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Gene: MBD1 |
Gene summary for MBD1 |
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Gene information | Species | Human | Gene symbol | MBD1 | Gene ID | 4152 |
Gene name | methyl-CpG binding domain protein 1 | |
Gene Alias | CXXC3 | |
Cytomap | 18q21.1 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | A8K654 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
4152 | MBD1 | LZE4T | Human | Esophagus | ESCC | 1.12e-03 | 2.44e-01 | 0.0811 |
4152 | MBD1 | LZE7T | Human | Esophagus | ESCC | 1.32e-07 | 4.00e-01 | 0.0667 |
4152 | MBD1 | LZE8T | Human | Esophagus | ESCC | 4.49e-02 | 8.70e-02 | 0.067 |
4152 | MBD1 | LZE20T | Human | Esophagus | ESCC | 1.44e-05 | 7.30e-02 | 0.0662 |
4152 | MBD1 | LZE24T | Human | Esophagus | ESCC | 5.11e-09 | 2.19e-01 | 0.0596 |
4152 | MBD1 | P1T-E | Human | Esophagus | ESCC | 1.10e-13 | 5.22e-01 | 0.0875 |
4152 | MBD1 | P2T-E | Human | Esophagus | ESCC | 3.64e-20 | 3.44e-01 | 0.1177 |
4152 | MBD1 | P4T-E | Human | Esophagus | ESCC | 3.02e-17 | 4.94e-01 | 0.1323 |
4152 | MBD1 | P5T-E | Human | Esophagus | ESCC | 7.92e-13 | 1.46e-01 | 0.1327 |
4152 | MBD1 | P8T-E | Human | Esophagus | ESCC | 1.19e-13 | 3.69e-01 | 0.0889 |
4152 | MBD1 | P9T-E | Human | Esophagus | ESCC | 9.67e-15 | 4.04e-01 | 0.1131 |
4152 | MBD1 | P10T-E | Human | Esophagus | ESCC | 2.60e-29 | 3.42e-01 | 0.116 |
4152 | MBD1 | P11T-E | Human | Esophagus | ESCC | 1.64e-05 | 2.17e-01 | 0.1426 |
4152 | MBD1 | P12T-E | Human | Esophagus | ESCC | 2.61e-08 | 2.50e-01 | 0.1122 |
4152 | MBD1 | P15T-E | Human | Esophagus | ESCC | 6.58e-11 | 2.34e-01 | 0.1149 |
4152 | MBD1 | P16T-E | Human | Esophagus | ESCC | 2.35e-22 | 3.36e-01 | 0.1153 |
4152 | MBD1 | P17T-E | Human | Esophagus | ESCC | 2.38e-10 | 1.93e-01 | 0.1278 |
4152 | MBD1 | P19T-E | Human | Esophagus | ESCC | 6.59e-05 | 5.82e-01 | 0.1662 |
4152 | MBD1 | P20T-E | Human | Esophagus | ESCC | 3.62e-20 | 4.22e-01 | 0.1124 |
4152 | MBD1 | P21T-E | Human | Esophagus | ESCC | 3.89e-16 | 3.88e-01 | 0.1617 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:000941019 | Oral cavity | LP | response to xenobiotic stimulus | 141/4623 | 462/18723 | 2.33e-03 | 1.68e-02 | 141 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
MBD1 | TFH | Breast | Precancer | CHI3L1,USPL1,ADTRP, etc. | 3.54e-02 | ![]() |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
MBD1 | SNV | Missense_Mutation | novel | c.1763N>T | p.Ala588Val | p.A588V | Q9UIS9 | protein_coding | deleterious_low_confidence(0) | benign(0.412) | TCGA-AO-A0JD-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | cyclophosphamide | SD |
MBD1 | SNV | Missense_Mutation | rs545375854 | c.455N>T | p.Thr152Met | p.T152M | Q9UIS9 | protein_coding | deleterious(0.01) | probably_damaging(0.999) | TCGA-BH-A0HA-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
MBD1 | SNV | Missense_Mutation | c.640N>T | p.Arg214Cys | p.R214C | Q9UIS9 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-E2-A15K-06 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | SD | |
MBD1 | insertion | Frame_Shift_Ins | novel | c.1760_1761insTGAATATTTTCTTTTAATT | p.Ala588GlufsTer25 | p.A588Efs*25 | Q9UIS9 | protein_coding | TCGA-AO-A0JD-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | cyclophosphamide | SD | ||
MBD1 | deletion | Frame_Shift_Del | c.1592delA | p.Asp531AlafsTer7 | p.D531Afs*7 | Q9UIS9 | protein_coding | TCGA-AR-A0TX-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |||
MBD1 | deletion | Frame_Shift_Del | novel | c.83delN | p.Cys28LeufsTer22 | p.C28Lfs*22 | Q9UIS9 | protein_coding | TCGA-D8-A27V-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD | ||
MBD1 | deletion | Frame_Shift_Del | novel | c.1205delN | p.Pro402LeufsTer20 | p.P402Lfs*20 | Q9UIS9 | protein_coding | TCGA-EW-A2FV-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | docetaxel | SD | ||
MBD1 | SNV | Missense_Mutation | rs775229161 | c.1282N>T | p.Arg428Cys | p.R428C | Q9UIS9 | protein_coding | tolerated(0.16) | benign(0.007) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
MBD1 | SNV | Missense_Mutation | novel | c.297N>T | p.Gln99His | p.Q99H | Q9UIS9 | protein_coding | tolerated(0.14) | probably_damaging(0.996) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
MBD1 | SNV | Missense_Mutation | novel | c.55N>A | p.Glu19Lys | p.E19K | Q9UIS9 | protein_coding | deleterious(0.01) | probably_damaging(0.993) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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