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Gene: JKAMP |
Gene summary for JKAMP |
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Gene information | Species | Human | Gene symbol | JKAMP | Gene ID | 51528 |
Gene name | JNK1/MAPK8 associated membrane protein | |
Gene Alias | C14orf100 | |
Cytomap | 14q23.1 | |
Gene Type | protein-coding | GO ID | GO:0006508 | UniProtAcc | Q9P055 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
51528 | JKAMP | LZE4T | Human | Esophagus | ESCC | 2.51e-17 | 5.78e-01 | 0.0811 |
51528 | JKAMP | LZE8T | Human | Esophagus | ESCC | 2.03e-11 | 4.79e-01 | 0.067 |
51528 | JKAMP | LZE20T | Human | Esophagus | ESCC | 1.03e-04 | 3.42e-01 | 0.0662 |
51528 | JKAMP | LZE22T | Human | Esophagus | ESCC | 3.75e-06 | 5.64e-01 | 0.068 |
51528 | JKAMP | LZE24T | Human | Esophagus | ESCC | 4.17e-14 | 4.40e-01 | 0.0596 |
51528 | JKAMP | LZE6T | Human | Esophagus | ESCC | 5.92e-03 | 3.20e-01 | 0.0845 |
51528 | JKAMP | P2T-E | Human | Esophagus | ESCC | 9.33e-29 | 4.32e-01 | 0.1177 |
51528 | JKAMP | P4T-E | Human | Esophagus | ESCC | 8.34e-17 | 5.08e-01 | 0.1323 |
51528 | JKAMP | P5T-E | Human | Esophagus | ESCC | 4.37e-19 | 4.36e-01 | 0.1327 |
51528 | JKAMP | P8T-E | Human | Esophagus | ESCC | 5.07e-32 | 6.37e-01 | 0.0889 |
51528 | JKAMP | P9T-E | Human | Esophagus | ESCC | 1.48e-08 | 2.71e-01 | 0.1131 |
51528 | JKAMP | P10T-E | Human | Esophagus | ESCC | 3.57e-25 | 4.85e-01 | 0.116 |
51528 | JKAMP | P11T-E | Human | Esophagus | ESCC | 2.17e-22 | 9.11e-01 | 0.1426 |
51528 | JKAMP | P12T-E | Human | Esophagus | ESCC | 2.53e-44 | 7.62e-01 | 0.1122 |
51528 | JKAMP | P15T-E | Human | Esophagus | ESCC | 1.25e-45 | 1.02e+00 | 0.1149 |
51528 | JKAMP | P16T-E | Human | Esophagus | ESCC | 1.31e-24 | 4.37e-01 | 0.1153 |
51528 | JKAMP | P17T-E | Human | Esophagus | ESCC | 1.31e-06 | 4.29e-01 | 0.1278 |
51528 | JKAMP | P19T-E | Human | Esophagus | ESCC | 8.70e-13 | 8.09e-01 | 0.1662 |
51528 | JKAMP | P20T-E | Human | Esophagus | ESCC | 7.19e-21 | 4.72e-01 | 0.1124 |
51528 | JKAMP | P21T-E | Human | Esophagus | ESCC | 8.59e-41 | 7.57e-01 | 0.1617 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00304336 | Skin | cSCC | ubiquitin-dependent ERAD pathway | 43/4864 | 85/18723 | 1.02e-06 | 1.82e-05 | 43 |
GO:00365037 | Skin | cSCC | ERAD pathway | 51/4864 | 107/18723 | 1.11e-06 | 1.95e-05 | 51 |
GO:0010498113 | Thyroid | PTC | proteasomal protein catabolic process | 297/5968 | 490/18723 | 4.58e-40 | 9.63e-37 | 297 |
GO:0043161113 | Thyroid | PTC | proteasome-mediated ubiquitin-dependent protein catabolic process | 254/5968 | 412/18723 | 3.91e-36 | 4.54e-33 | 254 |
GO:0034976113 | Thyroid | PTC | response to endoplasmic reticulum stress | 161/5968 | 256/18723 | 1.14e-24 | 3.27e-22 | 161 |
GO:0035966113 | Thyroid | PTC | response to topologically incorrect protein | 101/5968 | 159/18723 | 2.00e-16 | 1.66e-14 | 101 |
GO:0006986113 | Thyroid | PTC | response to unfolded protein | 87/5968 | 137/18723 | 2.46e-14 | 1.57e-12 | 87 |
GO:00365038 | Thyroid | PTC | ERAD pathway | 71/5968 | 107/18723 | 2.37e-13 | 1.22e-11 | 71 |
GO:003043315 | Thyroid | PTC | ubiquitin-dependent ERAD pathway | 59/5968 | 85/18723 | 1.30e-12 | 5.91e-11 | 59 |
GO:001049832 | Thyroid | ATC | proteasomal protein catabolic process | 309/6293 | 490/18723 | 1.78e-41 | 1.13e-37 | 309 |
GO:0043161210 | Thyroid | ATC | proteasome-mediated ubiquitin-dependent protein catabolic process | 265/6293 | 412/18723 | 7.09e-38 | 1.49e-34 | 265 |
GO:003497633 | Thyroid | ATC | response to endoplasmic reticulum stress | 167/6293 | 256/18723 | 2.62e-25 | 1.03e-22 | 167 |
GO:003596633 | Thyroid | ATC | response to topologically incorrect protein | 102/6293 | 159/18723 | 2.87e-15 | 1.99e-13 | 102 |
GO:000698633 | Thyroid | ATC | response to unfolded protein | 88/6293 | 137/18723 | 2.04e-13 | 9.91e-12 | 88 |
GO:003650322 | Thyroid | ATC | ERAD pathway | 72/6293 | 107/18723 | 1.05e-12 | 4.41e-11 | 72 |
GO:003043322 | Thyroid | ATC | ubiquitin-dependent ERAD pathway | 60/6293 | 85/18723 | 3.38e-12 | 1.38e-10 | 60 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
JKAMP | SNV | Missense_Mutation | c.58C>G | p.Gln20Glu | p.Q20E | protein_coding | tolerated(0.33) | benign(0.017) | TCGA-FU-A40J-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Chemotherapy | carboplatin | CR | ||
JKAMP | SNV | Missense_Mutation | c.529T>C | p.Phe177Leu | p.F177L | protein_coding | tolerated(0.85) | benign(0.391) | TCGA-AA-3815-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
JKAMP | SNV | Missense_Mutation | c.898N>G | p.Thr300Ala | p.T300A | protein_coding | tolerated(0.34) | benign(0) | TCGA-AA-3854-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
JKAMP | SNV | Missense_Mutation | c.393T>G | p.Ile131Met | p.I131M | protein_coding | deleterious(0) | benign(0.428) | TCGA-AA-3977-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | ||
JKAMP | SNV | Missense_Mutation | c.277N>C | p.Tyr93His | p.Y93H | protein_coding | tolerated(0.48) | benign(0.366) | TCGA-AG-3892-01 | Colorectum | rectum adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
JKAMP | SNV | Missense_Mutation | c.772N>A | p.Leu258Ile | p.L258I | protein_coding | tolerated(0.06) | benign(0.319) | TCGA-AG-3892-01 | Colorectum | rectum adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
JKAMP | SNV | Missense_Mutation | novel | c.833G>A | p.Gly278Glu | p.G278E | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD | |
JKAMP | SNV | Missense_Mutation | novel | c.302C>A | p.Ala101Glu | p.A101E | protein_coding | tolerated(0.47) | possibly_damaging(0.698) | TCGA-AP-A051-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
JKAMP | SNV | Missense_Mutation | novel | c.444C>A | p.Asn148Lys | p.N148K | protein_coding | deleterious(0.01) | probably_damaging(0.996) | TCGA-AP-A051-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
JKAMP | SNV | Missense_Mutation | c.812A>G | p.His271Arg | p.H271R | protein_coding | deleterious(0) | benign(0.343) | TCGA-AP-A056-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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