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Gene: SNUPN |
Gene summary for SNUPN |
Gene summary. |
Gene information | Species | Human | Gene symbol | SNUPN | Gene ID | 10073 |
Gene name | snurportin 1 | |
Gene Alias | KPNBL | |
Cytomap | 15q24.2 | |
Gene Type | protein-coding | GO ID | GO:0006403 | UniProtAcc | O95149 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
10073 | SNUPN | LZE2T | Human | Esophagus | ESCC | 4.88e-02 | 3.13e-01 | 0.082 |
10073 | SNUPN | LZE4T | Human | Esophagus | ESCC | 1.31e-09 | 1.73e-01 | 0.0811 |
10073 | SNUPN | LZE7T | Human | Esophagus | ESCC | 9.37e-07 | 3.65e-01 | 0.0667 |
10073 | SNUPN | LZE8T | Human | Esophagus | ESCC | 7.28e-06 | 1.62e-01 | 0.067 |
10073 | SNUPN | LZE20T | Human | Esophagus | ESCC | 6.07e-05 | 1.04e-01 | 0.0662 |
10073 | SNUPN | LZE24T | Human | Esophagus | ESCC | 5.87e-07 | 1.63e-01 | 0.0596 |
10073 | SNUPN | LZE6T | Human | Esophagus | ESCC | 5.53e-04 | 3.33e-01 | 0.0845 |
10073 | SNUPN | P1T-E | Human | Esophagus | ESCC | 4.30e-08 | 3.49e-01 | 0.0875 |
10073 | SNUPN | P2T-E | Human | Esophagus | ESCC | 7.96e-19 | 2.21e-01 | 0.1177 |
10073 | SNUPN | P4T-E | Human | Esophagus | ESCC | 7.83e-23 | 6.28e-01 | 0.1323 |
10073 | SNUPN | P5T-E | Human | Esophagus | ESCC | 9.39e-11 | 1.94e-01 | 0.1327 |
10073 | SNUPN | P8T-E | Human | Esophagus | ESCC | 1.30e-18 | 2.89e-01 | 0.0889 |
10073 | SNUPN | P9T-E | Human | Esophagus | ESCC | 1.06e-25 | 6.66e-01 | 0.1131 |
10073 | SNUPN | P10T-E | Human | Esophagus | ESCC | 1.73e-35 | 5.55e-01 | 0.116 |
10073 | SNUPN | P11T-E | Human | Esophagus | ESCC | 1.68e-07 | 2.02e-01 | 0.1426 |
10073 | SNUPN | P12T-E | Human | Esophagus | ESCC | 1.05e-20 | 3.88e-01 | 0.1122 |
10073 | SNUPN | P15T-E | Human | Esophagus | ESCC | 3.08e-29 | 5.46e-01 | 0.1149 |
10073 | SNUPN | P16T-E | Human | Esophagus | ESCC | 3.79e-40 | 7.03e-01 | 0.1153 |
10073 | SNUPN | P17T-E | Human | Esophagus | ESCC | 1.05e-08 | 2.35e-01 | 0.1278 |
10073 | SNUPN | P19T-E | Human | Esophagus | ESCC | 1.17e-08 | 6.72e-01 | 0.1662 |
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Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:005116918 | Oral cavity | LP | nuclear transport | 130/4623 | 301/18723 | 1.19e-12 | 9.77e-11 | 130 |
GO:001703816 | Oral cavity | LP | protein import | 95/4623 | 206/18723 | 1.55e-11 | 1.13e-09 | 95 |
GO:005065715 | Oral cavity | LP | nucleic acid transport | 78/4623 | 163/18723 | 1.11e-10 | 6.44e-09 | 78 |
GO:005065815 | Oral cavity | LP | RNA transport | 78/4623 | 163/18723 | 1.11e-10 | 6.44e-09 | 78 |
GO:005123615 | Oral cavity | LP | establishment of RNA localization | 79/4623 | 166/18723 | 1.18e-10 | 6.81e-09 | 79 |
GO:001593115 | Oral cavity | LP | nucleobase-containing compound transport | 95/4623 | 222/18723 | 2.23e-09 | 9.98e-08 | 95 |
GO:005117013 | Oral cavity | LP | import into nucleus | 65/4623 | 159/18723 | 4.78e-06 | 9.69e-05 | 65 |
GO:000660612 | Oral cavity | LP | protein import into nucleus | 62/4623 | 155/18723 | 1.76e-05 | 3.04e-04 | 62 |
GO:007259427 | Skin | cSCC | establishment of protein localization to organelle | 213/4864 | 422/18723 | 1.40e-27 | 5.15e-25 | 213 |
GO:000691324 | Skin | cSCC | nucleocytoplasmic transport | 162/4864 | 301/18723 | 4.20e-25 | 1.10e-22 | 162 |
GO:005116924 | Skin | cSCC | nuclear transport | 162/4864 | 301/18723 | 4.20e-25 | 1.10e-22 | 162 |
GO:0006403111 | Skin | cSCC | RNA localization | 120/4864 | 201/18723 | 4.17e-24 | 1.01e-21 | 120 |
GO:0034504110 | Skin | cSCC | protein localization to nucleus | 143/4864 | 290/18723 | 8.98e-18 | 1.02e-15 | 143 |
GO:005065719 | Skin | cSCC | nucleic acid transport | 92/4864 | 163/18723 | 1.35e-16 | 1.33e-14 | 92 |
GO:005065819 | Skin | cSCC | RNA transport | 92/4864 | 163/18723 | 1.35e-16 | 1.33e-14 | 92 |
GO:005123619 | Skin | cSCC | establishment of RNA localization | 93/4864 | 166/18723 | 1.78e-16 | 1.69e-14 | 93 |
GO:0017038110 | Skin | cSCC | protein import | 100/4864 | 206/18723 | 2.50e-12 | 1.36e-10 | 100 |
GO:001593119 | Skin | cSCC | nucleobase-containing compound transport | 105/4864 | 222/18723 | 5.49e-12 | 2.89e-10 | 105 |
GO:005117016 | Skin | cSCC | import into nucleus | 77/4864 | 159/18723 | 9.17e-10 | 3.58e-08 | 77 |
GO:000660615 | Skin | cSCC | protein import into nucleus | 73/4864 | 155/18723 | 1.13e-08 | 3.48e-07 | 73 |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0301321 | Esophagus | ESCC | Nucleocytoplasmic transport | 89/4205 | 108/8465 | 1.20e-12 | 2.37e-11 | 1.21e-11 | 89 |
hsa0301331 | Esophagus | ESCC | Nucleocytoplasmic transport | 89/4205 | 108/8465 | 1.20e-12 | 2.37e-11 | 1.21e-11 | 89 |
hsa03013 | Liver | HCC | Nucleocytoplasmic transport | 81/4020 | 108/8465 | 4.28e-09 | 6.83e-08 | 3.80e-08 | 81 |
hsa030131 | Liver | HCC | Nucleocytoplasmic transport | 81/4020 | 108/8465 | 4.28e-09 | 6.83e-08 | 3.80e-08 | 81 |
hsa030136 | Oral cavity | OSCC | Nucleocytoplasmic transport | 82/3704 | 108/8465 | 7.93e-12 | 1.33e-10 | 6.77e-11 | 82 |
hsa0301311 | Oral cavity | OSCC | Nucleocytoplasmic transport | 82/3704 | 108/8465 | 7.93e-12 | 1.33e-10 | 6.77e-11 | 82 |
hsa030132 | Oral cavity | LP | Nucleocytoplasmic transport | 53/2418 | 108/8465 | 4.68e-06 | 4.10e-05 | 2.64e-05 | 53 |
hsa030133 | Oral cavity | LP | Nucleocytoplasmic transport | 53/2418 | 108/8465 | 4.68e-06 | 4.10e-05 | 2.64e-05 | 53 |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SNUPN | SNV | Missense_Mutation | rs779696140 | c.128N>A | p.Arg43His | p.R43H | O95149 | protein_coding | deleterious(0) | probably_damaging(0.963) | TCGA-AC-A3W7-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | femara | SD |
SNUPN | SNV | Missense_Mutation | c.274A>G | p.Lys92Glu | p.K92E | O95149 | protein_coding | deleterious(0.03) | benign(0.175) | TCGA-BH-A18R-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
SNUPN | SNV | Missense_Mutation | c.658N>A | p.Glu220Lys | p.E220K | O95149 | protein_coding | tolerated(0.07) | benign(0.071) | TCGA-E9-A1R4-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | 5-fluorouracil | SD | |
SNUPN | SNV | Missense_Mutation | novel | c.1034N>T | p.Lys345Met | p.K345M | O95149 | protein_coding | tolerated_low_confidence(0.07) | benign(0.068) | TCGA-JL-A3YW-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
SNUPN | SNV | Missense_Mutation | novel | c.1008G>T | p.Leu336Phe | p.L336F | O95149 | protein_coding | deleterious_low_confidence(0.01) | probably_damaging(0.998) | TCGA-UU-A93S-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | PD |
SNUPN | SNV | Missense_Mutation | rs377184433 | c.367G>A | p.Val123Met | p.V123M | O95149 | protein_coding | deleterious(0.05) | possibly_damaging(0.576) | TCGA-AA-3846-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
SNUPN | SNV | Missense_Mutation | rs142962123 | c.718N>A | p.Glu240Lys | p.E240K | O95149 | protein_coding | deleterious(0.04) | benign(0.006) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
SNUPN | SNV | Missense_Mutation | c.922N>A | p.Gln308Lys | p.Q308K | O95149 | protein_coding | deleterious(0.04) | probably_damaging(0.96) | TCGA-EI-7004-01 | Colorectum | rectum adenocarcinoma | Female | <65 | III/IV | Chemotherapy | xeloda | SD | |
SNUPN | SNV | Missense_Mutation | rs142962123 | c.718N>A | p.Glu240Lys | p.E240K | O95149 | protein_coding | deleterious(0.04) | benign(0.006) | TCGA-A5-A0G1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
SNUPN | SNV | Missense_Mutation | novel | c.114N>T | p.Leu38Phe | p.L38F | O95149 | protein_coding | tolerated(0.37) | probably_damaging(0.965) | TCGA-A5-A0G1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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