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Gene: SELENOW |
Gene summary for SELENOW |
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Gene information | Species | Human | Gene symbol | SELENOW | Gene ID | 6415 |
Gene name | selenoprotein W | |
Gene Alias | SEPW1 | |
Cytomap | 19q13.33 | |
Gene Type | protein-coding | GO ID | GO:0008150 | UniProtAcc | P63302 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
6415 | SELENOW | GSM4909281 | Human | Breast | IDC | 1.18e-28 | 7.29e-01 | 0.21 |
6415 | SELENOW | GSM4909285 | Human | Breast | IDC | 1.65e-10 | 1.85e-01 | 0.21 |
6415 | SELENOW | GSM4909286 | Human | Breast | IDC | 5.62e-14 | -7.34e-02 | 0.1081 |
6415 | SELENOW | GSM4909288 | Human | Breast | IDC | 5.19e-05 | 5.21e-01 | 0.0988 |
6415 | SELENOW | GSM4909289 | Human | Breast | IDC | 8.10e-07 | 5.91e-01 | 0.1064 |
6415 | SELENOW | GSM4909290 | Human | Breast | IDC | 3.74e-14 | 4.78e-01 | 0.2096 |
6415 | SELENOW | GSM4909291 | Human | Breast | IDC | 5.13e-29 | 8.02e-01 | 0.1753 |
6415 | SELENOW | GSM4909293 | Human | Breast | IDC | 1.16e-12 | 3.01e-01 | 0.1581 |
6415 | SELENOW | GSM4909295 | Human | Breast | IDC | 1.33e-02 | 1.93e-01 | 0.0898 |
6415 | SELENOW | GSM4909296 | Human | Breast | IDC | 3.84e-11 | 4.71e-01 | 0.1524 |
6415 | SELENOW | GSM4909297 | Human | Breast | IDC | 3.96e-12 | 3.37e-01 | 0.1517 |
6415 | SELENOW | GSM4909298 | Human | Breast | IDC | 1.89e-12 | 3.88e-01 | 0.1551 |
6415 | SELENOW | GSM4909301 | Human | Breast | IDC | 8.20e-14 | 5.70e-01 | 0.1577 |
6415 | SELENOW | GSM4909302 | Human | Breast | IDC | 1.07e-07 | 3.83e-01 | 0.1545 |
6415 | SELENOW | GSM4909303 | Human | Breast | IDC | 6.59e-05 | 5.14e-01 | 0.0438 |
6415 | SELENOW | GSM4909304 | Human | Breast | IDC | 3.76e-14 | 4.65e-01 | 0.1636 |
6415 | SELENOW | GSM4909305 | Human | Breast | IDC | 3.66e-08 | 2.85e-01 | 0.0436 |
6415 | SELENOW | GSM4909306 | Human | Breast | IDC | 4.12e-38 | 8.32e-01 | 0.1564 |
6415 | SELENOW | GSM4909307 | Human | Breast | IDC | 2.58e-08 | 4.90e-01 | 0.1569 |
6415 | SELENOW | GSM4909308 | Human | Breast | IDC | 4.56e-23 | 4.68e-01 | 0.158 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:000963610 | Endometrium | AEH | response to toxic substance | 52/2100 | 262/18723 | 2.89e-05 | 5.40e-04 | 52 |
GO:009886910 | Endometrium | AEH | cellular oxidant detoxification | 26/2100 | 101/18723 | 3.57e-05 | 6.26e-04 | 26 |
GO:009875410 | Endometrium | AEH | detoxification | 31/2100 | 152/18723 | 6.85e-04 | 6.62e-03 | 31 |
GO:009723715 | Endometrium | EEC | cellular response to toxic substance | 35/2168 | 124/18723 | 3.44e-07 | 1.37e-05 | 35 |
GO:199074815 | Endometrium | EEC | cellular detoxification | 31/2168 | 116/18723 | 5.54e-06 | 1.36e-04 | 31 |
GO:000963615 | Endometrium | EEC | response to toxic substance | 54/2168 | 262/18723 | 1.65e-05 | 3.18e-04 | 54 |
GO:009886915 | Endometrium | EEC | cellular oxidant detoxification | 27/2168 | 101/18723 | 2.17e-05 | 3.89e-04 | 27 |
GO:009875415 | Endometrium | EEC | detoxification | 32/2168 | 152/18723 | 5.52e-04 | 5.52e-03 | 32 |
GO:199074820 | Esophagus | HGIN | cellular detoxification | 30/2587 | 116/18723 | 4.05e-04 | 6.15e-03 | 30 |
GO:009723720 | Esophagus | HGIN | cellular response to toxic substance | 30/2587 | 124/18723 | 1.32e-03 | 1.57e-02 | 30 |
GO:009886920 | Esophagus | HGIN | cellular oxidant detoxification | 25/2587 | 101/18723 | 2.29e-03 | 2.34e-02 | 25 |
GO:000963620 | Esophagus | ESCC | response to toxic substance | 150/8552 | 262/18723 | 1.00e-04 | 7.12e-04 | 150 |
GO:1990748110 | Esophagus | ESCC | cellular detoxification | 70/8552 | 116/18723 | 1.02e-03 | 5.17e-03 | 70 |
GO:0097237110 | Esophagus | ESCC | cellular response to toxic substance | 72/8552 | 124/18723 | 3.65e-03 | 1.49e-02 | 72 |
GO:0098869110 | Esophagus | ESCC | cellular oxidant detoxification | 60/8552 | 101/18723 | 3.76e-03 | 1.53e-02 | 60 |
GO:000963622 | Liver | HCC | response to toxic substance | 153/7958 | 262/18723 | 1.37e-07 | 2.58e-06 | 153 |
GO:199074812 | Liver | HCC | cellular detoxification | 70/7958 | 116/18723 | 7.87e-05 | 7.02e-04 | 70 |
GO:009723712 | Liver | HCC | cellular response to toxic substance | 74/7958 | 124/18723 | 8.36e-05 | 7.36e-04 | 74 |
GO:009875412 | Liver | HCC | detoxification | 87/7958 | 152/18723 | 1.70e-04 | 1.35e-03 | 87 |
GO:009886912 | Liver | HCC | cellular oxidant detoxification | 59/7958 | 101/18723 | 9.00e-04 | 5.31e-03 | 59 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SELENOW | SNV | Missense_Mutation | novel | c.210A>C | p.Glu70Asp | p.E70D | P63302 | protein_coding | tolerated(0.48) | possibly_damaging(0.787) | TCGA-F5-6814-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
SELENOW | SNV | Missense_Mutation | c.235G>A | p.Ala79Thr | p.A79T | P63302 | protein_coding | tolerated(0.16) | possibly_damaging(0.893) | TCGA-AJ-A3BH-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | Unknown | I/II | Unknown | Unknown | SD | |
SELENOW | SNV | Missense_Mutation | novel | c.212N>T | p.Ser71Ile | p.S71I | P63302 | protein_coding | tolerated(0.06) | benign(0.006) | TCGA-AX-A0J1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
SELENOW | SNV | Missense_Mutation | novel | c.72G>T | p.Lys24Asn | p.K24N | P63302 | protein_coding | tolerated(0.11) | possibly_damaging(0.463) | TCGA-BS-A0UF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
SELENOW | SNV | Missense_Mutation | novel | c.251N>C | p.Leu84Ser | p.L84S | P63302 | protein_coding | deleterious(0) | benign(0.146) | TCGA-EO-A3AU-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
SELENOW | SNV | Missense_Mutation | novel | c.157N>T | p.Ala53Ser | p.A53S | P63302 | protein_coding | tolerated(0.56) | benign(0.303) | TCGA-VQ-A8DT-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Chemotherapy | fluorouracil | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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