Tissue | Expression Dynamics | Abbreviation |
Breast | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Breast/RABEP1_pca_on_diff_genes.png) | IDC: Invasive ductal carcinoma |
DCIS: Ductal carcinoma in situ |
Precancer(BRCA1-mut): Precancerous lesion from BRCA1 mutation carriers |
Esophagus | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Esophagus/RABEP1_pca_on_diff_genes.png) | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias |
LGIN: Low-grade intraepithelial neoplasias |
Liver | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Liver/RABEP1_pca_on_diff_genes.png) | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
Oral Cavity | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/OralCavity/RABEP1_pca_on_diff_genes.png) | EOLP: Erosive Oral lichen planus |
LP: leukoplakia |
NEOLP: Non-erosive oral lichen planus |
OSCC: Oral squamous cell carcinoma |
Prostate | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Prostate/RABEP1_pca_on_diff_genes.png) | BPH: Benign Prostatic Hyperplasia |
Skin | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Skin/RABEP1_pca_on_diff_genes.png) | AK: Actinic keratosis |
cSCC: Cutaneous squamous cell carcinoma |
SCCIS:squamous cell carcinoma in situ |
Thyroid | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Thyroid/RABEP1_pca_on_diff_genes.png) | ATC: Anaplastic thyroid cancer |
HT: Hashimoto's thyroiditis |
PTC: Papillary thyroid cancer |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:199077815 | Prostate | Tumor | protein localization to cell periphery | 97/3246 | 333/18723 | 5.88e-08 | 1.75e-06 | 97 |
GO:000689213 | Prostate | Tumor | post-Golgi vesicle-mediated transport | 35/3246 | 104/18723 | 4.14e-05 | 4.70e-04 | 35 |
GO:009887613 | Prostate | Tumor | vesicle-mediated transport to the plasma membrane | 42/3246 | 136/18723 | 7.47e-05 | 7.84e-04 | 42 |
GO:000689313 | Prostate | Tumor | Golgi to plasma membrane transport | 19/3246 | 60/18723 | 4.84e-03 | 2.37e-02 | 19 |
GO:199077820 | Skin | AK | protein localization to cell periphery | 66/1910 | 333/18723 | 9.18e-08 | 4.21e-06 | 66 |
GO:004819319 | Skin | AK | Golgi vesicle transport | 47/1910 | 296/18723 | 1.46e-03 | 1.06e-02 | 47 |
GO:000689216 | Skin | AK | post-Golgi vesicle-mediated transport | 20/1910 | 104/18723 | 3.91e-03 | 2.30e-02 | 20 |
GO:000689310 | Skin | AK | Golgi to plasma membrane transport | 13/1910 | 60/18723 | 6.62e-03 | 3.50e-02 | 13 |
GO:009887616 | Skin | AK | vesicle-mediated transport to the plasma membrane | 23/1910 | 136/18723 | 1.05e-02 | 4.96e-02 | 23 |
GO:0048193110 | Skin | cSCC | Golgi vesicle transport | 153/4864 | 296/18723 | 1.85e-21 | 3.41e-19 | 153 |
GO:199077824 | Skin | cSCC | protein localization to cell periphery | 134/4864 | 333/18723 | 7.09e-09 | 2.30e-07 | 134 |
GO:000689217 | Skin | cSCC | post-Golgi vesicle-mediated transport | 49/4864 | 104/18723 | 2.71e-06 | 4.30e-05 | 49 |
GO:009887617 | Skin | cSCC | vesicle-mediated transport to the plasma membrane | 59/4864 | 136/18723 | 7.60e-06 | 1.04e-04 | 59 |
GO:000689316 | Skin | cSCC | Golgi to plasma membrane transport | 30/4864 | 60/18723 | 5.67e-05 | 5.67e-04 | 30 |
GO:00610255 | Skin | cSCC | membrane fusion | 63/4864 | 163/18723 | 2.49e-04 | 2.03e-03 | 63 |
GO:004819320 | Thyroid | PTC | Golgi vesicle transport | 186/5968 | 296/18723 | 3.09e-28 | 1.22e-25 | 186 |
GO:1990778111 | Thyroid | PTC | protein localization to cell periphery | 172/5968 | 333/18723 | 3.71e-14 | 2.30e-12 | 172 |
GO:000689218 | Thyroid | PTC | post-Golgi vesicle-mediated transport | 66/5968 | 104/18723 | 3.36e-11 | 1.24e-09 | 66 |
GO:000689317 | Thyroid | PTC | Golgi to plasma membrane transport | 41/5968 | 60/18723 | 7.26e-09 | 1.82e-07 | 41 |
GO:009887618 | Thyroid | PTC | vesicle-mediated transport to the plasma membrane | 74/5968 | 136/18723 | 4.20e-08 | 9.08e-07 | 74 |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
RABEP1 | SNV | Missense_Mutation | | c.2578N>G | p.Pro860Ala | p.P860A | Q15276 | protein_coding | deleterious_low_confidence(0) | probably_damaging(0.991) | TCGA-A2-A259-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | arimidex | SD |
RABEP1 | SNV | Missense_Mutation | novel | c.1346N>A | p.Ser449Tyr | p.S449Y | Q15276 | protein_coding | deleterious(0.03) | possibly_damaging(0.453) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
RABEP1 | SNV | Missense_Mutation | rs773135833 | c.376N>T | p.Arg126Cys | p.R126C | Q15276 | protein_coding | tolerated(0.21) | benign(0.017) | TCGA-AO-A03R-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | SD |
RABEP1 | insertion | Frame_Shift_Ins | novel | c.2451_2452insGAAAATGT | p.Gln818GlufsTer8 | p.Q818Efs*8 | Q15276 | protein_coding | | | TCGA-A7-A0CG-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
RABEP1 | insertion | Nonsense_Mutation | novel | c.2452_2453insATTCCATTTGACTGATGTATCAAATCCTA | p.Gln818HisfsTer4 | p.Q818Hfs*4 | Q15276 | protein_coding | | | TCGA-A7-A0CG-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
RABEP1 | deletion | In_Frame_Del | | c.2253_2261delNNNNNNNNN | p.Val753_Lys755del | p.V753_K755del | Q15276 | protein_coding | | | TCGA-AR-A0TS-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | SD |
RABEP1 | deletion | Frame_Shift_Del | novel | c.1951delA | p.Ser651ValfsTer32 | p.S651Vfs*32 | Q15276 | protein_coding | | | TCGA-UL-AAZ6-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | herceptin | SD |
RABEP1 | SNV | Missense_Mutation | rs375323638 | c.1063N>A | p.Glu355Lys | p.E355K | Q15276 | protein_coding | tolerated(0.17) | benign(0.058) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
RABEP1 | SNV | Missense_Mutation | novel | c.2299C>G | p.Gln767Glu | p.Q767E | Q15276 | protein_coding | tolerated(0.92) | benign(0.003) | TCGA-JW-A5VL-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
RABEP1 | SNV | Missense_Mutation | | c.1060C>G | p.Gln354Glu | p.Q354E | Q15276 | protein_coding | tolerated(0.6) | benign(0.001) | TCGA-JX-A3Q0-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Unknown | Unknown | SD |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
9135 | RABEP1 | CLINICALLY ACTIONABLE, GROWTH FACTOR | | lithium | LITHIUM | 28694205 |
9135 | RABEP1 | CLINICALLY ACTIONABLE, GROWTH FACTOR | | amisulpride | AMISULPRIDE | 28694205 |
9135 | RABEP1 | CLINICALLY ACTIONABLE, GROWTH FACTOR | | valproic acid | | 28694205 |
9135 | RABEP1 | CLINICALLY ACTIONABLE, GROWTH FACTOR | | risperidone | RISPERIDONE | 28694205 |
9135 | RABEP1 | CLINICALLY ACTIONABLE, GROWTH FACTOR | | olanzapine | OLANZAPINE | 28694205 |
9135 | RABEP1 | CLINICALLY ACTIONABLE, GROWTH FACTOR | | mirtazapine | MIRTAZAPINE | 28694205 |
9135 | RABEP1 | CLINICALLY ACTIONABLE, GROWTH FACTOR | | clozapine | CLOZAPINE | 28694205 |
9135 | RABEP1 | CLINICALLY ACTIONABLE, GROWTH FACTOR | | aripiprazole | ARIPIPRAZOLE | 28694205 |
9135 | RABEP1 | CLINICALLY ACTIONABLE, GROWTH FACTOR | | quetiapine | QUETIAPINE | 28694205 |
9135 | RABEP1 | CLINICALLY ACTIONABLE, GROWTH FACTOR | | paliperidone | PALIPERIDONE | 28694205 |