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Gene: RRAS |
Gene summary for RRAS |
Gene summary. |
Gene information | Species | Human | Gene symbol | RRAS | Gene ID | 6237 |
Gene name | RAS related | |
Gene Alias | R-Ras | |
Cytomap | 19q13.33 | |
Gene Type | protein-coding | GO ID | GO:0000165 | UniProtAcc | A0A024QZF2 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
6237 | RRAS | GSM4909295 | Human | Breast | IDC | 2.85e-04 | 4.06e-01 | 0.0898 |
6237 | RRAS | GSM4909304 | Human | Breast | IDC | 5.56e-18 | 5.02e-01 | 0.1636 |
6237 | RRAS | GSM4909311 | Human | Breast | IDC | 2.34e-05 | -9.98e-02 | 0.1534 |
6237 | RRAS | GSM4909315 | Human | Breast | IDC | 1.00e-21 | 6.95e-01 | 0.21 |
6237 | RRAS | GSM4909316 | Human | Breast | IDC | 2.44e-11 | 7.17e-01 | 0.21 |
6237 | RRAS | GSM4909319 | Human | Breast | IDC | 3.66e-07 | -5.27e-02 | 0.1563 |
6237 | RRAS | DCIS2 | Human | Breast | DCIS | 2.67e-45 | 1.98e-01 | 0.0085 |
6237 | RRAS | CA_HPV_1 | Human | Cervix | CC | 1.78e-02 | -1.49e-01 | 0.0264 |
6237 | RRAS | CCII_1 | Human | Cervix | CC | 3.71e-03 | -2.61e-01 | 0.3249 |
6237 | RRAS | Tumor | Human | Cervix | CC | 3.38e-18 | 5.06e-01 | 0.1241 |
6237 | RRAS | sample3 | Human | Cervix | CC | 2.98e-22 | 5.59e-01 | 0.1387 |
6237 | RRAS | T3 | Human | Cervix | CC | 1.77e-23 | 5.06e-01 | 0.1389 |
6237 | RRAS | HTA11_2487_2000001011 | Human | Colorectum | SER | 3.31e-22 | 6.88e-01 | -0.1808 |
6237 | RRAS | HTA11_1938_2000001011 | Human | Colorectum | AD | 2.70e-23 | 7.27e-01 | -0.0811 |
6237 | RRAS | HTA11_78_2000001011 | Human | Colorectum | AD | 4.92e-04 | 1.84e-01 | -0.1088 |
6237 | RRAS | HTA11_347_2000001011 | Human | Colorectum | AD | 1.17e-07 | 2.37e-01 | -0.1954 |
6237 | RRAS | HTA11_411_2000001011 | Human | Colorectum | SER | 3.46e-11 | 1.28e+00 | -0.2602 |
6237 | RRAS | HTA11_2112_2000001011 | Human | Colorectum | SER | 3.00e-07 | 6.06e-01 | -0.2196 |
6237 | RRAS | HTA11_3361_2000001011 | Human | Colorectum | AD | 4.39e-05 | 3.21e-01 | -0.1207 |
6237 | RRAS | HTA11_696_2000001011 | Human | Colorectum | AD | 8.08e-14 | 3.57e-01 | -0.1464 |
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Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00457662 | Breast | DCIS | positive regulation of angiogenesis | 25/1390 | 181/18723 | 1.93e-03 | 1.82e-02 | 25 |
GO:19040182 | Breast | DCIS | positive regulation of vasculature development | 25/1390 | 181/18723 | 1.93e-03 | 1.82e-02 | 25 |
GO:001081124 | Breast | DCIS | positive regulation of cell-substrate adhesion | 18/1390 | 123/18723 | 4.23e-03 | 3.32e-02 | 18 |
GO:001081010 | Cervix | CC | regulation of cell-substrate adhesion | 69/2311 | 221/18723 | 8.57e-14 | 5.69e-11 | 69 |
GO:00315898 | Cervix | CC | cell-substrate adhesion | 96/2311 | 363/18723 | 1.48e-13 | 8.85e-11 | 96 |
GO:009013210 | Cervix | CC | epithelium migration | 90/2311 | 360/18723 | 2.45e-11 | 6.11e-09 | 90 |
GO:00016679 | Cervix | CC | ameboidal-type cell migration | 110/2311 | 475/18723 | 2.66e-11 | 6.36e-09 | 110 |
GO:001063110 | Cervix | CC | epithelial cell migration | 89/2311 | 357/18723 | 3.72e-11 | 8.54e-09 | 89 |
GO:009013010 | Cervix | CC | tissue migration | 90/2311 | 365/18723 | 5.42e-11 | 1.05e-08 | 90 |
GO:004578510 | Cervix | CC | positive regulation of cell adhesion | 101/2311 | 437/18723 | 1.96e-10 | 3.08e-08 | 101 |
GO:001063210 | Cervix | CC | regulation of epithelial cell migration | 72/2311 | 292/18723 | 4.52e-09 | 4.43e-07 | 72 |
GO:00072656 | Cervix | CC | Ras protein signal transduction | 79/2311 | 337/18723 | 9.49e-09 | 7.77e-07 | 79 |
GO:00019528 | Cervix | CC | regulation of cell-matrix adhesion | 40/2311 | 128/18723 | 1.32e-08 | 1.04e-06 | 40 |
GO:00071608 | Cervix | CC | cell-matrix adhesion | 60/2311 | 233/18723 | 1.58e-08 | 1.23e-06 | 60 |
GO:00106349 | Cervix | CC | positive regulation of epithelial cell migration | 47/2311 | 176/18723 | 1.73e-07 | 8.01e-06 | 47 |
GO:001081110 | Cervix | CC | positive regulation of cell-substrate adhesion | 34/2311 | 123/18723 | 3.66e-06 | 9.68e-05 | 34 |
GO:00435427 | Cervix | CC | endothelial cell migration | 60/2311 | 279/18723 | 1.05e-05 | 2.33e-04 | 60 |
GO:00105944 | Cervix | CC | regulation of endothelial cell migration | 52/2311 | 232/18723 | 1.20e-05 | 2.54e-04 | 52 |
GO:00512713 | Cervix | CC | negative regulation of cellular component movement | 73/2311 | 367/18723 | 2.22e-05 | 3.95e-04 | 73 |
GO:00400133 | Cervix | CC | negative regulation of locomotion | 76/2311 | 391/18723 | 3.47e-05 | 5.60e-04 | 76 |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0513224 | Breast | IDC | Salmonella infection | 55/867 | 249/8465 | 2.07e-08 | 4.49e-07 | 3.36e-07 | 55 |
hsa0421824 | Breast | IDC | Cellular senescence | 35/867 | 156/8465 | 5.49e-06 | 7.43e-05 | 5.56e-05 | 35 |
hsa0520523 | Breast | IDC | Proteoglycans in cancer | 42/867 | 205/8465 | 7.69e-06 | 9.99e-05 | 7.48e-05 | 42 |
hsa0413723 | Breast | IDC | Mitophagy - animal | 17/867 | 72/8465 | 7.61e-04 | 6.04e-03 | 4.52e-03 | 17 |
hsa0481014 | Breast | IDC | Regulation of actin cytoskeleton | 36/867 | 229/8465 | 5.79e-03 | 3.13e-02 | 2.34e-02 | 36 |
hsa0513234 | Breast | IDC | Salmonella infection | 55/867 | 249/8465 | 2.07e-08 | 4.49e-07 | 3.36e-07 | 55 |
hsa0421834 | Breast | IDC | Cellular senescence | 35/867 | 156/8465 | 5.49e-06 | 7.43e-05 | 5.56e-05 | 35 |
hsa0520533 | Breast | IDC | Proteoglycans in cancer | 42/867 | 205/8465 | 7.69e-06 | 9.99e-05 | 7.48e-05 | 42 |
hsa0413733 | Breast | IDC | Mitophagy - animal | 17/867 | 72/8465 | 7.61e-04 | 6.04e-03 | 4.52e-03 | 17 |
hsa0481015 | Breast | IDC | Regulation of actin cytoskeleton | 36/867 | 229/8465 | 5.79e-03 | 3.13e-02 | 2.34e-02 | 36 |
hsa0520542 | Breast | DCIS | Proteoglycans in cancer | 39/846 | 205/8465 | 5.36e-05 | 5.58e-04 | 4.11e-04 | 39 |
hsa0520552 | Breast | DCIS | Proteoglycans in cancer | 39/846 | 205/8465 | 5.36e-05 | 5.58e-04 | 4.11e-04 | 39 |
hsa0513220 | Cervix | CC | Salmonella infection | 74/1267 | 249/8465 | 1.33e-09 | 2.54e-08 | 1.50e-08 | 74 |
hsa0520516 | Cervix | CC | Proteoglycans in cancer | 60/1267 | 205/8465 | 9.13e-08 | 1.18e-06 | 7.00e-07 | 60 |
hsa0421810 | Cervix | CC | Cellular senescence | 49/1267 | 156/8465 | 1.30e-07 | 1.63e-06 | 9.61e-07 | 49 |
hsa0481016 | Cervix | CC | Regulation of actin cytoskeleton | 64/1267 | 229/8465 | 2.24e-07 | 2.59e-06 | 1.53e-06 | 64 |
hsa0401512 | Cervix | CC | Rap1 signaling pathway | 56/1267 | 210/8465 | 6.23e-06 | 5.61e-05 | 3.32e-05 | 56 |
hsa043609 | Cervix | CC | Axon guidance | 47/1267 | 182/8465 | 8.13e-05 | 5.38e-04 | 3.18e-04 | 47 |
hsa0413718 | Cervix | CC | Mitophagy - animal | 22/1267 | 72/8465 | 5.77e-04 | 2.75e-03 | 1.63e-03 | 22 |
hsa040142 | Cervix | CC | Ras signaling pathway | 51/1267 | 236/8465 | 3.55e-03 | 1.34e-02 | 7.91e-03 | 51 |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
RRAS | SNV | Missense_Mutation | c.382N>T | p.Arg128Trp | p.R128W | P10301 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-G4-6628-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
RRAS | SNV | Missense_Mutation | c.422N>A | p.Gly141Glu | p.G141E | P10301 | protein_coding | deleterious(0) | probably_damaging(0.993) | TCGA-NH-A5IV-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
RRAS | SNV | Missense_Mutation | c.173N>G | p.Tyr58Cys | p.Y58C | P10301 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-A5-A0GH-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
RRAS | SNV | Missense_Mutation | novel | c.566N>T | p.Ala189Val | p.A189V | P10301 | protein_coding | tolerated(0.41) | benign(0) | TCGA-A5-A2K3-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Chemotherapy | carboplatin | SD |
RRAS | SNV | Missense_Mutation | novel | c.287N>G | p.Gln96Arg | p.Q96R | P10301 | protein_coding | tolerated(0.06) | probably_damaging(0.971) | TCGA-AJ-A2QO-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
RRAS | SNV | Missense_Mutation | rs748655822 | c.646G>A | p.Val216Ile | p.V216I | P10301 | protein_coding | tolerated(0.2) | benign(0) | TCGA-AJ-A3OK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Chemotherapy | carboplatin | CR |
RRAS | SNV | Missense_Mutation | rs747724851 | c.281G>A | p.Arg94Lys | p.R94K | P10301 | protein_coding | deleterious(0.03) | probably_damaging(0.981) | TCGA-AP-A0LM-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | cisplatin | SD |
RRAS | SNV | Missense_Mutation | novel | c.518N>T | p.Ala173Val | p.A173V | P10301 | protein_coding | deleterious(0) | possibly_damaging(0.786) | TCGA-AX-A2HD-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
RRAS | SNV | Missense_Mutation | c.418N>T | p.Val140Phe | p.V140F | P10301 | protein_coding | deleterious(0) | possibly_damaging(0.785) | TCGA-B5-A0JY-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | doxorubicin | SD | |
RRAS | SNV | Missense_Mutation | novel | c.147N>A | p.Phe49Leu | p.F49L | P10301 | protein_coding | tolerated(0.26) | probably_damaging(0.989) | TCGA-B5-A0JY-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | doxorubicin | SD |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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