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Gene: S100A7 |
Gene summary for S100A7 |
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Gene information | Species | Human | Gene symbol | S100A7 | Gene ID | 6278 |
Gene name | S100 calcium binding protein A7 | |
Gene Alias | PSOR1 | |
Cytomap | 1q21.3 | |
Gene Type | protein-coding | GO ID | GO:0000165 | UniProtAcc | P31151 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
6278 | S100A7 | GSM4909298 | Human | Breast | IDC | 3.11e-02 | -1.86e-01 | 0.1551 |
6278 | S100A7 | GSM4909302 | Human | Breast | IDC | 1.42e-02 | -1.86e-01 | 0.1545 |
6278 | S100A7 | GSM4909317 | Human | Breast | IDC | 1.19e-17 | 7.55e-01 | 0.1355 |
6278 | S100A7 | brca2 | Human | Breast | Precancer | 1.24e-05 | 1.74e-01 | -0.024 |
6278 | S100A7 | M2 | Human | Breast | IDC | 9.83e-22 | 1.38e+00 | 0.21 |
6278 | S100A7 | NCCBC11 | Human | Breast | DCIS | 2.04e-06 | 9.01e-01 | 0.1232 |
6278 | S100A7 | NCCBC14 | Human | Breast | DCIS | 1.17e-35 | 1.22e+00 | 0.2021 |
6278 | S100A7 | NCCBC5 | Human | Breast | DCIS | 1.08e-08 | 6.67e-01 | 0.2046 |
6278 | S100A7 | NCCBC6 | Human | Breast | DCIS | 1.45e-12 | 1.20e+00 | 0.2095 |
6278 | S100A7 | CA_HPV_1 | Human | Cervix | CC | 1.78e-27 | -5.25e-01 | 0.0264 |
6278 | S100A7 | CA_HPV_2 | Human | Cervix | CC | 2.56e-26 | -5.23e-01 | 0.0391 |
6278 | S100A7 | CA_HPV_3 | Human | Cervix | CC | 2.64e-24 | -5.19e-01 | 0.0414 |
6278 | S100A7 | HSIL_HPV_1 | Human | Cervix | HSIL_HPV | 1.78e-13 | -5.13e-01 | 0.0116 |
6278 | S100A7 | HSIL_HPV_2 | Human | Cervix | HSIL_HPV | 2.50e-18 | -4.92e-01 | 0.0208 |
6278 | S100A7 | N_HPV_1 | Human | Cervix | N_HPV | 5.76e-22 | -5.11e-01 | 0.0079 |
6278 | S100A7 | N_HPV_2 | Human | Cervix | N_HPV | 5.86e-09 | -6.57e-02 | -0.0131 |
6278 | S100A7 | CCI_1 | Human | Cervix | CC | 1.83e-04 | -5.25e-01 | 0.528 |
6278 | S100A7 | CCI_2 | Human | Cervix | CC | 5.85e-04 | -5.25e-01 | 0.5249 |
6278 | S100A7 | CCI_3 | Human | Cervix | CC | 4.72e-02 | -4.63e-01 | 0.516 |
6278 | S100A7 | CCII_1 | Human | Cervix | CC | 8.58e-03 | -4.47e-01 | 0.3249 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:001973011 | Breast | IDC | antimicrobial humoral response | 23/1434 | 122/18723 | 4.67e-05 | 1.04e-03 | 23 |
GO:000268511 | Breast | IDC | regulation of leukocyte migration | 33/1434 | 210/18723 | 6.10e-05 | 1.27e-03 | 33 |
GO:003249612 | Breast | IDC | response to lipopolysaccharide | 47/1434 | 343/18723 | 7.13e-05 | 1.43e-03 | 47 |
GO:000223712 | Breast | IDC | response to molecule of bacterial origin | 49/1434 | 363/18723 | 7.40e-05 | 1.47e-03 | 49 |
GO:005123811 | Breast | IDC | sequestering of metal ion | 7/1434 | 16/18723 | 9.40e-05 | 1.81e-03 | 7 |
GO:003210311 | Breast | IDC | positive regulation of response to external stimulus | 54/1434 | 427/18723 | 1.85e-04 | 3.07e-03 | 54 |
GO:006184411 | Breast | IDC | antimicrobial humoral immune response mediated by antimicrobial peptide | 16/1434 | 79/18723 | 2.75e-04 | 4.24e-03 | 16 |
GO:007167711 | Breast | IDC | positive regulation of mononuclear cell migration | 14/1434 | 65/18723 | 3.35e-04 | 4.98e-03 | 14 |
GO:00703713 | Breast | IDC | ERK1 and ERK2 cascade | 43/1434 | 330/18723 | 4.28e-04 | 5.84e-03 | 43 |
GO:007167511 | Breast | IDC | regulation of mononuclear cell migration | 20/1434 | 115/18723 | 4.35e-04 | 5.90e-03 | 20 |
GO:007167411 | Breast | IDC | mononuclear cell migration | 29/1434 | 196/18723 | 4.68e-04 | 6.26e-03 | 29 |
GO:000268811 | Breast | IDC | regulation of leukocyte chemotaxis | 20/1434 | 122/18723 | 9.46e-04 | 1.08e-02 | 20 |
GO:000854412 | Breast | IDC | epidermis development | 41/1434 | 324/18723 | 1.03e-03 | 1.14e-02 | 41 |
GO:00900251 | Breast | IDC | regulation of monocyte chemotaxis | 8/1434 | 29/18723 | 1.16e-03 | 1.26e-02 | 8 |
GO:00069596 | Breast | IDC | humoral immune response | 40/1434 | 317/18723 | 1.25e-03 | 1.33e-02 | 40 |
GO:000268711 | Breast | IDC | positive regulation of leukocyte migration | 21/1434 | 135/18723 | 1.42e-03 | 1.46e-02 | 21 |
GO:000991312 | Breast | IDC | epidermal cell differentiation | 28/1434 | 202/18723 | 1.62e-03 | 1.60e-02 | 28 |
GO:00302161 | Breast | IDC | keratinocyte differentiation | 21/1434 | 139/18723 | 2.06e-03 | 1.95e-02 | 21 |
GO:000254811 | Breast | IDC | monocyte chemotaxis | 13/1434 | 70/18723 | 2.29e-03 | 2.09e-02 | 13 |
GO:00435883 | Breast | IDC | skin development | 33/1434 | 263/18723 | 3.46e-03 | 2.87e-02 | 33 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0465716 | Breast | Precancer | IL-17 signaling pathway | 20/684 | 94/8465 | 4.74e-05 | 4.54e-04 | 3.48e-04 | 20 |
hsa0465717 | Breast | Precancer | IL-17 signaling pathway | 20/684 | 94/8465 | 4.74e-05 | 4.54e-04 | 3.48e-04 | 20 |
hsa0465721 | Breast | IDC | IL-17 signaling pathway | 18/867 | 94/8465 | 6.39e-03 | 3.30e-02 | 2.47e-02 | 18 |
hsa0465731 | Breast | IDC | IL-17 signaling pathway | 18/867 | 94/8465 | 6.39e-03 | 3.30e-02 | 2.47e-02 | 18 |
hsa0465741 | Breast | DCIS | IL-17 signaling pathway | 18/846 | 94/8465 | 4.95e-03 | 2.67e-02 | 1.96e-02 | 18 |
hsa0465751 | Breast | DCIS | IL-17 signaling pathway | 18/846 | 94/8465 | 4.95e-03 | 2.67e-02 | 1.96e-02 | 18 |
hsa0465718 | Cervix | CC | IL-17 signaling pathway | 31/1267 | 94/8465 | 8.71e-06 | 7.43e-05 | 4.39e-05 | 31 |
hsa0465719 | Cervix | CC | IL-17 signaling pathway | 31/1267 | 94/8465 | 8.71e-06 | 7.43e-05 | 4.39e-05 | 31 |
hsa0465722 | Cervix | HSIL_HPV | IL-17 signaling pathway | 15/459 | 94/8465 | 1.45e-04 | 1.74e-03 | 1.40e-03 | 15 |
hsa0465732 | Cervix | HSIL_HPV | IL-17 signaling pathway | 15/459 | 94/8465 | 1.45e-04 | 1.74e-03 | 1.40e-03 | 15 |
hsa0465742 | Cervix | N_HPV | IL-17 signaling pathway | 16/349 | 94/8465 | 1.20e-06 | 1.64e-05 | 1.28e-05 | 16 |
hsa0465752 | Cervix | N_HPV | IL-17 signaling pathway | 16/349 | 94/8465 | 1.20e-06 | 1.64e-05 | 1.28e-05 | 16 |
hsa0465727 | Esophagus | ESCC | IL-17 signaling pathway | 66/4205 | 94/8465 | 3.93e-05 | 1.75e-04 | 8.99e-05 | 66 |
hsa0465734 | Esophagus | ESCC | IL-17 signaling pathway | 66/4205 | 94/8465 | 3.93e-05 | 1.75e-04 | 8.99e-05 | 66 |
hsa0465724 | Oral cavity | OSCC | IL-17 signaling pathway | 64/3704 | 94/8465 | 1.48e-06 | 7.87e-06 | 4.01e-06 | 64 |
hsa04657112 | Oral cavity | OSCC | IL-17 signaling pathway | 64/3704 | 94/8465 | 1.48e-06 | 7.87e-06 | 4.01e-06 | 64 |
hsa0465725 | Oral cavity | LP | IL-17 signaling pathway | 47/2418 | 94/8465 | 8.45e-06 | 6.25e-05 | 4.03e-05 | 47 |
hsa0465733 | Oral cavity | LP | IL-17 signaling pathway | 47/2418 | 94/8465 | 8.45e-06 | 6.25e-05 | 4.03e-05 | 47 |
hsa0465743 | Oral cavity | EOLP | IL-17 signaling pathway | 24/1218 | 94/8465 | 2.98e-03 | 9.61e-03 | 5.67e-03 | 24 |
hsa0465753 | Oral cavity | EOLP | IL-17 signaling pathway | 24/1218 | 94/8465 | 2.98e-03 | 9.61e-03 | 5.67e-03 | 24 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
S100A7 | SNV | Missense_Mutation | rs762356824 | c.166N>A | p.Ala56Thr | p.A56T | P31151 | protein_coding | tolerated(0.36) | benign(0) | TCGA-EA-A3HS-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
S100A7 | SNV | Missense_Mutation | c.43N>A | p.Asp15Asn | p.D15N | P31151 | protein_coding | tolerated(0.49) | benign(0) | TCGA-AD-A5EJ-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
S100A7 | SNV | Missense_Mutation | novel | c.199G>A | p.Asp67Asn | p.D67N | P31151 | protein_coding | deleterious(0) | possibly_damaging(0.9) | TCGA-AZ-4315-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
S100A7 | SNV | Missense_Mutation | rs370414457 | c.169N>A | p.Asp57Asn | p.D57N | P31151 | protein_coding | tolerated(1) | benign(0) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
S100A7 | SNV | Missense_Mutation | c.204G>T | p.Lys68Asn | p.K68N | P31151 | protein_coding | tolerated(0.14) | possibly_damaging(0.78) | TCGA-F5-6464-01 | Colorectum | rectum adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | |
S100A7 | SNV | Missense_Mutation | c.43N>A | p.Asp15Asn | p.D15N | P31151 | protein_coding | tolerated(0.49) | benign(0) | TCGA-AJ-A3EL-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
S100A7 | SNV | Missense_Mutation | c.43N>A | p.Asp15Asn | p.D15N | P31151 | protein_coding | tolerated(0.49) | benign(0) | TCGA-AJ-A5DW-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
S100A7 | SNV | Missense_Mutation | c.187G>T | p.Asp63Tyr | p.D63Y | P31151 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-AP-A056-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
S100A7 | SNV | Missense_Mutation | rs370414457 | c.169G>A | p.Asp57Asn | p.D57N | P31151 | protein_coding | tolerated(1) | benign(0) | TCGA-AP-A1E0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | paclitaxel | SD |
S100A7 | SNV | Missense_Mutation | novel | c.186N>T | p.Lys62Asn | p.K62N | P31151 | protein_coding | deleterious(0.05) | probably_damaging(0.971) | TCGA-AX-A06F-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatin | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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