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Gene: PTPRR |
Gene summary for PTPRR |
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Gene information | Species | Human | Gene symbol | PTPRR | Gene ID | 5801 |
Gene name | protein tyrosine phosphatase receptor type R | |
Gene Alias | EC-PTP | |
Cytomap | 12q15 | |
Gene Type | protein-coding | GO ID | GO:0000165 | UniProtAcc | Q15256 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
5801 | PTPRR | HTA11_2487_2000001011 | Human | Colorectum | SER | 1.98e-08 | 4.39e-01 | -0.1808 |
5801 | PTPRR | HTA11_411_2000001011 | Human | Colorectum | SER | 2.16e-05 | 1.42e+00 | -0.2602 |
5801 | PTPRR | HTA11_2112_2000001011 | Human | Colorectum | SER | 2.18e-02 | 5.97e-01 | -0.2196 |
5801 | PTPRR | HTA11_3361_2000001011 | Human | Colorectum | AD | 3.25e-02 | 2.29e-01 | -0.1207 |
5801 | PTPRR | HTA11_1391_2000001011 | Human | Colorectum | AD | 2.28e-02 | 1.38e-01 | -0.059 |
5801 | PTPRR | HTA11_7663_2000001011 | Human | Colorectum | SER | 5.83e-13 | 9.62e-01 | 0.0131 |
5801 | PTPRR | HTA11_6818_2000001011 | Human | Colorectum | AD | 7.51e-51 | 2.09e+00 | 0.0112 |
5801 | PTPRR | HTA11_6818_2000001021 | Human | Colorectum | AD | 1.01e-54 | 1.52e+00 | 0.0588 |
5801 | PTPRR | HTA11_99999965062_69753 | Human | Colorectum | MSI-H | 1.05e-03 | 6.85e-01 | 0.3487 |
5801 | PTPRR | ATC09 | Human | Thyroid | ATC | 2.95e-02 | 1.33e-01 | 0.2871 |
5801 | PTPRR | ATC13 | Human | Thyroid | ATC | 8.02e-68 | 1.87e+00 | 0.34 |
5801 | PTPRR | ATC1 | Human | Thyroid | ATC | 8.56e-03 | 1.56e-01 | 0.2878 |
5801 | PTPRR | ATC5 | Human | Thyroid | ATC | 7.60e-77 | 1.96e+00 | 0.34 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:200014617 | Thyroid | ATC | negative regulation of cell motility | 147/6293 | 359/18723 | 2.01e-03 | 9.60e-03 | 147 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
PTPRR | SNV | Missense_Mutation | rs144153905 | c.1238C>T | p.Pro413Leu | p.P413L | Q15256 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-AN-A0AK-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
PTPRR | SNV | Missense_Mutation | c.1748C>A | p.Pro583His | p.P583H | Q15256 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-BH-A0AV-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | taxotere | CR | |
PTPRR | SNV | Missense_Mutation | novel | c.1733C>T | p.Ser578Phe | p.S578F | Q15256 | protein_coding | tolerated(0.08) | possibly_damaging(0.837) | TCGA-PE-A5DE-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | taxotere | CR |
PTPRR | insertion | In_Frame_Ins | novel | c.1797_1798insTCACTTAGCATAATATCCTCAAGGTTCATCTATGTTGTA | p.Ile599_Ala600insSerLeuSerIleIleSerSerArgPheIleTyrValVal | p.I599_A600insSLSIISSRFIYVV | Q15256 | protein_coding | TCGA-A8-A07U-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Chemotherapy | 5-fluorouracil | SD | ||
PTPRR | SNV | Missense_Mutation | novel | c.1609N>A | p.Gln537Lys | p.Q537K | Q15256 | protein_coding | tolerated(0.36) | benign(0.049) | TCGA-C5-A1BF-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | PD |
PTPRR | SNV | Missense_Mutation | rs779525997 | c.742N>A | p.Leu248Ile | p.L248I | Q15256 | protein_coding | tolerated(0.09) | benign(0.012) | TCGA-A6-6141-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | 5-fu | SD |
PTPRR | SNV | Missense_Mutation | rs752997522 | c.1259N>A | p.Arg420His | p.R420H | Q15256 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-AA-3949-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
PTPRR | SNV | Missense_Mutation | c.1592N>A | p.Arg531Gln | p.R531Q | Q15256 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-AA-3984-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
PTPRR | SNV | Missense_Mutation | rs777721053 | c.1127N>A | p.Arg376Gln | p.R376Q | Q15256 | protein_coding | deleterious(0.01) | probably_damaging(0.981) | TCGA-AA-A00N-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
PTPRR | SNV | Missense_Mutation | c.1592N>A | p.Arg531Gln | p.R531Q | Q15256 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-AZ-4315-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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