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Gene: NET1 |
Gene summary for NET1 |
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Gene information | Species | Human | Gene symbol | NET1 | Gene ID | 10276 |
Gene name | neuroepithelial cell transforming 1 | |
Gene Alias | ARHGEF8 | |
Cytomap | 10p15.1 | |
Gene Type | protein-coding | GO ID | GO:0000302 | UniProtAcc | Q5SQI5 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
10276 | NET1 | HTA11_78_2000001011 | Human | Colorectum | AD | 2.98e-02 | 4.19e-01 | -0.1088 |
10276 | NET1 | HTA11_347_2000001011 | Human | Colorectum | AD | 5.80e-06 | 4.27e-01 | -0.1954 |
10276 | NET1 | HTA11_99999965104_69814 | Human | Colorectum | MSS | 9.84e-03 | 4.40e-01 | 0.281 |
10276 | NET1 | A015-C-203 | Human | Colorectum | FAP | 7.33e-11 | -8.05e-02 | -0.1294 |
10276 | NET1 | A001-C-108 | Human | Colorectum | FAP | 2.89e-05 | -1.21e-01 | -0.0272 |
10276 | NET1 | A002-C-205 | Human | Colorectum | FAP | 1.05e-06 | -1.67e-01 | -0.1236 |
10276 | NET1 | A015-C-006 | Human | Colorectum | FAP | 2.78e-05 | -2.22e-01 | -0.0994 |
10276 | NET1 | A015-C-106 | Human | Colorectum | FAP | 7.08e-06 | -1.05e-01 | -0.0511 |
10276 | NET1 | A002-C-114 | Human | Colorectum | FAP | 4.73e-06 | -2.71e-01 | -0.1561 |
10276 | NET1 | A015-C-104 | Human | Colorectum | FAP | 8.20e-14 | -1.98e-01 | -0.1899 |
10276 | NET1 | A001-C-014 | Human | Colorectum | FAP | 9.93e-05 | -1.02e-01 | 0.0135 |
10276 | NET1 | A002-C-016 | Human | Colorectum | FAP | 6.89e-06 | -1.49e-01 | 0.0521 |
10276 | NET1 | A015-C-002 | Human | Colorectum | FAP | 2.44e-02 | -2.21e-01 | -0.0763 |
10276 | NET1 | A001-C-203 | Human | Colorectum | FAP | 1.77e-05 | -8.66e-02 | -0.0481 |
10276 | NET1 | A002-C-116 | Human | Colorectum | FAP | 5.91e-14 | -1.57e-01 | -0.0452 |
10276 | NET1 | A014-C-008 | Human | Colorectum | FAP | 5.39e-04 | -2.59e-01 | -0.191 |
10276 | NET1 | A018-E-020 | Human | Colorectum | FAP | 2.87e-05 | -1.45e-02 | -0.2034 |
10276 | NET1 | F034 | Human | Colorectum | FAP | 4.34e-11 | -2.64e-01 | -0.0665 |
10276 | NET1 | CRC-3-11773 | Human | Colorectum | CRC | 5.18e-05 | -1.83e-01 | 0.2564 |
10276 | NET1 | LZE4T | Human | Esophagus | ESCC | 4.83e-05 | 6.08e-01 | 0.0811 |
Page: 1 2 3 4 5 6 7 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00346144 | Colorectum | FAP | cellular response to reactive oxygen species | 34/2622 | 155/18723 | 4.68e-03 | 3.16e-02 | 34 |
GO:0071214 | Colorectum | FAP | cellular response to abiotic stimulus | 63/2622 | 331/18723 | 6.38e-03 | 3.99e-02 | 63 |
GO:0104004 | Colorectum | FAP | cellular response to environmental stimulus | 63/2622 | 331/18723 | 6.38e-03 | 3.99e-02 | 63 |
GO:00510563 | Colorectum | CRC | regulation of small GTPase mediated signal transduction | 69/2078 | 302/18723 | 3.34e-09 | 9.08e-07 | 69 |
GO:00160494 | Colorectum | CRC | cell growth | 95/2078 | 482/18723 | 1.51e-08 | 2.75e-06 | 95 |
GO:00072653 | Colorectum | CRC | Ras protein signal transduction | 70/2078 | 337/18723 | 1.49e-07 | 1.66e-05 | 70 |
GO:00430874 | Colorectum | CRC | regulation of GTPase activity | 69/2078 | 348/18723 | 1.11e-06 | 6.69e-05 | 69 |
GO:00015584 | Colorectum | CRC | regulation of cell growth | 78/2078 | 414/18723 | 1.84e-06 | 9.11e-05 | 78 |
GO:00465782 | Colorectum | CRC | regulation of Ras protein signal transduction | 43/2078 | 189/18723 | 3.26e-06 | 1.47e-04 | 43 |
GO:00621975 | Colorectum | CRC | cellular response to chemical stress | 63/2078 | 337/18723 | 2.24e-05 | 6.49e-04 | 63 |
GO:00435473 | Colorectum | CRC | positive regulation of GTPase activity | 49/2078 | 255/18723 | 8.67e-05 | 1.77e-03 | 49 |
GO:00345995 | Colorectum | CRC | cellular response to oxidative stress | 53/2078 | 288/18723 | 1.47e-04 | 2.68e-03 | 53 |
GO:00069795 | Colorectum | CRC | response to oxidative stress | 73/2078 | 446/18723 | 4.31e-04 | 6.34e-03 | 73 |
GO:00425425 | Colorectum | CRC | response to hydrogen peroxide | 30/2078 | 146/18723 | 6.12e-04 | 8.15e-03 | 30 |
GO:00003025 | Colorectum | CRC | response to reactive oxygen species | 41/2078 | 222/18723 | 7.28e-04 | 9.35e-03 | 41 |
GO:00072662 | Colorectum | CRC | Rho protein signal transduction | 28/2078 | 137/18723 | 9.97e-04 | 1.19e-02 | 28 |
GO:00350231 | Colorectum | CRC | regulation of Rho protein signal transduction | 19/2078 | 86/18723 | 2.44e-03 | 2.31e-02 | 19 |
GO:0006979111 | Esophagus | ESCC | response to oxidative stress | 303/8552 | 446/18723 | 7.15e-22 | 1.30e-19 | 303 |
GO:0062197111 | Esophagus | ESCC | cellular response to chemical stress | 234/8552 | 337/18723 | 5.37e-19 | 5.97e-17 | 234 |
GO:0034599111 | Esophagus | ESCC | cellular response to oxidative stress | 197/8552 | 288/18723 | 3.76e-15 | 2.15e-13 | 197 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
NET1 | SNV | Missense_Mutation | novel | c.500N>T | p.Ser167Phe | p.S167F | Q7Z628 | protein_coding | deleterious(0.03) | benign(0.396) | TCGA-A2-A0CR-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | CR |
NET1 | SNV | Missense_Mutation | c.727N>A | p.Asp243Asn | p.D243N | Q7Z628 | protein_coding | tolerated(0.09) | benign(0.015) | TCGA-A2-A0CX-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | SD | |
NET1 | SNV | Missense_Mutation | rs773238555 | c.1081G>A | p.Glu361Lys | p.E361K | Q7Z628 | protein_coding | tolerated(0.19) | benign(0.075) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
NET1 | SNV | Missense_Mutation | c.199N>G | p.Arg67Gly | p.R67G | Q7Z628 | protein_coding | deleterious(0) | possibly_damaging(0.528) | TCGA-AN-A0XN-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | |
NET1 | SNV | Missense_Mutation | c.296N>T | p.Thr99Met | p.T99M | Q7Z628 | protein_coding | deleterious(0) | possibly_damaging(0.879) | TCGA-BH-A0WA-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
NET1 | SNV | Missense_Mutation | c.272G>C | p.Arg91Thr | p.R91T | Q7Z628 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-LP-A4AX-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
NET1 | SNV | Missense_Mutation | c.449G>C | p.Arg150Thr | p.R150T | Q7Z628 | protein_coding | deleterious(0) | probably_damaging(0.917) | TCGA-MY-A5BD-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
NET1 | SNV | Missense_Mutation | c.868N>A | p.Leu290Ile | p.L290I | Q7Z628 | protein_coding | deleterious(0) | probably_damaging(0.993) | TCGA-A6-2686-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
NET1 | SNV | Missense_Mutation | c.1038N>G | p.Ile346Met | p.I346M | Q7Z628 | protein_coding | deleterious(0.01) | possibly_damaging(0.487) | TCGA-A6-A565-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Unspecific | 5FU | PD | |
NET1 | SNV | Missense_Mutation | c.1019N>G | p.Glu340Gly | p.E340G | Q7Z628 | protein_coding | deleterious(0.04) | benign(0.073) | TCGA-AA-3663-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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