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Gene: RSL24D1 |
Gene summary for RSL24D1 |
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Gene information | Species | Human | Gene symbol | RSL24D1 | Gene ID | 51187 |
Gene name | ribosomal L24 domain containing 1 | |
Gene Alias | C15orf15 | |
Cytomap | 15q21.3 | |
Gene Type | protein-coding | GO ID | GO:0006412 | UniProtAcc | A0A024R5U8 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
51187 | RSL24D1 | GSM4909285 | Human | Breast | IDC | 9.26e-08 | -2.40e-01 | 0.21 |
51187 | RSL24D1 | GSM4909286 | Human | Breast | IDC | 3.83e-14 | -2.65e-01 | 0.1081 |
51187 | RSL24D1 | GSM4909287 | Human | Breast | IDC | 5.98e-03 | -3.46e-01 | 0.2057 |
51187 | RSL24D1 | GSM4909291 | Human | Breast | IDC | 8.13e-20 | -7.50e-01 | 0.1753 |
51187 | RSL24D1 | GSM4909293 | Human | Breast | IDC | 2.72e-12 | -3.79e-01 | 0.1581 |
51187 | RSL24D1 | GSM4909294 | Human | Breast | IDC | 5.26e-09 | -3.31e-01 | 0.2022 |
51187 | RSL24D1 | GSM4909296 | Human | Breast | IDC | 1.50e-38 | -7.21e-01 | 0.1524 |
51187 | RSL24D1 | GSM4909297 | Human | Breast | IDC | 5.69e-27 | -2.71e-01 | 0.1517 |
51187 | RSL24D1 | GSM4909301 | Human | Breast | IDC | 1.55e-22 | -6.85e-01 | 0.1577 |
51187 | RSL24D1 | GSM4909302 | Human | Breast | IDC | 2.85e-24 | -6.94e-01 | 0.1545 |
51187 | RSL24D1 | GSM4909304 | Human | Breast | IDC | 1.59e-10 | -4.65e-01 | 0.1636 |
51187 | RSL24D1 | GSM4909307 | Human | Breast | IDC | 9.93e-04 | -3.37e-01 | 0.1569 |
51187 | RSL24D1 | GSM4909311 | Human | Breast | IDC | 5.57e-54 | -6.97e-01 | 0.1534 |
51187 | RSL24D1 | GSM4909312 | Human | Breast | IDC | 3.55e-13 | -1.68e-01 | 0.1552 |
51187 | RSL24D1 | GSM4909316 | Human | Breast | IDC | 2.28e-03 | -4.66e-01 | 0.21 |
51187 | RSL24D1 | GSM4909317 | Human | Breast | IDC | 3.52e-04 | -3.78e-01 | 0.1355 |
51187 | RSL24D1 | GSM4909318 | Human | Breast | IDC | 1.31e-02 | -5.80e-01 | 0.2031 |
51187 | RSL24D1 | GSM4909319 | Human | Breast | IDC | 2.45e-65 | -8.14e-01 | 0.1563 |
51187 | RSL24D1 | GSM4909320 | Human | Breast | IDC | 2.53e-17 | -8.46e-01 | 0.1575 |
51187 | RSL24D1 | GSM4909321 | Human | Breast | IDC | 6.78e-25 | -5.11e-01 | 0.1559 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:004227325 | Oral cavity | EOLP | ribosomal large subunit biogenesis | 22/2218 | 72/18723 | 1.82e-05 | 2.91e-04 | 22 |
GO:004225425 | Oral cavity | EOLP | ribosome biogenesis | 57/2218 | 299/18723 | 1.82e-04 | 1.87e-03 | 57 |
GO:002261333 | Oral cavity | NEOLP | ribonucleoprotein complex biogenesis | 93/2005 | 463/18723 | 1.34e-09 | 9.49e-08 | 93 |
GO:004227334 | Oral cavity | NEOLP | ribosomal large subunit biogenesis | 21/2005 | 72/18723 | 1.32e-05 | 2.36e-04 | 21 |
GO:004225433 | Oral cavity | NEOLP | ribosome biogenesis | 55/2005 | 299/18723 | 4.32e-05 | 6.10e-04 | 55 |
GO:002261318 | Prostate | BPH | ribonucleoprotein complex biogenesis | 150/3107 | 463/18723 | 2.18e-17 | 5.62e-15 | 150 |
GO:004225418 | Prostate | BPH | ribosome biogenesis | 90/3107 | 299/18723 | 3.82e-09 | 1.44e-07 | 90 |
GO:004227318 | Prostate | BPH | ribosomal large subunit biogenesis | 33/3107 | 72/18723 | 6.29e-09 | 2.25e-07 | 33 |
GO:002261319 | Prostate | Tumor | ribonucleoprotein complex biogenesis | 159/3246 | 463/18723 | 3.17e-19 | 1.52e-16 | 159 |
GO:004225419 | Prostate | Tumor | ribosome biogenesis | 96/3246 | 299/18723 | 2.76e-10 | 1.51e-08 | 96 |
GO:004227319 | Prostate | Tumor | ribosomal large subunit biogenesis | 34/3246 | 72/18723 | 4.52e-09 | 1.82e-07 | 34 |
GO:002261328 | Skin | AK | ribonucleoprotein complex biogenesis | 108/1910 | 463/18723 | 8.48e-17 | 6.27e-14 | 108 |
GO:004225427 | Skin | AK | ribosome biogenesis | 73/1910 | 299/18723 | 8.44e-13 | 2.08e-10 | 73 |
GO:004227327 | Skin | AK | ribosomal large subunit biogenesis | 24/1910 | 72/18723 | 8.63e-08 | 4.02e-06 | 24 |
GO:002261329 | Skin | cSCC | ribonucleoprotein complex biogenesis | 302/4864 | 463/18723 | 5.13e-72 | 3.22e-68 | 302 |
GO:004225428 | Skin | cSCC | ribosome biogenesis | 206/4864 | 299/18723 | 3.33e-55 | 1.04e-51 | 206 |
GO:004227328 | Skin | cSCC | ribosomal large subunit biogenesis | 57/4864 | 72/18723 | 4.90e-21 | 8.53e-19 | 57 |
GO:00422736 | Stomach | GC | ribosomal large subunit biogenesis | 15/1159 | 72/18723 | 2.81e-05 | 7.88e-04 | 15 |
GO:00422546 | Stomach | GC | ribosome biogenesis | 36/1159 | 299/18723 | 1.02e-04 | 2.03e-03 | 36 |
GO:00226136 | Stomach | GC | ribonucleoprotein complex biogenesis | 49/1159 | 463/18723 | 1.72e-04 | 3.02e-03 | 49 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0517118 | Breast | Precancer | Coronavirus disease - COVID-19 | 81/684 | 232/8465 | 3.74e-32 | 2.36e-30 | 1.81e-30 | 81 |
hsa0517119 | Breast | Precancer | Coronavirus disease - COVID-19 | 81/684 | 232/8465 | 3.74e-32 | 2.36e-30 | 1.81e-30 | 81 |
hsa0301024 | Breast | IDC | Ribosome | 83/867 | 167/8465 | 6.07e-39 | 9.87e-37 | 7.38e-37 | 83 |
hsa0517124 | Breast | IDC | Coronavirus disease - COVID-19 | 86/867 | 232/8465 | 1.50e-28 | 9.72e-27 | 7.27e-27 | 86 |
hsa0301034 | Breast | IDC | Ribosome | 83/867 | 167/8465 | 6.07e-39 | 9.87e-37 | 7.38e-37 | 83 |
hsa0517134 | Breast | IDC | Coronavirus disease - COVID-19 | 86/867 | 232/8465 | 1.50e-28 | 9.72e-27 | 7.27e-27 | 86 |
hsa0301044 | Breast | DCIS | Ribosome | 82/846 | 167/8465 | 8.69e-39 | 1.40e-36 | 1.03e-36 | 82 |
hsa0517144 | Breast | DCIS | Coronavirus disease - COVID-19 | 86/846 | 232/8465 | 2.42e-29 | 1.56e-27 | 1.15e-27 | 86 |
hsa0301054 | Breast | DCIS | Ribosome | 82/846 | 167/8465 | 8.69e-39 | 1.40e-36 | 1.03e-36 | 82 |
hsa0517154 | Breast | DCIS | Coronavirus disease - COVID-19 | 86/846 | 232/8465 | 2.42e-29 | 1.56e-27 | 1.15e-27 | 86 |
hsa0517120 | Cervix | CC | Coronavirus disease - COVID-19 | 111/1267 | 232/8465 | 1.82e-33 | 5.90e-31 | 3.49e-31 | 111 |
hsa0301020 | Cervix | CC | Ribosome | 85/1267 | 167/8465 | 3.17e-28 | 5.14e-26 | 3.04e-26 | 85 |
hsa05171110 | Cervix | CC | Coronavirus disease - COVID-19 | 111/1267 | 232/8465 | 1.82e-33 | 5.90e-31 | 3.49e-31 | 111 |
hsa03010110 | Cervix | CC | Ribosome | 85/1267 | 167/8465 | 3.17e-28 | 5.14e-26 | 3.04e-26 | 85 |
hsa0301026 | Endometrium | AEH | Ribosome | 89/1197 | 167/8465 | 1.88e-33 | 6.09e-31 | 4.46e-31 | 89 |
hsa0517126 | Endometrium | AEH | Coronavirus disease - COVID-19 | 99/1197 | 232/8465 | 5.19e-27 | 3.37e-25 | 2.47e-25 | 99 |
hsa03010112 | Endometrium | AEH | Ribosome | 89/1197 | 167/8465 | 1.88e-33 | 6.09e-31 | 4.46e-31 | 89 |
hsa05171112 | Endometrium | AEH | Coronavirus disease - COVID-19 | 99/1197 | 232/8465 | 5.19e-27 | 3.37e-25 | 2.47e-25 | 99 |
hsa0301027 | Endometrium | EEC | Ribosome | 89/1237 | 167/8465 | 2.55e-32 | 8.39e-30 | 6.26e-30 | 89 |
hsa0517127 | Endometrium | EEC | Coronavirus disease - COVID-19 | 99/1237 | 232/8465 | 7.43e-26 | 4.89e-24 | 3.65e-24 | 99 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
RSL24D1 | insertion | Frame_Shift_Ins | novel | c.370_371insGAAT | p.Ile124ArgfsTer54 | p.I124Rfs*54 | Q9UHA3 | protein_coding | TCGA-A7-A26I-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | cytoxan | SD | ||
RSL24D1 | SNV | Missense_Mutation | c.26G>C | p.Cys9Ser | p.C9S | Q9UHA3 | protein_coding | deleterious(0) | benign(0.185) | TCGA-EK-A3GK-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
RSL24D1 | SNV | Missense_Mutation | rs572620938 | c.131N>A | p.Arg44His | p.R44H | Q9UHA3 | protein_coding | tolerated(0.05) | benign(0.036) | TCGA-AA-3947-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
RSL24D1 | SNV | Missense_Mutation | rs781511293 | c.441N>T | p.Glu147Asp | p.E147D | Q9UHA3 | protein_coding | tolerated(0.33) | benign(0.001) | TCGA-CA-6718-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | PD |
RSL24D1 | SNV | Missense_Mutation | rs199758477 | c.308N>A | p.Arg103His | p.R103H | Q9UHA3 | protein_coding | deleterious(0) | possibly_damaging(0.731) | TCGA-AX-A06F-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatin | SD |
RSL24D1 | SNV | Missense_Mutation | c.320T>G | p.Phe107Cys | p.F107C | Q9UHA3 | protein_coding | deleterious(0.03) | benign(0.062) | TCGA-BS-A0UF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
RSL24D1 | SNV | Missense_Mutation | novel | c.166N>T | p.Arg56Trp | p.R56W | Q9UHA3 | protein_coding | deleterious(0.02) | benign(0.074) | TCGA-EO-A22U-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
RSL24D1 | SNV | Missense_Mutation | rs754119174 | c.130N>T | p.Arg44Cys | p.R44C | Q9UHA3 | protein_coding | deleterious(0.02) | benign(0.015) | TCGA-FI-A2D5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatinum | PD |
RSL24D1 | insertion | Frame_Shift_Ins | novel | c.219_220insA | p.Arg74ThrfsTer2 | p.R74Tfs*2 | Q9UHA3 | protein_coding | TCGA-B5-A3FC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
RSL24D1 | SNV | Missense_Mutation | c.350N>G | p.Glu117Gly | p.E117G | Q9UHA3 | protein_coding | deleterious(0.03) | benign(0.001) | TCGA-ED-A7XO-01 | Liver | liver hepatocellular carcinoma | Male | <65 | III/IV | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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