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Gene: MGP |
Gene summary for MGP |
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Gene information | Species | Human | Gene symbol | MGP | Gene ID | 4256 |
Gene name | matrix Gla protein | |
Gene Alias | GIG36 | |
Cytomap | 12p12.3 | |
Gene Type | protein-coding | GO ID | GO:0001501 | UniProtAcc | A0A024RAX0 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
4256 | MGP | GSM4909277 | Human | Breast | Precancer | 4.44e-02 | -8.88e-01 | 0.0177 |
4256 | MGP | GSM4909280 | Human | Breast | Precancer | 8.53e-05 | 5.57e-01 | 0.0305 |
4256 | MGP | GSM4909282 | Human | Breast | IDC | 1.01e-40 | -1.09e+00 | -0.0288 |
4256 | MGP | GSM4909285 | Human | Breast | IDC | 4.86e-06 | 1.01e-01 | 0.21 |
4256 | MGP | GSM4909286 | Human | Breast | IDC | 2.45e-10 | -1.26e-01 | 0.1081 |
4256 | MGP | GSM4909288 | Human | Breast | IDC | 8.14e-03 | 3.87e-02 | 0.0988 |
4256 | MGP | GSM4909289 | Human | Breast | IDC | 7.56e-05 | 6.02e-01 | 0.1064 |
4256 | MGP | GSM4909291 | Human | Breast | IDC | 8.94e-34 | -1.31e+00 | 0.1753 |
4256 | MGP | GSM4909292 | Human | Breast | IDC | 3.79e-02 | -7.79e-01 | 0.1236 |
4256 | MGP | GSM4909293 | Human | Breast | IDC | 1.58e-07 | 2.92e-01 | 0.1581 |
4256 | MGP | GSM4909294 | Human | Breast | IDC | 9.02e-19 | -7.20e-01 | 0.2022 |
4256 | MGP | GSM4909295 | Human | Breast | IDC | 5.34e-04 | 4.16e-01 | 0.0898 |
4256 | MGP | GSM4909297 | Human | Breast | IDC | 3.19e-50 | -1.06e+00 | 0.1517 |
4256 | MGP | GSM4909299 | Human | Breast | IDC | 4.37e-132 | 1.09e+00 | 0.035 |
4256 | MGP | GSM4909300 | Human | Breast | IDC | 2.70e-45 | 9.40e-01 | 0.0334 |
4256 | MGP | GSM4909301 | Human | Breast | IDC | 1.33e-43 | -1.11e+00 | 0.1577 |
4256 | MGP | GSM4909304 | Human | Breast | IDC | 1.10e-42 | -1.13e+00 | 0.1636 |
4256 | MGP | GSM4909305 | Human | Breast | IDC | 6.25e-49 | 8.46e-01 | 0.0436 |
4256 | MGP | GSM4909306 | Human | Breast | IDC | 3.85e-29 | 5.79e-01 | 0.1564 |
4256 | MGP | GSM4909308 | Human | Breast | IDC | 4.15e-06 | -2.19e-01 | 0.158 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:000150332 | Thyroid | ATC | ossification | 206/6293 | 408/18723 | 9.23e-13 | 3.95e-11 | 206 |
GO:003027813 | Thyroid | ATC | regulation of ossification | 60/6293 | 115/18723 | 3.01e-05 | 2.51e-04 | 60 |
GO:00487053 | Thyroid | ATC | skeletal system morphogenesis | 101/6293 | 220/18723 | 9.48e-05 | 6.93e-04 | 101 |
GO:00614484 | Thyroid | ATC | connective tissue development | 112/6293 | 252/18723 | 2.08e-04 | 1.38e-03 | 112 |
GO:00512163 | Thyroid | ATC | cartilage development | 81/6293 | 190/18723 | 5.70e-03 | 2.30e-02 | 81 |
GO:01101492 | Thyroid | ATC | regulation of biomineralization | 45/6293 | 99/18723 | 9.34e-03 | 3.44e-02 | 45 |
GO:00701672 | Thyroid | ATC | regulation of biomineral tissue development | 44/6293 | 97/18723 | 1.05e-02 | 3.81e-02 | 44 |
GO:0030500 | Thyroid | ATC | regulation of bone mineralization | 36/6293 | 78/18723 | 1.43e-02 | 4.92e-02 | 36 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
MGP | SNV | Missense_Mutation | rs112598629 | c.43N>T | p.Val15Leu | p.V15L | P08493 | protein_coding | tolerated(0.11) | benign(0.041) | TCGA-AN-A03X-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
MGP | SNV | Missense_Mutation | rs112598629 | c.43N>T | p.Val15Leu | p.V15L | P08493 | protein_coding | tolerated(0.11) | benign(0.041) | TCGA-AO-A0JE-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | doxorubicin | SD |
MGP | SNV | Missense_Mutation | rs112598629 | c.43G>T | p.Val15Leu | p.V15L | P08493 | protein_coding | tolerated(0.11) | benign(0.041) | TCGA-BH-A0BW-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | adriamycin | CR |
MGP | insertion | Frame_Shift_Ins | novel | c.334_335insCACC | p.Gly112AlafsTer8 | p.G112Afs*8 | P08493 | protein_coding | TCGA-A8-A07R-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Ancillary | zoledronic | SD | ||
MGP | insertion | Frame_Shift_Ins | novel | c.333_334insATTCTCTTGTCTGGCT | p.Gly112IlefsTer12 | p.G112Ifs*12 | P08493 | protein_coding | TCGA-A8-A07R-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Ancillary | zoledronic | SD | ||
MGP | SNV | Missense_Mutation | novel | c.113C>T | p.Ser38Phe | p.S38F | P08493 | protein_coding | tolerated_low_confidence(0.1) | benign(0.364) | TCGA-FU-A3YQ-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
MGP | SNV | Missense_Mutation | c.256C>T | p.Arg86Cys | p.R86C | P08493 | protein_coding | deleterious(0) | probably_damaging(0.931) | TCGA-AA-A02R-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
MGP | SNV | Missense_Mutation | rs550754490 | c.274N>A | p.Glu92Lys | p.E92K | P08493 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-AZ-4315-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
MGP | SNV | Missense_Mutation | rs753350275 | c.316C>T | p.Arg106Cys | p.R106C | P08493 | protein_coding | tolerated(0.17) | probably_damaging(0.983) | TCGA-CM-4744-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
MGP | SNV | Missense_Mutation | rs753350275 | c.316N>T | p.Arg106Cys | p.R106C | P08493 | protein_coding | tolerated(0.17) | probably_damaging(0.983) | TCGA-CM-5860-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Ancillary | leucovorin | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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