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Gene: RIPK2 |
Gene summary for RIPK2 |
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Gene information | Species | Human | Gene symbol | RIPK2 | Gene ID | 8767 |
Gene name | receptor interacting serine/threonine kinase 2 | |
Gene Alias | CARD3 | |
Cytomap | 8q21.3 | |
Gene Type | protein-coding | GO ID | GO:0000165 | UniProtAcc | A0A0S2Z4Z8 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
8767 | RIPK2 | AEH-subject1 | Human | Endometrium | AEH | 3.62e-13 | 4.45e-01 | -0.3059 |
8767 | RIPK2 | AEH-subject2 | Human | Endometrium | AEH | 3.78e-04 | 2.52e-01 | -0.2525 |
8767 | RIPK2 | AEH-subject3 | Human | Endometrium | AEH | 1.08e-05 | 3.25e-01 | -0.2576 |
8767 | RIPK2 | AEH-subject4 | Human | Endometrium | AEH | 1.34e-15 | 5.29e-01 | -0.2657 |
8767 | RIPK2 | AEH-subject5 | Human | Endometrium | AEH | 5.58e-32 | 8.62e-01 | -0.2953 |
8767 | RIPK2 | EEC-subject1 | Human | Endometrium | EEC | 3.71e-15 | 5.25e-01 | -0.2682 |
8767 | RIPK2 | EEC-subject2 | Human | Endometrium | EEC | 1.64e-03 | 2.63e-01 | -0.2607 |
8767 | RIPK2 | EEC-subject4 | Human | Endometrium | EEC | 2.15e-07 | 3.41e-01 | -0.2571 |
8767 | RIPK2 | EEC-subject5 | Human | Endometrium | EEC | 9.07e-06 | 3.00e-01 | -0.249 |
8767 | RIPK2 | GSM6177620_NYU_UCEC1_lib1_lib1 | Human | Endometrium | EEC | 4.10e-06 | 2.65e-01 | -0.1869 |
8767 | RIPK2 | GSM6177620_NYU_UCEC1_lib2_lib2 | Human | Endometrium | EEC | 2.56e-07 | 2.43e-01 | -0.1875 |
8767 | RIPK2 | GSM6177620_NYU_UCEC1_lib3_lib3 | Human | Endometrium | EEC | 2.63e-05 | 1.82e-01 | -0.1883 |
8767 | RIPK2 | GSM6177621_NYU_UCEC2_lib1_lib1 | Human | Endometrium | EEC | 3.30e-07 | 3.24e-01 | -0.1934 |
8767 | RIPK2 | GSM6177622_NYU_UCEC3_lib1_lib1 | Human | Endometrium | EEC | 1.86e-10 | 2.06e-01 | -0.1917 |
8767 | RIPK2 | GSM6177622_NYU_UCEC3_lib2_lib2 | Human | Endometrium | EEC | 1.05e-07 | 1.70e-01 | -0.1916 |
8767 | RIPK2 | LZE4T | Human | Esophagus | ESCC | 6.14e-07 | 2.22e-01 | 0.0811 |
8767 | RIPK2 | LZE8T | Human | Esophagus | ESCC | 6.27e-04 | 1.66e-01 | 0.067 |
8767 | RIPK2 | LZE24T | Human | Esophagus | ESCC | 7.80e-06 | 7.19e-02 | 0.0596 |
8767 | RIPK2 | LZE6T | Human | Esophagus | ESCC | 1.29e-03 | 9.50e-02 | 0.0845 |
8767 | RIPK2 | P2T-E | Human | Esophagus | ESCC | 1.98e-33 | 7.92e-01 | 0.1177 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:200105610 | Endometrium | AEH | positive regulation of cysteine-type endopeptidase activity | 30/2100 | 148/18723 | 9.19e-04 | 8.39e-03 | 30 |
GO:19030379 | Endometrium | AEH | regulation of leukocyte cell-cell adhesion | 57/2100 | 336/18723 | 9.42e-04 | 8.57e-03 | 57 |
GO:00508525 | Endometrium | AEH | T cell receptor signaling pathway | 26/2100 | 123/18723 | 1.03e-03 | 9.15e-03 | 26 |
GO:00619125 | Endometrium | AEH | selective autophagy | 17/2100 | 68/18723 | 1.10e-03 | 9.61e-03 | 17 |
GO:00105068 | Endometrium | AEH | regulation of autophagy | 54/2100 | 317/18723 | 1.15e-03 | 9.97e-03 | 54 |
GO:00105085 | Endometrium | AEH | positive regulation of autophagy | 26/2100 | 124/18723 | 1.17e-03 | 1.01e-02 | 26 |
GO:00321036 | Endometrium | AEH | positive regulation of response to external stimulus | 68/2100 | 427/18723 | 1.82e-03 | 1.44e-02 | 68 |
GO:00181077 | Endometrium | AEH | peptidyl-threonine phosphorylation | 24/2100 | 116/18723 | 2.14e-03 | 1.65e-02 | 24 |
GO:00510905 | Endometrium | AEH | regulation of DNA-binding transcription factor activity | 69/2100 | 440/18723 | 2.51e-03 | 1.87e-02 | 69 |
GO:00182107 | Endometrium | AEH | peptidyl-threonine modification | 25/2100 | 125/18723 | 2.84e-03 | 2.04e-02 | 25 |
GO:00328743 | Endometrium | AEH | positive regulation of stress-activated MAPK cascade | 25/2100 | 126/18723 | 3.18e-03 | 2.24e-02 | 25 |
GO:00712229 | Endometrium | AEH | cellular response to lipopolysaccharide | 37/2100 | 209/18723 | 3.30e-03 | 2.31e-02 | 37 |
GO:00712169 | Endometrium | AEH | cellular response to biotic stimulus | 42/2100 | 246/18723 | 3.65e-03 | 2.50e-02 | 42 |
GO:00703044 | Endometrium | AEH | positive regulation of stress-activated protein kinase signaling cascade | 25/2100 | 128/18723 | 3.95e-03 | 2.65e-02 | 25 |
GO:00420989 | Endometrium | AEH | T cell proliferation | 35/2100 | 199/18723 | 4.66e-03 | 2.98e-02 | 35 |
GO:00421298 | Endometrium | AEH | regulation of T cell proliferation | 31/2100 | 171/18723 | 4.73e-03 | 3.00e-02 | 31 |
GO:00018198 | Endometrium | AEH | positive regulation of cytokine production | 71/2100 | 467/18723 | 4.76e-03 | 3.02e-02 | 71 |
GO:00022213 | Endometrium | AEH | pattern recognition receptor signaling pathway | 31/2100 | 172/18723 | 5.16e-03 | 3.23e-02 | 31 |
GO:00706638 | Endometrium | AEH | regulation of leukocyte proliferation | 41/2100 | 245/18723 | 5.77e-03 | 3.52e-02 | 41 |
GO:00072546 | Endometrium | AEH | JNK cascade | 30/2100 | 167/18723 | 6.16e-03 | 3.70e-02 | 30 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0513126 | Endometrium | AEH | Shigellosis | 78/1197 | 247/8465 | 9.23e-13 | 2.00e-11 | 1.46e-11 | 78 |
hsa0513226 | Endometrium | AEH | Salmonella infection | 71/1197 | 249/8465 | 1.69e-09 | 3.44e-08 | 2.52e-08 | 71 |
hsa0472216 | Endometrium | AEH | Neurotrophin signaling pathway | 31/1197 | 119/8465 | 4.07e-04 | 3.07e-03 | 2.25e-03 | 31 |
hsa05131111 | Endometrium | AEH | Shigellosis | 78/1197 | 247/8465 | 9.23e-13 | 2.00e-11 | 1.46e-11 | 78 |
hsa05132112 | Endometrium | AEH | Salmonella infection | 71/1197 | 249/8465 | 1.69e-09 | 3.44e-08 | 2.52e-08 | 71 |
hsa0472217 | Endometrium | AEH | Neurotrophin signaling pathway | 31/1197 | 119/8465 | 4.07e-04 | 3.07e-03 | 2.25e-03 | 31 |
hsa0513127 | Endometrium | EEC | Shigellosis | 79/1237 | 247/8465 | 1.80e-12 | 3.95e-11 | 2.95e-11 | 79 |
hsa0513227 | Endometrium | EEC | Salmonella infection | 71/1237 | 249/8465 | 7.11e-09 | 1.30e-07 | 9.69e-08 | 71 |
hsa0472222 | Endometrium | EEC | Neurotrophin signaling pathway | 30/1237 | 119/8465 | 1.54e-03 | 9.55e-03 | 7.12e-03 | 30 |
hsa0513136 | Endometrium | EEC | Shigellosis | 79/1237 | 247/8465 | 1.80e-12 | 3.95e-11 | 2.95e-11 | 79 |
hsa0513236 | Endometrium | EEC | Salmonella infection | 71/1237 | 249/8465 | 7.11e-09 | 1.30e-07 | 9.69e-08 | 71 |
hsa0472232 | Endometrium | EEC | Neurotrophin signaling pathway | 30/1237 | 119/8465 | 1.54e-03 | 9.55e-03 | 7.12e-03 | 30 |
hsa05132211 | Esophagus | ESCC | Salmonella infection | 191/4205 | 249/8465 | 6.51e-19 | 5.45e-17 | 2.79e-17 | 191 |
hsa05131211 | Esophagus | ESCC | Shigellosis | 176/4205 | 247/8465 | 2.27e-12 | 4.01e-11 | 2.05e-11 | 176 |
hsa0472225 | Esophagus | ESCC | Neurotrophin signaling pathway | 80/4205 | 119/8465 | 7.33e-05 | 3.07e-04 | 1.57e-04 | 80 |
hsa0462122 | Esophagus | ESCC | NOD-like receptor signaling pathway | 116/4205 | 186/8465 | 2.90e-04 | 1.03e-03 | 5.30e-04 | 116 |
hsa051527 | Esophagus | ESCC | Tuberculosis | 111/4205 | 180/8465 | 7.14e-04 | 2.32e-03 | 1.19e-03 | 111 |
hsa05132310 | Esophagus | ESCC | Salmonella infection | 191/4205 | 249/8465 | 6.51e-19 | 5.45e-17 | 2.79e-17 | 191 |
hsa05131310 | Esophagus | ESCC | Shigellosis | 176/4205 | 247/8465 | 2.27e-12 | 4.01e-11 | 2.05e-11 | 176 |
hsa04722111 | Esophagus | ESCC | Neurotrophin signaling pathway | 80/4205 | 119/8465 | 7.33e-05 | 3.07e-04 | 1.57e-04 | 80 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
RIPK2 | SNV | Missense_Mutation | c.510N>T | p.Trp170Cys | p.W170C | O43353 | protein_coding | tolerated(0.13) | probably_damaging(1) | TCGA-AO-A128-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | SD | |
RIPK2 | SNV | Missense_Mutation | c.206T>A | p.Ile69Asn | p.I69N | O43353 | protein_coding | deleterious(0.02) | probably_damaging(0.983) | TCGA-C8-A133-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | |
RIPK2 | SNV | Missense_Mutation | c.1336N>C | p.Asp446His | p.D446H | O43353 | protein_coding | deleterious(0) | possibly_damaging(0.721) | TCGA-C8-A26Y-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
RIPK2 | insertion | Frame_Shift_Ins | novel | c.1618_1619insAACATAGTTTTTCTTCAGTTGTTCATTTCTTC | p.Met540LysfsTer14 | p.M540Kfs*14 | O43353 | protein_coding | TCGA-A2-A04Y-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cytoxan | SD | ||
RIPK2 | SNV | Missense_Mutation | c.1218N>A | p.Phe406Leu | p.F406L | O43353 | protein_coding | tolerated(0.78) | benign(0) | TCGA-AA-3977-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
RIPK2 | SNV | Missense_Mutation | c.218C>A | p.Ala73Asp | p.A73D | O43353 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR | |
RIPK2 | SNV | Missense_Mutation | novel | c.570N>G | p.Ile190Met | p.I190M | O43353 | protein_coding | deleterious(0) | probably_damaging(0.978) | TCGA-AZ-4315-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
RIPK2 | SNV | Missense_Mutation | c.821C>T | p.Ala274Val | p.A274V | O43353 | protein_coding | tolerated(0.09) | probably_damaging(0.91) | TCGA-CK-6746-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
RIPK2 | SNV | Missense_Mutation | rs775421386 | c.1600N>G | p.Leu534Val | p.L534V | O43353 | protein_coding | tolerated_low_confidence(0.05) | benign(0) | TCGA-F5-6814-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
RIPK2 | SNV | Missense_Mutation | c.422C>A | p.Pro141His | p.P141H | O43353 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
8767 | RIPK2 | SERINE THREONINE KINASE, KINASE, DRUGGABLE GENOME, ENZYME | inhibitor | 315661219 | ||
8767 | RIPK2 | SERINE THREONINE KINASE, KINASE, DRUGGABLE GENOME, ENZYME | PD-169316 | PD-169316 | 18408713 | |
8767 | RIPK2 | SERINE THREONINE KINASE, KINASE, DRUGGABLE GENOME, ENZYME | inhibitor | 384403681 | ||
8767 | RIPK2 | SERINE THREONINE KINASE, KINASE, DRUGGABLE GENOME, ENZYME | inhibitor | 178102513 | PONATINIB | |
8767 | RIPK2 | SERINE THREONINE KINASE, KINASE, DRUGGABLE GENOME, ENZYME | inhibitor | 385612179 | ||
8767 | RIPK2 | SERINE THREONINE KINASE, KINASE, DRUGGABLE GENOME, ENZYME | inhibitor | 381118799 | ||
8767 | RIPK2 | SERINE THREONINE KINASE, KINASE, DRUGGABLE GENOME, ENZYME | SB-202190 | SB-202190 | 22951114 | |
8767 | RIPK2 | SERINE THREONINE KINASE, KINASE, DRUGGABLE GENOME, ENZYME | inhibitor | 178102664 | ||
8767 | RIPK2 | SERINE THREONINE KINASE, KINASE, DRUGGABLE GENOME, ENZYME | inhibitor | 348353647 | ||
8767 | RIPK2 | SERINE THREONINE KINASE, KINASE, DRUGGABLE GENOME, ENZYME | inhibitor | 385612168 |
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