Tissue | Expression Dynamics | Abbreviation |
Esophagus | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Esophagus/NMB_pca_on_diff_genes.png) | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias |
LGIN: Low-grade intraepithelial neoplasias |
Liver | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Liver/NMB_pca_on_diff_genes.png) | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
Oral Cavity | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/OralCavity/NMB_pca_on_diff_genes.png) | EOLP: Erosive Oral lichen planus |
LP: leukoplakia |
NEOLP: Non-erosive oral lichen planus |
OSCC: Oral squamous cell carcinoma |
Skin | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Skin/NMB_pca_on_diff_genes.png) | AK: Actinic keratosis |
cSCC: Cutaneous squamous cell carcinoma |
SCCIS:squamous cell carcinoma in situ |
Thyroid | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Thyroid/NMB_pca_on_diff_genes.png) | ATC: Anaplastic thyroid cancer |
HT: Hashimoto's thyroiditis |
PTC: Papillary thyroid cancer |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:005067011 | Breast | DCIS | regulation of lymphocyte proliferation | 30/1390 | 225/18723 | 1.29e-03 | 1.35e-02 | 30 |
GO:000734612 | Breast | DCIS | regulation of mitotic cell cycle | 52/1390 | 457/18723 | 1.38e-03 | 1.43e-02 | 52 |
GO:003294411 | Breast | DCIS | regulation of mononuclear cell proliferation | 30/1390 | 227/18723 | 1.48e-03 | 1.50e-02 | 30 |
GO:003264021 | Breast | DCIS | tumor necrosis factor production | 25/1390 | 181/18723 | 1.93e-03 | 1.82e-02 | 25 |
GO:003268021 | Breast | DCIS | regulation of tumor necrosis factor production | 25/1390 | 181/18723 | 1.93e-03 | 1.82e-02 | 25 |
GO:007170621 | Breast | DCIS | tumor necrosis factor superfamily cytokine production | 25/1390 | 186/18723 | 2.81e-03 | 2.43e-02 | 25 |
GO:190355521 | Breast | DCIS | regulation of tumor necrosis factor superfamily cytokine production | 25/1390 | 186/18723 | 2.81e-03 | 2.43e-02 | 25 |
GO:000716212 | Breast | DCIS | negative regulation of cell adhesion | 36/1390 | 303/18723 | 3.49e-03 | 2.90e-02 | 36 |
GO:00706616 | Breast | DCIS | leukocyte proliferation | 37/1390 | 318/18723 | 4.39e-03 | 3.41e-02 | 37 |
GO:00466515 | Breast | DCIS | lymphocyte proliferation | 34/1390 | 288/18723 | 4.91e-03 | 3.70e-02 | 34 |
GO:000150321 | Breast | DCIS | ossification | 45/1390 | 408/18723 | 4.98e-03 | 3.72e-02 | 45 |
GO:00329434 | Breast | DCIS | mononuclear cell proliferation | 34/1390 | 291/18723 | 5.75e-03 | 4.14e-02 | 34 |
GO:00447724 | Breast | DCIS | mitotic cell cycle phase transition | 46/1390 | 424/18723 | 6.16e-03 | 4.39e-02 | 46 |
GO:002240710 | Cervix | CC | regulation of cell-cell adhesion | 103/2311 | 448/18723 | 1.78e-10 | 2.87e-08 | 103 |
GO:00421108 | Cervix | CC | T cell activation | 107/2311 | 487/18723 | 1.24e-09 | 1.46e-07 | 107 |
GO:00508638 | Cervix | CC | regulation of T cell activation | 80/2311 | 329/18723 | 1.28e-09 | 1.47e-07 | 80 |
GO:00071598 | Cervix | CC | leukocyte cell-cell adhesion | 85/2311 | 371/18723 | 8.27e-09 | 7.07e-07 | 85 |
GO:00071626 | Cervix | CC | negative regulation of cell adhesion | 72/2311 | 303/18723 | 2.36e-08 | 1.70e-06 | 72 |
GO:00026837 | Cervix | CC | negative regulation of immune system process | 94/2311 | 434/18723 | 2.63e-08 | 1.87e-06 | 94 |
GO:19030378 | Cervix | CC | regulation of leukocyte cell-cell adhesion | 77/2311 | 336/18723 | 4.08e-08 | 2.54e-06 | 77 |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
NMB | insertion | Frame_Shift_Ins | novel | c.230_231insAGCATATAGTGTGTGCATTTTGAAGGGA | p.Arg78AlafsTer19 | p.R78Afs*19 | P08949 | protein_coding | | | TCGA-A2-A0CP-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cytoxan | SD |
NMB | SNV | Missense_Mutation | | c.365C>A | p.Pro122Gln | p.P122Q | P08949 | protein_coding | tolerated_low_confidence(0.25) | benign(0.005) | TCGA-G4-6309-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Chemotherapy | xeloda | PD |
NMB | SNV | Missense_Mutation | novel | c.384N>C | p.Gln128His | p.Q128H | P08949 | protein_coding | tolerated_low_confidence(0.21) | benign(0.138) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
NMB | SNV | Missense_Mutation | novel | c.418G>T | p.Val140Leu | p.V140L | P08949 | protein_coding | tolerated_low_confidence(0.59) | benign(0.001) | TCGA-AJ-A3BG-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Chemotherapy | carboplatin | PD |
NMB | SNV | Missense_Mutation | | c.341N>A | p.Gly114Asp | p.G114D | P08949 | protein_coding | tolerated_low_confidence(0.12) | benign(0.058) | TCGA-BS-A0U7-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
NMB | SNV | Missense_Mutation | | c.406N>A | p.His136Asn | p.H136N | P08949 | protein_coding | tolerated_low_confidence(0.05) | benign(0.015) | TCGA-D1-A0ZS-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
NMB | SNV | Missense_Mutation | | c.388C>T | p.Arg130Cys | p.R130C | P08949 | protein_coding | tolerated_low_confidence(0.05) | benign(0.003) | TCGA-D1-A103-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
NMB | SNV | Missense_Mutation | novel | c.455G>A | p.Cys152Tyr | p.C152Y | P08949 | protein_coding | deleterious_low_confidence(0.02) | benign(0.01) | TCGA-22-1002-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
NMB | SNV | Missense_Mutation | novel | c.83G>A | p.Ser28Asn | p.S28N | P08949 | protein_coding | tolerated(0.13) | benign(0.006) | TCGA-CN-5373-01 | Oral cavity | head & neck squamous cell carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
NMB | SNV | Missense_Mutation | novel | c.289G>C | p.Ala97Pro | p.A97P | P08949 | protein_coding | deleterious(0.02) | possibly_damaging(0.735) | TCGA-CR-7364-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD |