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Gene: PAIP1 |
Gene summary for PAIP1 |
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Gene information | Species | Human | Gene symbol | PAIP1 | Gene ID | 10605 |
Gene name | poly(A) binding protein interacting protein 1 | |
Gene Alias | PAIP1 | |
Cytomap | 5p12 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | Q9H074 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
10605 | PAIP1 | LZE2T | Human | Esophagus | ESCC | 4.68e-05 | 8.89e-01 | 0.082 |
10605 | PAIP1 | LZE4T | Human | Esophagus | ESCC | 1.85e-21 | 4.99e-01 | 0.0811 |
10605 | PAIP1 | LZE5T | Human | Esophagus | ESCC | 2.19e-11 | 9.70e-01 | 0.0514 |
10605 | PAIP1 | LZE7T | Human | Esophagus | ESCC | 3.33e-05 | 3.61e-01 | 0.0667 |
10605 | PAIP1 | LZE8T | Human | Esophagus | ESCC | 7.55e-09 | 1.71e-01 | 0.067 |
10605 | PAIP1 | LZE20T | Human | Esophagus | ESCC | 5.24e-17 | 6.62e-01 | 0.0662 |
10605 | PAIP1 | LZE22T | Human | Esophagus | ESCC | 1.70e-12 | 1.09e+00 | 0.068 |
10605 | PAIP1 | LZE24T | Human | Esophagus | ESCC | 2.33e-37 | 9.68e-01 | 0.0596 |
10605 | PAIP1 | LZE21T | Human | Esophagus | ESCC | 2.43e-02 | 2.63e-01 | 0.0655 |
10605 | PAIP1 | LZE6T | Human | Esophagus | ESCC | 1.28e-13 | 8.18e-01 | 0.0845 |
10605 | PAIP1 | P1T-E | Human | Esophagus | ESCC | 2.25e-11 | 8.21e-01 | 0.0875 |
10605 | PAIP1 | P2T-E | Human | Esophagus | ESCC | 8.90e-71 | 1.28e+00 | 0.1177 |
10605 | PAIP1 | P4T-E | Human | Esophagus | ESCC | 2.18e-74 | 1.68e+00 | 0.1323 |
10605 | PAIP1 | P5T-E | Human | Esophagus | ESCC | 1.76e-36 | 8.67e-01 | 0.1327 |
10605 | PAIP1 | P8T-E | Human | Esophagus | ESCC | 3.97e-55 | 1.08e+00 | 0.0889 |
10605 | PAIP1 | P9T-E | Human | Esophagus | ESCC | 5.29e-45 | 1.04e+00 | 0.1131 |
10605 | PAIP1 | P10T-E | Human | Esophagus | ESCC | 7.19e-84 | 1.61e+00 | 0.116 |
10605 | PAIP1 | P11T-E | Human | Esophagus | ESCC | 4.41e-18 | 9.05e-01 | 0.1426 |
10605 | PAIP1 | P12T-E | Human | Esophagus | ESCC | 4.71e-53 | 1.21e+00 | 0.1122 |
10605 | PAIP1 | P15T-E | Human | Esophagus | ESCC | 1.95e-42 | 8.99e-01 | 0.1149 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:004348911 | Liver | Cirrhotic | RNA stabilization | 25/4634 | 65/18723 | 9.85e-03 | 4.43e-02 | 25 |
GO:004427021 | Liver | HCC | cellular nitrogen compound catabolic process | 303/7958 | 451/18723 | 9.76e-27 | 3.64e-24 | 303 |
GO:004670021 | Liver | HCC | heterocycle catabolic process | 299/7958 | 445/18723 | 2.07e-26 | 7.29e-24 | 299 |
GO:190136121 | Liver | HCC | organic cyclic compound catabolic process | 325/7958 | 495/18723 | 6.52e-26 | 2.18e-23 | 325 |
GO:001943921 | Liver | HCC | aromatic compound catabolic process | 309/7958 | 467/18723 | 1.56e-25 | 4.94e-23 | 309 |
GO:000640121 | Liver | HCC | RNA catabolic process | 201/7958 | 278/18723 | 3.88e-24 | 1.02e-21 | 201 |
GO:003465521 | Liver | HCC | nucleobase-containing compound catabolic process | 273/7958 | 407/18723 | 4.84e-24 | 1.23e-21 | 273 |
GO:190331121 | Liver | HCC | regulation of mRNA metabolic process | 205/7958 | 288/18723 | 3.38e-23 | 6.90e-21 | 205 |
GO:000640221 | Liver | HCC | mRNA catabolic process | 169/7958 | 232/18723 | 4.50e-21 | 6.96e-19 | 169 |
GO:000641722 | Liver | HCC | regulation of translation | 287/7958 | 468/18723 | 8.79e-17 | 8.08e-15 | 287 |
GO:000641322 | Liver | HCC | translational initiation | 94/7958 | 118/18723 | 1.39e-16 | 1.24e-14 | 94 |
GO:004348721 | Liver | HCC | regulation of RNA stability | 119/7958 | 170/18723 | 3.20e-13 | 1.71e-11 | 119 |
GO:004348821 | Liver | HCC | regulation of mRNA stability | 110/7958 | 158/18723 | 4.36e-12 | 1.93e-10 | 110 |
GO:006101321 | Liver | HCC | regulation of mRNA catabolic process | 114/7958 | 166/18723 | 7.38e-12 | 3.12e-10 | 114 |
GO:000989522 | Liver | HCC | negative regulation of catabolic process | 196/7958 | 320/18723 | 7.98e-12 | 3.35e-10 | 196 |
GO:004572712 | Liver | HCC | positive regulation of translation | 97/7958 | 136/18723 | 8.51e-12 | 3.55e-10 | 97 |
GO:003133022 | Liver | HCC | negative regulation of cellular catabolic process | 164/7958 | 262/18723 | 3.52e-11 | 1.35e-09 | 164 |
GO:003425022 | Liver | HCC | positive regulation of cellular amide metabolic process | 110/7958 | 162/18723 | 5.14e-11 | 1.92e-09 | 110 |
GO:000644622 | Liver | HCC | regulation of translational initiation | 62/7958 | 79/18723 | 6.85e-11 | 2.48e-09 | 62 |
GO:190331222 | Liver | HCC | negative regulation of mRNA metabolic process | 63/7958 | 92/18723 | 4.14e-07 | 6.97e-06 | 63 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
PAIP1 | SNV | Missense_Mutation | novel | c.326N>T | p.Ser109Leu | p.S109L | Q9H074 | protein_coding | tolerated(0.37) | benign(0.062) | TCGA-OL-A6VQ-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
PAIP1 | SNV | Missense_Mutation | novel | c.1222N>A | p.Asp408Asn | p.D408N | Q9H074 | protein_coding | deleterious(0) | possibly_damaging(0.637) | TCGA-C5-A8XH-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
PAIP1 | SNV | Missense_Mutation | c.1420N>A | p.Glu474Lys | p.E474K | Q9H074 | protein_coding | deleterious(0) | possibly_damaging(0.681) | TCGA-EK-A3GK-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
PAIP1 | SNV | Missense_Mutation | c.1005G>T | p.Lys335Asn | p.K335N | Q9H074 | protein_coding | deleterious(0.01) | possibly_damaging(0.895) | TCGA-AZ-6598-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
PAIP1 | SNV | Missense_Mutation | c.1381N>C | p.Glu461Gln | p.E461Q | Q9H074 | protein_coding | deleterious(0) | probably_damaging(0.991) | TCGA-CK-4950-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Chemotherapy | folfox | SD | |
PAIP1 | SNV | Missense_Mutation | c.1263G>T | p.Glu421Asp | p.E421D | Q9H074 | protein_coding | tolerated(0.13) | benign(0.063) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
PAIP1 | SNV | Missense_Mutation | c.658C>T | p.Arg220Cys | p.R220C | Q9H074 | protein_coding | deleterious(0.01) | probably_damaging(1) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
PAIP1 | SNV | Missense_Mutation | novel | c.429T>G | p.Ser143Arg | p.S143R | Q9H074 | protein_coding | tolerated(0.28) | benign(0.005) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
PAIP1 | SNV | Missense_Mutation | c.340N>C | p.Ala114Pro | p.A114P | Q9H074 | protein_coding | deleterious(0.02) | possibly_damaging(0.502) | TCGA-BM-6198-01 | Colorectum | rectum adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | xeloda | SD | |
PAIP1 | SNV | Missense_Mutation | novel | c.1034N>G | p.Ile345Ser | p.I345S | Q9H074 | protein_coding | deleterious(0) | benign(0.162) | TCGA-F5-6814-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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