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Gene: TIMM13 |
Gene summary for TIMM13 |
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Gene information | Species | Human | Gene symbol | TIMM13 | Gene ID | 26517 |
Gene name | translocase of inner mitochondrial membrane 13 | |
Gene Alias | TIM13 | |
Cytomap | 19p13.3 | |
Gene Type | protein-coding | GO ID | GO:0003008 | UniProtAcc | Q9Y5L4 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
26517 | TIMM13 | GSM4909285 | Human | Breast | IDC | 1.09e-10 | -3.87e-01 | 0.21 |
26517 | TIMM13 | GSM4909286 | Human | Breast | IDC | 6.22e-06 | 2.24e-01 | 0.1081 |
26517 | TIMM13 | GSM4909290 | Human | Breast | IDC | 2.03e-04 | 2.97e-01 | 0.2096 |
26517 | TIMM13 | GSM4909291 | Human | Breast | IDC | 7.93e-13 | 4.62e-01 | 0.1753 |
26517 | TIMM13 | GSM4909293 | Human | Breast | IDC | 2.94e-06 | -3.41e-02 | 0.1581 |
26517 | TIMM13 | GSM4909296 | Human | Breast | IDC | 1.41e-08 | 1.98e-01 | 0.1524 |
26517 | TIMM13 | GSM4909297 | Human | Breast | IDC | 1.32e-12 | -1.00e-01 | 0.1517 |
26517 | TIMM13 | GSM4909298 | Human | Breast | IDC | 8.55e-10 | 3.62e-01 | 0.1551 |
26517 | TIMM13 | GSM4909302 | Human | Breast | IDC | 9.03e-05 | 1.88e-01 | 0.1545 |
26517 | TIMM13 | GSM4909304 | Human | Breast | IDC | 2.27e-08 | 4.09e-01 | 0.1636 |
26517 | TIMM13 | GSM4909306 | Human | Breast | IDC | 2.36e-15 | 5.05e-01 | 0.1564 |
26517 | TIMM13 | GSM4909308 | Human | Breast | IDC | 2.03e-05 | 2.66e-01 | 0.158 |
26517 | TIMM13 | GSM4909311 | Human | Breast | IDC | 5.05e-35 | 9.57e-02 | 0.1534 |
26517 | TIMM13 | GSM4909312 | Human | Breast | IDC | 3.76e-16 | 3.47e-01 | 0.1552 |
26517 | TIMM13 | GSM4909316 | Human | Breast | IDC | 2.01e-05 | 1.95e-01 | 0.21 |
26517 | TIMM13 | GSM4909318 | Human | Breast | IDC | 1.29e-04 | 3.96e-01 | 0.2031 |
26517 | TIMM13 | GSM4909319 | Human | Breast | IDC | 4.41e-43 | -3.52e-01 | 0.1563 |
26517 | TIMM13 | GSM4909320 | Human | Breast | IDC | 6.64e-11 | 1.79e-01 | 0.1575 |
26517 | TIMM13 | GSM4909321 | Human | Breast | IDC | 2.69e-11 | 4.29e-02 | 0.1559 |
26517 | TIMM13 | brca1 | Human | Breast | Precancer | 3.36e-18 | 5.14e-01 | -0.0338 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0070585 | Colorectum | AD | protein localization to mitochondrion | 51/3918 | 125/18723 | 3.40e-07 | 1.33e-05 | 51 |
GO:0007006 | Colorectum | AD | mitochondrial membrane organization | 48/3918 | 116/18723 | 4.53e-07 | 1.72e-05 | 48 |
GO:0072655 | Colorectum | AD | establishment of protein localization to mitochondrion | 47/3918 | 120/18723 | 3.76e-06 | 1.04e-04 | 47 |
GO:0006626 | Colorectum | AD | protein targeting to mitochondrion | 37/3918 | 100/18723 | 1.58e-04 | 2.20e-03 | 37 |
GO:0007007 | Colorectum | AD | inner mitochondrial membrane organization | 18/3918 | 38/18723 | 2.45e-04 | 3.09e-03 | 18 |
GO:0090151 | Colorectum | AD | establishment of protein localization to mitochondrial membrane | 15/3918 | 30/18723 | 3.85e-04 | 4.39e-03 | 15 |
GO:0051205 | Colorectum | AD | protein insertion into membrane | 23/3918 | 57/18723 | 6.62e-04 | 6.80e-03 | 23 |
GO:0051204 | Colorectum | AD | protein insertion into mitochondrial membrane | 12/3918 | 25/18723 | 2.30e-03 | 1.80e-02 | 12 |
GO:00068391 | Colorectum | SER | mitochondrial transport | 87/2897 | 254/18723 | 7.91e-14 | 3.03e-11 | 87 |
GO:00725941 | Colorectum | SER | establishment of protein localization to organelle | 111/2897 | 422/18723 | 4.98e-09 | 4.49e-07 | 111 |
GO:00705851 | Colorectum | SER | protein localization to mitochondrion | 42/2897 | 125/18723 | 3.75e-07 | 1.98e-05 | 42 |
GO:00070061 | Colorectum | SER | mitochondrial membrane organization | 38/2897 | 116/18723 | 2.66e-06 | 1.10e-04 | 38 |
GO:00901501 | Colorectum | SER | establishment of protein localization to membrane | 68/2897 | 260/18723 | 5.55e-06 | 2.01e-04 | 68 |
GO:00726551 | Colorectum | SER | establishment of protein localization to mitochondrion | 38/2897 | 120/18723 | 6.60e-06 | 2.33e-04 | 38 |
GO:00066051 | Colorectum | SER | protein targeting | 76/2897 | 314/18723 | 3.19e-05 | 8.47e-04 | 76 |
GO:00066261 | Colorectum | SER | protein targeting to mitochondrion | 31/2897 | 100/18723 | 7.09e-05 | 1.61e-03 | 31 |
GO:00512051 | Colorectum | SER | protein insertion into membrane | 19/2897 | 57/18723 | 6.32e-04 | 8.58e-03 | 19 |
GO:00901511 | Colorectum | SER | establishment of protein localization to mitochondrial membrane | 12/2897 | 30/18723 | 1.03e-03 | 1.22e-02 | 12 |
GO:00070071 | Colorectum | SER | inner mitochondrial membrane organization | 14/2897 | 38/18723 | 1.06e-03 | 1.23e-02 | 14 |
GO:00512041 | Colorectum | SER | protein insertion into mitochondrial membrane | 10/2897 | 25/18723 | 2.70e-03 | 2.44e-02 | 10 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TIMM13 | SNV | Missense_Mutation | c.269N>T | p.Arg90Leu | p.R90L | Q9Y5L4 | protein_coding | deleterious(0) | possibly_damaging(0.713) | TCGA-EW-A1J5-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | SD | |
TIMM13 | SNV | Missense_Mutation | c.85N>A | p.Gln29Lys | p.Q29K | Q9Y5L4 | protein_coding | deleterious(0.05) | possibly_damaging(0.794) | TCGA-AP-A0LE-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
TIMM13 | SNV | Missense_Mutation | c.70G>A | p.Glu24Lys | p.E24K | Q9Y5L4 | protein_coding | tolerated(0.29) | benign(0.372) | TCGA-AP-A0LM-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | cisplatin | SD | |
TIMM13 | SNV | Missense_Mutation | c.154N>A | p.Gly52Arg | p.G52R | Q9Y5L4 | protein_coding | tolerated(0.36) | benign(0.048) | TCGA-DD-A4NO-01 | Liver | liver hepatocellular carcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
TIMM13 | SNV | Missense_Mutation | novel | c.198N>G | p.Ile66Met | p.I66M | Q9Y5L4 | protein_coding | deleterious(0) | probably_damaging(0.937) | TCGA-CN-6011-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | cisplatin | SD |
TIMM13 | SNV | Missense_Mutation | novel | c.88N>G | p.Ile30Val | p.I30V | Q9Y5L4 | protein_coding | tolerated(0.23) | benign(0.268) | TCGA-F7-A50I-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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