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Gene: IFT20 |
Gene summary for IFT20 |
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Gene information | Species | Human | Gene symbol | IFT20 | Gene ID | 90410 |
Gene name | intraflagellar transport 20 | |
Gene Alias | IFT20 | |
Cytomap | 17q11.2 | |
Gene Type | protein-coding | GO ID | GO:0000003 | UniProtAcc | Q8IY31 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
90410 | IFT20 | GSM4909292 | Human | Breast | IDC | 1.58e-04 | 5.53e-01 | 0.1236 |
90410 | IFT20 | GSM4909293 | Human | Breast | IDC | 2.98e-05 | 2.69e-01 | 0.1581 |
90410 | IFT20 | GSM4909294 | Human | Breast | IDC | 6.27e-25 | 5.65e-01 | 0.2022 |
90410 | IFT20 | GSM4909296 | Human | Breast | IDC | 6.30e-07 | -1.57e-01 | 0.1524 |
90410 | IFT20 | GSM4909297 | Human | Breast | IDC | 2.14e-05 | -9.81e-02 | 0.1517 |
90410 | IFT20 | GSM4909311 | Human | Breast | IDC | 6.55e-19 | -1.77e-01 | 0.1534 |
90410 | IFT20 | GSM4909312 | Human | Breast | IDC | 1.35e-05 | -3.40e-02 | 0.1552 |
90410 | IFT20 | GSM4909313 | Human | Breast | IDC | 2.26e-02 | -6.24e-02 | 0.0391 |
90410 | IFT20 | GSM4909316 | Human | Breast | IDC | 5.34e-07 | 2.15e-01 | 0.21 |
90410 | IFT20 | GSM4909319 | Human | Breast | IDC | 2.82e-23 | -1.31e-01 | 0.1563 |
90410 | IFT20 | GSM4909320 | Human | Breast | IDC | 1.06e-02 | -2.28e-01 | 0.1575 |
90410 | IFT20 | GSM4909321 | Human | Breast | IDC | 5.08e-08 | -1.04e-01 | 0.1559 |
90410 | IFT20 | NCCBC14 | Human | Breast | DCIS | 5.64e-06 | 6.76e-02 | 0.2021 |
90410 | IFT20 | NCCBC5 | Human | Breast | DCIS | 9.16e-15 | 2.05e-01 | 0.2046 |
90410 | IFT20 | P1 | Human | Breast | IDC | 2.96e-10 | -1.01e-01 | 0.1527 |
90410 | IFT20 | DCIS2 | Human | Breast | DCIS | 3.17e-36 | 1.18e-01 | 0.0085 |
90410 | IFT20 | LZE2T | Human | Esophagus | ESCC | 2.79e-02 | 5.09e-01 | 0.082 |
90410 | IFT20 | LZE4T | Human | Esophagus | ESCC | 2.67e-08 | 1.92e-01 | 0.0811 |
90410 | IFT20 | LZE5T | Human | Esophagus | ESCC | 1.83e-02 | 3.22e-01 | 0.0514 |
90410 | IFT20 | LZE7T | Human | Esophagus | ESCC | 5.88e-04 | 1.91e-01 | 0.0667 |
Page: 1 2 3 4 5 6 7 8 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:003070518 | Esophagus | ESCC | cytoskeleton-dependent intracellular transport | 133/8552 | 195/18723 | 1.48e-10 | 4.27e-09 | 133 |
GO:001605517 | Esophagus | ESCC | Wnt signaling pathway | 268/8552 | 444/18723 | 2.32e-10 | 6.58e-09 | 268 |
GO:019873817 | Esophagus | ESCC | cell-cell signaling by wnt | 269/8552 | 446/18723 | 2.41e-10 | 6.79e-09 | 269 |
GO:000716320 | Esophagus | ESCC | establishment or maintenance of cell polarity | 143/8552 | 218/18723 | 2.05e-09 | 4.65e-08 | 143 |
GO:001097013 | Esophagus | ESCC | transport along microtubule | 107/8552 | 155/18723 | 3.17e-09 | 6.80e-08 | 107 |
GO:003150314 | Esophagus | ESCC | protein-containing complex localization | 139/8552 | 220/18723 | 1.14e-07 | 1.85e-06 | 139 |
GO:003001018 | Esophagus | ESCC | establishment of cell polarity | 96/8552 | 143/18723 | 1.69e-07 | 2.67e-06 | 96 |
GO:190503712 | Esophagus | ESCC | autophagosome organization | 73/8552 | 103/18723 | 1.88e-07 | 2.93e-06 | 73 |
GO:003011117 | Esophagus | ESCC | regulation of Wnt signaling pathway | 194/8552 | 328/18723 | 5.39e-07 | 7.14e-06 | 194 |
GO:006007016 | Esophagus | ESCC | canonical Wnt signaling pathway | 180/8552 | 303/18723 | 9.15e-07 | 1.17e-05 | 180 |
GO:000004513 | Esophagus | ESCC | autophagosome assembly | 69/8552 | 99/18723 | 1.10e-06 | 1.38e-05 | 69 |
GO:006082817 | Esophagus | ESCC | regulation of canonical Wnt signaling pathway | 153/8552 | 253/18723 | 1.38e-06 | 1.67e-05 | 153 |
GO:190211514 | Esophagus | ESCC | regulation of organelle assembly | 116/8552 | 186/18723 | 3.15e-06 | 3.53e-05 | 116 |
GO:00618428 | Esophagus | ESCC | microtubule organizing center localization | 28/8552 | 33/18723 | 3.80e-06 | 4.12e-05 | 28 |
GO:00516428 | Esophagus | ESCC | centrosome localization | 27/8552 | 32/18723 | 7.10e-06 | 7.12e-05 | 27 |
GO:00480087 | Esophagus | ESCC | platelet-derived growth factor receptor signaling pathway | 42/8552 | 56/18723 | 7.62e-06 | 7.54e-05 | 42 |
GO:000941611 | Esophagus | ESCC | response to light stimulus | 183/8552 | 320/18723 | 2.03e-05 | 1.76e-04 | 183 |
GO:00017387 | Esophagus | ESCC | morphogenesis of a polarized epithelium | 63/8552 | 94/18723 | 2.34e-05 | 2.00e-04 | 63 |
GO:00991114 | Esophagus | ESCC | microtubule-based transport | 115/8552 | 190/18723 | 2.54e-05 | 2.15e-04 | 115 |
GO:009016216 | Esophagus | ESCC | establishment of epithelial cell polarity | 25/8552 | 31/18723 | 7.13e-05 | 5.38e-04 | 25 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
IFT20 | SNV | Missense_Mutation | c.152N>T | p.Glu51Val | p.E51V | Q8IY31 | protein_coding | deleterious(0.01) | probably_damaging(0.914) | TCGA-E9-A22E-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | cyclophosphane | SD | |
IFT20 | insertion | In_Frame_Ins | novel | c.190_191insTGAAAGGGTCCACGAAGTTGGCTGGCTCTCTGAAAG | p.Lys64delinsMetLysGlySerThrLysLeuAlaGlySerLeuLysGlu | p.K64delinsMKGSTKLAGSLKE | Q8IY31 | protein_coding | TCGA-B6-A0IK-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | PD | ||
IFT20 | SNV | Missense_Mutation | novel | c.247N>T | p.Leu83Phe | p.L83F | Q8IY31 | protein_coding | deleterious(0.01) | possibly_damaging(0.51) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
IFT20 | SNV | Missense_Mutation | c.341N>A | p.Ala114Asp | p.A114D | Q8IY31 | protein_coding | tolerated(0.05) | possibly_damaging(0.857) | TCGA-AP-A051-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
IFT20 | SNV | Missense_Mutation | rs372746932 | c.401N>A | p.Arg134Gln | p.R134Q | Q8IY31 | protein_coding | tolerated(0.11) | benign(0.169) | TCGA-AX-A1CE-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unspecific | Paclitaxel | SD |
IFT20 | SNV | Missense_Mutation | novel | c.80N>C | p.Met27Thr | p.M27T | Q8IY31 | protein_coding | deleterious(0) | benign(0.023) | TCGA-BG-A222-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
IFT20 | SNV | Missense_Mutation | novel | c.81N>A | p.Met27Ile | p.M27I | Q8IY31 | protein_coding | deleterious(0.03) | benign(0.013) | TCGA-86-7954-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Chemotherapy | carboplatin | CR |
IFT20 | SNV | Missense_Mutation | novel | c.281A>G | p.Glu94Gly | p.E94G | Q8IY31 | protein_coding | deleterious(0) | probably_damaging(0.967) | TCGA-MN-A4N4-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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