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Gene: SCX |
Gene summary for SCX |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | SCX | Gene ID | 642658 |
| Gene name | scleraxis bHLH transcription factor | |
| Gene Alias | SCXA | |
| Cytomap | 8q24.3 | |
| Gene Type | protein-coding | GO ID | GO:0000003 | UniProtAcc | Q7RTU7 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 642658 | SCX | male-WTA | Human | Thyroid | PTC | 1.84e-47 | 6.68e-01 | 0.1037 |
| 642658 | SCX | female-WTA | Human | Thyroid | PTC | 2.41e-03 | 4.05e-01 | 0.0726 |
| 642658 | SCX | PTC01 | Human | Thyroid | PTC | 4.81e-09 | 4.84e-01 | 0.1899 |
| 642658 | SCX | PTC03 | Human | Thyroid | PTC | 1.38e-07 | 8.39e-01 | 0.1784 |
| 642658 | SCX | PTC04 | Human | Thyroid | PTC | 1.08e-17 | 8.71e-01 | 0.1927 |
| 642658 | SCX | PTC05 | Human | Thyroid | PTC | 7.86e-23 | 1.20e+00 | 0.2065 |
| 642658 | SCX | PTC06 | Human | Thyroid | PTC | 4.51e-63 | 2.03e+00 | 0.2057 |
| 642658 | SCX | PTC07 | Human | Thyroid | PTC | 1.71e-64 | 1.51e+00 | 0.2044 |
| 642658 | SCX | ATC13 | Human | Thyroid | ATC | 1.44e-22 | 8.69e-01 | 0.34 |
| 642658 | SCX | ATC5 | Human | Thyroid | ATC | 6.53e-28 | 9.02e-01 | 0.34 |
| Page: 1 |
| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Thyroid |  | ATC: Anaplastic thyroid cancer |
| HT: Hashimoto's thyroiditis | ||
| PTC: Papillary thyroid cancer |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| GO:000717823 | Thyroid | ATC | transmembrane receptor protein serine/threonine kinase signaling pathway | 170/6293 | 355/18723 | 1.40e-08 | 2.87e-07 | 170 |
| GO:006145827 | Thyroid | ATC | reproductive system development | 193/6293 | 427/18723 | 3.32e-07 | 4.92e-06 | 193 |
| GO:004860825 | Thyroid | ATC | reproductive structure development | 190/6293 | 424/18723 | 8.40e-07 | 1.11e-05 | 190 |
| GO:006034813 | Thyroid | ATC | bone development | 102/6293 | 205/18723 | 1.18e-06 | 1.52e-05 | 102 |
| GO:006053724 | Thyroid | ATC | muscle tissue development | 181/6293 | 403/18723 | 1.27e-06 | 1.62e-05 | 181 |
| GO:006048521 | Thyroid | ATC | mesenchyme development | 136/6293 | 291/18723 | 2.04e-06 | 2.43e-05 | 136 |
| GO:000961225 | Thyroid | ATC | response to mechanical stimulus | 105/6293 | 216/18723 | 3.29e-06 | 3.70e-05 | 105 |
| GO:006032511 | Thyroid | ATC | face morphogenesis | 21/6293 | 28/18723 | 8.94e-06 | 8.95e-05 | 21 |
| GO:007126022 | Thyroid | ATC | cellular response to mechanical stimulus | 46/6293 | 81/18723 | 1.51e-05 | 1.41e-04 | 46 |
| GO:000736915 | Thyroid | ATC | gastrulation | 90/6293 | 185/18723 | 1.54e-05 | 1.43e-04 | 90 |
| GO:004654621 | Thyroid | ATC | development of primary male sexual characteristics | 72/6293 | 142/18723 | 1.85e-05 | 1.69e-04 | 72 |
| GO:001470622 | Thyroid | ATC | striated muscle tissue development | 168/6293 | 384/18723 | 1.91e-05 | 1.73e-04 | 168 |
| GO:001017111 | Thyroid | ATC | body morphogenesis | 28/6293 | 43/18723 | 2.35e-05 | 2.06e-04 | 28 |
| GO:000858421 | Thyroid | ATC | male gonad development | 71/6293 | 141/18723 | 2.83e-05 | 2.38e-04 | 71 |
| GO:006032411 | Thyroid | ATC | face development | 28/6293 | 44/18723 | 4.39e-05 | 3.54e-04 | 28 |
| GO:0060349 | Thyroid | ATC | bone morphogenesis | 50/6293 | 93/18723 | 4.87e-05 | 3.88e-04 | 50 |
| GO:006032311 | Thyroid | ATC | head morphogenesis | 22/6293 | 32/18723 | 5.14e-05 | 3.99e-04 | 22 |
| GO:000317012 | Thyroid | ATC | heart valve development | 37/6293 | 65/18723 | 9.43e-05 | 6.91e-04 | 37 |
| GO:00487053 | Thyroid | ATC | skeletal system morphogenesis | 101/6293 | 220/18723 | 9.48e-05 | 6.93e-04 | 101 |
| GO:00020624 | Thyroid | ATC | chondrocyte differentiation | 54/6293 | 106/18723 | 1.67e-04 | 1.14e-03 | 54 |
| Page: 1 2 3 4 |
| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
| Page: 1 |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
| Page: 1 |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| SCX | NK | Endometrium | AEH | KRT81,KRT86,CD7, etc. | 9.78e-02 |  |
| SCX | CD8TEXINT | Thyroid | ADJ | KRT86,KLRB1,KRT81, etc. | 8.79e-02 |  |
| SCX | TH2 | Thyroid | ADJ | KRT86,KLRB1,KRT81, etc. | 1.44e-02 | |
| SCX | CD8TEXP | Thyroid | ADJ | KRT86,KLRB1,KRT81, etc. | 4.05e-02 | |
| SCX | GC | Thyroid | ADJ | KRT86,KLRB1,KRT81, etc. | 5.55e-03 | |
| SCX | NKT | Thyroid | ADJ | KRT86,KLRB1,KRT81, etc. | 3.74e-03 | |
| SCX | BMEM | Thyroid | ATC | KRT86,KLRB1,KRT81, etc. | 0.00e+00 |  |
| SCX | PLA | Thyroid | ATC | KRT86,KLRB1,KRT81, etc. | 1.64e-03 | |
| SCX | GDT | Thyroid | ATC | KRT86,KLRB1,KRT81, etc. | 5.82e-02 | |
| SCX | GC | Thyroid | ATC | KRT86,KLRB1,KRT81, etc. | 2.09e-03 | |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 2 3 |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| SCX | SNV | Missense_Mutation | novel | c.283N>C | p.Phe95Leu | p.F95L | Q7RTU7 | protein_coding | deleterious(0) | probably_damaging(0.994) | TCGA-DD-AACD-01 | Liver | liver hepatocellular carcinoma | Male | <65 | I/II | Unknown | Unknown | PD |
| SCX | SNV | Missense_Mutation | novel | c.442G>A | p.Ala148Thr | p.A148T | Q7RTU7 | protein_coding | tolerated(0.37) | benign(0.006) | TCGA-63-A5MM-01 | Lung | lung squamous cell carcinoma | Female | >=65 | I/II | Chemotherapy | cisplatin | PD |
| SCX | SNV | Missense_Mutation | novel | c.434C>T | p.Ser145Phe | p.S145F | Q7RTU7 | protein_coding | deleterious(0.02) | benign(0.284) | TCGA-85-8071-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
| Page: 1 |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
| Page: 1 |
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