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Gene: S100A9 |
Gene summary for S100A9 |
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Gene information | Species | Human | Gene symbol | S100A9 | Gene ID | 6280 |
Gene name | S100 calcium binding protein A9 | |
Gene Alias | 60B8AG | |
Cytomap | 1q21.3 | |
Gene Type | protein-coding | GO ID | GO:0001558 | UniProtAcc | P06702 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
6280 | S100A9 | GSM4909281 | Human | Breast | IDC | 5.40e-04 | -5.69e-01 | 0.21 |
6280 | S100A9 | GSM4909282 | Human | Breast | IDC | 1.96e-25 | 3.92e-01 | -0.0288 |
6280 | S100A9 | GSM4909285 | Human | Breast | IDC | 8.51e-06 | -6.47e-01 | 0.21 |
6280 | S100A9 | GSM4909286 | Human | Breast | IDC | 2.52e-23 | -8.00e-01 | 0.1081 |
6280 | S100A9 | GSM4909290 | Human | Breast | IDC | 1.38e-13 | 4.63e-01 | 0.2096 |
6280 | S100A9 | GSM4909291 | Human | Breast | IDC | 1.08e-04 | -7.08e-01 | 0.1753 |
6280 | S100A9 | GSM4909293 | Human | Breast | IDC | 9.60e-13 | -7.23e-01 | 0.1581 |
6280 | S100A9 | GSM4909296 | Human | Breast | IDC | 1.55e-04 | -6.09e-01 | 0.1524 |
6280 | S100A9 | GSM4909297 | Human | Breast | IDC | 4.02e-21 | -7.75e-01 | 0.1517 |
6280 | S100A9 | GSM4909298 | Human | Breast | IDC | 1.18e-18 | -7.87e-01 | 0.1551 |
6280 | S100A9 | GSM4909300 | Human | Breast | IDC | 1.06e-07 | 4.86e-01 | 0.0334 |
6280 | S100A9 | GSM4909301 | Human | Breast | IDC | 9.03e-20 | -7.93e-01 | 0.1577 |
6280 | S100A9 | GSM4909302 | Human | Breast | IDC | 1.25e-07 | -6.66e-01 | 0.1545 |
6280 | S100A9 | GSM4909303 | Human | Breast | IDC | 2.40e-02 | -7.57e-01 | 0.0438 |
6280 | S100A9 | GSM4909304 | Human | Breast | IDC | 3.61e-19 | -7.81e-01 | 0.1636 |
6280 | S100A9 | GSM4909305 | Human | Breast | IDC | 3.13e-02 | -4.63e-01 | 0.0436 |
6280 | S100A9 | GSM4909306 | Human | Breast | IDC | 2.82e-10 | -6.82e-01 | 0.1564 |
6280 | S100A9 | GSM4909307 | Human | Breast | IDC | 5.68e-14 | -7.42e-01 | 0.1569 |
6280 | S100A9 | GSM4909308 | Human | Breast | IDC | 1.63e-15 | -7.96e-01 | 0.158 |
6280 | S100A9 | GSM4909311 | Human | Breast | IDC | 2.20e-11 | -6.85e-01 | 0.1534 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00618446 | Breast | Precancer | antimicrobial humoral immune response mediated by antimicrobial peptide | 14/1080 | 79/18723 | 1.53e-04 | 2.61e-03 | 14 |
GO:00420633 | Breast | Precancer | gliogenesis | 33/1080 | 301/18723 | 3.06e-04 | 4.40e-03 | 33 |
GO:00469165 | Breast | Precancer | cellular transition metal ion homeostasis | 17/1080 | 115/18723 | 3.15e-04 | 4.49e-03 | 17 |
GO:00160497 | Breast | Precancer | cell growth | 46/1080 | 482/18723 | 5.63e-04 | 7.16e-03 | 46 |
GO:00100013 | Breast | Precancer | glial cell differentiation | 25/1080 | 225/18723 | 1.29e-03 | 1.37e-02 | 25 |
GO:00015587 | Breast | Precancer | regulation of cell growth | 39/1080 | 414/18723 | 1.81e-03 | 1.78e-02 | 39 |
GO:0072503 | Breast | Precancer | cellular divalent inorganic cation homeostasis | 42/1080 | 486/18723 | 5.91e-03 | 4.21e-02 | 42 |
GO:0048708 | Breast | Precancer | astrocyte differentiation | 11/1080 | 81/18723 | 6.65e-03 | 4.57e-02 | 11 |
GO:0021782 | Breast | Precancer | glial cell development | 14/1080 | 116/18723 | 6.92e-03 | 4.67e-02 | 14 |
GO:200123314 | Breast | IDC | regulation of apoptotic signaling pathway | 82/1434 | 356/18723 | 6.27e-20 | 5.93e-17 | 82 |
GO:005254714 | Breast | IDC | regulation of peptidase activity | 96/1434 | 461/18723 | 7.58e-20 | 6.15e-17 | 96 |
GO:009719314 | Breast | IDC | intrinsic apoptotic signaling pathway | 69/1434 | 288/18723 | 6.32e-18 | 2.99e-15 | 69 |
GO:005254814 | Breast | IDC | regulation of endopeptidase activity | 88/1434 | 432/18723 | 1.20e-17 | 4.85e-15 | 88 |
GO:200124214 | Breast | IDC | regulation of intrinsic apoptotic signaling pathway | 47/1434 | 164/18723 | 8.25e-16 | 2.93e-13 | 47 |
GO:200011614 | Breast | IDC | regulation of cysteine-type endopeptidase activity | 55/1434 | 235/18723 | 4.25e-14 | 1.21e-11 | 55 |
GO:004328114 | Breast | IDC | regulation of cysteine-type endopeptidase activity involved in apoptotic process | 50/1434 | 209/18723 | 2.49e-13 | 6.14e-11 | 50 |
GO:004586214 | Breast | IDC | positive regulation of proteolysis | 66/1434 | 372/18723 | 9.76e-11 | 1.29e-08 | 66 |
GO:200123514 | Breast | IDC | positive regulation of apoptotic signaling pathway | 31/1434 | 126/18723 | 4.13e-09 | 3.35e-07 | 31 |
GO:001095214 | Breast | IDC | positive regulation of peptidase activity | 40/1434 | 197/18723 | 1.04e-08 | 7.67e-07 | 40 |
GO:004328013 | Breast | IDC | positive regulation of cysteine-type endopeptidase activity involved in apoptotic process | 29/1434 | 129/18723 | 1.10e-07 | 6.35e-06 | 29 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0465716 | Breast | Precancer | IL-17 signaling pathway | 20/684 | 94/8465 | 4.74e-05 | 4.54e-04 | 3.48e-04 | 20 |
hsa0465717 | Breast | Precancer | IL-17 signaling pathway | 20/684 | 94/8465 | 4.74e-05 | 4.54e-04 | 3.48e-04 | 20 |
hsa0465721 | Breast | IDC | IL-17 signaling pathway | 18/867 | 94/8465 | 6.39e-03 | 3.30e-02 | 2.47e-02 | 18 |
hsa0465731 | Breast | IDC | IL-17 signaling pathway | 18/867 | 94/8465 | 6.39e-03 | 3.30e-02 | 2.47e-02 | 18 |
hsa0465741 | Breast | DCIS | IL-17 signaling pathway | 18/846 | 94/8465 | 4.95e-03 | 2.67e-02 | 1.96e-02 | 18 |
hsa0465751 | Breast | DCIS | IL-17 signaling pathway | 18/846 | 94/8465 | 4.95e-03 | 2.67e-02 | 1.96e-02 | 18 |
hsa0465718 | Cervix | CC | IL-17 signaling pathway | 31/1267 | 94/8465 | 8.71e-06 | 7.43e-05 | 4.39e-05 | 31 |
hsa0465719 | Cervix | CC | IL-17 signaling pathway | 31/1267 | 94/8465 | 8.71e-06 | 7.43e-05 | 4.39e-05 | 31 |
hsa0465722 | Cervix | HSIL_HPV | IL-17 signaling pathway | 15/459 | 94/8465 | 1.45e-04 | 1.74e-03 | 1.40e-03 | 15 |
hsa0465732 | Cervix | HSIL_HPV | IL-17 signaling pathway | 15/459 | 94/8465 | 1.45e-04 | 1.74e-03 | 1.40e-03 | 15 |
hsa0465742 | Cervix | N_HPV | IL-17 signaling pathway | 16/349 | 94/8465 | 1.20e-06 | 1.64e-05 | 1.28e-05 | 16 |
hsa0465752 | Cervix | N_HPV | IL-17 signaling pathway | 16/349 | 94/8465 | 1.20e-06 | 1.64e-05 | 1.28e-05 | 16 |
hsa0465720 | Endometrium | EEC | IL-17 signaling pathway | 23/1237 | 94/8465 | 7.61e-03 | 3.63e-02 | 2.71e-02 | 23 |
hsa04657110 | Endometrium | EEC | IL-17 signaling pathway | 23/1237 | 94/8465 | 7.61e-03 | 3.63e-02 | 2.71e-02 | 23 |
hsa0465726 | Esophagus | HGIN | IL-17 signaling pathway | 25/1383 | 94/8465 | 7.52e-03 | 4.63e-02 | 3.68e-02 | 25 |
hsa04657113 | Esophagus | HGIN | IL-17 signaling pathway | 25/1383 | 94/8465 | 7.52e-03 | 4.63e-02 | 3.68e-02 | 25 |
hsa0465727 | Esophagus | ESCC | IL-17 signaling pathway | 66/4205 | 94/8465 | 3.93e-05 | 1.75e-04 | 8.99e-05 | 66 |
hsa0465734 | Esophagus | ESCC | IL-17 signaling pathway | 66/4205 | 94/8465 | 3.93e-05 | 1.75e-04 | 8.99e-05 | 66 |
hsa0465724 | Oral cavity | OSCC | IL-17 signaling pathway | 64/3704 | 94/8465 | 1.48e-06 | 7.87e-06 | 4.01e-06 | 64 |
hsa04657112 | Oral cavity | OSCC | IL-17 signaling pathway | 64/3704 | 94/8465 | 1.48e-06 | 7.87e-06 | 4.01e-06 | 64 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
S100A9 | SNV | Missense_Mutation | c.29N>C | p.Arg10Pro | p.R10P | P06702 | protein_coding | tolerated(0.19) | possibly_damaging(0.613) | TCGA-EK-A3GJ-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
S100A9 | SNV | Missense_Mutation | c.17N>T | p.Ser6Leu | p.S6L | P06702 | protein_coding | deleterious(0) | possibly_damaging(0.88) | TCGA-A6-6141-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | 5-fu | SD | |
S100A9 | SNV | Missense_Mutation | c.17N>T | p.Ser6Leu | p.S6L | P06702 | protein_coding | deleterious(0) | possibly_damaging(0.88) | TCGA-AU-6004-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
S100A9 | SNV | Missense_Mutation | rs142015410 | c.125N>A | p.Arg42Gln | p.R42Q | P06702 | protein_coding | tolerated(0.62) | benign(0) | TCGA-D5-6929-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Chemotherapy | oxaliplatinum+ | SD |
S100A9 | SNV | Missense_Mutation | rs142015410 | c.125G>A | p.Arg42Gln | p.R42Q | P06702 | protein_coding | tolerated(0.62) | benign(0) | TCGA-F5-6814-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
S100A9 | SNV | Missense_Mutation | rs140601192 | c.28N>T | p.Arg10Cys | p.R10C | P06702 | protein_coding | tolerated(0.25) | benign(0.017) | TCGA-AJ-A3EL-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
S100A9 | SNV | Missense_Mutation | rs147137403 | c.251C>T | p.Ala84Val | p.A84V | P06702 | protein_coding | tolerated(0.19) | benign(0.048) | TCGA-AX-A2HD-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
S100A9 | SNV | Missense_Mutation | novel | c.76N>A | p.Leu26Met | p.L26M | P06702 | protein_coding | tolerated(0.25) | benign(0.268) | TCGA-E6-A1LX-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
S100A9 | SNV | Missense_Mutation | novel | c.98A>G | p.Asn33Ser | p.N33S | P06702 | protein_coding | tolerated(1) | benign(0.031) | TCGA-FI-A2D5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatinum | PD |
S100A9 | SNV | Missense_Mutation | novel | c.259N>C | p.Thr87Pro | p.T87P | P06702 | protein_coding | tolerated(0.08) | possibly_damaging(0.825) | TCGA-BR-A4J8-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Chemotherapy | xeloda | CR |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
6280 | S100A9 | DRUGGABLE GENOME, KINASE, ENZYME | Paquinimod | PAQUINIMOD | ||
6280 | S100A9 | DRUGGABLE GENOME, KINASE, ENZYME | Tasquinimod | TASQUINIMOD | 24162378 |
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