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Gene: KIF3B |
Gene summary for KIF3B |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | KIF3B | Gene ID | 9371 |
| Gene name | kinesin family member 3B | |
| Gene Alias | FLA8 | |
| Cytomap | 20q11.21 | |
| Gene Type | protein-coding | GO ID | GO:0000226 | UniProtAcc | O15066 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 9371 | KIF3B | HTA11_3410_2000001011 | Human | Colorectum | AD | 2.38e-02 | 1.68e-01 | 0.0155 |
| 9371 | KIF3B | HTA11_1938_2000001011 | Human | Colorectum | AD | 7.23e-05 | 5.03e-01 | -0.0811 |
| 9371 | KIF3B | HTA11_347_2000001011 | Human | Colorectum | AD | 6.04e-15 | 5.90e-01 | -0.1954 |
| 9371 | KIF3B | HTA11_696_2000001011 | Human | Colorectum | AD | 6.16e-09 | 4.02e-01 | -0.1464 |
| 9371 | KIF3B | HTA11_866_2000001011 | Human | Colorectum | AD | 1.36e-07 | 3.03e-01 | -0.1001 |
| 9371 | KIF3B | HTA11_1391_2000001011 | Human | Colorectum | AD | 2.54e-07 | 6.20e-01 | -0.059 |
| 9371 | KIF3B | HTA11_546_2000001011 | Human | Colorectum | AD | 1.66e-02 | 4.04e-01 | -0.0842 |
| 9371 | KIF3B | HTA11_7663_2000001011 | Human | Colorectum | SER | 4.54e-03 | 6.01e-01 | 0.0131 |
| 9371 | KIF3B | HTA11_7696_3000711011 | Human | Colorectum | AD | 3.86e-11 | 3.92e-01 | 0.0674 |
| 9371 | KIF3B | HTA11_99999965104_69814 | Human | Colorectum | MSS | 4.89e-02 | 3.72e-01 | 0.281 |
| 9371 | KIF3B | HTA11_99999971662_82457 | Human | Colorectum | MSS | 1.04e-40 | 1.12e+00 | 0.3859 |
| 9371 | KIF3B | HTA11_99999973899_84307 | Human | Colorectum | MSS | 4.26e-06 | 6.91e-01 | 0.2585 |
| 9371 | KIF3B | HTA11_99999974143_84620 | Human | Colorectum | MSS | 1.25e-03 | 2.59e-01 | 0.3005 |
| 9371 | KIF3B | A002-C-205 | Human | Colorectum | FAP | 8.21e-03 | 1.15e-01 | -0.1236 |
| 9371 | KIF3B | A015-C-104 | Human | Colorectum | FAP | 1.66e-02 | 6.78e-03 | -0.1899 |
| 9371 | KIF3B | A002-C-116 | Human | Colorectum | FAP | 1.00e-02 | 4.09e-03 | -0.0452 |
| 9371 | KIF3B | CRC-3-11773 | Human | Colorectum | CRC | 4.91e-08 | 4.84e-01 | 0.2564 |
| 9371 | KIF3B | LZE4T | Human | Esophagus | ESCC | 2.50e-08 | 2.01e-01 | 0.0811 |
| 9371 | KIF3B | LZE20T | Human | Esophagus | ESCC | 3.97e-02 | 5.39e-02 | 0.0662 |
| 9371 | KIF3B | LZE24T | Human | Esophagus | ESCC | 1.33e-21 | 7.32e-01 | 0.0596 |
| Page: 1 2 3 4 5 6 7 |
| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Colorectum (GSE201348) |  | FAP: Familial adenomatous polyposis |
| CRC: Colorectal cancer | ||
| Colorectum (HTA11) |  | AD: Adenomas |
| SER: Sessile serrated lesions | ||
| MSI-H: Microsatellite-high colorectal cancer | ||
| MSS: Microsatellite stable colorectal cancer | ||
| Esophagus |  | ESCC: Esophageal squamous cell carcinoma |
| HGIN: High-grade intraepithelial neoplasias | ||
| LGIN: Low-grade intraepithelial neoplasias | ||
| Liver |  | HCC: Hepatocellular carcinoma |
| NAFLD: Non-alcoholic fatty liver disease | ||
| Oral Cavity |  | EOLP: Erosive Oral lichen planus |
| LP: leukoplakia | ||
| NEOLP: Non-erosive oral lichen planus | ||
| OSCC: Oral squamous cell carcinoma | ||
| Prostate |  | BPH: Benign Prostatic Hyperplasia |
| Thyroid |  | ATC: Anaplastic thyroid cancer |
| HT: Hashimoto's thyroiditis | ||
| PTC: Papillary thyroid cancer |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| GO:00009103 | Colorectum | FAP | cytokinesis | 37/2622 | 173/18723 | 5.10e-03 | 3.37e-02 | 37 |
| GO:0008088 | Colorectum | FAP | axo-dendritic transport | 19/2622 | 75/18723 | 6.44e-03 | 4.01e-02 | 19 |
| GO:00516564 | Colorectum | CRC | establishment of organelle localization | 76/2078 | 390/18723 | 6.53e-07 | 4.50e-05 | 76 |
| GO:00307054 | Colorectum | CRC | cytoskeleton-dependent intracellular transport | 45/2078 | 195/18723 | 1.29e-06 | 7.21e-05 | 45 |
| GO:00516504 | Colorectum | CRC | establishment of vesicle localization | 39/2078 | 161/18723 | 1.82e-06 | 9.07e-05 | 39 |
| GO:00516484 | Colorectum | CRC | vesicle localization | 41/2078 | 177/18723 | 3.39e-06 | 1.50e-04 | 41 |
| GO:00995181 | Colorectum | CRC | vesicle cytoskeletal trafficking | 21/2078 | 73/18723 | 2.87e-05 | 7.61e-04 | 21 |
| GO:00457873 | Colorectum | CRC | positive regulation of cell cycle | 55/2078 | 313/18723 | 3.76e-04 | 5.57e-03 | 55 |
| GO:00009104 | Colorectum | CRC | cytokinesis | 34/2078 | 173/18723 | 6.47e-04 | 8.55e-03 | 34 |
| GO:00903072 | Colorectum | CRC | mitotic spindle assembly | 16/2078 | 65/18723 | 1.62e-03 | 1.69e-02 | 16 |
| GO:0010970 | Colorectum | CRC | transport along microtubule | 30/2078 | 155/18723 | 1.67e-03 | 1.73e-02 | 30 |
| GO:00723842 | Colorectum | CRC | organelle transport along microtubule | 19/2078 | 85/18723 | 2.12e-03 | 2.09e-02 | 19 |
| GO:00080881 | Colorectum | CRC | axo-dendritic transport | 17/2078 | 75/18723 | 3.04e-03 | 2.71e-02 | 17 |
| GO:00070513 | Colorectum | CRC | spindle organization | 32/2078 | 184/18723 | 6.70e-03 | 4.77e-02 | 32 |
| GO:00900682 | Colorectum | CRC | positive regulation of cell cycle process | 39/2078 | 236/18723 | 7.23e-03 | 4.98e-02 | 39 |
| GO:014001414 | Esophagus | ESCC | mitotic nuclear division | 218/8552 | 287/18723 | 6.17e-26 | 1.78e-23 | 218 |
| GO:005165617 | Esophagus | ESCC | establishment of organelle localization | 273/8552 | 390/18723 | 9.13e-23 | 1.81e-20 | 273 |
| GO:190285015 | Esophagus | ESCC | microtubule cytoskeleton organization involved in mitosis | 116/8552 | 147/18723 | 1.25e-16 | 9.91e-15 | 116 |
| GO:000705214 | Esophagus | ESCC | mitotic spindle organization | 97/8552 | 120/18723 | 2.17e-15 | 1.33e-13 | 97 |
| GO:000705114 | Esophagus | ESCC | spindle organization | 134/8552 | 184/18723 | 5.70e-14 | 2.87e-12 | 134 |
| Page: 1 2 3 4 5 6 7 8 9 10 11 12 |
| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
| Page: 1 |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
| Page: 1 |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| KIF3B | SNV | Missense_Mutation | c.1484N>T | p.Lys495Ile | p.K495I | O15066 | protein_coding | deleterious(0) | possibly_damaging(0.514) | TCGA-A7-A13D-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cytoxan | SD | |
| KIF3B | SNV | Missense_Mutation | c.1579T>C | p.Tyr527His | p.Y527H | O15066 | protein_coding | tolerated(0.07) | probably_damaging(0.947) | TCGA-AO-A128-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | SD | |
| KIF3B | SNV | Missense_Mutation | novel | c.122N>G | p.Val41Gly | p.V41G | O15066 | protein_coding | deleterious(0) | probably_damaging(0.99) | TCGA-BH-A1F8-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD |
| KIF3B | SNV | Missense_Mutation | novel | c.1367A>G | p.Glu456Gly | p.E456G | O15066 | protein_coding | deleterious(0) | possibly_damaging(0.71) | TCGA-C8-A273-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD |
| KIF3B | insertion | Nonsense_Mutation | novel | c.2191_2192insATCATT | p.Gly731delinsAspHisTer | p.G731delinsDH* | O15066 | protein_coding | TCGA-AR-A0TY-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unspecific | Paclitaxel | PD | ||
| KIF3B | insertion | In_Frame_Ins | novel | c.2192_2193insGAAACTACATCCTAT | p.Gly731_Thr732insLysLeuHisProIle | p.G731_T732insKLHPI | O15066 | protein_coding | TCGA-AR-A0TY-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unspecific | Paclitaxel | PD | ||
| KIF3B | SNV | Missense_Mutation | novel | c.952N>A | p.Gly318Arg | p.G318R | O15066 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
| KIF3B | SNV | Missense_Mutation | c.646N>G | p.His216Asp | p.H216D | O15066 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-BI-A0VR-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Unknown | Unknown | SD | |
| KIF3B | SNV | Missense_Mutation | novel | c.1231N>T | p.Asp411Tyr | p.D411Y | O15066 | protein_coding | deleterious(0.01) | benign(0.396) | TCGA-C5-A1MN-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Chemotherapy | cisplatin | SD |
| KIF3B | SNV | Missense_Mutation | novel | c.2186N>T | p.Ser729Phe | p.S729F | O15066 | protein_coding | deleterious(0.04) | benign(0.133) | TCGA-C5-A2LY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | SD |
| Page: 1 2 3 4 5 6 7 8 |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
| Page: 1 |
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