Schematic overview of the cellular and molecular mechanisms involved in the cancer progression, including the proposed cellular and molecular mechanisms in cancer cells trajectory. AT1: alveolar type 1 cells; AT2: alveolar type 2 cells; AAH: atypical adenomatous hyperplasia; AIS: adenocarcinoma in situ; MIA: minimally invasive adenocarcinoma; IA: invasive adenocarcinoma; EMT: epithelial-mesenchymal transition

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Center for Computational Systems Medicine
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Gene summary

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Malignant transformation analysis

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Malignant transformation related pathway analysis

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Cell-cell communication analysis

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Single-cell gene regulatory network inference analysis

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Somatic mutation of malignant transformation related genes

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Related drugs of malignant transformation related genes

Gene: KLHL2

Gene summary for KLHL2

check button Gene summary.

Gene informationSpeciesHuman
Gene symbol

KLHL2

Gene ID

11275

Gene namekelch like family member 2
Gene AliasABP-KELCH
Cytomap4q32.3
Gene Typeprotein-coding
GO ID

GO:0006464

UniProtAcc

O95198


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Malignant transformation analysis

check button Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells
check button Malignant transformation involving gene list.
Entrez IDSymbolReplicatesSpeciesOrganTissueAdj P-valueLog2FCMalignancy
11275KLHL2CCI_1HumanCervixCC1.29e-025.89e-010.528
11275KLHL2CCI_2HumanCervixCC4.68e-049.53e-010.5249
11275KLHL2CCI_3HumanCervixCC1.68e-045.80e-010.516
11275KLHL2HTA12-15-2HumanPancreasPDAC3.81e-023.41e-010.2315
11275KLHL2HTA12-25-1HumanPancreasPDAC1.12e-077.86e-010.313
11275KLHL2HTA12-26-1HumanPancreasPDAC2.80e-178.93e-010.3728
11275KLHL2HTA12-29-1HumanPancreasPDAC5.12e-184.96e-010.3722
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check button Transcriptomic changes along malignancy continuum.
TissueExpression DynamicsAbbreviation
CervixThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.CC: Cervix cancer
HSIL_HPV: HPV-infected high-grade squamous intraepithelial lesions
N_HPV: HPV-infected normal cervix
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.

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Malignant transformation related pathway analysis

check buttonFind out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer
check button Figure of enriched GO biological processes.
TissueDisease StageEnriched GO biological Processes
ColorectumADGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumSERGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSSGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSI-HGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumFAPGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
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check button Enriched GO biological processes.
GO IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustCount
GO:00324093ColorectumCRCregulation of transporter activity59/2078310/187232.34e-056.65e-0459
GO:00068141ColorectumCRCsodium ion transport49/2078245/187233.01e-057.86e-0449
GO:00109591ColorectumCRCregulation of metal ion transport69/2078406/187232.05e-043.48e-0369
GO:00518653ColorectumCRCprotein autoubiquitination18/207873/187238.33e-041.04e-0218
GO:19040621ColorectumCRCregulation of cation transmembrane transport58/2078357/187231.89e-031.93e-0258
GO:1901379ColorectumCRCregulation of potassium ion transmembrane transport20/207895/187233.46e-032.94e-0220
GO:0043266ColorectumCRCregulation of potassium ion transport22/2078109/187233.87e-033.22e-0222
GO:1901016ColorectumCRCregulation of potassium ion transmembrane transporter activity15/207868/187236.77e-034.77e-0215
GO:0010498111EsophagusESCCproteasomal protein catabolic process369/8552490/187231.13e-411.80e-38369
GO:0043161111EsophagusESCCproteasome-mediated ubiquitin-dependent protein catabolic process312/8552412/187233.53e-364.48e-33312
GO:004819318EsophagusESCCGolgi vesicle transport231/8552296/187231.82e-309.63e-28231
GO:014001414EsophagusESCCmitotic nuclear division218/8552287/187236.17e-261.78e-23218
GO:000007011EsophagusESCCmitotic sister chromatid segregation138/8552168/187231.37e-222.63e-20138
GO:00008194EsophagusESCCsister chromatid segregation157/8552202/187238.41e-211.33e-18157
GO:003304416EsophagusESCCregulation of chromosome organization145/8552187/187233.80e-194.31e-17145
GO:000705911EsophagusESCCchromosome segregation238/8552346/187231.72e-181.82e-16238
GO:004477216EsophagusESCCmitotic cell cycle phase transition281/8552424/187234.63e-184.45e-16281
GO:001050617EsophagusESCCregulation of autophagy220/8552317/187236.72e-186.36e-16220
GO:000020917EsophagusESCCprotein polyubiquitination170/8552236/187231.40e-161.09e-14170
GO:000734615EsophagusESCCregulation of mitotic cell cycle293/8552457/187238.00e-165.64e-14293
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check button Enriched KEGG pathways.
Pathway IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustqvalueCount
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Cell-cell communication analysis

check buttonIdentification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states
LigandReceptorLRpairPathwayTissueDisease Stage
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Single-cell gene regulatory network inference analysis

check buttonFind out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states
TFCell TypeTissueDisease StageTarget GeneRSSRegulon Activity
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
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Somatic mutation of malignant transformation related genes

check buttonAnnotation of somatic variants for genes involved in malignant transformation
Hugo SymbolVariant ClassVariant ClassificationdbSNP RSHGVScHGVSpHGVSp ShortSWISSPROTBIOTYPESIFTPolyPhenTumor Sample BarcodeTissueHistologySexAgeStageTherapy TypesDrugsOutcome
KLHL2SNVMissense_Mutationc.359N>Tp.Thr120Ilep.T120IO95198protein_codingdeleterious(0.01)possibly_damaging(0.461)TCGA-AN-A0AK-01Breastbreast invasive carcinomaFemale>=65I/IIUnknownUnknownSD
KLHL2deletionFrame_Shift_Delnovelc.20delNp.Gln9ArgfsTer28p.Q9Rfs*28O95198protein_codingTCGA-D8-A27V-01Breastbreast invasive carcinomaFemale<65I/IIHormone TherapytamoxiphenSD
KLHL2SNVMissense_Mutationnovelc.575T>Cp.Val192Alap.V192AO95198protein_codingdeleterious(0.03)possibly_damaging(0.895)TCGA-2W-A8YY-01Cervixcervical & endocervical cancerFemale<65I/IIChemotherapycisplatinCR
KLHL2SNVMissense_Mutationnovelc.1390C>Tp.Arg464Cysp.R464CO95198protein_codingdeleterious(0)probably_damaging(1)TCGA-2W-A8YY-01Cervixcervical & endocervical cancerFemale<65I/IIChemotherapycisplatinCR
KLHL2SNVMissense_Mutationc.1525N>Cp.Asp509Hisp.D509HO95198protein_codingdeleterious(0)probably_damaging(0.996)TCGA-C5-A1BK-01Cervixcervical & endocervical cancerFemale<65I/IIUnknownUnknownSD
KLHL2SNVMissense_Mutationc.1170N>Ap.Met390Ilep.M390IO95198protein_codingdeleterious(0)probably_damaging(0.987)TCGA-C5-A1MK-01Cervixcervical & endocervical cancerFemale>=65III/IVChemotherapycarboplatinPD
KLHL2SNVMissense_Mutationrs770856919c.905N>Ap.Arg302Glnp.R302QO95198protein_codingdeleterious(0.05)benign(0.285)TCGA-EA-A410-01Cervixcervical & endocervical cancerFemale<65I/IIUnknownUnknownSD
KLHL2SNVMissense_Mutationc.1237N>Cp.Asp413Hisp.D413HO95198protein_codingdeleterious(0.01)probably_damaging(0.992)TCGA-EK-A3GK-01Cervixcervical & endocervical cancerFemale<65I/IIUnknownUnknownSD
KLHL2SNVMissense_Mutationnovelc.1435G>Cp.Glu479Glnp.E479QO95198protein_codingtolerated(0.33)benign(0.043)TCGA-MA-AA41-01Cervixcervical & endocervical cancerFemale<65I/IIUnknownUnknownSD
KLHL2SNVMissense_Mutationnovelc.726N>Ap.Met242Ilep.M242IO95198protein_codingtolerated(0.12)benign(0.026)TCGA-A6-2686-01Colorectumcolon adenocarcinomaFemale>=65I/IIUnknownUnknownSD
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Related drugs of malignant transformation related genes

check buttonIdentification of chemicals and drugs interact with genes involved in malignant transfromation
(DGIdb 4.0)
Entrez IDSymbolCategoryInteraction TypesDrug Claim NameDrug NamePMIDs
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