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Gene: LGALS7 |
Gene summary for LGALS7 |
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Gene information | Species | Human | Gene symbol | LGALS7 | Gene ID | 3963 |
Gene name | galectin 7 | |
Gene Alias | GAL7 | |
Cytomap | 19q13.2 | |
Gene Type | protein-coding | GO ID | NA | UniProtAcc | P47929 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
3963 | LGALS7 | CA_HPV_1 | Human | Cervix | CC | 1.91e-09 | -2.73e-01 | 0.0264 |
3963 | LGALS7 | CA_HPV_3 | Human | Cervix | CC | 4.16e-05 | -2.47e-01 | 0.0414 |
3963 | LGALS7 | HSIL_HPV_1 | Human | Cervix | HSIL_HPV | 7.11e-03 | -1.53e-01 | 0.0116 |
3963 | LGALS7 | CCII_1 | Human | Cervix | CC | 8.34e-03 | -2.73e-01 | 0.3249 |
3963 | LGALS7 | Tumor | Human | Cervix | CC | 5.89e-19 | 5.98e-01 | 0.1241 |
3963 | LGALS7 | sample3 | Human | Cervix | CC | 2.85e-11 | 3.77e-01 | 0.1387 |
3963 | LGALS7 | H2 | Human | Cervix | HSIL_HPV | 5.96e-05 | -2.32e-01 | 0.0632 |
3963 | LGALS7 | L1 | Human | Cervix | CC | 1.39e-23 | 9.87e-01 | 0.0802 |
3963 | LGALS7 | T3 | Human | Cervix | CC | 6.20e-12 | 3.96e-01 | 0.1389 |
3963 | LGALS7 | LZE4T | Human | Esophagus | ESCC | 7.27e-04 | -2.24e-01 | 0.0811 |
3963 | LGALS7 | LZE20T | Human | Esophagus | ESCC | 2.38e-09 | 1.52e+00 | 0.0662 |
3963 | LGALS7 | LZE22T | Human | Esophagus | ESCC | 1.49e-06 | 1.24e+00 | 0.068 |
3963 | LGALS7 | LZE24T | Human | Esophagus | ESCC | 5.89e-06 | 8.08e-01 | 0.0596 |
3963 | LGALS7 | LZE21T | Human | Esophagus | ESCC | 3.28e-09 | 3.29e+00 | 0.0655 |
3963 | LGALS7 | P1T-E | Human | Esophagus | ESCC | 1.78e-07 | 1.40e+00 | 0.0875 |
3963 | LGALS7 | P4T-E | Human | Esophagus | ESCC | 1.62e-19 | 1.19e+00 | 0.1323 |
3963 | LGALS7 | P5T-E | Human | Esophagus | ESCC | 2.95e-50 | 1.83e+00 | 0.1327 |
3963 | LGALS7 | P9T-E | Human | Esophagus | ESCC | 1.42e-42 | 2.34e+00 | 0.1131 |
3963 | LGALS7 | P10T-E | Human | Esophagus | ESCC | 4.57e-13 | 9.55e-01 | 0.116 |
3963 | LGALS7 | P11T-E | Human | Esophagus | ESCC | 1.56e-07 | 3.12e+00 | 0.1426 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:002240821 | Cervix | N_HPV | negative regulation of cell-cell adhesion | 15/534 | 196/18723 | 5.19e-04 | 6.96e-03 | 15 |
GO:004209822 | Cervix | N_HPV | T cell proliferation | 15/534 | 199/18723 | 6.09e-04 | 7.94e-03 | 15 |
GO:007066321 | Cervix | N_HPV | regulation of leukocyte proliferation | 17/534 | 245/18723 | 6.99e-04 | 8.92e-03 | 17 |
GO:005067021 | Cervix | N_HPV | regulation of lymphocyte proliferation | 16/534 | 225/18723 | 7.65e-04 | 9.60e-03 | 16 |
GO:003294421 | Cervix | N_HPV | regulation of mononuclear cell proliferation | 16/534 | 227/18723 | 8.41e-04 | 1.03e-02 | 16 |
GO:004665121 | Cervix | N_HPV | lymphocyte proliferation | 18/534 | 288/18723 | 1.63e-03 | 1.68e-02 | 18 |
GO:003294321 | Cervix | N_HPV | mononuclear cell proliferation | 18/534 | 291/18723 | 1.83e-03 | 1.82e-02 | 18 |
GO:0098742 | Cervix | N_HPV | cell-cell adhesion via plasma-membrane adhesion molecules | 17/534 | 273/18723 | 2.26e-03 | 2.11e-02 | 17 |
GO:00026952 | Cervix | N_HPV | negative regulation of leukocyte activation | 13/534 | 187/18723 | 2.82e-03 | 2.45e-02 | 13 |
GO:00508662 | Cervix | N_HPV | negative regulation of cell activation | 14/534 | 210/18723 | 2.90e-03 | 2.50e-02 | 14 |
GO:00512502 | Cervix | N_HPV | negative regulation of lymphocyte activation | 11/534 | 157/18723 | 5.45e-03 | 3.89e-02 | 11 |
GO:19030381 | Cervix | N_HPV | negative regulation of leukocyte cell-cell adhesion | 10/534 | 141/18723 | 7.24e-03 | 4.75e-02 | 10 |
GO:002240720 | Esophagus | ESCC | regulation of cell-cell adhesion | 239/8552 | 448/18723 | 5.88e-04 | 3.19e-03 | 239 |
GO:000268316 | Esophagus | ESCC | negative regulation of immune system process | 231/8552 | 434/18723 | 8.48e-04 | 4.36e-03 | 231 |
GO:004211018 | Esophagus | ESCC | T cell activation | 256/8552 | 487/18723 | 1.18e-03 | 5.87e-03 | 256 |
GO:000715918 | Esophagus | ESCC | leukocyte cell-cell adhesion | 192/8552 | 371/18723 | 1.03e-02 | 3.51e-02 | 192 |
GO:190303717 | Esophagus | ESCC | regulation of leukocyte cell-cell adhesion | 174/8552 | 336/18723 | 1.36e-02 | 4.43e-02 | 174 |
GO:004211016 | Oral cavity | OSCC | T cell activation | 245/7305 | 487/18723 | 2.00e-07 | 3.22e-06 | 245 |
GO:002240718 | Oral cavity | OSCC | regulation of cell-cell adhesion | 218/7305 | 448/18723 | 1.71e-05 | 1.68e-04 | 218 |
GO:005086315 | Oral cavity | OSCC | regulation of T cell activation | 161/7305 | 329/18723 | 1.44e-04 | 1.02e-03 | 161 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
LGALS7 | SNV | Missense_Mutation | novel | c.215N>A | p.Arg72His | p.R72H | P47929 | protein_coding | tolerated(0.16) | benign(0.009) | TCGA-CM-6162-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Chemotherapy | oxaliplatin | SD |
LGALS7 | SNV | Missense_Mutation | novel | c.96N>C | p.Arg32Ser | p.R32S | P47929 | protein_coding | tolerated(0.05) | possibly_damaging(0.476) | TCGA-DD-A1EL-01 | Liver | liver hepatocellular carcinoma | Male | <65 | I/II | Unknown | Unknown | PD |
LGALS7 | SNV | Missense_Mutation | novel | c.235N>T | p.Val79Phe | p.V79F | P47929 | protein_coding | tolerated(0.17) | benign(0.158) | TCGA-K7-A6G5-01 | Liver | liver hepatocellular carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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