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Gene: SPDL1 |
Gene summary for SPDL1 |
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Gene information | Species | Human | Gene symbol | SPDL1 | Gene ID | 54908 |
Gene name | spindle apparatus coiled-coil protein 1 | |
Gene Alias | CCDC99 | |
Cytomap | 5q35.1 | |
Gene Type | protein-coding | GO ID | GO:0000070 | UniProtAcc | Q96EA4 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
54908 | SPDL1 | LZE24T | Human | Esophagus | ESCC | 2.76e-07 | 2.27e-01 | 0.0596 |
54908 | SPDL1 | P2T-E | Human | Esophagus | ESCC | 6.15e-08 | 1.87e-01 | 0.1177 |
54908 | SPDL1 | P4T-E | Human | Esophagus | ESCC | 5.13e-05 | 1.17e-01 | 0.1323 |
54908 | SPDL1 | P5T-E | Human | Esophagus | ESCC | 4.58e-14 | 2.93e-01 | 0.1327 |
54908 | SPDL1 | P8T-E | Human | Esophagus | ESCC | 6.46e-08 | 1.14e-01 | 0.0889 |
54908 | SPDL1 | P9T-E | Human | Esophagus | ESCC | 1.43e-02 | 8.85e-02 | 0.1131 |
54908 | SPDL1 | P10T-E | Human | Esophagus | ESCC | 1.97e-10 | 1.98e-01 | 0.116 |
54908 | SPDL1 | P12T-E | Human | Esophagus | ESCC | 9.18e-05 | 1.58e-01 | 0.1122 |
54908 | SPDL1 | P15T-E | Human | Esophagus | ESCC | 7.31e-09 | 2.18e-01 | 0.1149 |
54908 | SPDL1 | P16T-E | Human | Esophagus | ESCC | 3.90e-03 | 1.19e-01 | 0.1153 |
54908 | SPDL1 | P17T-E | Human | Esophagus | ESCC | 2.91e-04 | 3.46e-01 | 0.1278 |
54908 | SPDL1 | P19T-E | Human | Esophagus | ESCC | 8.68e-04 | 3.33e-01 | 0.1662 |
54908 | SPDL1 | P22T-E | Human | Esophagus | ESCC | 1.43e-06 | 9.40e-02 | 0.1236 |
54908 | SPDL1 | P23T-E | Human | Esophagus | ESCC | 2.74e-04 | 1.58e-01 | 0.108 |
54908 | SPDL1 | P24T-E | Human | Esophagus | ESCC | 1.96e-05 | 1.70e-01 | 0.1287 |
54908 | SPDL1 | P26T-E | Human | Esophagus | ESCC | 4.97e-04 | 1.24e-01 | 0.1276 |
54908 | SPDL1 | P27T-E | Human | Esophagus | ESCC | 1.86e-11 | 1.15e-01 | 0.1055 |
54908 | SPDL1 | P28T-E | Human | Esophagus | ESCC | 2.29e-06 | 1.62e-01 | 0.1149 |
54908 | SPDL1 | P30T-E | Human | Esophagus | ESCC | 1.13e-04 | 2.43e-01 | 0.137 |
54908 | SPDL1 | P31T-E | Human | Esophagus | ESCC | 1.59e-03 | 1.66e-01 | 0.1251 |
Page: 1 2 3 4 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:20012513 | Esophagus | ESCC | negative regulation of chromosome organization | 60/8552 | 86/18723 | 5.20e-06 | 5.45e-05 | 60 |
GO:00458393 | Esophagus | ESCC | negative regulation of mitotic nuclear division | 37/8552 | 48/18723 | 8.99e-06 | 8.65e-05 | 37 |
GO:00513042 | Esophagus | ESCC | chromosome separation | 64/8552 | 96/18723 | 2.61e-05 | 2.20e-04 | 64 |
GO:00517843 | Esophagus | ESCC | negative regulation of nuclear division | 41/8552 | 56/18723 | 2.64e-05 | 2.21e-04 | 41 |
GO:00315772 | Esophagus | ESCC | spindle checkpoint | 30/8552 | 39/18723 | 6.93e-05 | 5.25e-04 | 30 |
GO:00330472 | Esophagus | ESCC | regulation of mitotic sister chromatid segregation | 34/8552 | 46/18723 | 9.39e-05 | 6.70e-04 | 34 |
GO:00070942 | Esophagus | ESCC | mitotic spindle assembly checkpoint | 29/8552 | 38/18723 | 1.18e-04 | 8.13e-04 | 29 |
GO:00711732 | Esophagus | ESCC | spindle assembly checkpoint | 29/8552 | 38/18723 | 1.18e-04 | 8.13e-04 | 29 |
GO:00711742 | Esophagus | ESCC | mitotic spindle checkpoint | 29/8552 | 38/18723 | 1.18e-04 | 8.13e-04 | 29 |
GO:00458412 | Esophagus | ESCC | negative regulation of mitotic metaphase/anaphase transition | 30/8552 | 40/18723 | 1.56e-04 | 1.03e-03 | 30 |
GO:19021002 | Esophagus | ESCC | negative regulation of metaphase/anaphase transition of cell cycle | 31/8552 | 42/18723 | 2.00e-04 | 1.27e-03 | 31 |
GO:00330462 | Esophagus | ESCC | negative regulation of sister chromatid segregation | 31/8552 | 43/18723 | 4.04e-04 | 2.30e-03 | 31 |
GO:00330482 | Esophagus | ESCC | negative regulation of mitotic sister chromatid segregation | 31/8552 | 43/18723 | 4.04e-04 | 2.30e-03 | 31 |
GO:20008162 | Esophagus | ESCC | negative regulation of mitotic sister chromatid separation | 31/8552 | 43/18723 | 4.04e-04 | 2.30e-03 | 31 |
GO:00519852 | Esophagus | ESCC | negative regulation of chromosome segregation | 32/8552 | 45/18723 | 4.87e-04 | 2.70e-03 | 32 |
GO:19058192 | Esophagus | ESCC | negative regulation of chromosome separation | 32/8552 | 45/18723 | 4.87e-04 | 2.70e-03 | 32 |
GO:0000132 | Esophagus | ESCC | establishment of mitotic spindle orientation | 23/8552 | 30/18723 | 5.47e-04 | 3.00e-03 | 23 |
GO:00400011 | Esophagus | ESCC | establishment of mitotic spindle localization | 26/8552 | 35/18723 | 5.57e-04 | 3.04e-03 | 26 |
GO:00512941 | Esophagus | ESCC | establishment of spindle orientation | 27/8552 | 37/18723 | 7.00e-04 | 3.66e-03 | 27 |
GO:00516533 | Esophagus | ESCC | spindle localization | 37/8552 | 56/18723 | 1.65e-03 | 7.65e-03 | 37 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SPDL1 | SNV | Missense_Mutation | c.272N>A | p.Leu91Gln | p.L91Q | Q96EA4 | protein_coding | deleterious(0.01) | probably_damaging(0.999) | TCGA-AR-A250-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | SD | |
SPDL1 | SNV | Missense_Mutation | rs750996171 | c.1420N>A | p.Gly474Arg | p.G474R | Q96EA4 | protein_coding | tolerated(0.5) | benign(0.003) | TCGA-Z7-A8R5-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | adriamycin | PD |
SPDL1 | SNV | Missense_Mutation | c.496C>G | p.Leu166Val | p.L166V | Q96EA4 | protein_coding | tolerated(0.19) | possibly_damaging(0.853) | TCGA-IR-A3LA-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
SPDL1 | SNV | Missense_Mutation | rs774516530 | c.997N>G | p.Leu333Val | p.L333V | Q96EA4 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-IR-A3LH-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
SPDL1 | SNV | Missense_Mutation | rs759699420 | c.1333N>A | p.Glu445Lys | p.E445K | Q96EA4 | protein_coding | tolerated(1) | benign(0.003) | TCGA-IR-A3LK-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Chemotherapy | cisplatin | PD |
SPDL1 | SNV | Missense_Mutation | rs143182474 | c.1564G>A | p.Val522Met | p.V522M | Q96EA4 | protein_coding | tolerated(0.6) | benign(0) | TCGA-AA-3837-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
SPDL1 | SNV | Missense_Mutation | rs201660793 | c.689N>A | p.Arg230His | p.R230H | Q96EA4 | protein_coding | tolerated(0.05) | benign(0.191) | TCGA-AA-3947-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
SPDL1 | SNV | Missense_Mutation | rs373642839 | c.212N>A | p.Arg71Gln | p.R71Q | Q96EA4 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-AA-A00N-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
SPDL1 | SNV | Missense_Mutation | rs747766603 | c.1436N>A | p.Arg479Gln | p.R479Q | Q96EA4 | protein_coding | tolerated(0.7) | benign(0.199) | TCGA-AA-A00N-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
SPDL1 | SNV | Missense_Mutation | c.1175N>G | p.Gln392Arg | p.Q392R | Q96EA4 | protein_coding | deleterious(0) | probably_damaging(0.975) | TCGA-AA-A01P-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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