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Gene: PRMT1 |
Gene summary for PRMT1 |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | PRMT1 | Gene ID | 3276 |
| Gene name | protein arginine methyltransferase 1 | |
| Gene Alias | ANM1 | |
| Cytomap | 19q13.33 | |
| Gene Type | protein-coding | GO ID | GO:0000165 | UniProtAcc | A0A087X1W2 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 3276 | PRMT1 | HTA11_3410_2000001011 | Human | Colorectum | AD | 4.03e-07 | 2.47e-01 | 0.0155 |
| 3276 | PRMT1 | HTA11_1938_2000001011 | Human | Colorectum | AD | 1.45e-09 | 4.72e-01 | -0.0811 |
| 3276 | PRMT1 | HTA11_347_2000001011 | Human | Colorectum | AD | 5.16e-07 | 2.72e-01 | -0.1954 |
| 3276 | PRMT1 | HTA11_3361_2000001011 | Human | Colorectum | AD | 5.54e-03 | 3.93e-01 | -0.1207 |
| 3276 | PRMT1 | HTA11_83_2000001011 | Human | Colorectum | SER | 1.66e-07 | 3.68e-01 | -0.1526 |
| 3276 | PRMT1 | HTA11_696_2000001011 | Human | Colorectum | AD | 9.44e-08 | 4.36e-01 | -0.1464 |
| 3276 | PRMT1 | HTA11_866_2000001011 | Human | Colorectum | AD | 3.37e-02 | 1.85e-01 | -0.1001 |
| 3276 | PRMT1 | HTA11_1391_2000001011 | Human | Colorectum | AD | 4.86e-19 | 7.08e-01 | -0.059 |
| 3276 | PRMT1 | HTA11_2992_2000001011 | Human | Colorectum | SER | 8.75e-04 | 5.33e-01 | -0.1706 |
| 3276 | PRMT1 | HTA11_5212_2000001011 | Human | Colorectum | AD | 5.10e-03 | 3.70e-01 | -0.2061 |
| 3276 | PRMT1 | HTA11_546_2000001011 | Human | Colorectum | AD | 2.97e-02 | 3.33e-01 | -0.0842 |
| 3276 | PRMT1 | HTA11_866_3004761011 | Human | Colorectum | AD | 2.31e-23 | 5.81e-01 | 0.096 |
| 3276 | PRMT1 | HTA11_8622_2000001021 | Human | Colorectum | SER | 3.08e-03 | 4.35e-01 | 0.0528 |
| 3276 | PRMT1 | HTA11_7663_2000001011 | Human | Colorectum | SER | 1.32e-03 | 4.34e-01 | 0.0131 |
| 3276 | PRMT1 | HTA11_6801_2000001011 | Human | Colorectum | SER | 7.16e-04 | 6.06e-01 | 0.0171 |
| 3276 | PRMT1 | HTA11_10711_2000001011 | Human | Colorectum | AD | 6.00e-09 | 4.14e-01 | 0.0338 |
| 3276 | PRMT1 | HTA11_7696_3000711011 | Human | Colorectum | AD | 7.04e-41 | 9.40e-01 | 0.0674 |
| 3276 | PRMT1 | HTA11_6818_2000001011 | Human | Colorectum | AD | 1.03e-05 | 5.26e-01 | 0.0112 |
| 3276 | PRMT1 | HTA11_7469_2000001011 | Human | Colorectum | AD | 1.71e-04 | 5.96e-01 | -0.0124 |
| 3276 | PRMT1 | HTA11_6818_2000001021 | Human | Colorectum | AD | 8.61e-10 | 4.39e-01 | 0.0588 |
| Page: 1 2 3 4 5 6 7 8 9 10 |
| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Colorectum (GSE201348) |  | FAP: Familial adenomatous polyposis |
| CRC: Colorectal cancer | ||
| Colorectum (HTA11) |  | AD: Adenomas |
| SER: Sessile serrated lesions | ||
| MSI-H: Microsatellite-high colorectal cancer | ||
| MSS: Microsatellite stable colorectal cancer | ||
| Endometrium |  | AEH: Atypical endometrial hyperplasia |
| EEC: Endometrioid Cancer | ||
| Esophagus |  | ESCC: Esophageal squamous cell carcinoma |
| HGIN: High-grade intraepithelial neoplasias | ||
| LGIN: Low-grade intraepithelial neoplasias | ||
| Liver |  | HCC: Hepatocellular carcinoma |
| NAFLD: Non-alcoholic fatty liver disease | ||
| Oral Cavity |  | EOLP: Erosive Oral lichen planus |
| LP: leukoplakia | ||
| NEOLP: Non-erosive oral lichen planus | ||
| OSCC: Oral squamous cell carcinoma | ||
| Prostate |  | BPH: Benign Prostatic Hyperplasia |
| Skin |  | AK: Actinic keratosis |
| cSCC: Cutaneous squamous cell carcinoma | ||
| SCCIS:squamous cell carcinoma in situ | ||
| Thyroid |  | ATC: Anaplastic thyroid cancer |
| HT: Hashimoto's thyroiditis | ||
| PTC: Papillary thyroid cancer |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| GO:00341013 | Colorectum | MSI-H | erythrocyte homeostasis | 24/1319 | 129/18723 | 1.03e-05 | 4.79e-04 | 24 |
| GO:00300993 | Colorectum | MSI-H | myeloid cell differentiation | 50/1319 | 381/18723 | 1.52e-05 | 6.62e-04 | 50 |
| GO:00022623 | Colorectum | MSI-H | myeloid cell homeostasis | 26/1319 | 157/18723 | 3.79e-05 | 1.43e-03 | 26 |
| GO:00302183 | Colorectum | MSI-H | erythrocyte differentiation | 20/1319 | 120/18723 | 2.62e-04 | 6.65e-03 | 20 |
| GO:00488723 | Colorectum | MSI-H | homeostasis of number of cells | 34/1319 | 272/18723 | 8.10e-04 | 1.49e-02 | 34 |
| GO:19037062 | Colorectum | MSI-H | regulation of hemopoiesis | 41/1319 | 367/18723 | 2.31e-03 | 3.09e-02 | 41 |
| GO:000838016 | Endometrium | AEH | RNA splicing | 111/2100 | 434/18723 | 2.42e-17 | 1.12e-14 | 111 |
| GO:00605376 | Endometrium | AEH | muscle tissue development | 83/2100 | 403/18723 | 2.57e-08 | 1.50e-06 | 83 |
| GO:00017019 | Endometrium | AEH | in utero embryonic development | 73/2100 | 367/18723 | 7.18e-07 | 2.63e-05 | 73 |
| GO:00147065 | Endometrium | AEH | striated muscle tissue development | 75/2100 | 384/18723 | 1.06e-06 | 3.62e-05 | 75 |
| GO:00514039 | Endometrium | AEH | stress-activated MAPK cascade | 50/2100 | 239/18723 | 9.33e-06 | 2.18e-04 | 50 |
| GO:00310989 | Endometrium | AEH | stress-activated protein kinase signaling cascade | 51/2100 | 247/18723 | 1.12e-05 | 2.52e-04 | 51 |
| GO:00328728 | Endometrium | AEH | regulation of stress-activated MAPK cascade | 42/2100 | 192/18723 | 1.53e-05 | 3.23e-04 | 42 |
| GO:00380665 | Endometrium | AEH | p38MAPK cascade | 18/2100 | 55/18723 | 1.77e-05 | 3.65e-04 | 18 |
| GO:00434105 | Endometrium | AEH | positive regulation of MAPK cascade | 84/2100 | 480/18723 | 2.19e-05 | 4.25e-04 | 84 |
| GO:00703028 | Endometrium | AEH | regulation of stress-activated protein kinase signaling cascade | 42/2100 | 195/18723 | 2.27e-05 | 4.35e-04 | 42 |
| GO:00456469 | Endometrium | AEH | regulation of erythrocyte differentiation | 16/2100 | 47/18723 | 2.96e-05 | 5.47e-04 | 16 |
| GO:004887216 | Endometrium | AEH | homeostasis of number of cells | 53/2100 | 272/18723 | 4.10e-05 | 6.99e-04 | 53 |
| GO:000226216 | Endometrium | AEH | myeloid cell homeostasis | 35/2100 | 157/18723 | 5.03e-05 | 8.16e-04 | 35 |
| GO:003410116 | Endometrium | AEH | erythrocyte homeostasis | 30/2100 | 129/18723 | 7.46e-05 | 1.13e-03 | 30 |
| Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 |
| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
| hsa04922 | Colorectum | AD | Glucagon signaling pathway | 41/2092 | 107/8465 | 1.18e-03 | 7.75e-03 | 4.94e-03 | 41 |
| hsa049221 | Colorectum | AD | Glucagon signaling pathway | 41/2092 | 107/8465 | 1.18e-03 | 7.75e-03 | 4.94e-03 | 41 |
| hsa049222 | Colorectum | SER | Glucagon signaling pathway | 38/1580 | 107/8465 | 2.57e-05 | 3.28e-04 | 2.38e-04 | 38 |
| hsa049223 | Colorectum | SER | Glucagon signaling pathway | 38/1580 | 107/8465 | 2.57e-05 | 3.28e-04 | 2.38e-04 | 38 |
| hsa049224 | Colorectum | MSS | Glucagon signaling pathway | 39/1875 | 107/8465 | 5.00e-04 | 3.45e-03 | 2.11e-03 | 39 |
| hsa049225 | Colorectum | MSS | Glucagon signaling pathway | 39/1875 | 107/8465 | 5.00e-04 | 3.45e-03 | 2.11e-03 | 39 |
| hsa040689 | Esophagus | ESCC | FoxO signaling pathway | 89/4205 | 131/8465 | 1.56e-05 | 7.98e-05 | 4.09e-05 | 89 |
| hsa0492214 | Esophagus | ESCC | Glucagon signaling pathway | 64/4205 | 107/8465 | 2.18e-02 | 4.80e-02 | 2.46e-02 | 64 |
| hsa0406814 | Esophagus | ESCC | FoxO signaling pathway | 89/4205 | 131/8465 | 1.56e-05 | 7.98e-05 | 4.09e-05 | 89 |
| hsa0492215 | Esophagus | ESCC | Glucagon signaling pathway | 64/4205 | 107/8465 | 2.18e-02 | 4.80e-02 | 2.46e-02 | 64 |
| hsa040682 | Liver | Cirrhotic | FoxO signaling pathway | 52/2530 | 131/8465 | 9.98e-03 | 3.32e-02 | 2.05e-02 | 52 |
| hsa0492221 | Liver | Cirrhotic | Glucagon signaling pathway | 43/2530 | 107/8465 | 1.42e-02 | 4.35e-02 | 2.68e-02 | 43 |
| hsa040683 | Liver | Cirrhotic | FoxO signaling pathway | 52/2530 | 131/8465 | 9.98e-03 | 3.32e-02 | 2.05e-02 | 52 |
| hsa0492231 | Liver | Cirrhotic | Glucagon signaling pathway | 43/2530 | 107/8465 | 1.42e-02 | 4.35e-02 | 2.68e-02 | 43 |
| hsa040684 | Liver | HCC | FoxO signaling pathway | 85/4020 | 131/8465 | 3.99e-05 | 2.16e-04 | 1.20e-04 | 85 |
| hsa0492241 | Liver | HCC | Glucagon signaling pathway | 64/4020 | 107/8465 | 6.70e-03 | 1.87e-02 | 1.04e-02 | 64 |
| hsa040685 | Liver | HCC | FoxO signaling pathway | 85/4020 | 131/8465 | 3.99e-05 | 2.16e-04 | 1.20e-04 | 85 |
| hsa0492251 | Liver | HCC | Glucagon signaling pathway | 64/4020 | 107/8465 | 6.70e-03 | 1.87e-02 | 1.04e-02 | 64 |
| hsa040688 | Oral cavity | OSCC | FoxO signaling pathway | 85/3704 | 131/8465 | 7.50e-07 | 4.33e-06 | 2.21e-06 | 85 |
| hsa0406813 | Oral cavity | OSCC | FoxO signaling pathway | 85/3704 | 131/8465 | 7.50e-07 | 4.33e-06 | 2.21e-06 | 85 |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
| Page: 1 |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| PRMT1 | deletion | Frame_Shift_Del | c.945delN | p.Val316CysfsTer8 | p.V316Cfs*8 | protein_coding | TCGA-D8-A27V-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD | ||||
| PRMT1 | SNV | Missense_Mutation | rs544334510 | c.562N>A | p.Asp188Asn | p.D188N | protein_coding | tolerated(0.34) | benign(0.007) | TCGA-DS-A0VM-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | PD | |
| PRMT1 | SNV | Missense_Mutation | c.584G>A | p.Arg195Gln | p.R195Q | protein_coding | tolerated(0.06) | probably_damaging(0.999) | TCGA-AD-6895-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD | ||
| PRMT1 | SNV | Missense_Mutation | c.896N>T | p.Thr299Ile | p.T299I | protein_coding | tolerated(1) | benign(0.139) | TCGA-CK-4951-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | ||
| PRMT1 | SNV | Missense_Mutation | c.536N>G | p.Tyr179Cys | p.Y179C | protein_coding | deleterious(0) | possibly_damaging(0.837) | TCGA-D5-6541-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | ||
| PRMT1 | SNV | Missense_Mutation | novel | c.298G>A | p.Gly100Ser | p.G100S | protein_coding | deleterious(0.04) | benign(0.308) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD | |
| PRMT1 | SNV | Missense_Mutation | novel | c.1015C>T | p.Pro339Ser | p.P339S | protein_coding | deleterious(0.03) | possibly_damaging(0.822) | TCGA-A5-A0GG-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
| PRMT1 | SNV | Missense_Mutation | c.985G>A | p.Glu329Lys | p.E329K | protein_coding | deleterious(0.01) | probably_damaging(0.938) | TCGA-AP-A0LM-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | cisplatin | SD | ||
| PRMT1 | SNV | Missense_Mutation | novel | c.90A>T | p.Glu30Asp | p.E30D | protein_coding | tolerated(0.43) | benign(0.001) | TCGA-AX-A06F-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatin | SD | |
| PRMT1 | SNV | Missense_Mutation | c.1021N>A | p.Ala341Thr | p.A341T | protein_coding | tolerated(0.12) | benign(0.006) | TCGA-AX-A0J1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
| 3276 | PRMT1 | ENZYME, METHYL TRANSFERASE | FURAMIDINE | FURAMIDINE | 24564570 | |
| 3276 | PRMT1 | ENZYME, METHYL TRANSFERASE | NSC-45174 | CHEMBL221047 | 20666457 | |
| 3276 | PRMT1 | ENZYME, METHYL TRANSFERASE | inhibitor | 310264736 | ||
| 3276 | PRMT1 | ENZYME, METHYL TRANSFERASE | inhibitor | 178103616 | ||
| 3276 | PRMT1 | ENZYME, METHYL TRANSFERASE | inhibitor | 178103608 | ||
| 3276 | PRMT1 | ENZYME, METHYL TRANSFERASE | inhibitor | 178103607 | ||
| 3276 | PRMT1 | ENZYME, METHYL TRANSFERASE | STILBAMIDINE | STILBAMIDINE | 20666457 | |
| 3276 | PRMT1 | ENZYME, METHYL TRANSFERASE | NSC-47762 | CHEMBL1092740 | 20666457 | |
| 3276 | PRMT1 | ENZYME, METHYL TRANSFERASE | EOSIN | EOSIN | 18348515 |
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