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Gene: HUS1 |
Gene summary for HUS1 |
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Gene information | Species | Human | Gene symbol | HUS1 | Gene ID | 3364 |
Gene name | HUS1 checkpoint clamp component | |
Gene Alias | hHUS1 | |
Cytomap | 7p12.3 | |
Gene Type | protein-coding | GO ID | GO:0000003 | UniProtAcc | A4D2F2 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
3364 | HUS1 | LZE4T | Human | Esophagus | ESCC | 3.17e-13 | 4.38e-01 | 0.0811 |
3364 | HUS1 | LZE5T | Human | Esophagus | ESCC | 4.01e-03 | 2.48e-01 | 0.0514 |
3364 | HUS1 | LZE7T | Human | Esophagus | ESCC | 4.11e-06 | 2.58e-01 | 0.0667 |
3364 | HUS1 | LZE24T | Human | Esophagus | ESCC | 6.44e-08 | 2.25e-01 | 0.0596 |
3364 | HUS1 | LZE6T | Human | Esophagus | ESCC | 4.42e-04 | 3.23e-01 | 0.0845 |
3364 | HUS1 | P1T-E | Human | Esophagus | ESCC | 1.09e-04 | 2.35e-01 | 0.0875 |
3364 | HUS1 | P2T-E | Human | Esophagus | ESCC | 1.65e-23 | 3.18e-01 | 0.1177 |
3364 | HUS1 | P4T-E | Human | Esophagus | ESCC | 1.91e-17 | 5.00e-01 | 0.1323 |
3364 | HUS1 | P5T-E | Human | Esophagus | ESCC | 3.76e-16 | 2.36e-01 | 0.1327 |
3364 | HUS1 | P8T-E | Human | Esophagus | ESCC | 2.64e-05 | 1.19e-01 | 0.0889 |
3364 | HUS1 | P9T-E | Human | Esophagus | ESCC | 3.13e-13 | 4.13e-01 | 0.1131 |
3364 | HUS1 | P10T-E | Human | Esophagus | ESCC | 4.15e-25 | 4.10e-01 | 0.116 |
3364 | HUS1 | P11T-E | Human | Esophagus | ESCC | 6.30e-14 | 5.92e-01 | 0.1426 |
3364 | HUS1 | P12T-E | Human | Esophagus | ESCC | 6.33e-19 | 2.56e-01 | 0.1122 |
3364 | HUS1 | P15T-E | Human | Esophagus | ESCC | 1.88e-26 | 6.26e-01 | 0.1149 |
3364 | HUS1 | P16T-E | Human | Esophagus | ESCC | 1.83e-16 | 3.41e-01 | 0.1153 |
3364 | HUS1 | P17T-E | Human | Esophagus | ESCC | 1.13e-03 | 3.69e-01 | 0.1278 |
3364 | HUS1 | P20T-E | Human | Esophagus | ESCC | 1.97e-17 | 2.36e-01 | 0.1124 |
3364 | HUS1 | P21T-E | Human | Esophagus | ESCC | 6.84e-22 | 4.02e-01 | 0.1617 |
3364 | HUS1 | P22T-E | Human | Esophagus | ESCC | 3.17e-19 | 2.86e-01 | 0.1236 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:000072311 | Liver | HCC | telomere maintenance | 85/7958 | 131/18723 | 1.86e-07 | 3.40e-06 | 85 |
GO:007121421 | Liver | HCC | cellular response to abiotic stimulus | 183/7958 | 331/18723 | 1.59e-06 | 2.26e-05 | 183 |
GO:010400421 | Liver | HCC | cellular response to environmental stimulus | 183/7958 | 331/18723 | 1.59e-06 | 2.26e-05 | 183 |
GO:19019901 | Liver | HCC | regulation of mitotic cell cycle phase transition | 167/7958 | 299/18723 | 1.96e-06 | 2.71e-05 | 167 |
GO:19019871 | Liver | HCC | regulation of cell cycle phase transition | 211/7958 | 390/18723 | 2.11e-06 | 2.89e-05 | 211 |
GO:00427702 | Liver | HCC | signal transduction in response to DNA damage | 103/7958 | 172/18723 | 3.05e-06 | 4.04e-05 | 103 |
GO:00000751 | Liver | HCC | cell cycle checkpoint | 100/7958 | 169/18723 | 8.75e-06 | 1.02e-04 | 100 |
GO:001021221 | Liver | HCC | response to ionizing radiation | 89/7958 | 148/18723 | 1.10e-05 | 1.26e-04 | 89 |
GO:0045786 | Liver | HCC | negative regulation of cell cycle | 204/7958 | 385/18723 | 1.84e-05 | 1.99e-04 | 204 |
GO:0045930 | Liver | HCC | negative regulation of mitotic cell cycle | 130/7958 | 235/18723 | 4.69e-05 | 4.50e-04 | 130 |
GO:0007093 | Liver | HCC | mitotic cell cycle checkpoint | 77/7958 | 129/18723 | 6.00e-05 | 5.50e-04 | 77 |
GO:007147921 | Liver | HCC | cellular response to ionizing radiation | 47/7958 | 72/18723 | 7.95e-05 | 7.07e-04 | 47 |
GO:00714782 | Liver | HCC | cellular response to radiation | 104/7958 | 186/18723 | 1.48e-04 | 1.19e-03 | 104 |
GO:00000771 | Liver | HCC | DNA damage checkpoint | 68/7958 | 115/18723 | 2.33e-04 | 1.77e-03 | 68 |
GO:0009411 | Liver | HCC | response to UV | 85/7958 | 149/18723 | 2.34e-04 | 1.77e-03 | 85 |
GO:0031570 | Liver | HCC | DNA integrity checkpoint | 71/7958 | 123/18723 | 4.64e-04 | 3.08e-03 | 71 |
GO:1901988 | Liver | HCC | negative regulation of cell cycle phase transition | 132/7958 | 249/18723 | 4.97e-04 | 3.25e-03 | 132 |
GO:0010948 | Liver | HCC | negative regulation of cell cycle process | 152/7958 | 294/18723 | 8.50e-04 | 5.08e-03 | 152 |
GO:1901991 | Liver | HCC | negative regulation of mitotic cell cycle phase transition | 97/7958 | 179/18723 | 1.03e-03 | 5.91e-03 | 97 |
GO:00063021 | Liver | HCC | double-strand break repair | 131/7958 | 251/18723 | 1.17e-03 | 6.54e-03 | 131 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0421829 | Esophagus | ESCC | Cellular senescence | 119/4205 | 156/8465 | 5.89e-12 | 9.40e-11 | 4.81e-11 | 119 |
hsa0421838 | Esophagus | ESCC | Cellular senescence | 119/4205 | 156/8465 | 5.89e-12 | 9.40e-11 | 4.81e-11 | 119 |
hsa0421822 | Liver | HCC | Cellular senescence | 102/4020 | 156/8465 | 4.18e-06 | 3.59e-05 | 2.00e-05 | 102 |
hsa0421832 | Liver | HCC | Cellular senescence | 102/4020 | 156/8465 | 4.18e-06 | 3.59e-05 | 2.00e-05 | 102 |
hsa0421820 | Oral cavity | OSCC | Cellular senescence | 112/3704 | 156/8465 | 8.04e-13 | 1.42e-11 | 7.21e-12 | 112 |
hsa04218110 | Oral cavity | OSCC | Cellular senescence | 112/3704 | 156/8465 | 8.04e-13 | 1.42e-11 | 7.21e-12 | 112 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
HUS1 | SNV | Missense_Mutation | c.232G>A | p.Glu78Lys | p.E78K | O60921 | protein_coding | deleterious(0.01) | benign(0.395) | TCGA-BH-A208-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
HUS1 | insertion | Frame_Shift_Ins | novel | c.688_689insAACAATTTCTCATTGATGTTGTGAAAATCGTCATGTATTTAGA | p.Val230GlufsTer20 | p.V230Efs*20 | O60921 | protein_coding | TCGA-BH-A0HF-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | arimidex | SD | ||
HUS1 | SNV | Missense_Mutation | c.183N>T | p.Glu61Asp | p.E61D | O60921 | protein_coding | tolerated(0.51) | benign(0.068) | TCGA-AA-3510-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
HUS1 | SNV | Missense_Mutation | c.501G>T | p.Lys167Asn | p.K167N | O60921 | protein_coding | deleterious(0) | probably_damaging(0.974) | TCGA-AA-3713-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | 5-fluorouracil | PR | |
HUS1 | SNV | Missense_Mutation | c.667N>C | p.Asn223His | p.N223H | O60921 | protein_coding | tolerated(0.13) | benign(0.003) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR | |
HUS1 | SNV | Missense_Mutation | rs779721301 | c.341C>T | p.Thr114Met | p.T114M | O60921 | protein_coding | deleterious(0.01) | probably_damaging(0.987) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
HUS1 | SNV | Missense_Mutation | c.416N>A | p.Pro139His | p.P139H | O60921 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AP-A059-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
HUS1 | SNV | Missense_Mutation | rs779721301 | c.341N>T | p.Thr114Met | p.T114M | O60921 | protein_coding | deleterious(0.01) | probably_damaging(0.987) | TCGA-AP-A1DK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
HUS1 | SNV | Missense_Mutation | novel | c.265N>C | p.Ser89Pro | p.S89P | O60921 | protein_coding | tolerated(0.19) | possibly_damaging(0.747) | TCGA-AX-A2HD-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
HUS1 | SNV | Missense_Mutation | c.192N>A | p.Phe64Leu | p.F64L | O60921 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-B5-A0JY-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | doxorubicin | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
3364 | HUS1 | DNA REPAIR, KINASE | CAMPTOTHECIN | CAMPTOTHECIN | 14762204 |
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