Tissue | Expression Dynamics | Abbreviation |
Cervix | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Cervix/PRKCH_pca_on_diff_genes.png) | CC: Cervix cancer |
HSIL_HPV: HPV-infected high-grade squamous intraepithelial lesions |
N_HPV: HPV-infected normal cervix |
Endometrium | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Endometrium/PRKCH_pca_on_diff_genes.png) | AEH: Atypical endometrial hyperplasia |
EEC: Endometrioid Cancer |
Esophagus | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Esophagus/PRKCH_pca_on_diff_genes.png) | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias |
LGIN: Low-grade intraepithelial neoplasias |
Lung | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Lung/PRKCH_pca_on_diff_genes.png) | AAH: Atypical adenomatous hyperplasia |
AIS: Adenocarcinoma in situ |
IAC: Invasive lung adenocarcinoma |
MIA: Minimally invasive adenocarcinoma |
Oral Cavity | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/OralCavity/PRKCH_pca_on_diff_genes.png) | EOLP: Erosive Oral lichen planus |
LP: leukoplakia |
NEOLP: Non-erosive oral lichen planus |
OSCC: Oral squamous cell carcinoma |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:007265914 | Endometrium | AEH | protein localization to plasma membrane | 63/2100 | 284/18723 | 7.58e-08 | 3.92e-06 | 63 |
GO:19907789 | Endometrium | AEH | protein localization to cell periphery | 68/2100 | 333/18723 | 6.38e-07 | 2.38e-05 | 68 |
GO:00343299 | Endometrium | AEH | cell junction assembly | 78/2100 | 420/18723 | 4.80e-06 | 1.24e-04 | 78 |
GO:00107207 | Endometrium | AEH | positive regulation of cell development | 57/2100 | 298/18723 | 3.72e-05 | 6.49e-04 | 57 |
GO:004521610 | Endometrium | AEH | cell-cell junction organization | 42/2100 | 200/18723 | 4.26e-05 | 7.20e-04 | 42 |
GO:19054779 | Endometrium | AEH | positive regulation of protein localization to membrane | 26/2100 | 106/18723 | 8.63e-05 | 1.27e-03 | 26 |
GO:190437710 | Endometrium | AEH | positive regulation of protein localization to cell periphery | 19/2100 | 69/18723 | 1.49e-04 | 1.98e-03 | 19 |
GO:00308564 | Endometrium | AEH | regulation of epithelial cell differentiation | 33/2100 | 154/18723 | 1.81e-04 | 2.32e-03 | 33 |
GO:19030789 | Endometrium | AEH | positive regulation of protein localization to plasma membrane | 17/2100 | 62/18723 | 3.46e-04 | 3.80e-03 | 17 |
GO:00027645 | Endometrium | AEH | immune response-regulating signaling pathway | 76/2100 | 468/18723 | 5.76e-04 | 5.71e-03 | 76 |
GO:19018887 | Endometrium | AEH | regulation of cell junction assembly | 39/2100 | 204/18723 | 5.94e-04 | 5.86e-03 | 39 |
GO:000704310 | Endometrium | AEH | cell-cell junction assembly | 30/2100 | 146/18723 | 7.29e-04 | 6.98e-03 | 30 |
GO:19054759 | Endometrium | AEH | regulation of protein localization to membrane | 34/2100 | 175/18723 | 9.62e-04 | 8.75e-03 | 34 |
GO:00456823 | Endometrium | AEH | regulation of epidermis development | 16/2100 | 65/18723 | 1.81e-03 | 1.44e-02 | 16 |
GO:00432979 | Endometrium | AEH | apical junction assembly | 18/2100 | 78/18723 | 2.12e-03 | 1.64e-02 | 18 |
GO:19030769 | Endometrium | AEH | regulation of protein localization to plasma membrane | 22/2100 | 104/18723 | 2.40e-03 | 1.80e-02 | 22 |
GO:00510905 | Endometrium | AEH | regulation of DNA-binding transcription factor activity | 69/2100 | 440/18723 | 2.51e-03 | 1.87e-02 | 69 |
GO:00435885 | Endometrium | AEH | skin development | 45/2100 | 263/18723 | 2.58e-03 | 1.90e-02 | 45 |
GO:19043759 | Endometrium | AEH | regulation of protein localization to cell periphery | 25/2100 | 125/18723 | 2.84e-03 | 2.04e-02 | 25 |
GO:00456043 | Endometrium | AEH | regulation of epidermal cell differentiation | 14/2100 | 58/18723 | 4.12e-03 | 2.73e-02 | 14 |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
PRKCH | SNV | Missense_Mutation | novel | c.1532N>A | p.Thr511Lys | p.T511K | P24723 | protein_coding | deleterious(0) | probably_damaging(0.984) | TCGA-A2-A1G1-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
PRKCH | SNV | Missense_Mutation | novel | c.208N>A | p.Glu70Lys | p.E70K | P24723 | protein_coding | tolerated(0.06) | probably_damaging(0.941) | TCGA-AR-A2LE-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | tamoxiphen | PD |
PRKCH | SNV | Missense_Mutation | | c.1771N>G | p.Lys591Glu | p.K591E | P24723 | protein_coding | deleterious(0) | probably_damaging(0.974) | TCGA-BH-A0BZ-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | doxorubicin | CR |
PRKCH | SNV | Missense_Mutation | novel | c.1511G>C | p.Gly504Ala | p.G504A | P24723 | protein_coding | deleterious(0) | possibly_damaging(0.607) | TCGA-BH-A0DS-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Chemotherapy | cyclophosphamide | SD |
PRKCH | SNV | Missense_Mutation | | c.291N>A | p.Phe97Leu | p.F97L | P24723 | protein_coding | tolerated(0.12) | probably_damaging(1) | TCGA-E2-A152-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Targeted Molecular therapy | trastuzumab | PD |
PRKCH | SNV | Missense_Mutation | novel | c.1738G>T | p.Asp580Tyr | p.D580Y | P24723 | protein_coding | deleterious(0) | probably_damaging(0.969) | TCGA-E9-A1N9-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | SD |
PRKCH | insertion | Frame_Shift_Ins | novel | c.1247_1248insAAACCCAGGATCCTGGGTTATGCTTTTGTCTGGGGACCAGGCAGGA | p.Thr417AsnfsTer39 | p.T417Nfs*39 | P24723 | protein_coding | | | TCGA-BH-A0B1-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | adriamycin | SD |
PRKCH | insertion | Nonsense_Mutation | novel | c.1982_1983insGCTCCAGCCTGGGCAACTGAGTTAGACTTTGTCTCAAAAA | p.His662LeufsTer8 | p.H662Lfs*8 | P24723 | protein_coding | | | TCGA-BH-A0HW-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | SD |
PRKCH | SNV | Missense_Mutation | | c.291N>G | p.Phe97Leu | p.F97L | P24723 | protein_coding | tolerated(0.12) | probably_damaging(1) | TCGA-C5-A1BQ-01 | Cervix | cervical & endocervical cancer | Female | >=65 | III/IV | Chemotherapy | cisplatin | CR |
PRKCH | SNV | Missense_Mutation | novel | c.671N>A | p.Cys224Tyr | p.C224Y | P24723 | protein_coding | tolerated(0.19) | possibly_damaging(0.793) | TCGA-MY-A5BF-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Chemotherapy | cisplatin | CR |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
5583 | PRKCH | ENZYME, KINASE, DRUGGABLE GENOME, SERINE THREONINE KINASE | inhibitor | 249565629 | SOTRASTAURIN | |
5583 | PRKCH | ENZYME, KINASE, DRUGGABLE GENOME, SERINE THREONINE KINASE | inhibitor | CHEMBL3545332 | CEP-2563 | |
5583 | PRKCH | ENZYME, KINASE, DRUGGABLE GENOME, SERINE THREONINE KINASE | | BRYOSTATIN-1 | | |
5583 | PRKCH | ENZYME, KINASE, DRUGGABLE GENOME, SERINE THREONINE KINASE | | BRYOSTATIN | BRYOSTATIN | |
5583 | PRKCH | ENZYME, KINASE, DRUGGABLE GENOME, SERINE THREONINE KINASE | inhibitor | CHEMBL494089 | GSK-690693 | |
5583 | PRKCH | ENZYME, KINASE, DRUGGABLE GENOME, SERINE THREONINE KINASE | inhibitor | CHEMBL565612 | SOTRASTAURIN | |
5583 | PRKCH | ENZYME, KINASE, DRUGGABLE GENOME, SERINE THREONINE KINASE | | INGENOL MEBUTATE | | |
5583 | PRKCH | ENZYME, KINASE, DRUGGABLE GENOME, SERINE THREONINE KINASE | inhibitor | CHEMBL608533 | MIDOSTAURIN | |
5583 | PRKCH | ENZYME, KINASE, DRUGGABLE GENOME, SERINE THREONINE KINASE | inhibitor | 249565822 | BALANOL | |
5583 | PRKCH | ENZYME, KINASE, DRUGGABLE GENOME, SERINE THREONINE KINASE | inhibitor | SOPHORETIN | QUERCETIN | |