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Gene: TTC19 |
Gene summary for TTC19 |
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Gene information | Species | Human | Gene symbol | TTC19 | Gene ID | 54902 |
Gene name | tetratricopeptide repeat domain 19 | |
Gene Alias | 2010204O13Rik | |
Cytomap | 17p12 | |
Gene Type | protein-coding | GO ID | GO:0000278 | UniProtAcc | Q6DKK2 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
54902 | TTC19 | HTA11_3410_2000001011 | Human | Colorectum | AD | 3.65e-12 | -4.45e-01 | 0.0155 |
54902 | TTC19 | HTA11_3361_2000001011 | Human | Colorectum | AD | 1.64e-03 | -4.21e-01 | -0.1207 |
54902 | TTC19 | HTA11_696_2000001011 | Human | Colorectum | AD | 4.88e-02 | -2.49e-01 | -0.1464 |
54902 | TTC19 | HTA11_866_3004761011 | Human | Colorectum | AD | 7.04e-03 | -2.73e-01 | 0.096 |
54902 | TTC19 | HTA11_10711_2000001011 | Human | Colorectum | AD | 4.76e-02 | -3.49e-01 | 0.0338 |
54902 | TTC19 | HTA11_7696_3000711011 | Human | Colorectum | AD | 3.01e-03 | -3.05e-01 | 0.0674 |
54902 | TTC19 | HTA11_99999971662_82457 | Human | Colorectum | MSS | 2.35e-04 | -3.41e-01 | 0.3859 |
54902 | TTC19 | HTA11_99999973899_84307 | Human | Colorectum | MSS | 9.19e-04 | -4.93e-01 | 0.2585 |
54902 | TTC19 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 2.55e-06 | -3.63e-01 | 0.3005 |
54902 | TTC19 | A001-C-207 | Human | Colorectum | FAP | 1.31e-06 | -3.19e-01 | 0.1278 |
54902 | TTC19 | A015-C-203 | Human | Colorectum | FAP | 1.74e-27 | -4.88e-01 | -0.1294 |
54902 | TTC19 | A015-C-204 | Human | Colorectum | FAP | 2.31e-06 | -2.83e-01 | -0.0228 |
54902 | TTC19 | A014-C-040 | Human | Colorectum | FAP | 1.48e-05 | -4.34e-01 | -0.1184 |
54902 | TTC19 | A002-C-201 | Human | Colorectum | FAP | 7.24e-17 | -4.14e-01 | 0.0324 |
54902 | TTC19 | A002-C-203 | Human | Colorectum | FAP | 2.97e-03 | -1.78e-01 | 0.2786 |
54902 | TTC19 | A001-C-119 | Human | Colorectum | FAP | 2.81e-09 | -3.96e-01 | -0.1557 |
54902 | TTC19 | A001-C-108 | Human | Colorectum | FAP | 3.26e-14 | -2.35e-01 | -0.0272 |
54902 | TTC19 | A002-C-205 | Human | Colorectum | FAP | 8.85e-24 | -4.21e-01 | -0.1236 |
54902 | TTC19 | A001-C-104 | Human | Colorectum | FAP | 9.58e-03 | -1.64e-01 | 0.0184 |
54902 | TTC19 | A015-C-005 | Human | Colorectum | FAP | 1.47e-05 | -2.41e-01 | -0.0336 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:000091019 | Thyroid | PTC | cytokinesis | 82/5968 | 173/18723 | 1.37e-05 | 1.47e-04 | 82 |
GO:00616408 | Thyroid | PTC | cytoskeleton-dependent cytokinesis | 50/5968 | 100/18723 | 1.20e-04 | 9.59e-04 | 50 |
GO:00170046 | Thyroid | PTC | cytochrome complex assembly | 19/5968 | 36/18723 | 7.38e-03 | 3.16e-02 | 19 |
GO:003310832 | Thyroid | ATC | mitochondrial respiratory chain complex assembly | 65/6293 | 93/18723 | 8.86e-13 | 3.81e-11 | 65 |
GO:000028117 | Thyroid | ATC | mitotic cytokinesis | 50/6293 | 71/18723 | 2.46e-10 | 7.10e-09 | 50 |
GO:0000910110 | Thyroid | ATC | cytokinesis | 93/6293 | 173/18723 | 3.59e-08 | 6.67e-07 | 93 |
GO:006164017 | Thyroid | ATC | cytoskeleton-dependent cytokinesis | 57/6293 | 100/18723 | 1.29e-06 | 1.65e-05 | 57 |
GO:001700414 | Thyroid | ATC | cytochrome complex assembly | 19/6293 | 36/18723 | 1.37e-02 | 4.77e-02 | 19 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TTC19 | SNV | Missense_Mutation | rs762239880 | c.724N>A | p.Ala242Thr | p.A242T | Q6DKK2 | protein_coding | tolerated(0.21) | benign(0.019) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
TTC19 | insertion | In_Frame_Ins | novel | c.743_744insATTGATGTGCGGACTCTTAATCTACTTAAAATGTGG | p.Leu248_Phe249insLeuMetCysGlyLeuLeuIleTyrLeuLysCysGly | p.L248_F249insLMCGLLIYLKCG | Q6DKK2 | protein_coding | TCGA-A8-A08H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
TTC19 | SNV | Missense_Mutation | novel | c.628N>C | p.Glu210Gln | p.E210Q | Q6DKK2 | protein_coding | deleterious(0) | possibly_damaging(0.845) | TCGA-EA-A97N-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
TTC19 | SNV | Missense_Mutation | c.445C>T | p.Arg149Trp | p.R149W | Q6DKK2 | protein_coding | deleterious(0) | possibly_damaging(0.875) | TCGA-AU-6004-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
TTC19 | SNV | Missense_Mutation | rs749090956 | c.370N>T | p.Arg124Cys | p.R124C | Q6DKK2 | protein_coding | tolerated(0.11) | possibly_damaging(0.735) | TCGA-F5-6814-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
TTC19 | SNV | Missense_Mutation | novel | c.673N>C | p.Ser225Pro | p.S225P | Q6DKK2 | protein_coding | tolerated(0.38) | benign(0.006) | TCGA-A5-A1OF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
TTC19 | SNV | Missense_Mutation | c.1107N>T | p.Lys369Asn | p.K369N | Q6DKK2 | protein_coding | tolerated(0.19) | benign(0.03) | TCGA-A5-A2K5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
TTC19 | SNV | Missense_Mutation | rs759404597 | c.376N>A | p.Ala126Thr | p.A126T | Q6DKK2 | protein_coding | deleterious(0) | possibly_damaging(0.836) | TCGA-AJ-A3EL-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
TTC19 | SNV | Missense_Mutation | rs797046058 | c.478N>C | p.Lys160Gln | p.K160Q | Q6DKK2 | protein_coding | deleterious(0) | probably_damaging(0.959) | TCGA-AP-A1E0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | paclitaxel | SD |
TTC19 | SNV | Missense_Mutation | rs749090956 | c.370N>T | p.Arg124Cys | p.R124C | Q6DKK2 | protein_coding | tolerated(0.11) | possibly_damaging(0.735) | TCGA-B5-A1MR-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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