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Gene: MEPCE |
Gene summary for MEPCE |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | MEPCE | Gene ID | 56257 |
| Gene name | methylphosphate capping enzyme | |
| Gene Alias | BCDIN3 | |
| Cytomap | 7q22.1 | |
| Gene Type | protein-coding | GO ID | GO:0000082 | UniProtAcc | Q7L2J0 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 56257 | MEPCE | LZE4T | Human | Esophagus | ESCC | 7.05e-03 | -2.72e-02 | 0.0811 |
| 56257 | MEPCE | LZE7T | Human | Esophagus | ESCC | 7.17e-04 | 1.53e-01 | 0.0667 |
| 56257 | MEPCE | LZE20T | Human | Esophagus | ESCC | 5.33e-09 | 1.23e-01 | 0.0662 |
| 56257 | MEPCE | LZE24T | Human | Esophagus | ESCC | 7.77e-10 | 3.14e-01 | 0.0596 |
| 56257 | MEPCE | P1T-E | Human | Esophagus | ESCC | 4.12e-12 | 6.41e-01 | 0.0875 |
| 56257 | MEPCE | P2T-E | Human | Esophagus | ESCC | 2.21e-31 | 4.89e-01 | 0.1177 |
| 56257 | MEPCE | P4T-E | Human | Esophagus | ESCC | 5.17e-12 | 5.50e-02 | 0.1323 |
| 56257 | MEPCE | P5T-E | Human | Esophagus | ESCC | 4.89e-10 | -4.11e-02 | 0.1327 |
| 56257 | MEPCE | P8T-E | Human | Esophagus | ESCC | 1.14e-15 | 7.37e-02 | 0.0889 |
| 56257 | MEPCE | P9T-E | Human | Esophagus | ESCC | 3.06e-14 | 1.72e-01 | 0.1131 |
| 56257 | MEPCE | P10T-E | Human | Esophagus | ESCC | 6.18e-16 | 1.94e-01 | 0.116 |
| 56257 | MEPCE | P11T-E | Human | Esophagus | ESCC | 1.25e-05 | 3.18e-01 | 0.1426 |
| 56257 | MEPCE | P12T-E | Human | Esophagus | ESCC | 1.55e-16 | 2.02e-01 | 0.1122 |
| 56257 | MEPCE | P15T-E | Human | Esophagus | ESCC | 2.27e-16 | 2.08e-01 | 0.1149 |
| 56257 | MEPCE | P16T-E | Human | Esophagus | ESCC | 2.97e-14 | 1.64e-01 | 0.1153 |
| 56257 | MEPCE | P17T-E | Human | Esophagus | ESCC | 1.20e-06 | 3.21e-01 | 0.1278 |
| 56257 | MEPCE | P20T-E | Human | Esophagus | ESCC | 2.60e-12 | 1.82e-01 | 0.1124 |
| 56257 | MEPCE | P21T-E | Human | Esophagus | ESCC | 2.22e-17 | 7.79e-02 | 0.1617 |
| 56257 | MEPCE | P22T-E | Human | Esophagus | ESCC | 5.63e-12 | -3.29e-02 | 0.1236 |
| 56257 | MEPCE | P23T-E | Human | Esophagus | ESCC | 4.02e-13 | 4.01e-01 | 0.108 |
| Page: 1 2 3 4 5 |
| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Esophagus |  | ESCC: Esophageal squamous cell carcinoma |
| HGIN: High-grade intraepithelial neoplasias | ||
| LGIN: Low-grade intraepithelial neoplasias | ||
| Liver |  | HCC: Hepatocellular carcinoma |
| NAFLD: Non-alcoholic fatty liver disease | ||
| Oral Cavity |  | EOLP: Erosive Oral lichen planus |
| LP: leukoplakia | ||
| NEOLP: Non-erosive oral lichen planus | ||
| OSCC: Oral squamous cell carcinoma |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| GO:19034052 | Liver | Cirrhotic | protein localization to nuclear body | 11/4634 | 12/18723 | 1.96e-06 | 3.65e-05 | 11 |
| GO:19048672 | Liver | Cirrhotic | protein localization to Cajal body | 11/4634 | 12/18723 | 1.96e-06 | 3.65e-05 | 11 |
| GO:19901733 | Liver | Cirrhotic | protein localization to nucleoplasm | 12/4634 | 14/18723 | 2.84e-06 | 5.08e-05 | 12 |
| GO:00073463 | Liver | Cirrhotic | regulation of mitotic cell cycle | 154/4634 | 457/18723 | 8.73e-06 | 1.29e-04 | 154 |
| GO:00511006 | Liver | Cirrhotic | negative regulation of binding | 63/4634 | 162/18723 | 4.54e-05 | 5.31e-04 | 63 |
| GO:00459313 | Liver | Cirrhotic | positive regulation of mitotic cell cycle | 49/4634 | 121/18723 | 9.47e-05 | 1.01e-03 | 49 |
| GO:00447721 | Liver | Cirrhotic | mitotic cell cycle phase transition | 139/4634 | 424/18723 | 1.02e-04 | 1.06e-03 | 139 |
| GO:1901990 | Liver | Cirrhotic | regulation of mitotic cell cycle phase transition | 100/4634 | 299/18723 | 4.13e-04 | 3.41e-03 | 100 |
| GO:2000045 | Liver | Cirrhotic | regulation of G1/S transition of mitotic cell cycle | 51/4634 | 142/18723 | 1.91e-03 | 1.20e-02 | 51 |
| GO:00000821 | Liver | Cirrhotic | G1/S transition of mitotic cell cycle | 72/4634 | 214/18723 | 2.07e-03 | 1.28e-02 | 72 |
| GO:00448431 | Liver | Cirrhotic | cell cycle G1/S phase transition | 77/4634 | 241/18723 | 6.68e-03 | 3.30e-02 | 77 |
| GO:00457874 | Liver | Cirrhotic | positive regulation of cell cycle | 97/4634 | 313/18723 | 6.88e-03 | 3.38e-02 | 97 |
| GO:1901992 | Liver | Cirrhotic | positive regulation of mitotic cell cycle phase transition | 34/4634 | 93/18723 | 7.36e-03 | 3.52e-02 | 34 |
| GO:00346601 | Liver | HCC | ncRNA metabolic process | 332/7958 | 485/18723 | 1.48e-31 | 7.80e-29 | 332 |
| GO:190382922 | Liver | HCC | positive regulation of cellular protein localization | 199/7958 | 276/18723 | 1.15e-23 | 2.62e-21 | 199 |
| GO:003450421 | Liver | HCC | protein localization to nucleus | 194/7958 | 290/18723 | 2.84e-17 | 2.85e-15 | 194 |
| GO:005109822 | Liver | HCC | regulation of binding | 225/7958 | 363/18723 | 3.78e-14 | 2.37e-12 | 225 |
| GO:190018212 | Liver | HCC | positive regulation of protein localization to nucleus | 67/7958 | 87/18723 | 5.43e-11 | 2.00e-09 | 67 |
| GO:190018012 | Liver | HCC | regulation of protein localization to nucleus | 95/7958 | 136/18723 | 9.26e-11 | 3.26e-09 | 95 |
| GO:00447722 | Liver | HCC | mitotic cell cycle phase transition | 240/7958 | 424/18723 | 2.47e-09 | 6.84e-08 | 240 |
| Page: 1 2 3 4 5 6 7 |
| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
| Page: 1 |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
| Page: 1 |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| MEPCE | SNV | Missense_Mutation | rs754062405 | c.536N>G | p.Ser179Cys | p.S179C | Q7L2J0 | protein_coding | tolerated(0.11) | benign(0.417) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
| MEPCE | SNV | Missense_Mutation | c.1313N>C | p.Lys438Thr | p.K438T | Q7L2J0 | protein_coding | deleterious(0.03) | benign(0.11) | TCGA-AO-A128-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | SD | |
| MEPCE | SNV | Missense_Mutation | c.1933N>C | p.Glu645Gln | p.E645Q | Q7L2J0 | protein_coding | tolerated(0.1) | possibly_damaging(0.659) | TCGA-D8-A1JN-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Hormone Therapy | anastrozolum | SD | |
| MEPCE | SNV | Missense_Mutation | novel | c.1087N>T | p.Arg363Cys | p.R363C | Q7L2J0 | protein_coding | deleterious(0) | probably_damaging(0.985) | TCGA-GM-A3XL-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | fluorouracil | CR |
| MEPCE | SNV | Missense_Mutation | novel | c.1525G>A | p.Glu509Lys | p.E509K | Q7L2J0 | protein_coding | tolerated(0.09) | benign(0.003) | TCGA-PE-A5DE-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | taxotere | CR |
| MEPCE | insertion | Frame_Shift_Ins | novel | c.1909_1910insGTTTCGGGGCCGGG | p.Tyr637CysfsTer11 | p.Y637Cfs*11 | Q7L2J0 | protein_coding | TCGA-B6-A0IA-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
| MEPCE | insertion | Frame_Shift_Ins | novel | c.1911_1912insGTCC | p.Tyr638ValfsTer26 | p.Y638Vfs*26 | Q7L2J0 | protein_coding | TCGA-B6-A0IA-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
| MEPCE | deletion | Frame_Shift_Del | novel | c.2037delN | p.Leu680CysfsTer19 | p.L680Cfs*19 | Q7L2J0 | protein_coding | TCGA-D8-A27V-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD | ||
| MEPCE | SNV | Missense_Mutation | novel | c.1088G>A | p.Arg363His | p.R363H | Q7L2J0 | protein_coding | deleterious(0.05) | probably_damaging(0.98) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
| MEPCE | SNV | Missense_Mutation | novel | c.1058C>G | p.Ser353Cys | p.S353C | Q7L2J0 | protein_coding | deleterious(0.01) | benign(0.156) | TCGA-DG-A2KK-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Chemotherapy | cisplatin | SD |
| Page: 1 2 3 4 5 6 7 |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
| Page: 1 |
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