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Gene: MARCHF7 |
Gene summary for MARCHF7 |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | MARCHF7 | Gene ID | 64844 |
| Gene name | membrane associated ring-CH-type finger 7 | |
| Gene Alias | AXO | |
| Cytomap | 2q24.2 | |
| Gene Type | protein-coding | GO ID | GO:0000209 | UniProtAcc | B7ZAR7 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 64844 | MARCHF7 | HTA11_3410_2000001011 | Human | Colorectum | AD | 2.54e-08 | 2.08e-01 | 0.0155 |
| 64844 | MARCHF7 | HTA11_2487_2000001011 | Human | Colorectum | SER | 1.32e-08 | 2.58e-01 | -0.1808 |
| 64844 | MARCHF7 | HTA11_2951_2000001011 | Human | Colorectum | AD | 3.40e-02 | 1.93e-01 | 0.0216 |
| 64844 | MARCHF7 | HTA11_1938_2000001011 | Human | Colorectum | AD | 1.06e-19 | 5.17e-01 | -0.0811 |
| 64844 | MARCHF7 | HTA11_78_2000001011 | Human | Colorectum | AD | 1.18e-19 | 4.85e-01 | -0.1088 |
| 64844 | MARCHF7 | HTA11_347_2000001011 | Human | Colorectum | AD | 1.95e-38 | 6.45e-01 | -0.1954 |
| 64844 | MARCHF7 | HTA11_411_2000001011 | Human | Colorectum | SER | 1.20e-07 | 5.69e-01 | -0.2602 |
| 64844 | MARCHF7 | HTA11_2112_2000001011 | Human | Colorectum | SER | 1.50e-04 | 4.80e-01 | -0.2196 |
| 64844 | MARCHF7 | HTA11_3361_2000001011 | Human | Colorectum | AD | 2.57e-07 | 2.24e-01 | -0.1207 |
| 64844 | MARCHF7 | HTA11_83_2000001011 | Human | Colorectum | SER | 4.13e-10 | 3.09e-01 | -0.1526 |
| 64844 | MARCHF7 | HTA11_696_2000001011 | Human | Colorectum | AD | 3.84e-22 | 4.12e-01 | -0.1464 |
| 64844 | MARCHF7 | HTA11_866_2000001011 | Human | Colorectum | AD | 2.11e-21 | 3.91e-01 | -0.1001 |
| 64844 | MARCHF7 | HTA11_1391_2000001011 | Human | Colorectum | AD | 4.56e-17 | 4.83e-01 | -0.059 |
| 64844 | MARCHF7 | HTA11_2992_2000001011 | Human | Colorectum | SER | 1.94e-06 | 3.10e-01 | -0.1706 |
| 64844 | MARCHF7 | HTA11_5216_2000001011 | Human | Colorectum | SER | 3.22e-05 | 3.08e-01 | -0.1462 |
| 64844 | MARCHF7 | HTA11_546_2000001011 | Human | Colorectum | AD | 2.76e-07 | 3.18e-01 | -0.0842 |
| 64844 | MARCHF7 | HTA11_7862_2000001011 | Human | Colorectum | AD | 1.12e-06 | 3.39e-01 | -0.0179 |
| 64844 | MARCHF7 | HTA11_866_3004761011 | Human | Colorectum | AD | 1.67e-10 | 2.45e-01 | 0.096 |
| 64844 | MARCHF7 | HTA11_4255_2000001011 | Human | Colorectum | SER | 3.34e-04 | 2.80e-01 | 0.0446 |
| 64844 | MARCHF7 | HTA11_8622_2000001021 | Human | Colorectum | SER | 6.14e-04 | 2.26e-01 | 0.0528 |
| Page: 1 2 |
| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Colorectum (GSE201348) |  | FAP: Familial adenomatous polyposis |
| CRC: Colorectal cancer | ||
| Colorectum (HTA11) |  | AD: Adenomas |
| SER: Sessile serrated lesions | ||
| MSI-H: Microsatellite-high colorectal cancer | ||
| MSS: Microsatellite stable colorectal cancer |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| GO:00611361 | Colorectum | SER | regulation of proteasomal protein catabolic process | 62/2897 | 187/18723 | 1.28e-09 | 1.31e-07 | 62 |
| GO:00316471 | Colorectum | SER | regulation of protein stability | 86/2897 | 298/18723 | 2.56e-09 | 2.42e-07 | 86 |
| GO:19033201 | Colorectum | SER | regulation of protein modification by small protein conjugation or removal | 70/2897 | 242/18723 | 6.84e-08 | 4.42e-06 | 70 |
| GO:00508211 | Colorectum | SER | protein stabilization | 58/2897 | 191/18723 | 1.46e-07 | 8.59e-06 | 58 |
| GO:00313961 | Colorectum | SER | regulation of protein ubiquitination | 62/2897 | 210/18723 | 1.69e-07 | 9.71e-06 | 62 |
| GO:00098951 | Colorectum | SER | negative regulation of catabolic process | 84/2897 | 320/18723 | 3.93e-07 | 2.06e-05 | 84 |
| GO:20012341 | Colorectum | SER | negative regulation of apoptotic signaling pathway | 64/2897 | 224/18723 | 3.98e-07 | 2.06e-05 | 64 |
| GO:20012431 | Colorectum | SER | negative regulation of intrinsic apoptotic signaling pathway | 35/2897 | 98/18723 | 6.73e-07 | 3.23e-05 | 35 |
| GO:00458611 | Colorectum | SER | negative regulation of proteolysis | 88/2897 | 351/18723 | 1.74e-06 | 7.50e-05 | 88 |
| GO:00313301 | Colorectum | SER | negative regulation of cellular catabolic process | 70/2897 | 262/18723 | 1.79e-06 | 7.70e-05 | 70 |
| GO:19033631 | Colorectum | SER | negative regulation of cellular protein catabolic process | 28/2897 | 75/18723 | 3.17e-06 | 1.25e-04 | 28 |
| GO:00421771 | Colorectum | SER | negative regulation of protein catabolic process | 38/2897 | 121/18723 | 8.20e-06 | 2.76e-04 | 38 |
| GO:00313971 | Colorectum | SER | negative regulation of protein ubiquitination | 29/2897 | 83/18723 | 9.72e-06 | 3.22e-04 | 29 |
| GO:19022531 | Colorectum | SER | regulation of intrinsic apoptotic signaling pathway by p53 class mediator | 14/2897 | 29/18723 | 3.36e-05 | 8.85e-04 | 14 |
| GO:19030511 | Colorectum | SER | negative regulation of proteolysis involved in cellular protein catabolic process | 23/2897 | 64/18723 | 4.75e-05 | 1.18e-03 | 23 |
| GO:19033211 | Colorectum | SER | negative regulation of protein modification by small protein conjugation or removal | 30/2897 | 95/18723 | 6.29e-05 | 1.46e-03 | 30 |
| GO:00002091 | Colorectum | SER | protein polyubiquitination | 58/2897 | 236/18723 | 1.69e-04 | 3.18e-03 | 58 |
| GO:00723311 | Colorectum | SER | signal transduction by p53 class mediator | 43/2897 | 163/18723 | 2.22e-04 | 3.90e-03 | 43 |
| GO:19017991 | Colorectum | SER | negative regulation of proteasomal protein catabolic process | 18/2897 | 49/18723 | 2.24e-04 | 3.91e-03 | 18 |
| GO:00723321 | Colorectum | SER | intrinsic apoptotic signaling pathway by p53 class mediator | 24/2897 | 76/18723 | 3.29e-04 | 5.22e-03 | 24 |
| Page: 1 2 3 4 |
| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
| Page: 1 |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
| Page: 1 |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| Page: 1 |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
| Page: 1 |
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