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Gene: STOX1 |
Gene summary for STOX1 |
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Gene information | Species | Human | Gene symbol | STOX1 | Gene ID | 219736 |
Gene name | storkhead box 1 | |
Gene Alias | C10orf24 | |
Cytomap | 10q22.1 | |
Gene Type | protein-coding | GO ID | GO:0000002 | UniProtAcc | Q6ZVD7 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
219736 | STOX1 | LZE24T | Human | Esophagus | ESCC | 1.80e-03 | 1.72e-01 | 0.0596 |
219736 | STOX1 | P2T-E | Human | Esophagus | ESCC | 5.53e-63 | 1.20e+00 | 0.1177 |
219736 | STOX1 | P4T-E | Human | Esophagus | ESCC | 4.27e-09 | 2.36e-01 | 0.1323 |
219736 | STOX1 | P8T-E | Human | Esophagus | ESCC | 2.05e-07 | 1.69e-01 | 0.0889 |
219736 | STOX1 | P9T-E | Human | Esophagus | ESCC | 1.88e-05 | 1.63e-01 | 0.1131 |
219736 | STOX1 | P10T-E | Human | Esophagus | ESCC | 3.50e-02 | 6.19e-02 | 0.116 |
219736 | STOX1 | P12T-E | Human | Esophagus | ESCC | 9.44e-07 | 1.97e-01 | 0.1122 |
219736 | STOX1 | P20T-E | Human | Esophagus | ESCC | 8.24e-04 | 1.41e-01 | 0.1124 |
219736 | STOX1 | P26T-E | Human | Esophagus | ESCC | 7.90e-03 | 1.06e-01 | 0.1276 |
219736 | STOX1 | P27T-E | Human | Esophagus | ESCC | 6.31e-57 | 1.13e+00 | 0.1055 |
219736 | STOX1 | P28T-E | Human | Esophagus | ESCC | 2.02e-06 | 1.61e-01 | 0.1149 |
219736 | STOX1 | P30T-E | Human | Esophagus | ESCC | 2.13e-03 | 1.56e-01 | 0.137 |
219736 | STOX1 | P39T-E | Human | Esophagus | ESCC | 3.75e-03 | 1.70e-01 | 0.0894 |
219736 | STOX1 | P42T-E | Human | Esophagus | ESCC | 8.55e-05 | 2.21e-01 | 0.1175 |
219736 | STOX1 | P48T-E | Human | Esophagus | ESCC | 8.56e-12 | 2.38e-01 | 0.0959 |
219736 | STOX1 | P52T-E | Human | Esophagus | ESCC | 1.88e-04 | 1.04e-01 | 0.1555 |
219736 | STOX1 | P57T-E | Human | Esophagus | ESCC | 9.35e-10 | 2.99e-01 | 0.0926 |
219736 | STOX1 | P62T-E | Human | Esophagus | ESCC | 2.57e-02 | 9.51e-02 | 0.1302 |
219736 | STOX1 | P128T-E | Human | Esophagus | ESCC | 1.37e-04 | 1.76e-01 | 0.1241 |
219736 | STOX1 | P130T-E | Human | Esophagus | ESCC | 7.52e-23 | 5.53e-01 | 0.1676 |
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Tissue | Expression Dynamics | Abbreviation |
Esophagus | ![]() | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias | ||
LGIN: Low-grade intraepithelial neoplasias |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:190288220 | Esophagus | ESCC | regulation of response to oxidative stress | 58/8552 | 98/18723 | 4.86e-03 | 1.88e-02 | 58 |
GO:00331355 | Esophagus | ESCC | regulation of peptidyl-serine phosphorylation | 81/8552 | 144/18723 | 6.79e-03 | 2.48e-02 | 81 |
GO:20000274 | Esophagus | ESCC | regulation of animal organ morphogenesis | 71/8552 | 125/18723 | 7.97e-03 | 2.84e-02 | 71 |
GO:00109712 | Esophagus | ESCC | positive regulation of G2/M transition of mitotic cell cycle | 19/8552 | 27/18723 | 8.35e-03 | 2.95e-02 | 19 |
GO:001810710 | Esophagus | ESCC | peptidyl-threonine phosphorylation | 66/8552 | 116/18723 | 9.76e-03 | 3.37e-02 | 66 |
GO:001821010 | Esophagus | ESCC | peptidyl-threonine modification | 70/8552 | 125/18723 | 1.29e-02 | 4.25e-02 | 70 |
GO:00331383 | Esophagus | ESCC | positive regulation of peptidyl-serine phosphorylation | 61/8552 | 108/18723 | 1.54e-02 | 4.96e-02 | 61 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
STOX1 | SNV | Missense_Mutation | novel | c.1961C>G | p.Ser654Cys | p.S654C | Q6ZVD7 | protein_coding | tolerated(0.08) | possibly_damaging(0.817) | TCGA-A2-A4RW-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
STOX1 | SNV | Missense_Mutation | rs374535579 | c.953N>A | p.Arg318His | p.R318H | Q6ZVD7 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-A8-A09I-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | anastrozole | SD |
STOX1 | SNV | Missense_Mutation | c.2093N>T | p.Gly698Val | p.G698V | Q6ZVD7 | protein_coding | tolerated(0.19) | benign(0) | TCGA-AN-A0XN-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | |
STOX1 | SNV | Missense_Mutation | c.1030N>C | p.Val344Leu | p.V344L | Q6ZVD7 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-AR-A24Z-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | SD | |
STOX1 | SNV | Missense_Mutation | c.2779N>C | p.Glu927Gln | p.E927Q | Q6ZVD7 | protein_coding | deleterious(0.01) | probably_damaging(0.984) | TCGA-E2-A10C-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cytoxan | SD | |
STOX1 | SNV | Missense_Mutation | c.1702N>T | p.Asp568Tyr | p.D568Y | Q6ZVD7 | protein_coding | deleterious(0.01) | benign(0.001) | TCGA-AA-3510-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
STOX1 | SNV | Missense_Mutation | rs770130603 | c.1508N>A | p.Arg503Gln | p.R503Q | Q6ZVD7 | protein_coding | deleterious(0.01) | benign(0.297) | TCGA-AA-3664-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
STOX1 | SNV | Missense_Mutation | rs764960002 | c.1718N>A | p.Pro573His | p.P573H | Q6ZVD7 | protein_coding | deleterious(0.03) | possibly_damaging(0.65) | TCGA-AA-3864-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
STOX1 | SNV | Missense_Mutation | novel | c.2112G>T | p.Glu704Asp | p.E704D | Q6ZVD7 | protein_coding | tolerated(0.06) | benign(0.001) | TCGA-AA-3947-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
STOX1 | SNV | Missense_Mutation | novel | c.1606N>C | p.Ser536Pro | p.S536P | Q6ZVD7 | protein_coding | deleterious(0.01) | benign(0.042) | TCGA-AA-3984-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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