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Gene: TMEM14A |
Gene summary for TMEM14A |
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Gene information | Species | Human | Gene symbol | TMEM14A | Gene ID | 28978 |
Gene name | transmembrane protein 14A | |
Gene Alias | C6orf73 | |
Cytomap | 6p12.2 | |
Gene Type | protein-coding | GO ID | GO:0006810 | UniProtAcc | Q9Y6G1 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
28978 | TMEM14A | GSM4909281 | Human | Breast | IDC | 3.78e-24 | 6.31e-01 | 0.21 |
28978 | TMEM14A | GSM4909282 | Human | Breast | IDC | 6.52e-31 | 7.23e-01 | -0.0288 |
28978 | TMEM14A | GSM4909285 | Human | Breast | IDC | 9.62e-16 | 4.60e-01 | 0.21 |
28978 | TMEM14A | GSM4909291 | Human | Breast | IDC | 2.19e-06 | 4.20e-01 | 0.1753 |
28978 | TMEM14A | GSM4909293 | Human | Breast | IDC | 6.63e-06 | 2.53e-01 | 0.1581 |
28978 | TMEM14A | GSM4909296 | Human | Breast | IDC | 1.54e-02 | 1.44e-01 | 0.1524 |
28978 | TMEM14A | GSM4909297 | Human | Breast | IDC | 3.29e-03 | 3.67e-02 | 0.1517 |
28978 | TMEM14A | GSM4909301 | Human | Breast | IDC | 6.96e-06 | 3.60e-01 | 0.1577 |
28978 | TMEM14A | GSM4909306 | Human | Breast | IDC | 4.71e-04 | 3.55e-01 | 0.1564 |
28978 | TMEM14A | GSM4909307 | Human | Breast | IDC | 6.89e-20 | 6.32e-01 | 0.1569 |
28978 | TMEM14A | GSM4909308 | Human | Breast | IDC | 2.78e-30 | 6.81e-01 | 0.158 |
28978 | TMEM14A | GSM4909311 | Human | Breast | IDC | 4.30e-09 | -1.48e-01 | 0.1534 |
28978 | TMEM14A | GSM4909319 | Human | Breast | IDC | 1.17e-18 | -5.70e-02 | 0.1563 |
28978 | TMEM14A | GSM4909321 | Human | Breast | IDC | 2.60e-08 | 2.91e-01 | 0.1559 |
28978 | TMEM14A | brca2 | Human | Breast | Precancer | 2.54e-03 | 1.35e-01 | -0.024 |
28978 | TMEM14A | NCCBC5 | Human | Breast | DCIS | 1.08e-02 | 5.13e-02 | 0.2046 |
28978 | TMEM14A | P1 | Human | Breast | IDC | 1.40e-03 | -1.78e-01 | 0.1527 |
28978 | TMEM14A | DCIS2 | Human | Breast | DCIS | 5.62e-27 | -4.71e-02 | 0.0085 |
28978 | TMEM14A | LZE2T | Human | Esophagus | ESCC | 7.73e-10 | 2.22e+00 | 0.082 |
28978 | TMEM14A | LZE4T | Human | Esophagus | ESCC | 1.73e-17 | 8.74e-01 | 0.0811 |
Page: 1 2 3 4 5 6 7 8 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:190571021 | Breast | DCIS | positive regulation of membrane permeability | 11/1390 | 48/18723 | 6.34e-04 | 7.92e-03 | 11 |
GO:003579421 | Breast | DCIS | positive regulation of mitochondrial membrane permeability | 10/1390 | 43/18723 | 9.81e-04 | 1.09e-02 | 10 |
GO:190210821 | Breast | DCIS | regulation of mitochondrial membrane permeability involved in apoptotic process | 10/1390 | 45/18723 | 1.43e-03 | 1.46e-02 | 10 |
GO:190211021 | Breast | DCIS | positive regulation of mitochondrial membrane permeability involved in apoptotic process | 9/1390 | 38/18723 | 1.52e-03 | 1.53e-02 | 9 |
GO:190268621 | Breast | DCIS | mitochondrial outer membrane permeabilization involved in programmed cell death | 9/1390 | 40/18723 | 2.23e-03 | 2.04e-02 | 9 |
GO:001082322 | Breast | DCIS | negative regulation of mitochondrion organization | 10/1390 | 49/18723 | 2.80e-03 | 2.43e-02 | 10 |
GO:2001233111 | Esophagus | ESCC | regulation of apoptotic signaling pathway | 256/8552 | 356/18723 | 4.11e-24 | 1.04e-21 | 256 |
GO:0006839110 | Esophagus | ESCC | mitochondrial transport | 187/8552 | 254/18723 | 8.35e-20 | 9.81e-18 | 187 |
GO:2001234111 | Esophagus | ESCC | negative regulation of apoptotic signaling pathway | 161/8552 | 224/18723 | 1.24e-15 | 8.09e-14 | 161 |
GO:000700619 | Esophagus | ESCC | mitochondrial membrane organization | 93/8552 | 116/18723 | 2.16e-14 | 1.11e-12 | 93 |
GO:0010821110 | Esophagus | ESCC | regulation of mitochondrion organization | 107/8552 | 144/18723 | 2.31e-12 | 9.41e-11 | 107 |
GO:0008637110 | Esophagus | ESCC | apoptotic mitochondrial changes | 83/8552 | 107/18723 | 1.43e-11 | 5.08e-10 | 83 |
GO:0010639110 | Esophagus | ESCC | negative regulation of organelle organization | 215/8552 | 348/18723 | 8.20e-10 | 2.01e-08 | 215 |
GO:004690217 | Esophagus | ESCC | regulation of mitochondrial membrane permeability | 49/8552 | 63/18723 | 1.91e-07 | 2.97e-06 | 49 |
GO:00905599 | Esophagus | ESCC | regulation of membrane permeability | 58/8552 | 78/18723 | 2.38e-07 | 3.61e-06 | 58 |
GO:00357948 | Esophagus | ESCC | positive regulation of mitochondrial membrane permeability | 36/8552 | 43/18723 | 2.90e-07 | 4.20e-06 | 36 |
GO:009734510 | Esophagus | ESCC | mitochondrial outer membrane permeabilization | 28/8552 | 32/18723 | 1.02e-06 | 1.29e-05 | 28 |
GO:190268614 | Esophagus | ESCC | mitochondrial outer membrane permeabilization involved in programmed cell death | 33/8552 | 40/18723 | 1.80e-06 | 2.11e-05 | 33 |
GO:19021108 | Esophagus | ESCC | positive regulation of mitochondrial membrane permeability involved in apoptotic process | 31/8552 | 38/18723 | 5.93e-06 | 6.10e-05 | 31 |
GO:19057108 | Esophagus | ESCC | positive regulation of membrane permeability | 37/8552 | 48/18723 | 8.99e-06 | 8.65e-05 | 37 |
Page: 1 2 3 4 5 6 7 8 9 10 11 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TMEM14A | SNV | Missense_Mutation | novel | c.275T>G | p.Leu92Arg | p.L92R | Q9Y6G1 | protein_coding | tolerated(0.34) | probably_damaging(0.999) | TCGA-AA-3950-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
TMEM14A | SNV | Missense_Mutation | rs769068441 | c.234G>A | p.Met78Ile | p.M78I | Q9Y6G1 | protein_coding | deleterious(0.03) | benign(0.015) | TCGA-AX-A0J1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
TMEM14A | SNV | Missense_Mutation | novel | c.169C>A | p.Leu57Met | p.L57M | Q9Y6G1 | protein_coding | deleterious(0) | probably_damaging(0.992) | TCGA-B5-A1MX-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Hormone Therapy | megace | SD |
TMEM14A | SNV | Missense_Mutation | novel | c.172N>G | p.Phe58Val | p.F58V | Q9Y6G1 | protein_coding | tolerated(0.57) | benign(0.037) | TCGA-BK-A6W3-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
TMEM14A | SNV | Missense_Mutation | c.236N>A | p.Pro79His | p.P79H | Q9Y6G1 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-95-7039-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | PD | |
TMEM14A | insertion | In_Frame_Ins | novel | c.260_260+1insCCTCATGATGATCCTGAGACTTGTCTTGTTGCT | p.Met89_Met90insMetIleLeuArgLeuValLeuLeuLeuLeuMet | p.M89_M90insMILRLVLLLLM | Q9Y6G1 | protein_coding | TCGA-22-4613-01 | Lung | lung squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
TMEM14A | SNV | Missense_Mutation | novel | c.278N>C | p.Arg93Thr | p.R93T | Q9Y6G1 | protein_coding | deleterious(0) | probably_damaging(0.995) | TCGA-CV-5440-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | paclitaxel | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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