Tissue | Expression Dynamics | Abbreviation |
Esophagus | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Esophagus/KIF2A_pca_on_diff_genes.png) | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias |
LGIN: Low-grade intraepithelial neoplasias |
Liver | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Liver/KIF2A_pca_on_diff_genes.png) | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
Lung | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Lung/KIF2A_pca_on_diff_genes.png) | AAH: Atypical adenomatous hyperplasia |
AIS: Adenocarcinoma in situ |
IAC: Invasive lung adenocarcinoma |
MIA: Minimally invasive adenocarcinoma |
Oral Cavity | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/OralCavity/KIF2A_pca_on_diff_genes.png) | EOLP: Erosive Oral lichen planus |
LP: leukoplakia |
NEOLP: Non-erosive oral lichen planus |
OSCC: Oral squamous cell carcinoma |
Skin | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Skin/KIF2A_pca_on_diff_genes.png) | AK: Actinic keratosis |
cSCC: Cutaneous squamous cell carcinoma |
SCCIS:squamous cell carcinoma in situ |
Thyroid | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Thyroid/KIF2A_pca_on_diff_genes.png) | ATC: Anaplastic thyroid cancer |
HT: Hashimoto's thyroiditis |
PTC: Papillary thyroid cancer |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00070519 | Skin | AK | spindle organization | 37/1910 | 184/18723 | 4.21e-05 | 6.70e-04 | 37 |
GO:00903078 | Skin | AK | mitotic spindle assembly | 16/1910 | 65/18723 | 6.54e-04 | 5.64e-03 | 16 |
GO:00512257 | Skin | AK | spindle assembly | 24/1910 | 117/18723 | 6.54e-04 | 5.64e-03 | 24 |
GO:19028508 | Skin | AK | microtubule cytoskeleton organization involved in mitosis | 28/1910 | 147/18723 | 8.48e-04 | 7.02e-03 | 28 |
GO:00070528 | Skin | AK | mitotic spindle organization | 24/1910 | 120/18723 | 9.53e-04 | 7.64e-03 | 24 |
GO:00512615 | Skin | AK | protein depolymerization | 22/1910 | 114/18723 | 2.44e-03 | 1.59e-02 | 22 |
GO:00436246 | Skin | AK | cellular protein complex disassembly | 25/1910 | 136/18723 | 2.59e-03 | 1.67e-02 | 25 |
GO:01400147 | Skin | AK | mitotic nuclear division | 44/1910 | 287/18723 | 3.98e-03 | 2.34e-02 | 44 |
GO:00311095 | Skin | AK | microtubule polymerization or depolymerization | 22/1910 | 122/18723 | 5.74e-03 | 3.13e-02 | 22 |
GO:014001415 | Skin | cSCC | mitotic nuclear division | 149/4864 | 287/18723 | 3.59e-21 | 6.43e-19 | 149 |
GO:0022411112 | Skin | cSCC | cellular component disassembly | 201/4864 | 443/18723 | 4.09e-19 | 5.69e-17 | 201 |
GO:190285016 | Skin | cSCC | microtubule cytoskeleton organization involved in mitosis | 85/4864 | 147/18723 | 2.66e-16 | 2.39e-14 | 85 |
GO:000705215 | Skin | cSCC | mitotic spindle organization | 73/4864 | 120/18723 | 7.81e-16 | 6.80e-14 | 73 |
GO:000705115 | Skin | cSCC | spindle organization | 96/4864 | 184/18723 | 2.59e-14 | 1.77e-12 | 96 |
GO:00482854 | Skin | cSCC | organelle fission | 197/4864 | 488/18723 | 1.51e-12 | 8.36e-11 | 197 |
GO:00002803 | Skin | cSCC | nuclear division | 178/4864 | 439/18723 | 1.17e-11 | 5.93e-10 | 178 |
GO:009030716 | Skin | cSCC | mitotic spindle assembly | 41/4864 | 65/18723 | 3.34e-10 | 1.37e-08 | 41 |
GO:005122513 | Skin | cSCC | spindle assembly | 60/4864 | 117/18723 | 4.15e-09 | 1.41e-07 | 60 |
GO:003298418 | Skin | cSCC | protein-containing complex disassembly | 98/4864 | 224/18723 | 5.31e-09 | 1.77e-07 | 98 |
GO:003110911 | Skin | cSCC | microtubule polymerization or depolymerization | 45/4864 | 122/18723 | 5.05e-03 | 2.56e-02 | 45 |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
KIF2A | SNV | Missense_Mutation | rs767638932 | c.182N>T | p.Ser61Leu | p.S61L | O00139 | protein_coding | tolerated(0.11) | benign(0.007) | TCGA-A1-A0SF-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | tc | SD |
KIF2A | SNV | Missense_Mutation | | c.208N>A | p.Glu70Lys | p.E70K | O00139 | protein_coding | tolerated(0.36) | benign(0.155) | TCGA-A8-A09N-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
KIF2A | SNV | Missense_Mutation | | c.2045N>T | p.Ala682Val | p.A682V | O00139 | protein_coding | tolerated(0.48) | benign(0.001) | TCGA-A8-A09Z-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
KIF2A | SNV | Missense_Mutation | | c.1675N>C | p.Asp559His | p.D559H | O00139 | protein_coding | tolerated(0.08) | probably_damaging(0.996) | TCGA-B6-A0IE-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | PD |
KIF2A | SNV | Missense_Mutation | | c.674G>A | p.Cys225Tyr | p.C225Y | O00139 | protein_coding | deleterious(0) | probably_damaging(0.987) | TCGA-BH-A18G-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
KIF2A | SNV | Missense_Mutation | | c.72N>G | p.Ile24Met | p.I24M | O00139 | protein_coding | deleterious(0) | possibly_damaging(0.885) | TCGA-D8-A27M-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | methotrexate+5 | SD |
KIF2A | insertion | In_Frame_Ins | novel | c.1307_1308insGTCCTT | p.His436delinsGlnSerPhe | p.H436delinsQSF | O00139 | protein_coding | | | TCGA-AN-A0FS-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
KIF2A | insertion | Frame_Shift_Ins | novel | c.1309_1310insAAACTTTTCAACTT | p.Ala437GlufsTer55 | p.A437Efs*55 | O00139 | protein_coding | | | TCGA-AN-A0FS-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
KIF2A | SNV | Missense_Mutation | | c.177N>G | p.Ile59Met | p.I59M | O00139 | protein_coding | deleterious(0) | possibly_damaging(0.805) | TCGA-Q1-A73O-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
KIF2A | SNV | Missense_Mutation | | c.1741N>G | p.Phe581Val | p.F581V | O00139 | protein_coding | tolerated(0.52) | probably_damaging(0.943) | TCGA-Q1-A73O-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |