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Gene: SLC44A4 |
Gene summary for SLC44A4 |
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Gene information | Species | Human | Gene symbol | SLC44A4 | Gene ID | 80736 |
Gene name | solute carrier family 44 member 4 | |
Gene Alias | C6orf29 | |
Cytomap | 6p21.33 | |
Gene Type | protein-coding | GO ID | GO:0001505 | UniProtAcc | Q53GD3 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
80736 | SLC44A4 | HTA11_2487_2000001011 | Human | Colorectum | SER | 2.32e-24 | 1.33e+00 | -0.1808 |
80736 | SLC44A4 | HTA11_1938_2000001011 | Human | Colorectum | AD | 3.49e-20 | 1.12e+00 | -0.0811 |
80736 | SLC44A4 | HTA11_78_2000001011 | Human | Colorectum | AD | 1.01e-13 | 9.37e-01 | -0.1088 |
80736 | SLC44A4 | HTA11_347_2000001011 | Human | Colorectum | AD | 4.30e-55 | 1.53e+00 | -0.1954 |
80736 | SLC44A4 | HTA11_411_2000001011 | Human | Colorectum | SER | 3.07e-16 | 2.09e+00 | -0.2602 |
80736 | SLC44A4 | HTA11_2112_2000001011 | Human | Colorectum | SER | 1.55e-16 | 1.52e+00 | -0.2196 |
80736 | SLC44A4 | HTA11_3361_2000001011 | Human | Colorectum | AD | 2.19e-17 | 9.55e-01 | -0.1207 |
80736 | SLC44A4 | HTA11_83_2000001011 | Human | Colorectum | SER | 4.96e-13 | 9.33e-01 | -0.1526 |
80736 | SLC44A4 | HTA11_696_2000001011 | Human | Colorectum | AD | 3.15e-47 | 1.46e+00 | -0.1464 |
80736 | SLC44A4 | HTA11_866_2000001011 | Human | Colorectum | AD | 3.34e-22 | 8.49e-01 | -0.1001 |
80736 | SLC44A4 | HTA11_1391_2000001011 | Human | Colorectum | AD | 2.20e-20 | 1.07e+00 | -0.059 |
80736 | SLC44A4 | HTA11_2992_2000001011 | Human | Colorectum | SER | 7.47e-11 | 1.15e+00 | -0.1706 |
80736 | SLC44A4 | HTA11_5212_2000001011 | Human | Colorectum | AD | 3.95e-09 | 9.81e-01 | -0.2061 |
80736 | SLC44A4 | HTA11_5216_2000001011 | Human | Colorectum | SER | 1.28e-05 | 9.66e-01 | -0.1462 |
80736 | SLC44A4 | HTA11_546_2000001011 | Human | Colorectum | AD | 3.58e-11 | 9.64e-01 | -0.0842 |
80736 | SLC44A4 | HTA11_7663_2000001011 | Human | Colorectum | SER | 3.07e-08 | 9.27e-01 | 0.0131 |
80736 | SLC44A4 | HTA11_10623_2000001011 | Human | Colorectum | AD | 5.70e-07 | 8.18e-01 | -0.0177 |
80736 | SLC44A4 | HTA11_10711_2000001011 | Human | Colorectum | AD | 2.79e-02 | 4.72e-01 | 0.0338 |
80736 | SLC44A4 | HTA11_7696_3000711011 | Human | Colorectum | AD | 1.67e-02 | 3.72e-01 | 0.0674 |
80736 | SLC44A4 | HTA11_6818_2000001011 | Human | Colorectum | AD | 9.69e-04 | 6.95e-01 | 0.0112 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0046474 | Colorectum | FAP | glycerophospholipid biosynthetic process | 44/2622 | 211/18723 | 3.98e-03 | 2.76e-02 | 44 |
GO:00099132 | Colorectum | FAP | epidermal cell differentiation | 42/2622 | 202/18723 | 5.08e-03 | 3.37e-02 | 42 |
GO:00485682 | Colorectum | FAP | embryonic organ development | 79/2622 | 427/18723 | 5.32e-03 | 3.49e-02 | 79 |
GO:00450172 | Colorectum | FAP | glycerolipid biosynthetic process | 50/2622 | 252/18723 | 6.32e-03 | 3.95e-02 | 50 |
GO:00160494 | Colorectum | CRC | cell growth | 95/2078 | 482/18723 | 1.51e-08 | 2.75e-06 | 95 |
GO:00015584 | Colorectum | CRC | regulation of cell growth | 78/2078 | 414/18723 | 1.84e-06 | 9.11e-05 | 78 |
GO:00459274 | Colorectum | CRC | positive regulation of growth | 51/2078 | 259/18723 | 3.23e-05 | 8.27e-04 | 51 |
GO:00086541 | Colorectum | CRC | phospholipid biosynthetic process | 49/2078 | 253/18723 | 7.07e-05 | 1.51e-03 | 49 |
GO:00066503 | Colorectum | CRC | glycerophospholipid metabolic process | 55/2078 | 306/18723 | 2.10e-04 | 3.55e-03 | 55 |
GO:00450173 | Colorectum | CRC | glycerolipid biosynthetic process | 47/2078 | 252/18723 | 2.47e-04 | 4.06e-03 | 47 |
GO:00085442 | Colorectum | CRC | epidermis development | 57/2078 | 324/18723 | 2.88e-04 | 4.59e-03 | 57 |
GO:00303074 | Colorectum | CRC | positive regulation of cell growth | 34/2078 | 166/18723 | 2.94e-04 | 4.67e-03 | 34 |
GO:00066443 | Colorectum | CRC | phospholipid metabolic process | 65/2078 | 383/18723 | 3.21e-04 | 4.95e-03 | 65 |
GO:00464741 | Colorectum | CRC | glycerophospholipid biosynthetic process | 40/2078 | 211/18723 | 4.91e-04 | 7.02e-03 | 40 |
GO:00464861 | Colorectum | CRC | glycerolipid metabolic process | 64/2078 | 392/18723 | 1.01e-03 | 1.19e-02 | 64 |
GO:00099133 | Colorectum | CRC | epidermal cell differentiation | 37/2078 | 202/18723 | 1.50e-03 | 1.59e-02 | 37 |
GO:00230611 | Colorectum | CRC | signal release | 72/2078 | 463/18723 | 1.95e-03 | 1.96e-02 | 72 |
GO:00353154 | Colorectum | CRC | hair cell differentiation | 12/2078 | 47/18723 | 4.33e-03 | 3.47e-02 | 12 |
GO:00485683 | Colorectum | CRC | embryonic organ development | 65/2078 | 427/18723 | 5.15e-03 | 3.94e-02 | 65 |
GO:0090596 | Colorectum | CRC | sensory organ morphogenesis | 42/2078 | 256/18723 | 6.22e-03 | 4.54e-02 | 42 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa05231 | Colorectum | MSS | Choline metabolism in cancer | 34/1875 | 98/8465 | 2.90e-03 | 1.39e-02 | 8.50e-03 | 34 |
hsa052311 | Colorectum | MSS | Choline metabolism in cancer | 34/1875 | 98/8465 | 2.90e-03 | 1.39e-02 | 8.50e-03 | 34 |
hsa052312 | Colorectum | FAP | Choline metabolism in cancer | 29/1404 | 98/8465 | 9.03e-04 | 5.20e-03 | 3.16e-03 | 29 |
hsa052313 | Colorectum | FAP | Choline metabolism in cancer | 29/1404 | 98/8465 | 9.03e-04 | 5.20e-03 | 3.16e-03 | 29 |
hsa052314 | Colorectum | CRC | Choline metabolism in cancer | 24/1091 | 98/8465 | 1.21e-03 | 9.84e-03 | 6.67e-03 | 24 |
hsa052315 | Colorectum | CRC | Choline metabolism in cancer | 24/1091 | 98/8465 | 1.21e-03 | 9.84e-03 | 6.67e-03 | 24 |
hsa052319 | Esophagus | ESCC | Choline metabolism in cancer | 61/4205 | 98/8465 | 7.97e-03 | 1.92e-02 | 9.84e-03 | 61 |
hsa0523114 | Esophagus | ESCC | Choline metabolism in cancer | 61/4205 | 98/8465 | 7.97e-03 | 1.92e-02 | 9.84e-03 | 61 |
hsa052316 | Liver | HCC | Choline metabolism in cancer | 57/4020 | 98/8465 | 2.14e-02 | 4.90e-02 | 2.72e-02 | 57 |
hsa0523111 | Liver | HCC | Choline metabolism in cancer | 57/4020 | 98/8465 | 2.14e-02 | 4.90e-02 | 2.72e-02 | 57 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SLC44A4 | SNV | Missense_Mutation | rs780198573 | c.538C>A | p.Arg180Ser | p.R180S | Q53GD3 | protein_coding | deleterious(0) | probably_damaging(0.933) | TCGA-E9-A1R4-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | 5-fluorouracil | SD |
SLC44A4 | SNV | Missense_Mutation | rs372077719 | c.1747N>G | p.Arg583Gly | p.R583G | Q53GD3 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-EW-A1J5-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | SD |
SLC44A4 | SNV | Missense_Mutation | rs200350113 | c.569N>T | p.Pro190Leu | p.P190L | Q53GD3 | protein_coding | tolerated(0.15) | benign(0.003) | TCGA-C5-A8XH-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
SLC44A4 | SNV | Missense_Mutation | c.2023N>C | p.Glu675Gln | p.E675Q | Q53GD3 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-FU-A23K-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Unknown | Unknown | SD | |
SLC44A4 | SNV | Missense_Mutation | rs11551744 | c.31N>A | p.Glu11Lys | p.E11K | Q53GD3 | protein_coding | tolerated(0.62) | benign(0.003) | TCGA-VS-A958-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
SLC44A4 | SNV | Missense_Mutation | novel | c.839N>G | p.Tyr280Cys | p.Y280C | Q53GD3 | protein_coding | deleterious(0) | benign(0.365) | TCGA-XS-A8TJ-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | SD |
SLC44A4 | SNV | Missense_Mutation | c.1304N>G | p.Ile435Ser | p.I435S | Q53GD3 | protein_coding | deleterious(0.01) | benign(0.065) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR | |
SLC44A4 | SNV | Missense_Mutation | c.1940N>T | p.Gly647Val | p.G647V | Q53GD3 | protein_coding | deleterious(0) | probably_damaging(0.927) | TCGA-AZ-6598-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
SLC44A4 | SNV | Missense_Mutation | novel | c.484N>A | p.Leu162Met | p.L162M | Q53GD3 | protein_coding | tolerated(0.06) | benign(0.415) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
SLC44A4 | SNV | Missense_Mutation | novel | c.803N>G | p.Val268Gly | p.V268G | Q53GD3 | protein_coding | deleterious(0) | benign(0.127) | TCGA-AG-A023-01 | Colorectum | rectum adenocarcinoma | Female | <65 | III/IV | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
80736 | SLC44A4 | TRANSPORTER, DRUGGABLE GENOME | ASG-5ME | ASG-5ME |
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