Tissue | Expression Dynamics | Abbreviation |
Colorectum (GSE201348) | | FAP: Familial adenomatous polyposis |
CRC: Colorectal cancer |
Colorectum (HTA11) | | AD: Adenomas |
SER: Sessile serrated lesions |
MSI-H: Microsatellite-high colorectal cancer |
MSS: Microsatellite stable colorectal cancer |
Esophagus | | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias |
LGIN: Low-grade intraepithelial neoplasias |
Liver | | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
Prostate | | BPH: Benign Prostatic Hyperplasia |
Thyroid | | ATC: Anaplastic thyroid cancer |
HT: Hashimoto's thyroiditis |
PTC: Papillary thyroid cancer |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00300731 | Colorectum | SER | insulin secretion | 46/2897 | 195/18723 | 1.86e-03 | 1.90e-02 | 46 |
GO:00068871 | Colorectum | SER | exocytosis | 75/2897 | 352/18723 | 2.05e-03 | 2.03e-02 | 75 |
GO:00507961 | Colorectum | SER | regulation of insulin secretion | 40/2897 | 165/18723 | 2.10e-03 | 2.06e-02 | 40 |
GO:00712481 | Colorectum | SER | cellular response to metal ion | 46/2897 | 197/18723 | 2.31e-03 | 2.21e-02 | 46 |
GO:00158331 | Colorectum | SER | peptide transport | 58/2897 | 264/18723 | 3.08e-03 | 2.70e-02 | 58 |
GO:00900871 | Colorectum | SER | regulation of peptide transport | 46/2897 | 202/18723 | 3.86e-03 | 3.18e-02 | 46 |
GO:00027911 | Colorectum | SER | regulation of peptide secretion | 45/2897 | 200/18723 | 5.35e-03 | 4.03e-02 | 45 |
GO:00510471 | Colorectum | SER | positive regulation of secretion | 65/2897 | 310/18723 | 5.71e-03 | 4.19e-02 | 65 |
GO:00902761 | Colorectum | SER | regulation of peptide hormone secretion | 44/2897 | 196/18723 | 6.08e-03 | 4.42e-02 | 44 |
GO:00171571 | Colorectum | SER | regulation of exocytosis | 45/2897 | 202/18723 | 6.46e-03 | 4.63e-02 | 45 |
GO:00160502 | Colorectum | MSS | vesicle organization | 93/3467 | 300/18723 | 1.04e-07 | 4.97e-06 | 93 |
GO:00164822 | Colorectum | MSS | cytosolic transport | 59/3467 | 168/18723 | 2.29e-07 | 9.79e-06 | 59 |
GO:00420602 | Colorectum | MSS | wound healing | 119/3467 | 422/18723 | 5.93e-07 | 2.24e-05 | 119 |
GO:00507082 | Colorectum | MSS | regulation of protein secretion | 78/3467 | 268/18723 | 1.47e-05 | 3.33e-04 | 78 |
GO:00093062 | Colorectum | MSS | protein secretion | 98/3467 | 359/18723 | 2.43e-05 | 5.09e-04 | 98 |
GO:00355922 | Colorectum | MSS | establishment of protein localization to extracellular region | 98/3467 | 360/18723 | 2.75e-05 | 5.58e-04 | 98 |
GO:00716922 | Colorectum | MSS | protein localization to extracellular region | 99/3467 | 368/18723 | 4.17e-05 | 7.83e-04 | 99 |
GO:00507962 | Colorectum | MSS | regulation of insulin secretion | 50/3467 | 165/18723 | 1.61e-04 | 2.31e-03 | 50 |
GO:00300732 | Colorectum | MSS | insulin secretion | 56/3467 | 195/18723 | 3.21e-04 | 4.18e-03 | 56 |
GO:00158332 | Colorectum | MSS | peptide transport | 71/3467 | 264/18723 | 4.79e-04 | 5.60e-03 | 71 |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SYT7 | SNV | Missense_Mutation | novel | c.1253C>T | p.Thr418Met | p.T418M | O43581 | protein_coding | tolerated(0.23) | benign(0.02) | TCGA-AC-A3W6-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
SYT7 | SNV | Missense_Mutation | | c.730N>A | p.Gly244Ser | p.G244S | O43581 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-AQ-A1H3-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | adriamycin | SD |
SYT7 | SNV | Missense_Mutation | novel | c.621C>G | p.Ser207Arg | p.S207R | O43581 | protein_coding | tolerated(0.4) | possibly_damaging(0.452) | TCGA-B6-A0IC-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
SYT7 | SNV | Missense_Mutation | novel | c.752A>G | p.Lys251Arg | p.K251R | O43581 | protein_coding | tolerated(0.1) | benign(0.255) | TCGA-BH-A0B1-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | adriamycin | SD |
SYT7 | insertion | Nonsense_Mutation | novel | c.622_623insTCTGAAATAAGCAAG | p.Arg208delinsLeuTerAsnLysGlnGly | p.R208delinsL*NKQG | O43581 | protein_coding | | | TCGA-B6-A0IC-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
SYT7 | insertion | Nonsense_Mutation | novel | c.749_750insGATTAAGGAGTGATTTCTATCCCAGGGCCTTTGGGTGC | p.Lys251IlefsTer4 | p.K251Ifs*4 | O43581 | protein_coding | | | TCGA-BH-A0B1-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | adriamycin | SD |
SYT7 | SNV | Missense_Mutation | novel | c.1393N>T | p.Arg465Cys | p.R465C | O43581 | protein_coding | deleterious(0) | possibly_damaging(0.852) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
SYT7 | SNV | Missense_Mutation | rs550321037 | c.1237N>A | p.Ala413Thr | p.A413T | O43581 | protein_coding | tolerated(0.46) | benign(0.01) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
SYT7 | SNV | Missense_Mutation | | c.907C>T | p.Arg303Cys | p.R303C | O43581 | protein_coding | deleterious(0) | probably_damaging(0.993) | TCGA-C5-A1BF-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | PD |
SYT7 | SNV | Missense_Mutation | rs567302490 | c.1132G>T | p.Asp378Tyr | p.D378Y | O43581 | protein_coding | deleterious(0.01) | probably_damaging(1) | TCGA-EA-A3HQ-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |