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Gene: RASA1 |
Gene summary for RASA1 |
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Gene information | Species | Human | Gene symbol | RASA1 | Gene ID | 5921 |
Gene name | RAS p21 protein activator 1 | |
Gene Alias | CM-AVM | |
Cytomap | 5q14.3 | |
Gene Type | protein-coding | GO ID | GO:0000278 | UniProtAcc | P20936 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
5921 | RASA1 | CCI_2 | Human | Cervix | CC | 4.66e-14 | 1.14e+00 | 0.5249 |
5921 | RASA1 | CCI_3 | Human | Cervix | CC | 1.01e-08 | 6.15e-01 | 0.516 |
5921 | RASA1 | HTA11_3410_2000001011 | Human | Colorectum | AD | 3.14e-11 | -5.70e-01 | 0.0155 |
5921 | RASA1 | HTA11_866_2000001011 | Human | Colorectum | AD | 2.17e-02 | -2.81e-01 | -0.1001 |
5921 | RASA1 | HTA11_866_3004761011 | Human | Colorectum | AD | 1.89e-06 | -4.88e-01 | 0.096 |
5921 | RASA1 | HTA11_7696_3000711011 | Human | Colorectum | AD | 9.52e-06 | -3.88e-01 | 0.0674 |
5921 | RASA1 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 2.88e-16 | -5.47e-01 | 0.3005 |
5921 | RASA1 | A015-C-203 | Human | Colorectum | FAP | 1.07e-27 | -4.09e-01 | -0.1294 |
5921 | RASA1 | A015-C-204 | Human | Colorectum | FAP | 1.99e-03 | -2.77e-01 | -0.0228 |
5921 | RASA1 | A014-C-040 | Human | Colorectum | FAP | 8.63e-03 | -3.28e-01 | -0.1184 |
5921 | RASA1 | A002-C-201 | Human | Colorectum | FAP | 4.15e-10 | -3.25e-01 | 0.0324 |
5921 | RASA1 | A002-C-203 | Human | Colorectum | FAP | 4.17e-02 | -1.43e-01 | 0.2786 |
5921 | RASA1 | A001-C-119 | Human | Colorectum | FAP | 5.27e-08 | -5.00e-01 | -0.1557 |
5921 | RASA1 | A001-C-108 | Human | Colorectum | FAP | 2.66e-19 | -3.48e-01 | -0.0272 |
5921 | RASA1 | A002-C-205 | Human | Colorectum | FAP | 1.22e-18 | -4.20e-01 | -0.1236 |
5921 | RASA1 | A001-C-104 | Human | Colorectum | FAP | 3.02e-04 | -2.22e-01 | 0.0184 |
5921 | RASA1 | A015-C-005 | Human | Colorectum | FAP | 1.54e-03 | -2.46e-01 | -0.0336 |
5921 | RASA1 | A015-C-006 | Human | Colorectum | FAP | 1.21e-14 | -5.53e-01 | -0.0994 |
5921 | RASA1 | A015-C-106 | Human | Colorectum | FAP | 1.12e-09 | -2.45e-01 | -0.0511 |
5921 | RASA1 | A002-C-114 | Human | Colorectum | FAP | 1.68e-17 | -4.28e-01 | -0.1561 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0110053 | Colorectum | AD | regulation of actin filament organization | 108/3918 | 278/18723 | 5.02e-12 | 6.98e-10 | 108 |
GO:0008154 | Colorectum | AD | actin polymerization or depolymerization | 90/3918 | 218/18723 | 6.14e-12 | 8.23e-10 | 90 |
GO:0032271 | Colorectum | AD | regulation of protein polymerization | 94/3918 | 233/18723 | 1.01e-11 | 1.29e-09 | 94 |
GO:0030041 | Colorectum | AD | actin filament polymerization | 81/3918 | 191/18723 | 1.35e-11 | 1.69e-09 | 81 |
GO:0051258 | Colorectum | AD | protein polymerization | 112/3918 | 297/18723 | 1.85e-11 | 2.27e-09 | 112 |
GO:0043254 | Colorectum | AD | regulation of protein-containing complex assembly | 148/3918 | 428/18723 | 2.64e-11 | 3.18e-09 | 148 |
GO:0008064 | Colorectum | AD | regulation of actin polymerization or depolymerization | 79/3918 | 188/18723 | 4.17e-11 | 4.74e-09 | 79 |
GO:0030833 | Colorectum | AD | regulation of actin filament polymerization | 74/3918 | 172/18723 | 4.50e-11 | 5.03e-09 | 74 |
GO:0030832 | Colorectum | AD | regulation of actin filament length | 79/3918 | 189/18723 | 5.71e-11 | 6.27e-09 | 79 |
GO:0032956 | Colorectum | AD | regulation of actin cytoskeleton organization | 127/3918 | 358/18723 | 1.03e-10 | 1.04e-08 | 127 |
GO:0022604 | Colorectum | AD | regulation of cell morphogenesis | 109/3918 | 309/18723 | 3.08e-09 | 2.07e-07 | 109 |
GO:0010810 | Colorectum | AD | regulation of cell-substrate adhesion | 81/3918 | 221/18723 | 4.80e-08 | 2.55e-06 | 81 |
GO:0031589 | Colorectum | AD | cell-substrate adhesion | 116/3918 | 363/18723 | 4.68e-07 | 1.76e-05 | 116 |
GO:0070997 | Colorectum | AD | neuron death | 114/3918 | 361/18723 | 1.13e-06 | 3.72e-05 | 114 |
GO:0043087 | Colorectum | AD | regulation of GTPase activity | 110/3918 | 348/18723 | 1.64e-06 | 5.03e-05 | 110 |
GO:0001952 | Colorectum | AD | regulation of cell-matrix adhesion | 50/3918 | 128/18723 | 2.05e-06 | 6.05e-05 | 50 |
GO:0008360 | Colorectum | AD | regulation of cell shape | 56/3918 | 154/18723 | 7.01e-06 | 1.73e-04 | 56 |
GO:0007265 | Colorectum | AD | Ras protein signal transduction | 104/3918 | 337/18723 | 1.01e-05 | 2.35e-04 | 104 |
GO:1901214 | Colorectum | AD | regulation of neuron death | 99/3918 | 319/18723 | 1.26e-05 | 2.76e-04 | 99 |
GO:0051056 | Colorectum | AD | regulation of small GTPase mediated signal transduction | 94/3918 | 302/18723 | 1.81e-05 | 3.76e-04 | 94 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa043609 | Cervix | CC | Axon guidance | 47/1267 | 182/8465 | 8.13e-05 | 5.38e-04 | 3.18e-04 | 47 |
hsa040142 | Cervix | CC | Ras signaling pathway | 51/1267 | 236/8465 | 3.55e-03 | 1.34e-02 | 7.91e-03 | 51 |
hsa040109 | Cervix | CC | MAPK signaling pathway | 62/1267 | 302/8465 | 4.89e-03 | 1.67e-02 | 9.86e-03 | 62 |
hsa0436012 | Cervix | CC | Axon guidance | 47/1267 | 182/8465 | 8.13e-05 | 5.38e-04 | 3.18e-04 | 47 |
hsa0401411 | Cervix | CC | Ras signaling pathway | 51/1267 | 236/8465 | 3.55e-03 | 1.34e-02 | 7.91e-03 | 51 |
hsa0401012 | Cervix | CC | MAPK signaling pathway | 62/1267 | 302/8465 | 4.89e-03 | 1.67e-02 | 9.86e-03 | 62 |
hsa04360 | Colorectum | AD | Axon guidance | 61/2092 | 182/8465 | 4.36e-03 | 2.17e-02 | 1.38e-02 | 61 |
hsa043601 | Colorectum | AD | Axon guidance | 61/2092 | 182/8465 | 4.36e-03 | 2.17e-02 | 1.38e-02 | 61 |
hsa043602 | Colorectum | MSS | Axon guidance | 54/1875 | 182/8465 | 1.03e-02 | 3.69e-02 | 2.26e-02 | 54 |
hsa043603 | Colorectum | MSS | Axon guidance | 54/1875 | 182/8465 | 1.03e-02 | 3.69e-02 | 2.26e-02 | 54 |
hsa043604 | Colorectum | FAP | Axon guidance | 47/1404 | 182/8465 | 9.09e-04 | 5.20e-03 | 3.16e-03 | 47 |
hsa04010 | Colorectum | FAP | MAPK signaling pathway | 68/1404 | 302/8465 | 4.00e-03 | 1.67e-02 | 1.02e-02 | 68 |
hsa043605 | Colorectum | FAP | Axon guidance | 47/1404 | 182/8465 | 9.09e-04 | 5.20e-03 | 3.16e-03 | 47 |
hsa040101 | Colorectum | FAP | MAPK signaling pathway | 68/1404 | 302/8465 | 4.00e-03 | 1.67e-02 | 1.02e-02 | 68 |
hsa043606 | Colorectum | CRC | Axon guidance | 43/1091 | 182/8465 | 4.38e-05 | 8.70e-04 | 5.90e-04 | 43 |
hsa04014 | Colorectum | CRC | Ras signaling pathway | 49/1091 | 236/8465 | 4.04e-04 | 4.50e-03 | 3.05e-03 | 49 |
hsa040102 | Colorectum | CRC | MAPK signaling pathway | 56/1091 | 302/8465 | 2.76e-03 | 1.77e-02 | 1.20e-02 | 56 |
hsa043607 | Colorectum | CRC | Axon guidance | 43/1091 | 182/8465 | 4.38e-05 | 8.70e-04 | 5.90e-04 | 43 |
hsa040141 | Colorectum | CRC | Ras signaling pathway | 49/1091 | 236/8465 | 4.04e-04 | 4.50e-03 | 3.05e-03 | 49 |
hsa040103 | Colorectum | CRC | MAPK signaling pathway | 56/1091 | 302/8465 | 2.76e-03 | 1.77e-02 | 1.20e-02 | 56 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
RASA1 | SNV | Missense_Mutation | c.365N>T | p.Ser122Leu | p.S122L | P20936 | protein_coding | tolerated_low_confidence(0.2) | benign(0) | TCGA-A2-A0CT-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | cytoxan | SD | |
RASA1 | SNV | Missense_Mutation | novel | c.956N>T | p.Trp319Leu | p.W319L | P20936 | protein_coding | deleterious(0) | probably_damaging(0.935) | TCGA-A7-A0DB-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | arimidex | SD |
RASA1 | SNV | Missense_Mutation | c.733N>G | p.Arg245Gly | p.R245G | P20936 | protein_coding | deleterious(0.01) | possibly_damaging(0.893) | TCGA-A8-A07W-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Hormone Therapy | exemestane | SD | |
RASA1 | SNV | Missense_Mutation | c.974N>G | p.Thr325Arg | p.T325R | P20936 | protein_coding | deleterious(0.02) | benign(0.347) | TCGA-C8-A12P-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
RASA1 | insertion | In_Frame_Ins | novel | c.1969_1970insGTACTGGAAACC | p.Thr657delinsSerThrGlyAsnPro | p.T657delinsSTGNP | P20936 | protein_coding | TCGA-AR-A0U2-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Hormone Therapy | tamoxiphen | PD | ||
RASA1 | SNV | Missense_Mutation | c.581G>A | p.Arg194His | p.R194H | P20936 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
RASA1 | SNV | Missense_Mutation | novel | c.2246G>A | p.Arg749Gln | p.R749Q | P20936 | protein_coding | deleterious(0.01) | probably_damaging(0.962) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
RASA1 | SNV | Missense_Mutation | novel | c.275C>G | p.Ala92Gly | p.A92G | P20936 | protein_coding | tolerated_low_confidence(0.44) | benign(0.003) | TCGA-DS-A1OB-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | carboplatin | PD |
RASA1 | SNV | Missense_Mutation | c.346N>T | p.Leu116Phe | p.L116F | P20936 | protein_coding | tolerated_low_confidence(0.31) | benign(0) | TCGA-DS-A1OC-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | gemcitabine | SD | |
RASA1 | SNV | Missense_Mutation | c.1345N>T | p.Val449Leu | p.V449L | P20936 | protein_coding | tolerated(0.22) | benign(0.003) | TCGA-FU-A3HZ-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
5921 | RASA1 | CLINICALLY ACTIONABLE | TRAMETINIB | TRAMETINIB | 29127119 |
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