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Gene: MUS81 |
Gene summary for MUS81 |
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Gene information | Species | Human | Gene symbol | MUS81 | Gene ID | 80198 |
Gene name | MUS81 structure-specific endonuclease subunit | |
Gene Alias | SLX3 | |
Cytomap | 11q13.1 | |
Gene Type | protein-coding | GO ID | GO:0000003 | UniProtAcc | Q53ES5 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
80198 | MUS81 | LZE20T | Human | Esophagus | ESCC | 3.82e-06 | 2.38e-01 | 0.0662 |
80198 | MUS81 | LZE24T | Human | Esophagus | ESCC | 1.86e-14 | 4.59e-01 | 0.0596 |
80198 | MUS81 | P1T-E | Human | Esophagus | ESCC | 2.49e-05 | 3.61e-01 | 0.0875 |
80198 | MUS81 | P2T-E | Human | Esophagus | ESCC | 1.42e-17 | 3.20e-01 | 0.1177 |
80198 | MUS81 | P4T-E | Human | Esophagus | ESCC | 6.85e-21 | 5.31e-01 | 0.1323 |
80198 | MUS81 | P5T-E | Human | Esophagus | ESCC | 3.47e-13 | 3.66e-01 | 0.1327 |
80198 | MUS81 | P8T-E | Human | Esophagus | ESCC | 3.96e-15 | 2.61e-01 | 0.0889 |
80198 | MUS81 | P9T-E | Human | Esophagus | ESCC | 2.53e-06 | 1.61e-01 | 0.1131 |
80198 | MUS81 | P10T-E | Human | Esophagus | ESCC | 4.37e-13 | 2.08e-01 | 0.116 |
80198 | MUS81 | P11T-E | Human | Esophagus | ESCC | 2.09e-07 | 4.85e-01 | 0.1426 |
80198 | MUS81 | P12T-E | Human | Esophagus | ESCC | 1.03e-11 | 3.43e-01 | 0.1122 |
80198 | MUS81 | P15T-E | Human | Esophagus | ESCC | 1.11e-14 | 3.85e-01 | 0.1149 |
80198 | MUS81 | P16T-E | Human | Esophagus | ESCC | 6.23e-18 | 4.36e-01 | 0.1153 |
80198 | MUS81 | P17T-E | Human | Esophagus | ESCC | 3.06e-05 | 3.33e-01 | 0.1278 |
80198 | MUS81 | P20T-E | Human | Esophagus | ESCC | 3.86e-09 | 2.26e-01 | 0.1124 |
80198 | MUS81 | P21T-E | Human | Esophagus | ESCC | 8.66e-18 | 2.32e-01 | 0.1617 |
80198 | MUS81 | P22T-E | Human | Esophagus | ESCC | 2.79e-12 | 1.44e-01 | 0.1236 |
80198 | MUS81 | P23T-E | Human | Esophagus | ESCC | 1.92e-20 | 5.17e-01 | 0.108 |
80198 | MUS81 | P24T-E | Human | Esophagus | ESCC | 8.59e-11 | 2.58e-01 | 0.1287 |
80198 | MUS81 | P26T-E | Human | Esophagus | ESCC | 4.14e-11 | 2.04e-01 | 0.1276 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00000751 | Liver | HCC | cell cycle checkpoint | 100/7958 | 169/18723 | 8.75e-06 | 1.02e-04 | 100 |
GO:0048285 | Liver | HCC | organelle fission | 254/7958 | 488/18723 | 1.07e-05 | 1.23e-04 | 254 |
GO:0045786 | Liver | HCC | negative regulation of cell cycle | 204/7958 | 385/18723 | 1.84e-05 | 1.99e-04 | 204 |
GO:0045930 | Liver | HCC | negative regulation of mitotic cell cycle | 130/7958 | 235/18723 | 4.69e-05 | 4.50e-04 | 130 |
GO:0007093 | Liver | HCC | mitotic cell cycle checkpoint | 77/7958 | 129/18723 | 6.00e-05 | 5.50e-04 | 77 |
GO:00000771 | Liver | HCC | DNA damage checkpoint | 68/7958 | 115/18723 | 2.33e-04 | 1.77e-03 | 68 |
GO:0031570 | Liver | HCC | DNA integrity checkpoint | 71/7958 | 123/18723 | 4.64e-04 | 3.08e-03 | 71 |
GO:1901988 | Liver | HCC | negative regulation of cell cycle phase transition | 132/7958 | 249/18723 | 4.97e-04 | 3.25e-03 | 132 |
GO:0000280 | Liver | HCC | nuclear division | 220/7958 | 439/18723 | 6.90e-04 | 4.25e-03 | 220 |
GO:0010948 | Liver | HCC | negative regulation of cell cycle process | 152/7958 | 294/18723 | 8.50e-04 | 5.08e-03 | 152 |
GO:00063021 | Liver | HCC | double-strand break repair | 131/7958 | 251/18723 | 1.17e-03 | 6.54e-03 | 131 |
GO:00712166 | Liver | HCC | cellular response to biotic stimulus | 128/7958 | 246/18723 | 1.53e-03 | 8.10e-03 | 128 |
GO:0044773 | Liver | HCC | mitotic DNA damage checkpoint | 48/7958 | 81/18723 | 1.72e-03 | 8.96e-03 | 48 |
GO:0044774 | Liver | HCC | mitotic DNA integrity checkpoint | 49/7958 | 85/18723 | 3.44e-03 | 1.55e-02 | 49 |
GO:0051304 | Liver | HCC | chromosome separation | 53/7958 | 96/18723 | 8.05e-03 | 3.17e-02 | 53 |
GO:003465517 | Oral cavity | OSCC | nucleobase-containing compound catabolic process | 244/7305 | 407/18723 | 5.38e-18 | 5.49e-16 | 244 |
GO:00073469 | Oral cavity | OSCC | regulation of mitotic cell cycle | 266/7305 | 457/18723 | 3.87e-17 | 3.41e-15 | 266 |
GO:004670015 | Oral cavity | OSCC | heterocycle catabolic process | 254/7305 | 445/18723 | 5.07e-15 | 3.31e-13 | 254 |
GO:00070592 | Oral cavity | OSCC | chromosome segregation | 206/7305 | 346/18723 | 5.82e-15 | 3.76e-13 | 206 |
GO:004427016 | Oral cavity | OSCC | cellular nitrogen compound catabolic process | 256/7305 | 451/18723 | 9.67e-15 | 5.88e-13 | 256 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
MUS81 | SNV | Missense_Mutation | novel | c.1247C>T | p.Thr416Met | p.T416M | Q96NY9 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-AC-A2FO-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | chemo | CR |
MUS81 | SNV | Missense_Mutation | rs753119410 | c.1348N>T | p.Leu450Phe | p.L450F | Q96NY9 | protein_coding | tolerated(0.18) | benign(0.05) | TCGA-AC-A2QI-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Chemotherapy | cytoxan | CR |
MUS81 | SNV | Missense_Mutation | c.1187N>T | p.Gly396Val | p.G396V | Q96NY9 | protein_coding | deleterious(0) | probably_damaging(0.973) | TCGA-E2-A1BC-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | arimidex | SD | |
MUS81 | SNV | Missense_Mutation | rs753119410 | c.1348C>T | p.Leu450Phe | p.L450F | Q96NY9 | protein_coding | tolerated(0.18) | benign(0.05) | TCGA-GM-A3NY-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | arimidex | SD |
MUS81 | SNV | Missense_Mutation | rs754849594 | c.1201N>T | p.Arg401Cys | p.R401C | Q96NY9 | protein_coding | deleterious(0.01) | possibly_damaging(0.891) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
MUS81 | SNV | Missense_Mutation | rs753816989 | c.463C>T | p.His155Tyr | p.H155Y | Q96NY9 | protein_coding | tolerated(1) | benign(0.055) | TCGA-JW-A5VI-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | topotecan | PD |
MUS81 | SNV | Missense_Mutation | c.1417N>A | p.Glu473Lys | p.E473K | Q96NY9 | protein_coding | deleterious(0) | benign(0.407) | TCGA-Q1-A73O-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
MUS81 | SNV | Missense_Mutation | rs768086876 | c.1448N>A | p.Arg483His | p.R483H | Q96NY9 | protein_coding | tolerated(0.28) | benign(0) | TCGA-A6-5665-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
MUS81 | SNV | Missense_Mutation | novel | c.1282N>A | p.Leu428Ile | p.L428I | Q96NY9 | protein_coding | deleterious(0.04) | possibly_damaging(0.712) | TCGA-AA-3877-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
MUS81 | SNV | Missense_Mutation | rs768086876 | c.1448N>A | p.Arg483His | p.R483H | Q96NY9 | protein_coding | tolerated(0.28) | benign(0) | TCGA-AY-6197-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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