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Gene: MELK |
Gene summary for MELK |
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Gene information | Species | Human | Gene symbol | MELK | Gene ID | 9833 |
Gene name | maternal embryonic leucine zipper kinase | |
Gene Alias | HPK38 | |
Cytomap | 9p13.2 | |
Gene Type | protein-coding | GO ID | GO:0000086 | UniProtAcc | Q14680 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
9833 | MELK | GSM6177623_NYU_UCEC3_Vis | Human | Endometrium | EEC | 1.27e-03 | 1.98e-01 | -0.1269 |
9833 | MELK | LZE21T | Human | Esophagus | ESCC | 6.52e-03 | 2.29e-01 | 0.0655 |
9833 | MELK | P2T-E | Human | Esophagus | ESCC | 4.44e-08 | 2.94e-01 | 0.1177 |
9833 | MELK | P4T-E | Human | Esophagus | ESCC | 3.78e-04 | 1.55e-01 | 0.1323 |
9833 | MELK | P5T-E | Human | Esophagus | ESCC | 4.12e-11 | 1.99e-01 | 0.1327 |
9833 | MELK | P10T-E | Human | Esophagus | ESCC | 3.50e-02 | 1.11e-01 | 0.116 |
9833 | MELK | P17T-E | Human | Esophagus | ESCC | 8.50e-05 | 2.21e-01 | 0.1278 |
9833 | MELK | P19T-E | Human | Esophagus | ESCC | 6.53e-04 | 4.04e-01 | 0.1662 |
9833 | MELK | P21T-E | Human | Esophagus | ESCC | 8.40e-04 | 1.40e-01 | 0.1617 |
9833 | MELK | P24T-E | Human | Esophagus | ESCC | 3.60e-13 | 3.51e-01 | 0.1287 |
9833 | MELK | P28T-E | Human | Esophagus | ESCC | 1.46e-28 | 5.92e-01 | 0.1149 |
9833 | MELK | P30T-E | Human | Esophagus | ESCC | 9.20e-05 | 5.68e-01 | 0.137 |
9833 | MELK | P31T-E | Human | Esophagus | ESCC | 4.31e-06 | 2.20e-01 | 0.1251 |
9833 | MELK | P32T-E | Human | Esophagus | ESCC | 2.03e-09 | 2.64e-01 | 0.1666 |
9833 | MELK | P37T-E | Human | Esophagus | ESCC | 8.12e-03 | 1.28e-01 | 0.1371 |
9833 | MELK | P38T-E | Human | Esophagus | ESCC | 4.44e-08 | 5.44e-01 | 0.127 |
9833 | MELK | P49T-E | Human | Esophagus | ESCC | 6.53e-04 | 4.62e-01 | 0.1768 |
9833 | MELK | P52T-E | Human | Esophagus | ESCC | 3.60e-13 | 2.78e-01 | 0.1555 |
9833 | MELK | P74T-E | Human | Esophagus | ESCC | 1.02e-05 | 2.93e-01 | 0.1479 |
9833 | MELK | P75T-E | Human | Esophagus | ESCC | 1.88e-11 | 4.05e-01 | 0.1125 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:004483911 | Skin | cSCC | cell cycle G2/M phase transition | 61/4864 | 148/18723 | 3.61e-05 | 3.90e-04 | 61 |
GO:004677715 | Skin | cSCC | protein autophosphorylation | 84/4864 | 227/18723 | 1.53e-04 | 1.35e-03 | 84 |
GO:0036473111 | Skin | cSCC | cell death in response to oxidative stress | 41/4864 | 95/18723 | 2.02e-04 | 1.68e-03 | 41 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
MELK | SNV | Missense_Mutation | c.931N>A | p.Asp311Asn | p.D311N | Q14680 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-BH-A0DH-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cyclophosphamide | SD | |
MELK | SNV | Missense_Mutation | c.122N>A | p.Ile41Asn | p.I41N | Q14680 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-C8-A1HK-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
MELK | SNV | Missense_Mutation | c.344N>G | p.Gln115Arg | p.Q115R | Q14680 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-E9-A1R5-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD | |
MELK | SNV | Missense_Mutation | novel | c.1505N>A | p.Arg502Gln | p.R502Q | Q14680 | protein_coding | deleterious(0) | probably_damaging(0.981) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
MELK | SNV | Missense_Mutation | novel | c.1331C>T | p.Pro444Leu | p.P444L | Q14680 | protein_coding | tolerated(0.06) | benign(0.321) | TCGA-VS-A8EK-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Chemotherapy | cisplatin | PD |
MELK | SNV | Missense_Mutation | novel | c.236C>A | p.Ala79Asp | p.A79D | Q14680 | protein_coding | tolerated(0.4) | benign(0.001) | TCGA-AA-3530-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
MELK | SNV | Missense_Mutation | rs757367254 | c.308G>A | p.Arg103His | p.R103H | Q14680 | protein_coding | tolerated(0.06) | possibly_damaging(0.503) | TCGA-AA-3950-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
MELK | SNV | Missense_Mutation | novel | c.1898N>A | p.Gly633Asp | p.G633D | Q14680 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AZ-4315-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
MELK | SNV | Missense_Mutation | c.1943N>C | p.Ser648Thr | p.S648T | Q14680 | protein_coding | tolerated(0.25) | benign(0.144) | TCGA-AZ-6606-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | folfiri | PD | |
MELK | SNV | Missense_Mutation | novel | c.1653A>T | p.Arg551Ser | p.R551S | Q14680 | protein_coding | tolerated(0.28) | benign(0.007) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
9833 | MELK | KINASE, DRUGGABLE GENOME, ENZYME, SERINE THREONINE KINASE | TAE-684 | TAE-684 | ||
9833 | MELK | KINASE, DRUGGABLE GENOME, ENZYME, SERINE THREONINE KINASE | SNS-314 | SNS-314 | ||
9833 | MELK | KINASE, DRUGGABLE GENOME, ENZYME, SERINE THREONINE KINASE | GW843682X | GW843682X | ||
9833 | MELK | KINASE, DRUGGABLE GENOME, ENZYME, SERINE THREONINE KINASE | TOZASERTIB | TOZASERTIB | ||
9833 | MELK | KINASE, DRUGGABLE GENOME, ENZYME, SERINE THREONINE KINASE | PF-562271 | PF-00562271 | ||
9833 | MELK | KINASE, DRUGGABLE GENOME, ENZYME, SERINE THREONINE KINASE | OTSSP167 | |||
9833 | MELK | KINASE, DRUGGABLE GENOME, ENZYME, SERINE THREONINE KINASE | AG-1879 | CHEMBL406845 | ||
9833 | MELK | KINASE, DRUGGABLE GENOME, ENZYME, SERINE THREONINE KINASE | LINIFANIB | LINIFANIB | ||
9833 | MELK | KINASE, DRUGGABLE GENOME, ENZYME, SERINE THREONINE KINASE | RG-1530 | RG-1530 | ||
9833 | MELK | KINASE, DRUGGABLE GENOME, ENZYME, SERINE THREONINE KINASE | inhibitor | 328083468 |
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