Schematic overview of the cellular and molecular mechanisms involved in the cancer progression, including the proposed cellular and molecular mechanisms in cancer cells trajectory. AT1: alveolar type 1 cells; AT2: alveolar type 2 cells; AAH: atypical adenomatous hyperplasia; AIS: adenocarcinoma in situ; MIA: minimally invasive adenocarcinoma; IA: invasive adenocarcinoma; EMT: epithelial-mesenchymal transition

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Center for Computational Systems Medicine
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Gene summary

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Malignant transformation analysis

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Malignant transformation related pathway analysis

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Cell-cell communication analysis

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Single-cell gene regulatory network inference analysis

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Somatic mutation of malignant transformation related genes

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Related drugs of malignant transformation related genes

Gene: SLC4A1

Gene summary for SLC4A1

check button Gene summary.

Gene informationSpeciesHuman
Gene symbol

SLC4A1

Gene ID

6521

Gene namesolute carrier family 4 member 1 (Diego blood group)
Gene AliasAE1
Cytomap17q21.31
Gene Typeprotein-coding
GO ID

GO:0002262

UniProtAcc

P02730


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Malignant transformation analysis

check button Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells
check button Malignant transformation involving gene list.
Entrez IDSymbolReplicatesSpeciesOrganTissueAdj P-valueLog2FCMalignancy
6521SLC4A1HCC1HumanLiverHCC5.36e-211.23e+000.5336
6521SLC4A1HCC2HumanLiverHCC2.54e-341.79e+000.5341
6521SLC4A1HCC5HumanLiverHCC1.30e-531.94e+000.4932
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check button Transcriptomic changes along malignancy continuum.
TissueExpression DynamicsAbbreviation
LiverThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.HCC: Hepatocellular carcinoma
NAFLD: Non-alcoholic fatty liver disease
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.

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Malignant transformation related pathway analysis

check buttonFind out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer
check button Figure of enriched GO biological processes.
TissueDisease StageEnriched GO biological Processes
ColorectumADGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumSERGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSSGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSI-HGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumFAPGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
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check button Enriched GO biological processes.
GO IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustCount
GO:0015701ColorectumCRCbicarbonate transport9/207829/187233.18e-032.78e-029
GO:00300044ColorectumCRCcellular monovalent inorganic cation homeostasis21/2078103/187234.15e-033.40e-0221
GO:00352642ColorectumCRCmulticellular organism growth25/2078132/187235.21e-033.97e-0225
GO:0021953ColorectumCRCcentral nervous system neuron differentiation29/2078162/187236.36e-034.62e-0229
GO:00306414ColorectumCRCregulation of cellular pH17/207881/187236.93e-034.85e-0217
GO:0006979111EsophagusESCCresponse to oxidative stress303/8552446/187237.15e-221.30e-19303
GO:0062197111EsophagusESCCcellular response to chemical stress234/8552337/187235.37e-195.97e-17234
GO:0034599111EsophagusESCCcellular response to oxidative stress197/8552288/187233.76e-152.15e-13197
GO:007121419EsophagusESCCcellular response to abiotic stimulus206/8552331/187237.52e-101.88e-08206
GO:010400419EsophagusESCCcellular response to environmental stimulus206/8552331/187237.52e-101.88e-08206
GO:00069707EsophagusESCCresponse to osmotic stress57/855284/187233.26e-052.70e-0457
GO:005188110EsophagusESCCregulation of mitochondrial membrane potential51/855274/187234.42e-053.51e-0451
GO:00488638EsophagusESCCstem cell differentiation122/8552206/187235.95e-054.59e-04122
GO:00714707EsophagusESCCcellular response to osmotic stress31/855241/187239.32e-056.68e-0431
GO:200073614EsophagusESCCregulation of stem cell differentiation39/855258/187237.43e-043.86e-0339
GO:0006971EsophagusESCChypotonic response10/855211/187232.54e-031.08e-0210
GO:190260018EsophagusESCCproton transmembrane transport88/8552157/187235.62e-032.10e-0288
GO:000609122LiverHCCgeneration of precursor metabolites and energy340/7958490/187234.04e-342.85e-31340
GO:004603422LiverHCCATP metabolic process198/7958277/187238.30e-231.55e-20198
GO:000911722LiverHCCnucleotide metabolic process300/7958489/187231.61e-171.71e-15300
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check button Enriched KEGG pathways.
Pathway IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustqvalueCount
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Cell-cell communication analysis

check buttonIdentification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states
LigandReceptorLRpairPathwayTissueDisease Stage
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Single-cell gene regulatory network inference analysis

check buttonFind out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states
TFCell TypeTissueDisease StageTarget GeneRSSRegulon Activity
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
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Somatic mutation of malignant transformation related genes

check buttonAnnotation of somatic variants for genes involved in malignant transformation
Hugo SymbolVariant ClassVariant ClassificationdbSNP RSHGVScHGVSpHGVSp ShortSWISSPROTBIOTYPESIFTPolyPhenTumor Sample BarcodeTissueHistologySexAgeStageTherapy TypesDrugsOutcome
SLC4A1SNVMissense_Mutationrs28931585c.2608N>Tp.Arg870Trpp.R870WP02730protein_codingdeleterious(0)probably_damaging(0.998)TCGA-A2-A3KC-01Breastbreast invasive carcinomaFemale<65I/IIChemotherapyadriamycinSD
SLC4A1SNVMissense_Mutationc.2722N>Ap.Ala908Thrp.A908TP02730protein_codingtolerated(0.63)benign(0)TCGA-AN-A0AK-01Breastbreast invasive carcinomaFemale>=65I/IIUnknownUnknownSD
SLC4A1SNVMissense_Mutationrs775748758c.2185G>Ap.Val729Metp.V729MP02730protein_codingdeleterious(0)probably_damaging(1)TCGA-C8-A12L-01Breastbreast invasive carcinomaFemale>=65I/IIUnknownUnknownSD
SLC4A1SNVMissense_Mutationc.2147N>Ap.Ala716Aspp.A716DP02730protein_codingdeleterious(0.01)possibly_damaging(0.454)TCGA-E2-A15R-01Breastbreast invasive carcinomaFemale<65I/IIChemotherapycyclophosphamideSD
SLC4A1SNVMissense_Mutationc.1232N>Cp.Phe411Serp.F411SP02730protein_codingdeleterious(0.01)probably_damaging(0.996)TCGA-E2-A1L7-01Breastbreast invasive carcinomaFemale<65III/IVChemotherapycyclophosphamidePD
SLC4A1SNVMissense_Mutationc.1778N>Gp.Asn593Serp.N593SP02730protein_codingdeleterious(0.02)possibly_damaging(0.733)TCGA-GM-A2DK-01Breastbreast invasive carcinomaFemale<65I/IIHormone TherapyarimidexCR
SLC4A1insertionFrame_Shift_Insnovelc.2536_2537insGGGGAAATGAp.Val846GlyfsTer47p.V846Gfs*47P02730protein_codingTCGA-AO-A0J5-01Breastbreast invasive carcinomaFemale<65III/IVOther, specify in notesBisphosphonatezoledronicPD
SLC4A1insertionFrame_Shift_Insnovelc.2534_2535insTGTGTCTTCATTTTGCTCACCTGTAAp.Leu847SerfsTer13p.L847Sfs*13P02730protein_codingTCGA-AO-A0J5-01Breastbreast invasive carcinomaFemale<65III/IVOther, specify in notesBisphosphonatezoledronicPD
SLC4A1SNVMissense_Mutationnovelc.1735N>Ap.Ala579Thrp.A579TP02730protein_codingtolerated(0.09)benign(0.103)TCGA-2W-A8YY-01Cervixcervical & endocervical cancerFemale<65I/IIChemotherapycisplatinCR
SLC4A1SNVMissense_Mutationnovelc.856N>Tp.Ala286Serp.A286SP02730protein_codingtolerated(1)possibly_damaging(0.469)TCGA-C5-A1ME-01Cervixcervical & endocervical cancerFemale<65I/IIUnknownUnknownSD
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Related drugs of malignant transformation related genes

check buttonIdentification of chemicals and drugs interact with genes involved in malignant transfromation
(DGIdb 4.0)
Entrez IDSymbolCategoryInteraction TypesDrug Claim NameDrug NamePMIDs
6521SLC4A1ENZYME, TRANSPORTER, CELL SURFACE, DRUGGABLE GENOMEmetoprololMETOPROLOL
6521SLC4A1ENZYME, TRANSPORTER, CELL SURFACE, DRUGGABLE GENOMEatenololATENOLOL
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