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Gene: REV1 |
Gene summary for REV1 |
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Gene information | Species | Human | Gene symbol | REV1 | Gene ID | 51455 |
Gene name | REV1 DNA directed polymerase | |
Gene Alias | AIBP80 | |
Cytomap | 2q11.2 | |
Gene Type | protein-coding | GO ID | GO:0000731 | UniProtAcc | Q9UBZ9 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
51455 | REV1 | HTA11_3410_2000001011 | Human | Colorectum | AD | 7.07e-20 | -6.00e-01 | 0.0155 |
51455 | REV1 | HTA11_2487_2000001011 | Human | Colorectum | SER | 4.68e-08 | -4.86e-01 | -0.1808 |
51455 | REV1 | HTA11_3361_2000001011 | Human | Colorectum | AD | 4.07e-05 | -4.98e-01 | -0.1207 |
51455 | REV1 | HTA11_83_2000001011 | Human | Colorectum | SER | 4.65e-05 | -4.73e-01 | -0.1526 |
51455 | REV1 | HTA11_696_2000001011 | Human | Colorectum | AD | 8.26e-05 | -4.00e-01 | -0.1464 |
51455 | REV1 | HTA11_866_2000001011 | Human | Colorectum | AD | 2.94e-04 | -3.63e-01 | -0.1001 |
51455 | REV1 | HTA11_5212_2000001011 | Human | Colorectum | AD | 2.01e-02 | -4.85e-01 | -0.2061 |
51455 | REV1 | HTA11_546_2000001011 | Human | Colorectum | AD | 2.51e-02 | -3.97e-01 | -0.0842 |
51455 | REV1 | HTA11_7862_2000001011 | Human | Colorectum | AD | 4.55e-05 | -6.22e-01 | -0.0179 |
51455 | REV1 | HTA11_866_3004761011 | Human | Colorectum | AD | 3.81e-16 | -5.84e-01 | 0.096 |
51455 | REV1 | HTA11_9408_2000001011 | Human | Colorectum | AD | 4.28e-02 | -7.02e-01 | 0.0451 |
51455 | REV1 | HTA11_8622_2000001021 | Human | Colorectum | SER | 2.91e-02 | -5.39e-01 | 0.0528 |
51455 | REV1 | HTA11_10623_2000001011 | Human | Colorectum | AD | 1.51e-02 | -4.99e-01 | -0.0177 |
51455 | REV1 | HTA11_10711_2000001011 | Human | Colorectum | AD | 2.07e-03 | -4.07e-01 | 0.0338 |
51455 | REV1 | HTA11_7696_3000711011 | Human | Colorectum | AD | 3.06e-16 | -4.99e-01 | 0.0674 |
51455 | REV1 | HTA11_6818_2000001021 | Human | Colorectum | AD | 2.69e-06 | -5.02e-01 | 0.0588 |
51455 | REV1 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 1.28e-11 | -4.50e-01 | 0.294 |
51455 | REV1 | HTA11_99999971662_82457 | Human | Colorectum | MSS | 6.61e-11 | -4.72e-01 | 0.3859 |
51455 | REV1 | HTA11_99999973899_84307 | Human | Colorectum | MSS | 1.16e-02 | -4.75e-01 | 0.2585 |
51455 | REV1 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 5.73e-12 | -4.84e-01 | 0.3005 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:000931426 | Thyroid | ATC | response to radiation | 210/6293 | 456/18723 | 1.69e-08 | 3.39e-07 | 210 |
GO:000626013 | Thyroid | ATC | DNA replication | 124/6293 | 260/18723 | 1.58e-06 | 1.93e-05 | 124 |
GO:007189723 | Thyroid | ATC | DNA biosynthetic process | 91/6293 | 180/18723 | 1.84e-06 | 2.24e-05 | 91 |
GO:000941613 | Thyroid | ATC | response to light stimulus | 139/6293 | 320/18723 | 1.42e-04 | 9.88e-04 | 139 |
GO:000630111 | Thyroid | ATC | postreplication repair | 18/6293 | 31/18723 | 4.45e-03 | 1.84e-02 | 18 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
REV1 | SNV | Missense_Mutation | c.3368N>A | p.Pro1123His | p.P1123H | Q9UBZ9 | protein_coding | tolerated(0.14) | benign(0.315) | TCGA-A8-A09Z-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
REV1 | SNV | Missense_Mutation | c.3382N>G | p.Leu1128Val | p.L1128V | Q9UBZ9 | protein_coding | tolerated(0.32) | benign(0.039) | TCGA-AO-A0JD-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | cyclophosphamide | SD | |
REV1 | SNV | Missense_Mutation | c.2005N>A | p.Gly669Arg | p.G669R | Q9UBZ9 | protein_coding | deleterious(0) | possibly_damaging(0.844) | TCGA-BH-A0HF-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | arimidex | SD | |
REV1 | SNV | Missense_Mutation | c.731C>T | p.Pro244Leu | p.P244L | Q9UBZ9 | protein_coding | tolerated(0.06) | benign(0.343) | TCGA-BH-A18G-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
REV1 | SNV | Missense_Mutation | novel | c.451G>A | p.Glu151Lys | p.E151K | Q9UBZ9 | protein_coding | tolerated(0.12) | benign(0.063) | TCGA-LL-A73Y-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | taxotere | SD |
REV1 | insertion | In_Frame_Ins | novel | c.630_631insCTGTGGTGGGCTCCACCCAGTTCGAGTTTCCGGGCTGTTTTGATT | p.Arg210_Lys211insLeuTrpTrpAlaProProSerSerSerPheArgAlaValLeuIle | p.R210_K211insLWWAPPSSSFRAVLI | Q9UBZ9 | protein_coding | TCGA-A2-A0CP-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cytoxan | SD | ||
REV1 | insertion | Nonsense_Mutation | novel | c.517_518insTGTGATGCAGTCTTGAATGAGAAT | p.Lys173delinsMetTerCysSerLeuGluTerGluTer | p.K173delinsM*CSLE*E* | Q9UBZ9 | protein_coding | TCGA-BH-A0BA-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | cytoxan | SD | ||
REV1 | insertion | Nonsense_Mutation | novel | c.3049_3050insTTTTGCTTCCCTGAGGTATTTGCAAAT | p.Asp1017delinsValLeuLeuProTerGlyIleCysLysTyr | p.D1017delinsVLLP*GICKY | Q9UBZ9 | protein_coding | TCGA-BH-A0WA-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
REV1 | deletion | Frame_Shift_Del | novel | c.3128delG | p.Gly1043AlafsTer22 | p.G1043Afs*22 | Q9UBZ9 | protein_coding | TCGA-D8-A27V-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD | ||
REV1 | deletion | Frame_Shift_Del | c.3235delN | p.Thr1079ProfsTer12 | p.T1079Pfs*12 | Q9UBZ9 | protein_coding | TCGA-EW-A1IZ-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | taxotere | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
51455 | REV1 | NA | cisplatin | CISPLATIN |
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