Tissue | Expression Dynamics | Abbreviation |
Esophagus | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Esophagus/RANGAP1_pca_on_diff_genes.png) | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias |
LGIN: Low-grade intraepithelial neoplasias |
Liver | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Liver/RANGAP1_pca_on_diff_genes.png) | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
Oral Cavity | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/OralCavity/RANGAP1_pca_on_diff_genes.png) | EOLP: Erosive Oral lichen planus |
LP: leukoplakia |
NEOLP: Non-erosive oral lichen planus |
OSCC: Oral squamous cell carcinoma |
Skin | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Skin/RANGAP1_pca_on_diff_genes.png) | AK: Actinic keratosis |
cSCC: Cutaneous squamous cell carcinoma |
SCCIS:squamous cell carcinoma in situ |
Thyroid | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Thyroid/RANGAP1_pca_on_diff_genes.png) | ATC: Anaplastic thyroid cancer |
HT: Hashimoto's thyroiditis |
PTC: Papillary thyroid cancer |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:190382811 | Liver | HCC | negative regulation of cellular protein localization | 71/7958 | 117/18723 | 5.44e-05 | 5.12e-04 | 71 |
GO:005165112 | Liver | HCC | maintenance of location in cell | 119/7958 | 214/18723 | 7.11e-05 | 6.39e-04 | 119 |
GO:003250712 | Liver | HCC | maintenance of protein location in cell | 43/7958 | 65/18723 | 9.99e-05 | 8.60e-04 | 43 |
GO:00323871 | Liver | HCC | negative regulation of intracellular transport | 37/7958 | 58/18723 | 8.64e-04 | 5.13e-03 | 37 |
GO:007259511 | Liver | HCC | maintenance of protein localization in organelle | 28/7958 | 42/18723 | 1.35e-03 | 7.26e-03 | 28 |
GO:19049501 | Liver | HCC | negative regulation of establishment of protein localization | 72/7958 | 131/18723 | 2.65e-03 | 1.27e-02 | 72 |
GO:00903171 | Liver | HCC | negative regulation of intracellular protein transport | 27/7958 | 42/18723 | 3.60e-03 | 1.60e-02 | 27 |
GO:00512241 | Liver | HCC | negative regulation of protein transport | 69/7958 | 127/18723 | 4.67e-03 | 2.01e-02 | 69 |
GO:0046823 | Liver | HCC | negative regulation of nucleocytoplasmic transport | 15/7958 | 21/18723 | 7.03e-03 | 2.80e-02 | 15 |
GO:0051457 | Liver | HCC | maintenance of protein location in nucleus | 16/7958 | 23/18723 | 8.04e-03 | 3.17e-02 | 16 |
GO:000691317 | Oral cavity | OSCC | nucleocytoplasmic transport | 204/7305 | 301/18723 | 2.65e-24 | 6.98e-22 | 204 |
GO:005116917 | Oral cavity | OSCC | nuclear transport | 204/7305 | 301/18723 | 2.65e-24 | 6.98e-22 | 204 |
GO:003238615 | Oral cavity | OSCC | regulation of intracellular transport | 218/7305 | 337/18723 | 6.91e-22 | 1.41e-19 | 218 |
GO:003450415 | Oral cavity | OSCC | protein localization to nucleus | 193/7305 | 290/18723 | 1.22e-21 | 2.35e-19 | 193 |
GO:003315718 | Oral cavity | OSCC | regulation of intracellular protein transport | 155/7305 | 229/18723 | 1.05e-18 | 1.28e-16 | 155 |
GO:005116817 | Oral cavity | OSCC | nuclear export | 112/7305 | 154/18723 | 1.70e-17 | 1.56e-15 | 112 |
GO:004682217 | Oral cavity | OSCC | regulation of nucleocytoplasmic transport | 79/7305 | 106/18723 | 1.04e-13 | 5.37e-12 | 79 |
GO:005123518 | Oral cavity | OSCC | maintenance of location | 182/7305 | 327/18723 | 6.16e-10 | 1.58e-08 | 182 |
GO:003250710 | Oral cavity | OSCC | maintenance of protein location in cell | 49/7305 | 65/18723 | 2.61e-09 | 6.03e-08 | 49 |
GO:004518520 | Oral cavity | OSCC | maintenance of protein location | 65/7305 | 94/18723 | 3.00e-09 | 6.88e-08 | 65 |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
RANGAP1 | SNV | Missense_Mutation | novel | c.563N>C | p.Gly188Ala | p.G188A | P46060 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-A8-A07W-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Hormone Therapy | exemestane | SD |
RANGAP1 | SNV | Missense_Mutation | novel | c.215N>T | p.Ala72Val | p.A72V | P46060 | protein_coding | tolerated(0.07) | benign(0.049) | TCGA-A8-A083-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
RANGAP1 | SNV | Missense_Mutation | | c.1052N>T | p.Ala351Val | p.A351V | P46060 | protein_coding | tolerated(0.12) | benign(0.013) | TCGA-AN-A0XN-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
RANGAP1 | SNV | Missense_Mutation | | c.49N>G | p.Gln17Glu | p.Q17E | P46060 | protein_coding | tolerated(0.29) | benign(0.021) | TCGA-BH-A0DZ-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | docetaxel | SD |
RANGAP1 | insertion | Frame_Shift_Ins | novel | c.1188_1189insTTCTCCAGAGCCTCTGTGCCCCTACTTCCCAG | p.Glu397PhefsTer64 | p.E397Ffs*64 | P46060 | protein_coding | | | TCGA-A8-A07U-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Chemotherapy | 5-fluorouracil | SD |
RANGAP1 | insertion | Frame_Shift_Ins | novel | c.1186_1187insGGGTCCGG | p.Glu396GlyfsTer57 | p.E396Gfs*57 | P46060 | protein_coding | | | TCGA-A8-A07U-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Chemotherapy | 5-fluorouracil | SD |
RANGAP1 | insertion | Frame_Shift_Ins | novel | c.561_562insCACGTGCCCTCTCCAAGCCTGTTAACCCATCCGAAAATGA | p.Gly188HisfsTer21 | p.G188Hfs*21 | P46060 | protein_coding | | | TCGA-A8-A07W-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Hormone Therapy | exemestane | SD |
RANGAP1 | insertion | Nonsense_Mutation | novel | c.213_214insTTCTCTTTTTTTGTTTTTTGAGACGGAGTCTCACTCTGTC | p.Ala72PhefsTer7 | p.A72Ffs*7 | P46060 | protein_coding | | | TCGA-A8-A083-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
RANGAP1 | insertion | In_Frame_Ins | novel | c.1189_1190insTTCAAGTGATTCTTATGCCTCAGCCTCCCA | p.Glu397delinsValGlnValIleLeuMetProGlnProProLys | p.E397delinsVQVILMPQPPK | P46060 | protein_coding | | | TCGA-AN-A03X-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
RANGAP1 | SNV | Missense_Mutation | rs776060557 | c.277N>T | p.Arg93Trp | p.R93W | P46060 | protein_coding | deleterious(0) | probably_damaging(0.973) | TCGA-A6-2686-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |