Tissue | Expression Dynamics | Abbreviation |
Colorectum (GSE201348) | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Colorectum/Becker/PTK7_pca_on_diff_genes.png) | FAP: Familial adenomatous polyposis |
CRC: Colorectal cancer |
Colorectum (HTA11) | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Colorectum/Chen/PTK7_pca_on_diff_genes.png) | AD: Adenomas |
SER: Sessile serrated lesions |
MSI-H: Microsatellite-high colorectal cancer |
MSS: Microsatellite stable colorectal cancer |
Esophagus | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Esophagus/PTK7_pca_on_diff_genes.png) | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias |
LGIN: Low-grade intraepithelial neoplasias |
Lung | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Lung/PTK7_pca_on_diff_genes.png) | AAH: Atypical adenomatous hyperplasia |
AIS: Adenocarcinoma in situ |
IAC: Invasive lung adenocarcinoma |
MIA: Minimally invasive adenocarcinoma |
Oral Cavity | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/OralCavity/PTK7_pca_on_diff_genes.png) | EOLP: Erosive Oral lichen planus |
LP: leukoplakia |
NEOLP: Non-erosive oral lichen planus |
OSCC: Oral squamous cell carcinoma |
Skin | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Skin/PTK7_pca_on_diff_genes.png) | AK: Actinic keratosis |
cSCC: Cutaneous squamous cell carcinoma |
SCCIS:squamous cell carcinoma in situ |
Thyroid | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Thyroid/PTK7_pca_on_diff_genes.png) | ATC: Anaplastic thyroid cancer |
HT: Hashimoto's thyroiditis |
PTC: Papillary thyroid cancer |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00605621 | Colorectum | MSS | epithelial tube morphogenesis | 88/3467 | 325/18723 | 8.45e-05 | 1.37e-03 | 88 |
GO:00451972 | Colorectum | MSS | establishment or maintenance of epithelial cell apical/basal polarity | 19/3467 | 44/18723 | 1.38e-04 | 2.06e-03 | 19 |
GO:00301771 | Colorectum | MSS | positive regulation of Wnt signaling pathway | 44/3467 | 140/18723 | 1.57e-04 | 2.28e-03 | 44 |
GO:00350882 | Colorectum | MSS | establishment or maintenance of apical/basal cell polarity | 20/3467 | 49/18723 | 2.36e-04 | 3.24e-03 | 20 |
GO:00612452 | Colorectum | MSS | establishment or maintenance of bipolar cell polarity | 20/3467 | 49/18723 | 2.36e-04 | 3.24e-03 | 20 |
GO:00140201 | Colorectum | MSS | primary neural tube formation | 32/3467 | 94/18723 | 2.42e-04 | 3.30e-03 | 32 |
GO:00018412 | Colorectum | MSS | neural tube formation | 34/3467 | 102/18723 | 2.48e-04 | 3.37e-03 | 34 |
GO:00351481 | Colorectum | MSS | tube formation | 44/3467 | 148/18723 | 6.06e-04 | 6.68e-03 | 44 |
GO:00018381 | Colorectum | MSS | embryonic epithelial tube formation | 37/3467 | 121/18723 | 8.95e-04 | 9.13e-03 | 37 |
GO:00018431 | Colorectum | MSS | neural tube closure | 28/3467 | 88/18723 | 1.87e-03 | 1.64e-02 | 28 |
GO:00219151 | Colorectum | MSS | neural tube development | 43/3467 | 152/18723 | 2.05e-03 | 1.75e-02 | 43 |
GO:00901621 | Colorectum | MSS | establishment of epithelial cell polarity | 13/3467 | 31/18723 | 2.14e-03 | 1.80e-02 | 13 |
GO:00606061 | Colorectum | MSS | tube closure | 28/3467 | 89/18723 | 2.25e-03 | 1.86e-02 | 28 |
GO:00902631 | Colorectum | MSS | positive regulation of canonical Wnt signaling pathway | 32/3467 | 106/18723 | 2.41e-03 | 1.96e-02 | 32 |
GO:00605601 | Colorectum | MSS | developmental growth involved in morphogenesis | 61/3467 | 234/18723 | 2.56e-03 | 2.03e-02 | 61 |
GO:00721751 | Colorectum | MSS | epithelial tube formation | 38/3467 | 132/18723 | 2.59e-03 | 2.05e-02 | 38 |
GO:00485681 | Colorectum | MSS | embryonic organ development | 100/3467 | 427/18723 | 6.00e-03 | 4.03e-02 | 100 |
GO:0001655 | Colorectum | MSS | urogenital system development | 81/3467 | 338/18723 | 6.88e-03 | 4.43e-02 | 81 |
GO:0061162 | Colorectum | MSS | establishment of monopolar cell polarity | 10/3467 | 24/18723 | 7.25e-03 | 4.63e-02 | 10 |
GO:00071633 | Colorectum | FAP | establishment or maintenance of cell polarity | 64/2622 | 218/18723 | 2.83e-09 | 5.07e-07 | 64 |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
PTK7 | SNV | Missense_Mutation | | c.1028C>A | p.Ala343Asp | p.A343D | Q13308 | protein_coding | deleterious(0.01) | possibly_damaging(0.471) | TCGA-A2-A0D2-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | SD |
PTK7 | SNV | Missense_Mutation | novel | c.2262N>A | p.Met754Ile | p.M754I | Q13308 | protein_coding | deleterious(0.04) | benign(0.067) | TCGA-A7-A6VX-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | docetaxel | CR |
PTK7 | SNV | Missense_Mutation | | c.2124G>T | p.Lys708Asn | p.K708N | Q13308 | protein_coding | deleterious(0.04) | benign(0.082) | TCGA-A8-A0A9-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | anastrozole | SD |
PTK7 | SNV | Missense_Mutation | rs374956441 | c.493C>T | p.Arg165Trp | p.R165W | Q13308 | protein_coding | deleterious(0) | probably_damaging(0.983) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
PTK7 | SNV | Missense_Mutation | novel | c.2578N>C | p.Lys860Gln | p.K860Q | Q13308 | protein_coding | deleterious(0) | possibly_damaging(0.734) | TCGA-B6-A0IN-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | PD |
PTK7 | SNV | Missense_Mutation | | c.2317G>A | p.Glu773Lys | p.E773K | Q13308 | protein_coding | deleterious(0.03) | benign(0.119) | TCGA-D8-A1JN-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Hormone Therapy | anastrozolum | SD |
PTK7 | SNV | Missense_Mutation | novel | c.1769N>T | p.Ala590Val | p.A590V | Q13308 | protein_coding | deleterious(0.01) | possibly_damaging(0.475) | TCGA-E9-A228-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | SD |
PTK7 | SNV | Missense_Mutation | rs767634504 | c.581N>T | p.Thr194Met | p.T194M | Q13308 | protein_coding | deleterious(0.03) | benign(0.104) | TCGA-S3-AA14-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | CR |
PTK7 | insertion | In_Frame_Ins | novel | c.2208_2209insGATCTGGGCCCAAACAGAGTCCGGTTTGGCAGACGTGGAATGTCA | p.Lys736_Arg737insAspLeuGlyProAsnArgValArgPheGlyArgArgGlyMetSer | p.K736_R737insDLGPNRVRFGRRGMS | Q13308 | protein_coding | | | TCGA-AO-A0J9-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | cyclophosphamide | PD |
PTK7 | insertion | Frame_Shift_Ins | novel | c.2577_2578insCTTCC | p.Lys860LeufsTer4 | p.K860Lfs*4 | Q13308 | protein_coding | | | TCGA-B6-A0IN-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | PD |