|
|||||
|
 | |
| |
| |
| |
| |
| |
|
Gene: PLA2R1 |
Gene summary for PLA2R1 |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | PLA2R1 | Gene ID | 22925 |
| Gene name | phospholipase A2 receptor 1 | |
| Gene Alias | CLEC13C | |
| Cytomap | 2q24.2 | |
| Gene Type | protein-coding | GO ID | GO:0001816 | UniProtAcc | Q13018 |
Top |
Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 22925 | PLA2R1 | LZE4T | Human | Esophagus | ESCC | 1.11e-23 | 8.71e-01 | 0.0811 |
| 22925 | PLA2R1 | LZE22T | Human | Esophagus | ESCC | 1.59e-02 | 1.93e-01 | 0.068 |
| 22925 | PLA2R1 | P1T-E | Human | Esophagus | ESCC | 2.47e-02 | 1.26e-01 | 0.0875 |
| 22925 | PLA2R1 | P2T-E | Human | Esophagus | ESCC | 1.21e-02 | 2.71e-02 | 0.1177 |
| 22925 | PLA2R1 | P4T-E | Human | Esophagus | ESCC | 1.60e-10 | 2.57e-01 | 0.1323 |
| 22925 | PLA2R1 | P5T-E | Human | Esophagus | ESCC | 3.73e-03 | 5.18e-02 | 0.1327 |
| 22925 | PLA2R1 | P8T-E | Human | Esophagus | ESCC | 3.49e-06 | 1.36e-01 | 0.0889 |
| 22925 | PLA2R1 | P9T-E | Human | Esophagus | ESCC | 2.75e-04 | 7.71e-02 | 0.1131 |
| 22925 | PLA2R1 | P10T-E | Human | Esophagus | ESCC | 3.67e-05 | 1.63e-01 | 0.116 |
| 22925 | PLA2R1 | P11T-E | Human | Esophagus | ESCC | 9.31e-11 | 6.58e-01 | 0.1426 |
| 22925 | PLA2R1 | P12T-E | Human | Esophagus | ESCC | 2.69e-28 | 6.38e-01 | 0.1122 |
| 22925 | PLA2R1 | P15T-E | Human | Esophagus | ESCC | 9.43e-17 | 4.90e-01 | 0.1149 |
| 22925 | PLA2R1 | P16T-E | Human | Esophagus | ESCC | 6.09e-06 | 9.47e-02 | 0.1153 |
| 22925 | PLA2R1 | P17T-E | Human | Esophagus | ESCC | 4.68e-02 | 2.11e-01 | 0.1278 |
| 22925 | PLA2R1 | P20T-E | Human | Esophagus | ESCC | 6.95e-19 | 2.61e-01 | 0.1124 |
| 22925 | PLA2R1 | P21T-E | Human | Esophagus | ESCC | 1.36e-13 | 2.07e-01 | 0.1617 |
| 22925 | PLA2R1 | P22T-E | Human | Esophagus | ESCC | 2.62e-11 | 1.43e-01 | 0.1236 |
| 22925 | PLA2R1 | P23T-E | Human | Esophagus | ESCC | 2.67e-05 | 2.91e-01 | 0.108 |
| 22925 | PLA2R1 | P24T-E | Human | Esophagus | ESCC | 2.11e-11 | 4.41e-02 | 0.1287 |
| 22925 | PLA2R1 | P26T-E | Human | Esophagus | ESCC | 6.41e-25 | 4.89e-01 | 0.1276 |
| Page: 1 2 3 4 |
| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Esophagus |  | ESCC: Esophageal squamous cell carcinoma |
| HGIN: High-grade intraepithelial neoplasias | ||
| LGIN: Low-grade intraepithelial neoplasias | ||
| Thyroid |  | ATC: Anaplastic thyroid cancer |
| HT: Hashimoto's thyroiditis | ||
| PTC: Papillary thyroid cancer |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| GO:0072331113 | Thyroid | PTC | signal transduction by p53 class mediator | 92/5968 | 163/18723 | 7.29e-11 | 2.54e-09 | 92 |
| GO:2001020112 | Thyroid | PTC | regulation of response to DNA damage stimulus | 113/5968 | 219/18723 | 9.37e-10 | 2.77e-08 | 113 |
| GO:1901796113 | Thyroid | PTC | regulation of signal transduction by p53 class mediator | 58/5968 | 93/18723 | 1.38e-09 | 3.95e-08 | 58 |
| GO:0007568111 | Thyroid | PTC | aging | 153/5968 | 339/18723 | 1.80e-07 | 3.34e-06 | 153 |
| GO:000756917 | Thyroid | PTC | cell aging | 68/5968 | 132/18723 | 2.09e-06 | 2.84e-05 | 68 |
| GO:0006898110 | Thyroid | PTC | receptor-mediated endocytosis | 112/5968 | 244/18723 | 2.87e-06 | 3.74e-05 | 112 |
| GO:0072593110 | Thyroid | PTC | reactive oxygen species metabolic process | 108/5968 | 239/18723 | 1.02e-05 | 1.13e-04 | 108 |
| GO:004277010 | Thyroid | PTC | signal transduction in response to DNA damage | 81/5968 | 172/18723 | 2.07e-05 | 2.08e-04 | 81 |
| GO:1901798113 | Thyroid | PTC | positive regulation of signal transduction by p53 class mediator | 18/5968 | 25/18723 | 4.48e-05 | 4.05e-04 | 18 |
| GO:20010229 | Thyroid | PTC | positive regulation of response to DNA damage stimulus | 53/5968 | 105/18723 | 5.51e-05 | 4.89e-04 | 53 |
| GO:00903986 | Thyroid | PTC | cellular senescence | 47/5968 | 93/18723 | 1.37e-04 | 1.07e-03 | 47 |
| GO:0030330112 | Thyroid | PTC | DNA damage response, signal transduction by p53 class mediator | 38/5968 | 72/18723 | 1.85e-04 | 1.40e-03 | 38 |
| GO:004351617 | Thyroid | PTC | regulation of DNA damage response, signal transduction by p53 class mediator | 19/5968 | 34/18723 | 3.21e-03 | 1.57e-02 | 19 |
| GO:0051346112 | Thyroid | PTC | negative regulation of hydrolase activity | 146/5968 | 379/18723 | 3.33e-03 | 1.62e-02 | 146 |
| GO:00510518 | Thyroid | PTC | negative regulation of transport | 176/5968 | 470/18723 | 5.44e-03 | 2.49e-02 | 176 |
| GO:190401913 | Thyroid | PTC | epithelial cell apoptotic process | 52/5968 | 121/18723 | 6.56e-03 | 2.86e-02 | 52 |
| GO:000697934 | Thyroid | ATC | response to oxidative stress | 246/6293 | 446/18723 | 2.98e-21 | 6.09e-19 | 246 |
| GO:006219734 | Thyroid | ATC | cellular response to chemical stress | 188/6293 | 337/18723 | 3.16e-17 | 3.07e-15 | 188 |
| GO:007233135 | Thyroid | ATC | signal transduction by p53 class mediator | 102/6293 | 163/18723 | 3.16e-14 | 1.75e-12 | 102 |
| GO:003459934 | Thyroid | ATC | cellular response to oxidative stress | 158/6293 | 288/18723 | 7.35e-14 | 3.94e-12 | 158 |
| Page: 1 2 3 4 |
| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
| hsa0414530 | Esophagus | ESCC | Phagosome | 100/4205 | 152/8465 | 3.81e-05 | 1.72e-04 | 8.82e-05 | 100 |
| hsa051527 | Esophagus | ESCC | Tuberculosis | 111/4205 | 180/8465 | 7.14e-04 | 2.32e-03 | 1.19e-03 | 111 |
| hsa04145114 | Esophagus | ESCC | Phagosome | 100/4205 | 152/8465 | 3.81e-05 | 1.72e-04 | 8.82e-05 | 100 |
| hsa0515212 | Esophagus | ESCC | Tuberculosis | 111/4205 | 180/8465 | 7.14e-04 | 2.32e-03 | 1.19e-03 | 111 |
| Page: 1 |
Top |
Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
| Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| PLA2R1 | SNV | Missense_Mutation | c.2424N>A | p.Phe808Leu | p.F808L | Q13018 | protein_coding | tolerated(0.81) | benign(0.003) | TCGA-A2-A25A-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unspecific | Cytoxan | SD | |
| PLA2R1 | SNV | Missense_Mutation | novel | c.3556N>C | p.Asp1186His | p.D1186H | Q13018 | protein_coding | deleterious(0.03) | possibly_damaging(0.866) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
| PLA2R1 | SNV | Missense_Mutation | novel | c.3794N>A | p.Ser1265Tyr | p.S1265Y | Q13018 | protein_coding | deleterious(0) | probably_damaging(0.972) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
| PLA2R1 | SNV | Missense_Mutation | rs757654265 | c.1487N>T | p.Arg496Ile | p.R496I | Q13018 | protein_coding | tolerated(0.07) | benign(0.049) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
| PLA2R1 | SNV | Missense_Mutation | rs762241008 | c.1826N>C | p.His609Pro | p.H609P | Q13018 | protein_coding | deleterious(0) | possibly_damaging(0.765) | TCGA-BH-A0BS-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | adriamycin | CR |
| PLA2R1 | SNV | Missense_Mutation | c.938N>G | p.Tyr313Cys | p.Y313C | Q13018 | protein_coding | deleterious(0.01) | possibly_damaging(0.907) | TCGA-BH-A0HX-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adrimycin | SD | |
| PLA2R1 | SNV | Missense_Mutation | c.2059N>G | p.Leu687Val | p.L687V | Q13018 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-BH-A18V-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
| PLA2R1 | SNV | Missense_Mutation | novel | c.3919N>C | p.Gly1307Arg | p.G1307R | Q13018 | protein_coding | tolerated(0.19) | benign(0.027) | TCGA-BH-A2L8-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cytoxan | CR |
| PLA2R1 | SNV | Missense_Mutation | rs756774429 | c.1942N>A | p.Glu648Lys | p.E648K | Q13018 | protein_coding | tolerated(0.78) | benign(0) | TCGA-BH-A2L8-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cytoxan | CR |
| PLA2R1 | SNV | Missense_Mutation | c.2728C>G | p.Gln910Glu | p.Q910E | Q13018 | protein_coding | tolerated(0.35) | benign(0.007) | TCGA-EW-A1PB-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
| Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 |
Top |
Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
| Page: 1 |
Copyright 2023-Present -The University of Texas Health Science Center at Houston |