Schematic overview of the cellular and molecular mechanisms involved in the cancer progression, including the proposed cellular and molecular mechanisms in cancer cells trajectory. AT1: alveolar type 1 cells; AT2: alveolar type 2 cells; AAH: atypical adenomatous hyperplasia; AIS: adenocarcinoma in situ; MIA: minimally invasive adenocarcinoma; IA: invasive adenocarcinoma; EMT: epithelial-mesenchymal transition

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Center for Computational Systems Medicine
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Gene summary

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Malignant transformation analysis

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Malignant transformation related pathway analysis

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Cell-cell communication analysis

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Single-cell gene regulatory network inference analysis

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Somatic mutation of malignant transformation related genes

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Related drugs of malignant transformation related genes

Gene: KLF10

Gene summary for KLF10

check button Gene summary.

Gene informationSpeciesHuman
Gene symbol

KLF10

Gene ID

7071

Gene nameKruppel like factor 10
Gene AliasEGR-alpha
Cytomap8q22.3
Gene Typeprotein-coding
GO ID

GO:0000122

UniProtAcc

Q13118


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Malignant transformation analysis

check button Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells
check button Malignant transformation involving gene list.
Entrez IDSymbolReplicatesSpeciesOrganTissueAdj P-valueLog2FCMalignancy
7071KLF10LZE7THumanEsophagusESCC6.18e-10-3.26e-010.0667
7071KLF10LZE8THumanEsophagusESCC1.93e-068.14e-010.067
7071KLF10LZE22D1HumanEsophagusHGIN2.05e-02-5.50e-010.0595
7071KLF10LZE24THumanEsophagusESCC3.61e-131.23e+000.0596
7071KLF10LZE6THumanEsophagusESCC1.69e-04-4.05e-010.0845
7071KLF10P1T-EHumanEsophagusESCC4.98e-081.19e+000.0875
7071KLF10P2T-EHumanEsophagusESCC9.74e-341.09e+000.1177
7071KLF10P4T-EHumanEsophagusESCC2.73e-116.80e-010.1323
7071KLF10P5T-EHumanEsophagusESCC1.89e-156.75e-010.1327
7071KLF10P8T-EHumanEsophagusESCC1.40e-331.20e+000.0889
7071KLF10P9T-EHumanEsophagusESCC1.99e-031.36e-010.1131
7071KLF10P10T-EHumanEsophagusESCC2.72e-138.09e-010.116
7071KLF10P11T-EHumanEsophagusESCC6.67e-171.41e+000.1426
7071KLF10P12T-EHumanEsophagusESCC1.00e-271.45e+000.1122
7071KLF10P15T-EHumanEsophagusESCC3.89e-188.72e-010.1149
7071KLF10P16T-EHumanEsophagusESCC4.44e-146.58e-010.1153
7071KLF10P20T-EHumanEsophagusESCC1.78e-341.71e+000.1124
7071KLF10P21T-EHumanEsophagusESCC1.38e-178.89e-010.1617
7071KLF10P22T-EHumanEsophagusESCC1.10e-064.16e-010.1236
7071KLF10P23T-EHumanEsophagusESCC6.83e-362.10e+000.108
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check button Transcriptomic changes along malignancy continuum.
TissueExpression DynamicsAbbreviation
EsophagusThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ESCC: Esophageal squamous cell carcinoma
HGIN: High-grade intraepithelial neoplasias
LGIN: Low-grade intraepithelial neoplasias
LiverThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.HCC: Hepatocellular carcinoma
NAFLD: Non-alcoholic fatty liver disease
Oral CavityThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.EOLP: Erosive Oral lichen planus
LP: leukoplakia
NEOLP: Non-erosive oral lichen planus
OSCC: Oral squamous cell carcinoma
ProstateThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.BPH: Benign Prostatic Hyperplasia
SkinThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AK: Actinic keratosis
cSCC: Cutaneous squamous cell carcinoma
SCCIS:squamous cell carcinoma in situ
ThyroidThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ATC: Anaplastic thyroid cancer
HT: Hashimoto's thyroiditis
PTC: Papillary thyroid cancer
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.

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Malignant transformation related pathway analysis

check buttonFind out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer
check button Figure of enriched GO biological processes.
TissueDisease StageEnriched GO biological Processes
ColorectumADGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumSERGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSSGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSI-HGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumFAPGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
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check button Enriched GO biological processes.
GO IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustCount
GO:000276115EsophagusESCCregulation of myeloid leukocyte differentiation69/8552120/187236.00e-032.21e-0269
GO:00427529EsophagusESCCregulation of circadian rhythm68/8552121/187231.27e-024.21e-0268
GO:00303165EsophagusESCCosteoclast differentiation54/855294/187231.43e-024.65e-0254
GO:004259412LiverCirrhoticresponse to starvation87/4634197/187231.85e-097.78e-0887
GO:003166712LiverCirrhoticresponse to nutrient levels174/4634474/187233.08e-091.27e-07174
GO:007149612LiverCirrhoticcellular response to external stimulus123/4634320/187233.27e-081.10e-06123
GO:00316686LiverCirrhoticcellular response to extracellular stimulus96/4634246/187234.55e-071.05e-0596
GO:00092675LiverCirrhoticcellular response to starvation67/4634156/187234.58e-071.05e-0567
GO:000762312LiverCirrhoticcircadian rhythm84/4634210/187237.04e-071.50e-0584
GO:00316695LiverCirrhoticcellular response to nutrient levels85/4634215/187231.08e-062.20e-0585
GO:190165311LiverCirrhoticcellular response to peptide129/4634359/187231.23e-062.49e-05129
GO:003009912LiverCirrhoticmyeloid cell differentiation135/4634381/187231.69e-063.22e-05135
GO:004851111LiverCirrhoticrhythmic process103/4634298/187238.47e-059.19e-04103
GO:00427525LiverCirrhoticregulation of circadian rhythm45/4634121/187231.55e-031.01e-0245
GO:001982711LiverCirrhoticstem cell population maintenance48/4634131/187231.58e-031.03e-0248
GO:00015035LiverCirrhoticossification127/4634408/187231.89e-031.19e-02127
GO:00025735LiverCirrhoticmyeloid leukocyte differentiation70/4634208/187232.34e-031.42e-0270
GO:009872711LiverCirrhoticmaintenance of cell number48/4634134/187232.70e-031.58e-0248
GO:00456395LiverCirrhoticpositive regulation of myeloid cell differentiation37/4634103/187237.38e-033.52e-0237
GO:00456377LiverCirrhoticregulation of myeloid cell differentiation68/4634210/187237.40e-033.53e-0268
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check button Enriched KEGG pathways.
Pathway IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustqvalueCount
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Cell-cell communication analysis

check buttonIdentification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states
LigandReceptorLRpairPathwayTissueDisease Stage
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Single-cell gene regulatory network inference analysis

check buttonFind out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states
TFCell TypeTissueDisease StageTarget GeneRSSRegulon Activity
KLF10DCBreastADJPABPC4,CD83,IRF2BP2, etc.4.95e-02The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
KLF10INMONCervixCCCCL3L1,AZIN1-AS1,C15orf48, etc.1.98e-01The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
KLF10MONCervixCCCCL3L1,AZIN1-AS1,C15orf48, etc.2.13e-01The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
KLF10INMONCervixHSIL_HPVCCL3L1,AZIN1-AS1,C15orf48, etc.1.65e-01The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
KLF10MACColorectumCRCZSCAN5A,FOXK2,BRD1, etc.3.32e-01The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
KLF10MONColorectumCRCZSCAN5A,FOXK2,BRD1, etc.2.70e-01The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
KLF10MACColorectumHealthyZSCAN5A,FOXK2,BRD1, etc.4.38e-01The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
KLF10MONColorectumHealthyZSCAN5A,FOXK2,BRD1, etc.1.15e-01The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
KLF10MASTEndometriumADJMIIP,TJP2,MAPKAPK2, etc.1.02e-01The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
KLF10MASTEndometriumEECMIIP,TJP2,MAPKAPK2, etc.7.73e-02The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
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Somatic mutation of malignant transformation related genes

check buttonAnnotation of somatic variants for genes involved in malignant transformation
Hugo SymbolVariant ClassVariant ClassificationdbSNP RSHGVScHGVSpHGVSp ShortSWISSPROTBIOTYPESIFTPolyPhenTumor Sample BarcodeTissueHistologySexAgeStageTherapy TypesDrugsOutcome
KLF10SNVMissense_Mutationrs749961016c.551N>Ap.Ser184Tyrp.S184YQ13118protein_codingtolerated(0.98)benign(0.259)TCGA-AN-A046-01Breastbreast invasive carcinomaFemale>=65I/IIUnknownUnknownSD
KLF10SNVMissense_Mutationnovelc.442N>Tp.Pro148Serp.P148SQ13118protein_codingtolerated(0.23)benign(0.015)TCGA-BH-A0AV-01Breastbreast invasive carcinomaFemale<65I/IIChemotherapytaxotereCR
KLF10SNVMissense_Mutationnovelc.22N>Gp.Leu8Valp.L8VQ13118protein_codingtolerated_low_confidence(0.07)benign(0.014)TCGA-OL-A5RW-01Breastbreast invasive carcinomaFemale<65I/IIChemotherapyadriamycinCR
KLF10insertionIn_Frame_Insnovelc.1054_1055insATCAAAACTTGGACCCTTGGAAAACAAAAGTTTTAATTAp.Pro352delinsHisGlnAsnLeuAspProTrpLysThrLysValLeuIleThrp.P352delinsHQNLDPWKTKVLITQ13118protein_codingTCGA-A8-A0A4-01Breastbreast invasive carcinomaFemale>=65I/IIHormone TherapytamoxiphenCR
KLF10insertionIn_Frame_Insnovelc.578_579insCCCACACAGp.Val193_Glu194insProHisSerp.V193_E194insPHSQ13118protein_codingTCGA-AN-A04C-01Breastbreast invasive carcinomaFemale<65I/IIUnknownUnknownSD
KLF10insertionFrame_Shift_Insnovelc.577_578insACATTGCTCTACCTCCAACCCCTGCp.Val193AspfsTer10p.V193Dfs*10Q13118protein_codingTCGA-AN-A04C-01Breastbreast invasive carcinomaFemale<65I/IIUnknownUnknownSD
KLF10insertionNonsense_Mutationnovelc.1065_1066insTGAACTGAGTTCGCCCTCCCp.Lys356Terp.K356*Q13118protein_codingTCGA-B6-A0RG-01Breastbreast invasive carcinomaFemale<65I/IIUnknownUnknownSD
KLF10insertionNonsense_Mutationnovelc.60_61insTTCCAGTCAACATCGTGGATGTAGTGATTAAp.Glu21PhefsTer8p.E21Ffs*8Q13118protein_codingTCGA-BH-A0BA-01Breastbreast invasive carcinomaFemale<65III/IVChemotherapycytoxanSD
KLF10SNVMissense_Mutationnovelc.938N>Tp.Pro313Leup.P313LQ13118protein_codingdeleterious(0)possibly_damaging(0.665)TCGA-2W-A8YY-01Cervixcervical & endocervical cancerFemale<65I/IIChemotherapycisplatinCR
KLF10SNVMissense_Mutationnovelc.290N>Ap.Ser97Asnp.S97NQ13118protein_codingdeleterious(0)probably_damaging(0.996)TCGA-2W-A8YY-01Cervixcervical & endocervical cancerFemale<65I/IIChemotherapycisplatinCR
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Related drugs of malignant transformation related genes

check buttonIdentification of chemicals and drugs interact with genes involved in malignant transfromation
(DGIdb 4.0)
Entrez IDSymbolCategoryInteraction TypesDrug Claim NameDrug NamePMIDs
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