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Gene: SLC38A2 |
Gene summary for SLC38A2 |
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Gene information | Species | Human | Gene symbol | SLC38A2 | Gene ID | 54407 |
Gene name | solute carrier family 38 member 2 | |
Gene Alias | ATA2 | |
Cytomap | 12q13.11 | |
Gene Type | protein-coding | GO ID | GO:0000003 | UniProtAcc | Q8NHT5 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
54407 | SLC38A2 | GSM4909280 | Human | Breast | Precancer | 7.04e-03 | 3.81e-01 | 0.0305 |
54407 | SLC38A2 | GSM4909281 | Human | Breast | IDC | 7.87e-07 | -4.41e-01 | 0.21 |
54407 | SLC38A2 | GSM4909282 | Human | Breast | IDC | 3.00e-14 | -5.19e-01 | -0.0288 |
54407 | SLC38A2 | GSM4909285 | Human | Breast | IDC | 3.45e-07 | -3.95e-01 | 0.21 |
54407 | SLC38A2 | GSM4909286 | Human | Breast | IDC | 2.37e-08 | -4.48e-01 | 0.1081 |
54407 | SLC38A2 | GSM4909287 | Human | Breast | IDC | 2.65e-08 | -4.15e-01 | 0.2057 |
54407 | SLC38A2 | GSM4909288 | Human | Breast | IDC | 7.40e-04 | -4.88e-01 | 0.0988 |
54407 | SLC38A2 | GSM4909290 | Human | Breast | IDC | 4.20e-02 | -2.90e-01 | 0.2096 |
54407 | SLC38A2 | GSM4909293 | Human | Breast | IDC | 1.97e-03 | 2.42e-01 | 0.1581 |
54407 | SLC38A2 | GSM4909294 | Human | Breast | IDC | 5.91e-06 | -3.85e-01 | 0.2022 |
54407 | SLC38A2 | GSM4909296 | Human | Breast | IDC | 1.38e-12 | -3.86e-01 | 0.1524 |
54407 | SLC38A2 | GSM4909297 | Human | Breast | IDC | 1.27e-17 | -4.61e-01 | 0.1517 |
54407 | SLC38A2 | GSM4909302 | Human | Breast | IDC | 5.18e-08 | -3.88e-01 | 0.1545 |
54407 | SLC38A2 | GSM4909304 | Human | Breast | IDC | 2.30e-02 | 2.51e-01 | 0.1636 |
54407 | SLC38A2 | GSM4909307 | Human | Breast | IDC | 1.13e-16 | -5.72e-01 | 0.1569 |
54407 | SLC38A2 | GSM4909308 | Human | Breast | IDC | 4.68e-18 | -5.74e-01 | 0.158 |
54407 | SLC38A2 | GSM4909309 | Human | Breast | IDC | 1.67e-02 | -2.94e-01 | 0.0483 |
54407 | SLC38A2 | GSM4909311 | Human | Breast | IDC | 8.79e-33 | -4.58e-01 | 0.1534 |
54407 | SLC38A2 | GSM4909312 | Human | Breast | IDC | 1.30e-08 | -3.23e-01 | 0.1552 |
54407 | SLC38A2 | GSM4909316 | Human | Breast | IDC | 6.59e-04 | -4.17e-01 | 0.21 |
Page: 1 2 3 4 5 6 7 8 9 10 11 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:007124321 | Breast | DCIS | cellular response to arsenic-containing substance | 7/1390 | 20/18723 | 4.01e-04 | 5.48e-03 | 7 |
GO:003166922 | Breast | DCIS | cellular response to nutrient levels | 27/1390 | 215/18723 | 5.06e-03 | 3.74e-02 | 27 |
GO:000926713 | Breast | DCIS | cellular response to starvation | 21/1390 | 156/18723 | 5.74e-03 | 4.13e-02 | 21 |
GO:007149610 | Cervix | CC | cellular response to external stimulus | 78/2311 | 320/18723 | 1.82e-09 | 1.98e-07 | 78 |
GO:004348410 | Cervix | CC | regulation of RNA splicing | 42/2311 | 148/18723 | 1.25e-07 | 6.24e-06 | 42 |
GO:00316689 | Cervix | CC | cellular response to extracellular stimulus | 59/2311 | 246/18723 | 3.03e-07 | 1.24e-05 | 59 |
GO:003166710 | Cervix | CC | response to nutrient levels | 92/2311 | 474/18723 | 5.80e-06 | 1.42e-04 | 92 |
GO:00712148 | Cervix | CC | cellular response to abiotic stimulus | 69/2311 | 331/18723 | 7.36e-06 | 1.73e-04 | 69 |
GO:01040048 | Cervix | CC | cellular response to environmental stimulus | 69/2311 | 331/18723 | 7.36e-06 | 1.73e-04 | 69 |
GO:00092678 | Cervix | CC | cellular response to starvation | 39/2311 | 156/18723 | 1.04e-05 | 2.32e-04 | 39 |
GO:00425948 | Cervix | CC | response to starvation | 46/2311 | 197/18723 | 1.24e-05 | 2.59e-04 | 46 |
GO:00316698 | Cervix | CC | cellular response to nutrient levels | 49/2311 | 215/18723 | 1.32e-05 | 2.68e-04 | 49 |
GO:00096127 | Cervix | CC | response to mechanical stimulus | 48/2311 | 216/18723 | 3.23e-05 | 5.29e-04 | 48 |
GO:00075654 | Cervix | CC | female pregnancy | 43/2311 | 193/18723 | 7.62e-05 | 1.04e-03 | 43 |
GO:00712602 | Cervix | CC | cellular response to mechanical stimulus | 23/2311 | 81/18723 | 8.34e-05 | 1.12e-03 | 23 |
GO:00331208 | Cervix | CC | positive regulation of RNA splicing | 13/2311 | 37/18723 | 2.99e-04 | 3.21e-03 | 13 |
GO:00447064 | Cervix | CC | multi-multicellular organism process | 45/2311 | 220/18723 | 4.14e-04 | 4.21e-03 | 45 |
GO:000838010 | Cervix | CC | RNA splicing | 76/2311 | 434/18723 | 9.79e-04 | 8.19e-03 | 76 |
GO:00219873 | Cervix | CC | cerebral cortex development | 25/2311 | 114/18723 | 2.81e-03 | 1.88e-02 | 25 |
GO:00309003 | Cervix | CC | forebrain development | 64/2311 | 379/18723 | 5.53e-03 | 3.19e-02 | 64 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SLC38A2 | SNV | Missense_Mutation | c.501N>A | p.Phe167Leu | p.F167L | Q96QD8 | protein_coding | tolerated(0.12) | benign(0.248) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
SLC38A2 | SNV | Missense_Mutation | c.527T>C | p.Val176Ala | p.V176A | Q96QD8 | protein_coding | tolerated(0.22) | probably_damaging(0.996) | TCGA-D8-A1XQ-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
SLC38A2 | SNV | Missense_Mutation | novel | c.23N>A | p.Arg8Gln | p.R8Q | Q96QD8 | protein_coding | tolerated(0.14) | benign(0.078) | TCGA-D8-A73U-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | tamoxiphen | SD |
SLC38A2 | insertion | Frame_Shift_Ins | novel | c.11_12insATCTCCAAGATACTTCAAATATGTATGTGCAGGTA | p.Glu5SerfsTer45 | p.E5Sfs*45 | Q96QD8 | protein_coding | TCGA-A8-A06X-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
SLC38A2 | SNV | Missense_Mutation | c.1476N>C | p.Leu492Phe | p.L492F | Q96QD8 | protein_coding | tolerated(0.78) | probably_damaging(0.994) | TCGA-DR-A0ZM-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Unspecific | Cisplatin | SD | |
SLC38A2 | SNV | Missense_Mutation | rs771981553 | c.1126N>T | p.Arg376Cys | p.R376C | Q96QD8 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-IR-A3LK-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Chemotherapy | cisplatin | PD |
SLC38A2 | SNV | Missense_Mutation | rs773343163 | c.1297N>G | p.Thr433Ala | p.T433A | Q96QD8 | protein_coding | deleterious(0.04) | benign(0.223) | TCGA-AA-3664-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
SLC38A2 | SNV | Missense_Mutation | novel | c.319N>A | p.Leu107Ile | p.L107I | Q96QD8 | protein_coding | deleterious(0.01) | probably_damaging(0.998) | TCGA-F5-6814-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
SLC38A2 | insertion | Frame_Shift_Ins | novel | c.994_995insGTTTTTGTTTTTG | p.Phe332CysfsTer28 | p.F332Cfs*28 | Q96QD8 | protein_coding | TCGA-AM-5820-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
SLC38A2 | insertion | Frame_Shift_Ins | novel | c.14_15insTAGCAAATTAAAGC | p.Glu5AspfsTer38 | p.E5Dfs*38 | Q96QD8 | protein_coding | TCGA-AM-5820-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
54407 | SLC38A2 | TRANSPORTER | 178101264 | |||
54407 | SLC38A2 | TRANSPORTER | 178101263 |
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