mutation | c.684N>T | p.Lys228Asn | p.K228N | Q13454 | protein_coding | deleterious(0) | possibly_damaging(0.876) | TCGA-AA-3510-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
TUSC3 | SNV | Missense_Mutation | c.245G>A | p.Arg82Gln | p.R82Q | Q13454 | protein_coding | deleterious(0) | probably_damaging(0.993) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR | |
TUSC3 | SNV | Missense_Mutation | c.601A>G | p.Thr201Ala | p.T201A | Q13454 | protein_coding | tolerated(0.33) | benign(0.06) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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