Tissue | Expression Dynamics | Abbreviation |
Colorectum (GSE201348) | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Colorectum/Becker/KIF26B_pca_on_diff_genes.png) | FAP: Familial adenomatous polyposis |
CRC: Colorectal cancer |
Colorectum (HTA11) | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Colorectum/Chen/KIF26B_pca_on_diff_genes.png) | AD: Adenomas |
SER: Sessile serrated lesions |
MSI-H: Microsatellite-high colorectal cancer |
MSS: Microsatellite stable colorectal cancer |
Endometrium | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Endometrium/KIF26B_pca_on_diff_genes.png) | AEH: Atypical endometrial hyperplasia |
EEC: Endometrioid Cancer |
Liver | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Liver/KIF26B_pca_on_diff_genes.png) | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
Lung | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Lung/KIF26B_pca_on_diff_genes.png) | AAH: Atypical adenomatous hyperplasia |
AIS: Adenocarcinoma in situ |
IAC: Invasive lung adenocarcinoma |
MIA: Minimally invasive adenocarcinoma |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00609932 | Endometrium | AEH | kidney morphogenesis | 24/2100 | 93/18723 | 6.73e-05 | 1.04e-03 | 24 |
GO:002240910 | Endometrium | AEH | positive regulation of cell-cell adhesion | 54/2100 | 284/18723 | 6.94e-05 | 1.07e-03 | 54 |
GO:00016562 | Endometrium | AEH | metanephros development | 22/2100 | 85/18723 | 1.27e-04 | 1.74e-03 | 22 |
GO:00720736 | Endometrium | AEH | kidney epithelium development | 29/2100 | 136/18723 | 4.71e-04 | 4.91e-03 | 29 |
GO:00613263 | Endometrium | AEH | renal tubule development | 22/2100 | 94/18723 | 5.89e-04 | 5.82e-03 | 22 |
GO:00720093 | Endometrium | AEH | nephron epithelium development | 24/2100 | 109/18723 | 8.69e-04 | 8.03e-03 | 24 |
GO:00720064 | Endometrium | AEH | nephron development | 29/2100 | 142/18723 | 9.80e-04 | 8.89e-03 | 29 |
GO:0061333 | Endometrium | AEH | renal tubule morphogenesis | 18/2100 | 75/18723 | 1.32e-03 | 1.12e-02 | 18 |
GO:00018232 | Endometrium | AEH | mesonephros development | 21/2100 | 96/18723 | 1.93e-03 | 1.52e-02 | 21 |
GO:00016573 | Endometrium | AEH | ureteric bud development | 20/2100 | 91/18723 | 2.31e-03 | 1.74e-02 | 20 |
GO:00720804 | Endometrium | AEH | nephron tubule development | 20/2100 | 91/18723 | 2.31e-03 | 1.74e-02 | 20 |
GO:00721633 | Endometrium | AEH | mesonephric epithelium development | 20/2100 | 92/18723 | 2.64e-03 | 1.93e-02 | 20 |
GO:00721643 | Endometrium | AEH | mesonephric tubule development | 20/2100 | 92/18723 | 2.64e-03 | 1.93e-02 | 20 |
GO:00720282 | Endometrium | AEH | nephron morphogenesis | 17/2100 | 76/18723 | 3.92e-03 | 2.64e-02 | 17 |
GO:00720882 | Endometrium | AEH | nephron epithelium morphogenesis | 16/2100 | 73/18723 | 6.21e-03 | 3.70e-02 | 16 |
GO:0060675 | Endometrium | AEH | ureteric bud morphogenesis | 14/2100 | 62/18723 | 7.72e-03 | 4.33e-02 | 14 |
GO:0072171 | Endometrium | AEH | mesonephric tubule morphogenesis | 14/2100 | 63/18723 | 8.93e-03 | 4.84e-02 | 14 |
GO:004578517 | Endometrium | EEC | positive regulation of cell adhesion | 98/2168 | 437/18723 | 6.15e-11 | 8.38e-09 | 98 |
GO:000716315 | Endometrium | EEC | establishment or maintenance of cell polarity | 56/2168 | 218/18723 | 5.41e-09 | 3.57e-07 | 56 |
GO:006056013 | Endometrium | EEC | developmental growth involved in morphogenesis | 54/2168 | 234/18723 | 4.60e-07 | 1.78e-05 | 54 |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
KIF26B | SNV | Missense_Mutation | novel | c.4771N>G | p.Arg1591Gly | p.R1591G | Q2KJY2 | protein_coding | deleterious(0.02) | benign(0.313) | TCGA-3C-AALI-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unspecific | Poly E | Complete Response |
KIF26B | SNV | Missense_Mutation | | c.3383N>A | p.Pro1128Gln | p.P1128Q | Q2KJY2 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-A8-A06X-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
KIF26B | SNV | Missense_Mutation | rs369084969 | c.706N>A | p.Val236Met | p.V236M | Q2KJY2 | protein_coding | tolerated(0.6) | benign(0.001) | TCGA-A8-A06Z-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
KIF26B | SNV | Missense_Mutation | rs199933797 | c.6071G>A | p.Arg2024His | p.R2024H | Q2KJY2 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-A8-A08L-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
KIF26B | SNV | Missense_Mutation | novel | c.6133A>T | p.Thr2045Ser | p.T2045S | Q2KJY2 | protein_coding | deleterious(0) | probably_damaging(0.991) | TCGA-A8-A08P-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Chemotherapy | 5-fluorouracil | CR |
KIF26B | SNV | Missense_Mutation | | c.1455N>G | p.Asp485Glu | p.D485E | Q2KJY2 | protein_coding | tolerated(0.19) | benign(0.444) | TCGA-A8-A09E-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Hormone Therapy | anastrozole | SD |
KIF26B | SNV | Missense_Mutation | | c.935N>G | p.His312Arg | p.H312R | Q2KJY2 | protein_coding | deleterious(0.01) | possibly_damaging(0.626) | TCGA-A8-A09Z-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
KIF26B | SNV | Missense_Mutation | novel | c.543N>G | p.Asp181Glu | p.D181E | Q2KJY2 | protein_coding | tolerated(1) | benign(0.094) | TCGA-AC-A2BK-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Chemotherapy | cytoxan | CR |
KIF26B | SNV | Missense_Mutation | novel | c.3930N>A | p.Met1310Ile | p.M1310I | Q2KJY2 | protein_coding | deleterious(0.04) | benign(0.01) | TCGA-AC-A3HN-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
KIF26B | SNV | Missense_Mutation | novel | c.1758G>T | p.Lys586Asn | p.K586N | Q2KJY2 | protein_coding | deleterious(0) | probably_damaging(0.992) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |