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Gene: IFITM2 |
Gene summary for IFITM2 |
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Gene information | Species | Human | Gene symbol | IFITM2 | Gene ID | 10581 |
Gene name | interferon induced transmembrane protein 2 | |
Gene Alias | 1-8D | |
Cytomap | 11p15.5 | |
Gene Type | protein-coding | GO ID | GO:0002376 | UniProtAcc | Q01629 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
10581 | IFITM2 | GSM4909285 | Human | Breast | IDC | 2.29e-03 | -2.46e-01 | 0.21 |
10581 | IFITM2 | GSM4909286 | Human | Breast | IDC | 2.31e-20 | -3.74e-01 | 0.1081 |
10581 | IFITM2 | GSM4909287 | Human | Breast | IDC | 5.95e-06 | -2.64e-01 | 0.2057 |
10581 | IFITM2 | GSM4909290 | Human | Breast | IDC | 1.20e-02 | -2.76e-01 | 0.2096 |
10581 | IFITM2 | GSM4909293 | Human | Breast | IDC | 3.16e-03 | -2.29e-01 | 0.1581 |
10581 | IFITM2 | GSM4909294 | Human | Breast | IDC | 8.29e-03 | -1.75e-01 | 0.2022 |
10581 | IFITM2 | GSM4909296 | Human | Breast | IDC | 4.85e-38 | 8.90e-01 | 0.1524 |
10581 | IFITM2 | GSM4909297 | Human | Breast | IDC | 3.83e-13 | 3.70e-01 | 0.1517 |
10581 | IFITM2 | GSM4909299 | Human | Breast | IDC | 6.94e-20 | 6.70e-01 | 0.035 |
10581 | IFITM2 | GSM4909301 | Human | Breast | IDC | 2.59e-32 | 8.02e-01 | 0.1577 |
10581 | IFITM2 | GSM4909302 | Human | Breast | IDC | 9.26e-19 | 6.88e-01 | 0.1545 |
10581 | IFITM2 | GSM4909305 | Human | Breast | IDC | 1.98e-05 | 4.36e-01 | 0.0436 |
10581 | IFITM2 | GSM4909306 | Human | Breast | IDC | 2.84e-16 | 5.80e-01 | 0.1564 |
10581 | IFITM2 | GSM4909307 | Human | Breast | IDC | 7.54e-28 | 7.26e-01 | 0.1569 |
10581 | IFITM2 | GSM4909308 | Human | Breast | IDC | 3.11e-22 | 6.56e-01 | 0.158 |
10581 | IFITM2 | GSM4909311 | Human | Breast | IDC | 1.92e-28 | 2.20e-01 | 0.1534 |
10581 | IFITM2 | GSM4909312 | Human | Breast | IDC | 8.55e-11 | 2.78e-01 | 0.1552 |
10581 | IFITM2 | GSM4909315 | Human | Breast | IDC | 1.55e-16 | -3.59e-01 | 0.21 |
10581 | IFITM2 | GSM4909316 | Human | Breast | IDC | 1.59e-03 | -3.29e-01 | 0.21 |
10581 | IFITM2 | GSM4909319 | Human | Breast | IDC | 4.67e-45 | 5.54e-01 | 0.1563 |
Page: 1 2 3 4 5 6 7 8 9 10 11 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:001905824 | Breast | DCIS | viral life cycle | 59/1390 | 317/18723 | 4.05e-11 | 5.74e-09 | 59 |
GO:001907923 | Breast | DCIS | viral genome replication | 30/1390 | 131/18723 | 2.12e-08 | 1.45e-06 | 30 |
GO:005079222 | Breast | DCIS | regulation of viral process | 34/1390 | 164/18723 | 3.58e-08 | 2.30e-06 | 34 |
GO:004440323 | Breast | DCIS | biological process involved in symbiotic interaction | 49/1390 | 290/18723 | 4.70e-08 | 2.89e-06 | 49 |
GO:190390022 | Breast | DCIS | regulation of viral life cycle | 28/1390 | 148/18723 | 3.79e-06 | 1.16e-04 | 28 |
GO:005212624 | Breast | DCIS | movement in host environment | 31/1390 | 175/18723 | 4.93e-06 | 1.45e-04 | 31 |
GO:005170124 | Breast | DCIS | biological process involved in interaction with host | 34/1390 | 203/18723 | 6.30e-06 | 1.78e-04 | 34 |
GO:004440924 | Breast | DCIS | entry into host | 27/1390 | 151/18723 | 1.65e-05 | 4.00e-04 | 27 |
GO:004671824 | Breast | DCIS | viral entry into host cell | 26/1390 | 144/18723 | 1.97e-05 | 4.69e-04 | 26 |
GO:004506923 | Breast | DCIS | regulation of viral genome replication | 18/1390 | 85/18723 | 4.23e-05 | 8.98e-04 | 18 |
GO:000961512 | Breast | DCIS | response to virus | 45/1390 | 367/18723 | 6.16e-04 | 7.82e-03 | 45 |
GO:004390321 | Breast | DCIS | regulation of biological process involved in symbiotic interaction | 14/1390 | 72/18723 | 7.32e-04 | 8.69e-03 | 14 |
GO:005237221 | Breast | DCIS | modulation by symbiont of entry into host | 11/1390 | 49/18723 | 7.63e-04 | 8.95e-03 | 11 |
GO:004659621 | Breast | DCIS | regulation of viral entry into host cell | 10/1390 | 42/18723 | 8.06e-04 | 9.27e-03 | 10 |
GO:190390121 | Breast | DCIS | negative regulation of viral life cycle | 7/1390 | 25/18723 | 1.79e-03 | 1.73e-02 | 7 |
GO:00354561 | Breast | DCIS | response to interferon-beta | 8/1390 | 32/18723 | 1.90e-03 | 1.81e-02 | 8 |
GO:004852521 | Breast | DCIS | negative regulation of viral process | 15/1390 | 92/18723 | 3.07e-03 | 2.61e-02 | 15 |
GO:003545511 | Breast | DCIS | response to interferon-alpha | 6/1390 | 21/18723 | 3.40e-03 | 2.85e-02 | 6 |
GO:003434111 | Breast | DCIS | response to interferon-gamma | 20/1390 | 141/18723 | 3.83e-03 | 3.05e-02 | 20 |
GO:0035458 | Breast | DCIS | cellular response to interferon-beta | 6/1390 | 24/18723 | 6.97e-03 | 4.78e-02 | 6 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
IFITM2 | SNV | Missense_Mutation | novel | c.10N>T | p.Ile4Phe | p.I4F | Q01629 | protein_coding | deleterious(0.01) | benign(0.045) | TCGA-A2-A4RW-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
IFITM2 | SNV | Missense_Mutation | novel | c.131N>C | p.Val44Ala | p.V44A | Q01629 | protein_coding | deleterious(0.01) | possibly_damaging(0.816) | TCGA-D8-A1XA-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
IFITM2 | SNV | Missense_Mutation | c.24N>A | p.Phe8Leu | p.F8L | Q01629 | protein_coding | deleterious(0.02) | probably_damaging(0.997) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
IFITM2 | SNV | Missense_Mutation | rs530463865 | c.346N>G | p.Met116Val | p.M116V | Q01629 | protein_coding | tolerated(0.36) | benign(0.007) | TCGA-A5-A0GA-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Chemotherapy | taxol | PD |
IFITM2 | SNV | Missense_Mutation | novel | c.63N>A | p.Met21Ile | p.M21I | Q01629 | protein_coding | tolerated(0.05) | benign(0.005) | TCGA-AX-A1CE-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unspecific | Paclitaxel | SD |
IFITM2 | SNV | Missense_Mutation | novel | c.226N>A | p.Ala76Thr | p.A76T | Q01629 | protein_coding | deleterious(0.02) | possibly_damaging(0.702) | TCGA-AX-A1CE-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unspecific | Paclitaxel | SD |
IFITM2 | SNV | Missense_Mutation | novel | c.272N>G | p.Asp91Gly | p.D91G | Q01629 | protein_coding | deleterious(0.01) | possibly_damaging(0.61) | TCGA-DF-A2KU-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | Unknown | I/II | Unknown | Unknown | SD |
IFITM2 | SNV | Missense_Mutation | rs371736596 | c.50N>T | p.Pro17Leu | p.P17L | Q01629 | protein_coding | deleterious(0.05) | benign(0.018) | TCGA-55-6985-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
IFITM2 | SNV | Missense_Mutation | c.103N>A | p.His35Asn | p.H35N | Q01629 | protein_coding | tolerated(0.11) | possibly_damaging(0.71) | TCGA-22-5472-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Chemotherapy | carboplatin | PD | |
IFITM2 | SNV | Missense_Mutation | c.112G>T | p.Ala38Ser | p.A38S | Q01629 | protein_coding | deleterious(0.03) | possibly_damaging(0.489) | TCGA-CD-8536-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Chemotherapy | epirubicin | CR |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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