GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00991732 | Colorectum | MSS | postsynapse organization | 48/3467 | 168/18723 | 9.32e-04 | 9.44e-03 | 48 |
GO:00163582 | Colorectum | MSS | dendrite development | 65/3467 | 243/18723 | 9.41e-04 | 9.50e-03 | 65 |
GO:00717092 | Colorectum | MSS | membrane assembly | 19/3467 | 50/18723 | 9.61e-04 | 9.67e-03 | 19 |
GO:0030178 | Colorectum | MSS | negative regulation of Wnt signaling pathway | 48/3467 | 170/18723 | 1.23e-03 | 1.18e-02 | 48 |
GO:00487362 | Colorectum | MSS | appendage development | 48/3467 | 172/18723 | 1.61e-03 | 1.46e-02 | 48 |
GO:00601732 | Colorectum | MSS | limb development | 48/3467 | 172/18723 | 1.61e-03 | 1.46e-02 | 48 |
GO:00507701 | Colorectum | MSS | regulation of axonogenesis | 43/3467 | 154/18723 | 2.69e-03 | 2.12e-02 | 43 |
GO:00109771 | Colorectum | MSS | negative regulation of neuron projection development | 39/3467 | 137/18723 | 2.86e-03 | 2.22e-02 | 39 |
GO:00440912 | Colorectum | MSS | membrane biogenesis | 19/3467 | 55/18723 | 3.47e-03 | 2.59e-02 | 19 |
GO:00508082 | Colorectum | MSS | synapse organization | 101/3467 | 426/18723 | 3.96e-03 | 2.89e-02 | 101 |
GO:0050768 | Colorectum | MSS | negative regulation of neurogenesis | 39/3467 | 140/18723 | 4.30e-03 | 3.07e-02 | 39 |
GO:0051961 | Colorectum | MSS | negative regulation of nervous system development | 40/3467 | 145/18723 | 4.66e-03 | 3.27e-02 | 40 |
GO:0097242 | Colorectum | MSS | amyloid-beta clearance | 14/3467 | 38/18723 | 6.00e-03 | 4.03e-02 | 14 |
GO:00015032 | Colorectum | MSS | ossification | 96/3467 | 408/18723 | 6.09e-03 | 4.07e-02 | 96 |
GO:0051960 | Colorectum | MSS | regulation of nervous system development | 103/3467 | 443/18723 | 6.68e-03 | 4.38e-02 | 103 |
GO:0001655 | Colorectum | MSS | urogenital system development | 81/3467 | 338/18723 | 6.88e-03 | 4.43e-02 | 81 |
GO:19054753 | Colorectum | FAP | regulation of protein localization to membrane | 58/2622 | 175/18723 | 9.05e-11 | 2.92e-08 | 58 |
GO:19038294 | Colorectum | FAP | positive regulation of cellular protein localization | 79/2622 | 276/18723 | 1.59e-10 | 4.38e-08 | 79 |
GO:00343293 | Colorectum | FAP | cell junction assembly | 105/2622 | 420/18723 | 1.03e-09 | 2.18e-07 | 105 |
GO:19054773 | Colorectum | FAP | positive regulation of protein localization to membrane | 37/2622 | 106/18723 | 4.79e-08 | 3.86e-06 | 37 |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
LRP4 | SNV | Missense_Mutation | | c.4423N>A | p.Ala1475Thr | p.A1475T | O75096 | protein_coding | deleterious(0.02) | probably_damaging(0.95) | TCGA-A8-A06T-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Hormone Therapy | anastrozole | SD |
LRP4 | SNV | Missense_Mutation | rs772706817 | c.5424G>C | p.Lys1808Asn | p.K1808N | O75096 | protein_coding | deleterious_low_confidence(0.03) | benign(0.04) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
LRP4 | SNV | Missense_Mutation | | c.2761G>A | p.Asp921Asn | p.D921N | O75096 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
LRP4 | SNV | Missense_Mutation | | c.4620N>C | p.Glu1540Asp | p.E1540D | O75096 | protein_coding | tolerated(0.09) | probably_damaging(0.992) | TCGA-AR-A0TX-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
LRP4 | SNV | Missense_Mutation | | c.3361N>G | p.Thr1121Ala | p.T1121A | O75096 | protein_coding | tolerated(0.7) | benign(0.27) | TCGA-BH-A0HA-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
LRP4 | SNV | Missense_Mutation | | c.4199A>G | p.Tyr1400Cys | p.Y1400C | O75096 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-BH-A18K-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | PD |
LRP4 | SNV | Missense_Mutation | | c.5018N>G | p.Asn1673Ser | p.N1673S | O75096 | protein_coding | tolerated(0.29) | possibly_damaging(0.899) | TCGA-C8-A12P-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
LRP4 | SNV | Missense_Mutation | | c.631N>C | p.Asp211His | p.D211H | O75096 | protein_coding | deleterious(0) | probably_damaging(0.971) | TCGA-D8-A1JC-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | adriamycin | SD |
LRP4 | SNV | Missense_Mutation | novel | c.2072A>C | p.His691Pro | p.H691P | O75096 | protein_coding | deleterious(0) | possibly_damaging(0.884) | TCGA-D8-A1JI-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicine | SD |
LRP4 | SNV | Missense_Mutation | novel | c.3907N>C | p.Asp1303His | p.D1303H | O75096 | protein_coding | tolerated(0.26) | benign(0.014) | TCGA-E2-A1LG-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | SD |