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Gene: STXBP2 |
Gene summary for STXBP2 |
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Gene information | Species | Human | Gene symbol | STXBP2 | Gene ID | 6813 |
Gene name | syntaxin binding protein 2 | |
Gene Alias | FHL5 | |
Cytomap | 19p13.2 | |
Gene Type | protein-coding | GO ID | GO:0001505 | UniProtAcc | Q15833 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
6813 | STXBP2 | HTA11_2487_2000001011 | Human | Colorectum | SER | 3.04e-06 | 3.99e-01 | -0.1808 |
6813 | STXBP2 | HTA11_347_2000001011 | Human | Colorectum | AD | 1.16e-06 | 1.97e-01 | -0.1954 |
6813 | STXBP2 | HTA11_2112_2000001011 | Human | Colorectum | SER | 8.05e-06 | 5.29e-01 | -0.2196 |
6813 | STXBP2 | HTA11_696_2000001011 | Human | Colorectum | AD | 4.12e-06 | 2.53e-01 | -0.1464 |
6813 | STXBP2 | HTA11_1391_2000001011 | Human | Colorectum | AD | 1.45e-06 | 2.35e-01 | -0.059 |
6813 | STXBP2 | HTA11_2992_2000001011 | Human | Colorectum | SER | 1.41e-02 | 3.45e-01 | -0.1706 |
6813 | STXBP2 | HTA11_10711_2000001011 | Human | Colorectum | AD | 2.08e-03 | 2.11e-01 | 0.0338 |
6813 | STXBP2 | LZE4T | Human | Esophagus | ESCC | 7.97e-19 | 4.98e-01 | 0.0811 |
6813 | STXBP2 | LZE5T | Human | Esophagus | ESCC | 1.64e-03 | 4.06e-01 | 0.0514 |
6813 | STXBP2 | LZE7T | Human | Esophagus | ESCC | 9.10e-09 | 7.70e-01 | 0.0667 |
6813 | STXBP2 | LZE8T | Human | Esophagus | ESCC | 2.14e-11 | 5.02e-01 | 0.067 |
6813 | STXBP2 | LZE20T | Human | Esophagus | ESCC | 4.22e-07 | 1.80e-01 | 0.0662 |
6813 | STXBP2 | LZE22D1 | Human | Esophagus | HGIN | 1.13e-02 | 2.28e-01 | 0.0595 |
6813 | STXBP2 | LZE22T | Human | Esophagus | ESCC | 7.99e-05 | 4.06e-01 | 0.068 |
6813 | STXBP2 | LZE24T | Human | Esophagus | ESCC | 5.05e-37 | 9.89e-01 | 0.0596 |
6813 | STXBP2 | LZE21T | Human | Esophagus | ESCC | 8.64e-11 | 5.77e-01 | 0.0655 |
6813 | STXBP2 | LZE6T | Human | Esophagus | ESCC | 2.21e-10 | 5.30e-01 | 0.0845 |
6813 | STXBP2 | P1T-E | Human | Esophagus | ESCC | 1.01e-18 | 9.11e-01 | 0.0875 |
6813 | STXBP2 | P2T-E | Human | Esophagus | ESCC | 8.73e-20 | 2.69e-01 | 0.1177 |
6813 | STXBP2 | P4T-E | Human | Esophagus | ESCC | 2.10e-24 | 6.53e-01 | 0.1323 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:002240615 | Thyroid | PTC | membrane docking | 48/5968 | 86/18723 | 3.72e-06 | 4.73e-05 | 48 |
GO:01400569 | Thyroid | PTC | organelle localization by membrane tethering | 40/5968 | 77/18723 | 1.98e-04 | 1.49e-03 | 40 |
GO:00482783 | Thyroid | PTC | vesicle docking | 28/5968 | 59/18723 | 8.85e-03 | 3.68e-02 | 28 |
GO:005165625 | Thyroid | ATC | establishment of organelle localization | 206/6293 | 390/18723 | 2.62e-15 | 1.84e-13 | 206 |
GO:002240622 | Thyroid | ATC | membrane docking | 49/6293 | 86/18723 | 7.13e-06 | 7.34e-05 | 49 |
GO:014005613 | Thyroid | ATC | organelle localization by membrane tethering | 41/6293 | 77/18723 | 2.97e-04 | 1.88e-03 | 41 |
GO:004827811 | Thyroid | ATC | vesicle docking | 29/6293 | 59/18723 | 9.60e-03 | 3.52e-02 | 29 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
STXBP2 | SNV | Missense_Mutation | novel | c.1157N>T | p.Ser386Phe | p.S386F | Q15833 | protein_coding | deleterious(0.04) | benign(0.035) | TCGA-5L-AAT1-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Hormone Therapy | letrozol | SD |
STXBP2 | SNV | Missense_Mutation | c.1633C>T | p.Leu545Phe | p.L545F | Q15833 | protein_coding | deleterious(0.01) | probably_damaging(0.961) | TCGA-AN-A0XR-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD | |
STXBP2 | SNV | Missense_Mutation | c.245N>C | p.Lys82Thr | p.K82T | Q15833 | protein_coding | deleterious(0.02) | benign(0.178) | TCGA-BH-A0DG-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | taxotere | CR | |
STXBP2 | SNV | Missense_Mutation | c.1017N>C | p.Gln339His | p.Q339H | Q15833 | protein_coding | tolerated(0.18) | benign(0.018) | TCGA-E2-A1LH-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | SD | |
STXBP2 | deletion | Frame_Shift_Del | c.1167delN | p.Glu391ArgfsTer7 | p.E391Rfs*7 | Q15833 | protein_coding | TCGA-AN-A0AK-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |||
STXBP2 | SNV | Missense_Mutation | c.1191G>A | p.Met397Ile | p.M397I | Q15833 | protein_coding | deleterious(0.04) | possibly_damaging(0.734) | TCGA-EK-A2RK-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Unknown | Unknown | SD | |
STXBP2 | SNV | Missense_Mutation | c.337N>A | p.Ala113Thr | p.A113T | Q15833 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-A6-5661-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
STXBP2 | SNV | Missense_Mutation | c.1665N>A | p.Met555Ile | p.M555I | Q15833 | protein_coding | deleterious(0.01) | benign(0.102) | TCGA-AA-3492-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
STXBP2 | SNV | Missense_Mutation | c.296N>C | p.Ile99Thr | p.I99T | Q15833 | protein_coding | deleterious(0) | probably_damaging(0.987) | TCGA-G4-6628-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
STXBP2 | SNV | Missense_Mutation | rs767497356 | c.355N>A | p.Asp119Asn | p.D119N | Q15833 | protein_coding | deleterious(0) | probably_damaging(0.979) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
6813 | STXBP2 | NA | emapalumab | EMAPALUMAB | ||
6813 | STXBP2 | NA | Emapalumab-lzsg | EMAPALUMAB |
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