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Gene: ISG20 |
Gene summary for ISG20 |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | ISG20 | Gene ID | 3669 |
| Gene name | interferon stimulated exonuclease gene 20 | |
| Gene Alias | CD25 | |
| Cytomap | 15q26.1 | |
| Gene Type | protein-coding | GO ID | GO:0000738 | UniProtAcc | Q96AZ6 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 3669 | ISG20 | CA_HPV_1 | Human | Cervix | CC | 2.66e-13 | 5.01e-01 | 0.0264 |
| 3669 | ISG20 | Tumor | Human | Cervix | CC | 4.46e-08 | 3.68e-01 | 0.1241 |
| 3669 | ISG20 | sample1 | Human | Cervix | CC | 2.21e-10 | 5.98e-01 | 0.0959 |
| 3669 | ISG20 | sample3 | Human | Cervix | CC | 1.06e-15 | 3.85e-01 | 0.1387 |
| 3669 | ISG20 | T1 | Human | Cervix | CC | 1.20e-11 | 4.61e-01 | 0.0918 |
| 3669 | ISG20 | T3 | Human | Cervix | CC | 2.52e-08 | 3.92e-01 | 0.1389 |
| 3669 | ISG20 | HTA11_2487_2000001011 | Human | Colorectum | SER | 4.03e-11 | 6.08e-01 | -0.1808 |
| 3669 | ISG20 | HTA11_411_2000001011 | Human | Colorectum | SER | 1.78e-04 | 1.25e+00 | -0.2602 |
| 3669 | ISG20 | HTA11_2112_2000001011 | Human | Colorectum | SER | 3.48e-05 | 7.57e-01 | -0.2196 |
| 3669 | ISG20 | HTA11_696_2000001011 | Human | Colorectum | AD | 7.09e-03 | 2.00e-01 | -0.1464 |
| 3669 | ISG20 | AEH-subject5 | Human | Endometrium | AEH | 1.61e-04 | 3.00e-01 | -0.2953 |
| 3669 | ISG20 | EEC-subject4 | Human | Endometrium | EEC | 2.30e-21 | 6.66e-01 | -0.2571 |
| 3669 | ISG20 | EEC-subject5 | Human | Endometrium | EEC | 1.31e-07 | 4.56e-01 | -0.249 |
| 3669 | ISG20 | GSM5276934 | Human | Endometrium | EEC | 1.14e-02 | 3.39e-01 | -0.0913 |
| 3669 | ISG20 | GSM6177621_NYU_UCEC2_lib1_lib1 | Human | Endometrium | EEC | 3.02e-03 | -6.27e-02 | -0.1934 |
| 3669 | ISG20 | GSM6177622_NYU_UCEC3_lib1_lib1 | Human | Endometrium | EEC | 7.07e-03 | 4.58e-02 | -0.1917 |
| 3669 | ISG20 | GSM6177622_NYU_UCEC3_lib2_lib2 | Human | Endometrium | EEC | 4.80e-02 | 2.84e-02 | -0.1916 |
| 3669 | ISG20 | LZE4T | Human | Esophagus | ESCC | 4.69e-07 | 4.02e-01 | 0.0811 |
| 3669 | ISG20 | LZE5T | Human | Esophagus | ESCC | 1.46e-03 | 3.43e-01 | 0.0514 |
| 3669 | ISG20 | LZE7T | Human | Esophagus | ESCC | 1.18e-04 | 8.65e-01 | 0.0667 |
| Page: 1 2 3 4 5 6 7 8 |
| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Cervix |  | CC: Cervix cancer |
| HSIL_HPV: HPV-infected high-grade squamous intraepithelial lesions | ||
| N_HPV: HPV-infected normal cervix | ||
| Colorectum (GSE201348) |  | FAP: Familial adenomatous polyposis |
| CRC: Colorectal cancer | ||
| Colorectum (HTA11) |  | AD: Adenomas |
| SER: Sessile serrated lesions | ||
| MSI-H: Microsatellite-high colorectal cancer | ||
| MSS: Microsatellite stable colorectal cancer | ||
| Endometrium |  | AEH: Atypical endometrial hyperplasia |
| EEC: Endometrioid Cancer | ||
| Esophagus |  | ESCC: Esophageal squamous cell carcinoma |
| HGIN: High-grade intraepithelial neoplasias | ||
| LGIN: Low-grade intraepithelial neoplasias | ||
| GC |  | CAG: Chronic atrophic gastritis |
| CAG with IM: Chronic atrophic gastritis with intestinal metaplasia | ||
| CSG: Chronic superficial gastritis | ||
| GC: Gastric cancer | ||
| SIM: Severe intestinal metaplasia | ||
| WIM: Wild intestinal metaplasia | ||
| Liver |  | HCC: Hepatocellular carcinoma |
| NAFLD: Non-alcoholic fatty liver disease | ||
| Oral Cavity |  | EOLP: Erosive Oral lichen planus |
| LP: leukoplakia | ||
| NEOLP: Non-erosive oral lichen planus | ||
| OSCC: Oral squamous cell carcinoma | ||
| Prostate |  | BPH: Benign Prostatic Hyperplasia |
| Thyroid |  | ATC: Anaplastic thyroid cancer |
| HT: Hashimoto's thyroiditis | ||
| PTC: Papillary thyroid cancer |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| GO:00507921 | Colorectum | SER | regulation of viral process | 43/2897 | 164/18723 | 2.57e-04 | 4.31e-03 | 43 |
| GO:19013611 | Colorectum | SER | organic cyclic compound catabolic process | 104/2897 | 495/18723 | 5.46e-04 | 7.63e-03 | 104 |
| GO:00346551 | Colorectum | SER | nucleobase-containing compound catabolic process | 88/2897 | 407/18723 | 5.53e-04 | 7.71e-03 | 88 |
| GO:00194391 | Colorectum | SER | aromatic compound catabolic process | 98/2897 | 467/18723 | 8.09e-04 | 1.01e-02 | 98 |
| GO:19039001 | Colorectum | SER | regulation of viral life cycle | 38/2897 | 148/18723 | 8.76e-04 | 1.06e-02 | 38 |
| GO:00422541 | Colorectum | SER | ribosome biogenesis | 66/2897 | 299/18723 | 1.48e-03 | 1.60e-02 | 66 |
| GO:00064011 | Colorectum | SER | RNA catabolic process | 62/2897 | 278/18723 | 1.56e-03 | 1.67e-02 | 62 |
| GO:001603216 | Endometrium | AEH | viral process | 110/2100 | 415/18723 | 1.99e-18 | 1.09e-15 | 110 |
| GO:001905816 | Endometrium | AEH | viral life cycle | 86/2100 | 317/18723 | 2.53e-15 | 7.58e-13 | 86 |
| GO:002261316 | Endometrium | AEH | ribonucleoprotein complex biogenesis | 107/2100 | 463/18723 | 1.43e-13 | 4.08e-11 | 107 |
| GO:001907916 | Endometrium | AEH | viral genome replication | 43/2100 | 131/18723 | 3.22e-11 | 4.60e-09 | 43 |
| GO:004225416 | Endometrium | AEH | ribosome biogenesis | 67/2100 | 299/18723 | 1.95e-08 | 1.18e-06 | 67 |
| GO:000640110 | Endometrium | AEH | RNA catabolic process | 63/2100 | 278/18723 | 3.28e-08 | 1.87e-06 | 63 |
| GO:005079216 | Endometrium | AEH | regulation of viral process | 40/2100 | 164/18723 | 1.46e-06 | 4.66e-05 | 40 |
| GO:190390016 | Endometrium | AEH | regulation of viral life cycle | 36/2100 | 148/18723 | 5.13e-06 | 1.32e-04 | 36 |
| GO:00063648 | Endometrium | AEH | rRNA processing | 47/2100 | 225/18723 | 1.78e-05 | 3.65e-04 | 47 |
| GO:003465510 | Endometrium | AEH | nucleobase-containing compound catabolic process | 74/2100 | 407/18723 | 1.78e-05 | 3.65e-04 | 74 |
| GO:004427010 | Endometrium | AEH | cellular nitrogen compound catabolic process | 80/2100 | 451/18723 | 2.09e-05 | 4.13e-04 | 80 |
| GO:00467009 | Endometrium | AEH | heterocycle catabolic process | 79/2100 | 445/18723 | 2.27e-05 | 4.35e-04 | 79 |
| GO:00160728 | Endometrium | AEH | rRNA metabolic process | 48/2100 | 236/18723 | 3.01e-05 | 5.54e-04 | 48 |
| Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 |
| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
| Page: 1 |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| ISG20 | SNV | Missense_Mutation | rs371941091 | c.182N>A | p.Pro61His | p.P61H | Q96AZ6 | protein_coding | tolerated(0.08) | benign(0.222) | TCGA-A6-3809-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
| ISG20 | SNV | Missense_Mutation | novel | c.439N>T | p.Leu147Phe | p.L147F | Q96AZ6 | protein_coding | tolerated(0.07) | benign(0.003) | TCGA-AA-3947-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
| ISG20 | SNV | Missense_Mutation | rs549880749 | c.353N>A | p.Arg118His | p.R118H | Q96AZ6 | protein_coding | tolerated(0.2) | benign(0.006) | TCGA-AG-3731-01 | Colorectum | rectum adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | folinic | PR |
| ISG20 | SNV | Missense_Mutation | rs149381576 | c.380G>A | p.Arg127His | p.R127H | Q96AZ6 | protein_coding | tolerated(0.14) | benign(0.148) | TCGA-AP-A051-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
| ISG20 | SNV | Missense_Mutation | c.209N>G | p.Phe70Cys | p.F70C | Q96AZ6 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-AP-A056-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
| ISG20 | SNV | Missense_Mutation | c.325N>A | p.Asp109Asn | p.D109N | Q96AZ6 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-AX-A0J1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
| ISG20 | SNV | Missense_Mutation | rs772920253 | c.329C>T | p.Thr110Met | p.T110M | Q96AZ6 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AX-A1CE-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unspecific | Paclitaxel | SD |
| ISG20 | SNV | Missense_Mutation | novel | c.464N>T | p.Ala155Val | p.A155V | Q96AZ6 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-B5-A3FC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
| ISG20 | SNV | Missense_Mutation | rs760289978 | c.406N>T | p.Arg136Cys | p.R136C | Q96AZ6 | protein_coding | deleterious(0.01) | possibly_damaging(0.882) | TCGA-EY-A549-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
| ISG20 | SNV | Missense_Mutation | novel | c.378N>C | p.Arg126Ser | p.R126S | Q96AZ6 | protein_coding | tolerated(0.52) | benign(0.014) | TCGA-69-8254-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
| Page: 1 |
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